{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:58:29Z","timestamp":1785513509375,"version":"3.56.0"},"reference-count":41,"publisher":"Mattioli1885","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction: Seborrheic dermatitis (SD) is a chronic inflammatory dermatosis with multifactorial pathogenesis. Cytokines such as IL-18 and IL-22 are implicated in inflammatory and stress-related pathways, but their roles in SD remain unclear. Objectives: To investigate serum IL-18 and IL-22 levels in SD patients, evaluate their relationship with disease severity and perceived stress, and explore their potential relevance to SD pathophysiology. Methods: In this cross-sectional study, 46 SD patients and 42 healthy controls were included. Disease severity was assessed using the Seborrheic Dermatitis Area Severity Index, and stress with the Perceived Stress Scale-10. Serum cytokine levels were measured by ELISA. Group comparisons and correlation analyses between cytokines, disease severity, and stress were performed. Results: Patients had significantly higher stress scores than controls (mean 19.8 \u00b1 4.6 vs 13.7 \u00b1 4.2). Serum IL-22 levels were elevated in SD (median 369.3 vs 143.1 pg\/mL; P&lt;0.001). A cutoff of 202.8 pg\/mL for IL-22 distinguished patients from controls, with 100% sensitivity and 97.6% specificity. IL-18 levels did not differ significantly between groups. IL-18 and IL-22 showed a moderate negative correlation (r=\u22120.409; P=0.005). Stress scores correlated positively with disease severity (r=0.336; P=0.022), and IL-22 correlated with stress across all participants (r=0.541; P&lt;0.001). Conclusions: Elevated serum IL-22 levels observed in patients with SD suggest a possible involvement of IL-22 in SD-related inflammatory processes. The observed associations between IL-22 and perceived stress support a potential interaction between immunological and psychosocial factors in SD. These findings should be considered exploratory and warrant confirmation in larger studies.<\/jats:p>","DOI":"10.5826\/dpc.1603a7150","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:08:27Z","timestamp":1785510507000},"page":"7150","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation Of Stress, IL-18, And IL-22 Levels And Their Interrelationships In Patients With Seborrheic Dermatitis"],"prefix":"10.5826","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5241-4975","authenticated-orcid":false,"given":"L\u00fctfi","family":"I\u015f\u0131k","sequence":"first","affiliation":[{"name":"Usak University Faculty of Medicine Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1914-2175","authenticated-orcid":false,"given":"M\u00fczeyyen","family":"G\u00f6n\u00fcl","sequence":"first","affiliation":[{"name":"Ankara Etlik City Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7310-8635","authenticated-orcid":false,"given":"Selda Pelin","family":"Kartal","sequence":"first","affiliation":[{"name":"Ankara Etlik City Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5929-9199","authenticated-orcid":false,"given":"Funda","family":"G\u00fc\u00e7el","sequence":"first","affiliation":[{"name":"Ankara Etlik City Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27750","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"10.5826\/dpc.1603a7150_ref1","doi-asserted-by":"crossref","unstructured":"Park SY, Kwon HH, Min S, Yoon JY, Suh DH. 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