{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:59:02Z","timestamp":1785513542143,"version":"3.56.0"},"reference-count":23,"publisher":"Mattioli1885","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction: Chronic spontaneous urticaria (CSU) is often a psychophysiological comorbidity. Depression is believed to both cause and sustain CSU. Objectives: We aimed to investigate the severity of depression in patients with CSU and the impact of CSU on quality of life. Methods: We enrolled 150 CSU and 75 healthy controls. We calculated the disease activity with Urticaria Activity Score 7 (UAS7) and divided the chronic urticaria patients into two groups as mild-moderate CSU (N=75) and severe CSU (N=75). We used the Patient Health Questionnaire-9 (PHQ-9) to measure the severity of depression in all patients and the Dermatology Life Quality Index (DLQI) to measure the quality of life in 150 CSU patients. Results: Significant main effects were observed for disease severity (P&lt;0.001) and sex (P&lt;0.001) on rank-transformed DLQI scores and PHQ-9 scores. Patients with severe CSU had substantially higher adjusted rank-transformed DLQI and PHQ-9 scores than those with mild\u2013moderate CSU (P&lt;0.001). Similarly, females exhibited higher rank-transformed DLQI and PHQ-9 scores compared to males (P&lt;0.001). Among covariates, disease duration exerted a strong positive effect on rank-transformed DLQI and PHQ-9 scores (P&lt;0.001). Additionally, the presence of angioedema was associated with increased depressive symptoms (P=0.042), whereas allergic comorbidities had a minor protective effect (P=0.001). Conclusion: This multicenter study demonstrated that disease severity and duration are the primary determinants of elevated rank-transformed DLQI and PHQ-9 scores in patients with chronic spontaneous urticaria, while female sex contributes a modest but significant effect.<\/jats:p>","DOI":"10.5826\/dpc.1603a7067","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:08:37Z","timestamp":1785510517000},"page":"7067","source":"Crossref","is-referenced-by-count":0,"title":["Associations of Disease Activity, Depression Severity, and Quality of Life in Chronic Spontaneous Urticaria"],"prefix":"10.5826","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5304-382X","authenticated-orcid":false,"given":"Tuba","family":"Vural","sequence":"first","affiliation":[{"name":"Isparta City Hospital, Immunology and Allergy Diseases Clinic, Isparta, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4784-2833","authenticated-orcid":false,"given":"Hacer","family":"Vural Karatoprak","sequence":"first","affiliation":[{"name":"Sehit Yunus Emre State Hospital, Dermatology and Venereal Diseases Clinic, Isparta, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27750","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"10.5826\/dpc.1603a7067_ref1","doi-asserted-by":"crossref","unstructured":"Zuberbier T, Aberer W, Asero R, et al. 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