{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:52:01Z","timestamp":1785851521471,"version":"3.56.0"},"reference-count":68,"publisher":"Mattioli1885","issue":"Vol. 21 (2026)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:p>Subglottic stenosis (SGS) is a chronic fibroinflammatory condition that causes pathological narrowing of the airway between the vocal cords and the trachea, with symptoms ranging from dyspnea to stridor and respiratory failure. The causes are heterogeneous: traumatic iatrogenic forms (such as prolonged intubation), autoimmune (e.g., granulomatosis with polyangiitis), post-viral (including COATS related to COVID-19), and idiopathic (iSGS), the latter affecting primarily adult Caucasian women with no obvious predisposing factors. All forms share a common pathogenetic core: epithelial damage, immune activation, chronic inflammation, and progressive fibrosis. Recent molecular studies, however, reveal that different variants of SGS exhibit distinct biological signatures, suggesting the existence of molecular subtypes with differentiated clinical courses. The emerging approach therefore aims for a biomarker-based classification for precision medicine. Future treatments may include targeted immunotherapies (e.g., IL-17A\/IL-23 inhibitors), anti-fibrotic drugs, and epithelial regeneration strategies, alongside current surgical techniques to improve long-term prognosis.<\/jats:p>","DOI":"10.5826\/mrm.2026.1076","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:23:56Z","timestamp":1785849836000},"page":"1076","source":"Crossref","is-referenced-by-count":0,"title":["Exploring pathogenetic mechanisms in subglottic stenosis: A narrative\u00a0review toward an integrated molecular classification"],"prefix":"10.5826","volume":"21","author":[{"given":"Serafina","family":"Martella","sequence":"first","affiliation":[{"name":"Respiratory Medicine Unit, Policlinico \"G. Rodolico-San Marco\" University Hospital, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Cusumano","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Unit, Policlinico-San Marco Hospital, University of Catania, Catania, Italy; Department of General Surgery and Medical Surgical Specialties (CHIRMED), University of Catania, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giusi","family":"Bond\u00ec","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Unit, Policlinico-San Marco Hospital, University of Catania, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"La Via","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Medical Surgical Specialties (CHIRMED), University of Catania, Catania, Italy; Department of Anaesthesia and Intensive Care, University Hospital Policlinico \"G. Rodolico-San Marco\", Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Fruciano","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Muscato","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Unit, Policlinico \"G. Rodolico-San Marco\" University Hospital, Catania, Italy; Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Vancheri","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Unit, Policlinico \"G. 