{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:58:58Z","timestamp":1785513538325,"version":"3.56.0"},"reference-count":18,"publisher":"Mattioli1885","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction: Livedoid vasculopathy is a relatively uncommon chronic, recurrent occlusive vascular disorder. Previous reports on this condition have largely been based on small retrospective studies. Objectives: To analyze epidemiological patterns, clinical manifestations, histopathological features, laboratory parameters, therapeutic interventions, and prognostic outcomes of Chinese patients with livedoid vasculopathy. Methods: Patients with livedoid vasculopathy diagnosed in a single dermatology center between January 2010 and October 2022 were included for retrospective analysis. Results: A total of 358 patients were included in the study. A female predominance was observed (male-to-female ratio 1:2.4). The mean age at onset was 28.0 \u00b1 15.4 years (median: 23 years), with the highest proportion of patients (149\/358, 41.6%) developing symptom onset before age 20 years. The common alternate clinical diagnoses were allergic vasculitis and Henoch-Sch\u00f6nlein purpura. Disease exacerbation during summer occurred in 82.4% (150\/183) of patients. Beyond classic symptoms, atypical presentations included pigmented purpuric dermatosis-like lesions (64\/358, 17.9%) and stasis dermatitis-like lesions (12\/358, 3.4%). Of a total of 409 treatment episodes,\u00a070.7% involved anticoagulation therapy, both as a monotherapy and in combination regimens. During follow-up, 62.3% (147\/236) of patients experienced recurrences within two years. Conclusions: At our center, livedoid vasculopathy is not uncommon, and affected patients exhibit a substantially younger age at onset. Certain livedoid vasculopathy cases demonstrate atypical clinical presentations, such as pigmented purpuric dermatosis-like lesions or stasis dermatitis-like lesions. In our cohort, the primary therapeutic approaches consist of anticoagulation therapy alone or in combination with other medications. However, these strategies are associated with a high recurrence rate.<\/jats:p>","DOI":"10.5826\/dpc.1603a6930","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:08:08Z","timestamp":1785510488000},"page":"6930","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Features and Therapeutic Outcomes of Livedoid Vasculopathy: A Retrospective Study of 358 Chinese Patients"],"prefix":"10.5826","volume":"16","author":[{"given":"Fazhan","family":"Ban","sequence":"first","affiliation":[{"name":"Department of Dermatology, Xijing Hospital, The Fourth Military Medical University, Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xijing Hospital, The Fourth Military Medical University, Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daopei","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xijing Hospital, The Fourth Military Medical University, Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xijing Hospital, The Fourth Military Medical University, Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xijing Hospital, The Fourth Military Medical University, Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xijing Hospital, The Fourth Military Medical University, Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xijing Hospital, The Fourth Military Medical University, Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27750","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"10.5826\/dpc.1603a6930_ref1","doi-asserted-by":"crossref","unstructured":"Criado PR, Rivitti EA, Sotto MN, et al. 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