{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:58:27Z","timestamp":1785513507047,"version":"3.56.0"},"reference-count":40,"publisher":"Mattioli1885","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction: Mortality data in patients with acquired perforating dermatosis (APD) are limited. Objectives: To assess, for the first time, the risk of all-cause mortality in adult patients with APD and to explore associated systemic comorbidities. Methods: This retrospective multicenter case-control study included adult patients diagnosed with APD and age-, sex-, and year-matched controls. We evaluated overall survival and the prevalence of seven major comorbidities: systemic malignancy, chronic obstructive pulmonary disease (COPD), severe liver disease, diabetes mellitus, arterial disease, hypertension, and dyslipidemia. Statistical analyses included univariate comparisons (Fisher\u2019s exact test and logistic regression), Kaplan\u2013Meier survival estimates with log-rank tests, and multivariate Cox proportional hazards models. Results: Fifty-one patients with APD and 102 controls (1:2 ratio) were finally included in this investigation. Patients with APD had a significantly increased risk of mortality compared to controls (log-rank test, P&lt;0.001). In the multivariate Cox regression analysis, arterial disease emerged as the sole independent predictor of mortality (adjusted hazard ratio [HR]:7.716; 95% confidence interval [CI]: 2.774\u201321.464; P&lt;0.001). Conclusions: This is the first study to identify a potential association between APD and increased all-cause mortality, primarily driven by coexisting arterial disease. These findings highlight the importance of comprehensive management in APD patients and emphasize the dermatologist\u2019s role in multidisciplinary care aimed at improving long-term outcomes.<\/jats:p>","DOI":"10.5826\/dpc.1603a6672","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:08:02Z","timestamp":1785510482000},"page":"6672","source":"Crossref","is-referenced-by-count":0,"title":["Mortality in Patients with Acquired Perforating Dermatosis: Results from the First Multicenter Case-Control Study"],"prefix":"10.5826","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4519-4817","authenticated-orcid":false,"given":"Sebasti\u00e1n","family":"Reyes-Garc\u00eda","sequence":"first","affiliation":[{"name":"Dermatology Department, Hospital Universitario Central de Asturias, University of Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5789-9198","authenticated-orcid":false,"given":"Francisco","family":"V\u00e1zquez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario Central de Asturias, University of Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0274-2863","authenticated-orcid":false,"given":"Cristina","family":"Galache-Osuna","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario Central de Asturias, University of Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1940-4884","authenticated-orcid":false,"given":"Blanca","family":"Vivanco-Allende","sequence":"additional","affiliation":[{"name":"Pathology Department, Hospital Universitario Central de Asturias, University of Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1695-9203","authenticated-orcid":false,"given":"Carmen","family":"Gonz\u00e1lez-Vela","sequence":"additional","affiliation":[{"name":"Pathology Department, Hospital Universitario Marqu\u00e9s de Valdecilla, Cantabria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Santos-Juanes","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario Central de Asturias, University of Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2423-5800","authenticated-orcid":false,"given":"Marcos","family":"Gonz\u00e1lez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"GRIDER - Dermatology Investigation Group of Asturias, University of Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27750","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"10.5826\/dpc.1603a6672_ref1","doi-asserted-by":"crossref","unstructured":"Kawakami T, Akiyama M, Ishida\u2010Yamamoto A, et al. 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