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Idiopathic subglottic and tracheal stenosis: a survey of the patient experience. Ann Otol Rhinol Laryngol 2015;124(9):734-9. doi: 10.1177\/0003489415582255","DOI":"10.1177\/0003489415582255"},{"key":"10.5826\/mrm.2026.1076_ref3","doi-asserted-by":"crossref","unstructured":"3. Gelbard A, Francis DO, Sandulache VC, Simmons JC, Donovan DT, Ongkasuwan J. Causes and consequences of adult laryngotracheal stenosis. Laryngoscope 2015;125(5) :1137-43. doi: 10.1002\/lary.24956","DOI":"10.1002\/lary.24956"},{"key":"10.5826\/mrm.2026.1076_ref4","doi-asserted-by":"crossref","unstructured":"4. Gelbard A, Donovan DT, Ongkasuwan J, Nouraei SA, Sandhu G, Benninger MS, et al. Disease homogeneity and treatment heterogeneity in idiopathic subglottic stenosis. Laryngoscope 2016;126(6):1390-6. doi: 10.1002 \/lary.25708","DOI":"10.1002\/lary.25708"},{"key":"10.5826\/mrm.2026.1076_ref5","doi-asserted-by":"crossref","unstructured":"5. Gelbard A, Anderson C, Berry LD, Amin MR, Benninger MS, Blumin JH, et al. Comparative treatment outcomes for patients with idiopathic subglottic stenosis. JAMA Otolaryngol Head Neck Surg 2020;146(1):20-9. doi: 10.1001\/jamaoto.2019.3022","DOI":"10.1001\/jamaoto.2019.3022"},{"key":"10.5826\/mrm.2026.1076_ref6","doi-asserted-by":"crossref","unstructured":"6. Daniero JJ, Ekbom DC, Gelbard A, Akst LM, Hillel AT. Inaugural symposium on advanced surgical techniques in adult airway reconstruction: proceedings of the North American Airway Collaborative (NoAAC). JAMA Otolaryngol Head Neck Surg 2017;143(6):609-13. doi: 10.1001\/jamaoto.2016.4126","DOI":"10.1001\/jamaoto.2016.4126"},{"key":"10.5826\/mrm.2026.1076_ref7","doi-asserted-by":"crossref","unstructured":"7. Camelo A, Dunmore R, Sleeman MA, Clarke DL. The epithelium in idiopathic pulmonary fibrosis: breaking the barrier. Front Pharmacol 2014;4(1):173. doi: 10.3389\/fphar .2013.00173","DOI":"10.3389\/fphar.2013.00173"},{"key":"10.5826\/mrm.2026.1076_ref8","doi-asserted-by":"crossref","unstructured":"8. Aghapour M, Raee P, Moghaddam SJ, Hiemstra PS, Heijink IH. Airway epithelial barrier dysfunction in chronic obstructive pulmonary disease: role of cigarette smoke exposure. Am J Respir Cell Mol Biol 2018;58(2):157-69. doi: 10.1165\/rcmb.2017-0200TR","DOI":"10.1165\/rcmb.2017-0200TR"},{"key":"10.5826\/mrm.2026.1076_ref9","doi-asserted-by":"crossref","unstructured":"9. Lina IA, Tsai HW, Berges AJ, Ospino RA, Davis RJ, Motz KM, et al. Phenotypic epithelial changes in laryngotracheal stenosis. Laryngoscope 2022;132(11):2194-201. doi: 10.1002\/lary.30040","DOI":"10.1002\/lary.30040"},{"key":"10.5826\/mrm.2026.1076_ref10","doi-asserted-by":"crossref","unstructured":"10. Li LF, Kao KC, Liu YY, Lin CW, Chen NH, Lee CS, et al. Nintedanib reduces ventilation-augmented bleomycin- induced epithelial-mesenchymal transition and lung fibrosis through suppression of the Src pathway. J Cell Mol Med 2017;21(11):2937-49. doi: 10.1111\/jcmm.13206","DOI":"10.1111\/jcmm.13206"},{"key":"10.5826\/mrm.2026.1076_ref11","doi-asserted-by":"crossref","unstructured":"11. Zou J, Li Y, Yu J, Dong L, Husain AN, Shen L, et al. Idiopathic pulmonary fibrosis is associated with tight junction protein alterations. Biochim Biophys Acta Biomembr 2020;1862(5):183205. doi: 10.1016\/j.bbamem .2020.183205","DOI":"10.1016\/j.bbamem.2020.183205"},{"key":"10.5826\/mrm.2026.1076_ref12","doi-asserted-by":"crossref","unstructured":"12. Berges AJ, Ospino R, Mafla L, Collins S, Chan-Li Y, Ghosh B, et al. Dysfunctional epithelial barrier is characterized by reduced E-cadherin in idiopathic subglottic stenosis. Laryngoscope 2024;134(1):374-81. doi: 10.1002 \/lary.30951","DOI":"10.1002\/lary.30951"},{"key":"10.5826\/mrm.2026.1076_ref13","doi-asserted-by":"crossref","unstructured":"13. Ying S, Zeng PYF, Fung K, Khan H, Cecchini MJ, Woo E, et al. Transcriptomic features of recurrence rates in idiopathic subglottic stenosis. Laryngoscope 2025 ;135(9):3273-9. doi: 10.1002\/lary.32214","DOI":"10.1002\/lary.32214"},{"key":"10.5826\/mrm.2026.1076_ref14","doi-asserted-by":"crossref","unstructured":"14. Gelbard A, Shilts MH, Strickland B, Motz K, Tsai HW, Boone H, et al. Idiopathic subglottic stenosis arises at the epithelial interface of host and pathogen. Res Sq [Preprint] 2023:rs.3.rs-2945067. doi: 10.21203\/rs.3.rs-2945067\/v1","DOI":"10.21203\/rs.3.rs-2945067\/v1"},{"key":"10.5826\/mrm.2026.1076_ref15","doi-asserted-by":"crossref","unstructured":"15. Namba DR, Ma G, Samad I, Ding D, Pandian V, Powell JD, et al. Rapamycin inhibits human laryngotracheal stenosis-derived fibroblast proliferation, metabolism, and function in vitro. Otolaryngol Head Neck Surg 2015;152(5):881-8. doi: 10.1177\/0194599815573708","DOI":"10.1177\/0194599815573708"},{"key":"10.5826\/mrm.2026.1076_ref16","doi-asserted-by":"crossref","unstructured":"16. Motz KM, Lina IA, Samad I, Murphy MK, Duvvuri M, Davis RJ, et al. Sirolimus-eluting airway stent reduces profibrotic Th17 cells and inhibits laryngotracheal stenosis. JCI Insight 2023;8(11):e158456. doi: 10.1172\/jci .insight.158456","DOI":"10.1172\/jci.insight.158456"},{"key":"10.5826\/mrm.2026.1076_ref17","doi-asserted-by":"crossref","unstructured":"17. Simpson CB, White S, McGuff HS. Anti-transforming growth factor beta as a treatment for laryngotracheal stenosis in a canine model. Laryngoscope 2008;118(3): 546-51. doi: 10.1097\/MLG.0b013e31815daf6e","DOI":"10.1097\/MLG.0b013e31815daf6e"},{"key":"10.5826\/mrm.2026.1076_ref18","doi-asserted-by":"crossref","unstructured":"18. Sharif K, Tierney WS, Davis RJ, Wohler E, Sobreira N, Hillel AT, et al. Mapping genetic susceptibility to stenosis in the proximal airway. Laryngoscope 2023;133(11): 3049-56. doi: 10.1002\/lary.30718","DOI":"10.1002\/lary.30718"},{"key":"10.5826\/mrm.2026.1076_ref19","doi-asserted-by":"crossref","unstructured":"19. Zhang C, Wang S, Casal Moura M, Yi ES, Bowen AJ, Specks U, et al. RNA sequencing of idiopathic subglottic stenosis tissues uncovers putative profibrotic mechanisms and identifies a prognostic biomarker. Am J Pathol 2022;192(11):1506-30. doi: 10.1016\/j.ajpath.2022.07.005","DOI":"10.1016\/j.ajpath.2022.07.005"},{"key":"10.5826\/mrm.2026.1076_ref20","doi-asserted-by":"crossref","unstructured":"20. Karagiannidis C, Velehorschi V, Obertrifter B, Macha HN, Linder A, Freitag L. High-level expression of matrix- associated transforming growth factor-beta1 in benign airway stenosis. Chest 2006;129(5):1298-304. doi: 10.1378 \/chest.129.5.1298","DOI":"10.1378\/chest.129.5.1298"},{"key":"10.5826\/mrm.2026.1076_ref21","doi-asserted-by":"crossref","unstructured":"21. Motz KM, Gelbard A. The role of inflammatory cytokines in the development of idiopathic subglottic stenosis. Transl Cancer Res 2020;9(3):2102-7. doi: 10.21037 \/tcr.2019.12.37","DOI":"10.21037\/tcr.2019.12.37"},{"key":"10.5826\/mrm.2026.1076_ref22","doi-asserted-by":"crossref","unstructured":"22. Davis RJ, Hillel AT. Inflammatory pathways in the pathogenesis of iatrogenic laryngotracheal stenosis: what do we know? Transl Cancer Res 2020;9(3):2108-16. doi: 10.21037\/tcr.2020.01.21","DOI":"10.21037\/tcr.2020.01.21"},{"key":"10.5826\/mrm.2026.1076_ref23","doi-asserted-by":"crossref","unstructured":"23. Marchioni A, Tonelli R, Andreani A, Cappiello GF, Fermi M, Trentacosti F, et al. Molecular mechanisms and physiological changes behind benign tracheal and subglottic stenosis in adults. Int J Mol Sci 2022;23(5):2421. doi: 10.3390\/ijms23052421","DOI":"10.3390\/ijms23052421"},{"key":"10.5826\/mrm.2026.1076_ref24","doi-asserted-by":"crossref","unstructured":"24. Fan Z, Zhang L, Wei L, Huang X, Yang M, Xing X. Tracheal microbiome and metabolome profiling in iatrogenic subglottic tracheal stenosis. BMC Pulm Med 2023;23(1):361. doi: 10.1186\/s12890-023-02654-7","DOI":"10.1186\/s12890-023-02654-7"},{"key":"10.5826\/mrm.2026.1076_ref25","doi-asserted-by":"crossref","unstructured":"25. Direder M, Laggner M, Copic D, Klas K, Bormann D, Schweiger T, et al. Transcriptional profiling sheds light on the fibrotic aspects of idiopathic subglottic tracheal stenosis. Front Cell Dev Biol 2024;12(1):1380902. doi: 10.3389\/fcell.2024.1380902","DOI":"10.3389\/fcell.2024.1380902"},{"key":"10.5826\/mrm.2026.1076_ref26","doi-asserted-by":"crossref","unstructured":"26. Lin RJ, Zeng PYF, Fung K, Khan H, Cecchini MJ, Woo E, et al. Cohort-level clinical trajectory and molecular landscape of idiopathic subglottic stenosis for precision laryngology-a study of the Canadian Airways Research (CARE) group. EBioMedicine 2025;114(1):105629. doi: 10.1016\/j.ebiom.2025.105629","DOI":"10.1016\/j.ebiom.2025.105629"},{"key":"10.5826\/mrm.2026.1076_ref27","doi-asserted-by":"crossref","unstructured":"27. Zeng PYF, Lin RJ, Fung K, et al. Canadian Airways Research Group of the Canadian Society of Otolaryngology Collaborative Research Initiative. Cellular blueprint of healthy and diseased human epiglottis and subglottis-a study of the Canadian Airways Research (CARE) group. EBioMedicine 2025;114(1):105631. doi: 10.1016\/j.ebiom .2025.105631","DOI":"10.1016\/j.ebiom.2025.105631"},{"key":"10.5826\/mrm.2026.1076_ref28","doi-asserted-by":"crossref","unstructured":"28. Ghosh A, Malaisrie N, Leahy KP, Singhal S, Einhorn E, Howlett P, et al. Cellular adaptive inflammation mediates airway granulation in a murine model of subglottic stenosis. Otolaryngol Head Neck Surg 2011;144(6):927-33. doi: 10.1177\/0194599810397750","DOI":"10.1177\/0194599810397750"},{"key":"10.5826\/mrm.2026.1076_ref29","doi-asserted-by":"crossref","unstructured":"29. Haft S, Lee JY, Ghosh A, Philiponis G, Malaisrie N, Leahy KP, et al. Inflammatory protein expression in human subglottic stenosis tissue mirrors that in a murine model. Ann Otol Rhinol Laryngol 2014;123(1):65-70. doi: 10.1177\/0003489414521146","DOI":"10.1177\/0003489414521146"},{"key":"10.5826\/mrm.2026.1076_ref30","doi-asserted-by":"crossref","unstructured":"30. Valdez TA, Shapshay SM. Idiopathic subglottic stenosis revisited. Ann Otol Rhinol Laryngol 2002;111(8):690-5. doi: 10.1177\/000348940211100806","DOI":"10.1177\/000348940211100806"},{"key":"10.5826\/mrm.2026.1076_ref31","doi-asserted-by":"crossref","unstructured":"31. Talatala ERR, Clark E, Ye W, Davis RJ, Hillel AT, Collins SL, et al. Localizing hormone receptor expression to cellular compartments in idiopathic subglottic stenosis. Laryngoscope 2023;133(12):3506-11. doi: 10.1002\/lary.30856","DOI":"10.1002\/lary.30856"},{"key":"10.5826\/mrm.2026.1076_ref32","doi-asserted-by":"crossref","unstructured":"32. Martins RS, Weber J, Johnson B, Luo J, Poulikidis K, Latif MJ, et al. Identifying molecular pathophysiology and potential therapeutic options in iatrogenic tracheal stenosis. Biomedicines 2024;12(6):1323. doi: 10.3390 \/biomedicines12061323","DOI":"10.3390\/biomedicines12061323"},{"key":"10.5826\/mrm.2026.1076_ref33","doi-asserted-by":"crossref","unstructured":"33. Boilard E, Nigrovic PA, Larabee K, Watts GF, Coblyn JS, Weinblatt ME, et al. Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. Science 2010;327(5965):580-3. doi: 10.1126 \/science.1181928","DOI":"10.1126\/science.1181928"},{"key":"10.5826\/mrm.2026.1076_ref34","doi-asserted-by":"crossref","unstructured":"34. L\u00e4mmermann T, Afonso PV, Angermann BR, Wang JM, Kastenm\u00fcller W, Parent CA, et al. Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo. Nature 2013;498(7454):371-5. doi: 10.1038\/nature12175","DOI":"10.1038\/nature12175"},{"key":"10.5826\/mrm.2026.1076_ref35","doi-asserted-by":"crossref","unstructured":"35. Gelbard A, Katsantonis NG, Mizuta M, Newcomb D, Rotsinger J, Rousseau B, et al. Idiopathic subglottic stenosis is associated with activation of the inflammatory IL-17A\/IL-23 axis. Laryngoscope 2016;126(11):E356-61. doi: 10.1002\/lary.26098","DOI":"10.1002\/lary.26098"},{"key":"10.5826\/mrm.2026.1076_ref36","doi-asserted-by":"crossref","unstructured":"36. Morrison RJ, Katsantonis NG, Motz KM, Hillel AT, Garrett CG, Netterville JL, et al. Pathologic fibroblasts in idiopathic subglottic stenosis amplify local inflammatory signals. Otolaryngol Head Neck Surg 2019;160(1):107-15. doi: 10.1177\/0194599818803584","DOI":"10.1177\/0194599818803584"},{"key":"10.5826\/mrm.2026.1076_ref37","doi-asserted-by":"crossref","unstructured":"37. Yang IV, Pedersen BS, Rabinovich E, Hennessy CE, Davidson EJ, Murphy E, et al. Relationship of DNA methylation and gene expression in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2014;190(11):1263-72. doi: 10.1164\/rccm.201408-1452OC","DOI":"10.1164\/rccm.201408-1452OC"},{"key":"10.5826\/mrm.2026.1076_ref38","doi-asserted-by":"crossref","unstructured":"38. Robertson KD. DNA methylation and human disease. Nat Rev Genet 2005;6(8):597-610. doi: 10.1038\/nrg1655","DOI":"10.1038\/nrg1655"},{"key":"10.5826\/mrm.2026.1076_ref39","doi-asserted-by":"crossref","unstructured":"39. Magalh\u00e3es M, Tost J, Pineau F, Rivals I, Busato F, Alary N, et al. Dynamic changes of DNA methylation and lung disease in cystic fibrosis: lessons from a monogenic disease. Epigenomics 2018;10(8):1131-45. doi: 10.2217\/epi -2018-0005","DOI":"10.2217\/epi-2018-0005"},{"key":"10.5826\/mrm.2026.1076_ref40","doi-asserted-by":"crossref","unstructured":"40. Jones LR, Greene J, Chen KM, Divine G, Chitale D, Shah V, et al. Biological significance of genome-wide DNA methylation profiles in keloids. Laryngoscope 2017;127(1):70-8. doi: 10.1002\/lary.26063","DOI":"10.1002\/lary.26063"},{"key":"10.5826\/mrm.2026.1076_ref41","doi-asserted-by":"crossref","unstructured":"41. Motz K, Samad I, Yin LX, Murphy MK, Duvvuri M, Ding D, et al. Interferon-\u03b3 treatment of human laryngotracheal stenosis-derived fibroblasts. JAMA Otolaryngol Head Neck Surg 2017;143(11):1134-40. doi: 10.1001 \/jamaoto.2017.0977","DOI":"10.1001\/jamaoto.2017.0977"},{"key":"10.5826\/mrm.2026.1076_ref42","doi-asserted-by":"crossref","unstructured":"42. Hillel AT, Ding D, Samad I, Murphy MK, Motz K. T-helper 2 lymphocyte immunophenotype is associated with iatrogenic laryngotracheal stenosis. Laryngoscope 2019;129(1):177-86. doi: 10.1002\/lary.27321","DOI":"10.1002\/lary.27321"},{"key":"10.5826\/mrm.2026.1076_ref43","doi-asserted-by":"crossref","unstructured":"43. Schoeff SS, Shi X, Young WG, Whited CW, Soni RS, Liu P, et al. Proteomic and genomic methylation signatures of idiopathic subglottic stenosis. Laryngoscope 2021;131(2):E540-6. doi: 10.1002\/lary.28851","DOI":"10.1002\/lary.28851"},{"key":"10.5826\/mrm.2026.1076_ref44","doi-asserted-by":"crossref","unstructured":"44. Jozwik A, Habibi MS, Paras A, Zhu J, Guvenel A, Dhariwal J, et al. RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection. Nat Commun 2015;6(1):10224. doi: 10.1038\/ncomms10224","DOI":"10.1038\/ncomms10224"},{"key":"10.5826\/mrm.2026.1076_ref45","doi-asserted-by":"crossref","unstructured":"45. Feng X, Yu F, He XL, Cheng PP, Niu Q, Zhao LQ, et al. CD8+ tissue-resident memory T cells are essential in bleomycin-induced pulmonary fibrosis. Am J Physiol Cell Physiol 2024;327(5):C1178-91. doi: 10.1152\/ajpcell .00368.2024","DOI":"10.1152\/ajpcell.00368.2024"},{"key":"10.5826\/mrm.2026.1076_ref46","doi-asserted-by":"crossref","unstructured":"46. Zhang N, Bevan MJ. Transforming growth factor-\u03b2 signaling controls the formation and maintenance of gut-resident memory T cells by regulating migration and retention. Immunity 2013;39(4):687-96. doi: 10.1016 \/j.immuni.2013.08.019","DOI":"10.1016\/j.immuni.2013.08.019"},{"key":"10.5826\/mrm.2026.1076_ref47","doi-asserted-by":"crossref","unstructured":"47. Hombrink P, Helbig C, Backer RA, Piet B, Oja AE, Stark R, et al. Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells. Nat Immunol 2016;17(12):1467-78. doi: 10.1038\/ni.3589","DOI":"10.1038\/ni.3589"},{"key":"10.5826\/mrm.2026.1076_ref48","doi-asserted-by":"crossref","unstructured":"48. Gelbard A, Wanjalla C, Wootten CT, Drake WP, Lowery AS, Wheeler DA, et al. The proximal airway is a reservoir for adaptive immunologic memory in idiopathic subglottic stenosis. Laryngoscope 2021;131(3):610-7. doi: 10.1002\/lary.28840","DOI":"10.1002\/lary.28840"},{"key":"10.5826\/mrm.2026.1076_ref49","doi-asserted-by":"crossref","unstructured":"49. Kopf M, Le Gros G, Bachmann M, Lamers MC, Bluethmann H, K\u00f6hler G. Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature 1993;362(6417):245-8. doi: 10.1038\/362245a0","DOI":"10.1038\/362245a0"},{"key":"10.5826\/mrm.2026.1076_ref50","doi-asserted-by":"crossref","unstructured":"50. Huaux F, Liu T, McGarry B, Ullenbruch M, Phan SH. Dual roles of IL-4 in lung injury and fibrosis. J Immunol 2003;170(4):2083-92. doi: 10.4049\/jimmunol.170.4.2083","DOI":"10.4049\/jimmunol.170.4.2083"},{"key":"10.5826\/mrm.2026.1076_ref51","doi-asserted-by":"crossref","unstructured":"51. Peng H, Sarwar Z, Yang XP, Peterson EL, Xu J, Janic B, et al. Profibrotic role for interleukin-4 in cardiac remodeling and dysfunction. Hypertension 2015;66(3):582-9. doi: 10.1161\/HYPERTENSIONAHA.115.05627","DOI":"10.1161\/HYPERTENSIONAHA.115.05627"},{"key":"10.5826\/mrm.2026.1076_ref52","doi-asserted-by":"crossref","unstructured":"52. Bringardner BD, Baran CP, Eubank TD, Marsh CB. The role of inflammation in the pathogenesis of idiopathic pulmonary fibrosis. Antioxid Redox Signal 2008;10(2):287-301. doi: 10.1089\/ars.2007.1897","DOI":"10.1089\/ars.2007.1897"},{"key":"10.5826\/mrm.2026.1076_ref53","doi-asserted-by":"crossref","unstructured":"53. Xu M, Hu B, Chen J, Wang J, Li X. Mechanisms of fibrosis in iatrogenic laryngotracheal stenosis: new discoveries and novel targets. Biomed Pharmacother 2024;170:115995. doi: 10.1016\/j.biopha.2023.115995","DOI":"10.1016\/j.biopha.2023.115995"},{"key":"10.5826\/mrm.2026.1076_ref54","doi-asserted-by":"crossref","unstructured":"54. Ospino R, Berges A, Mafla L, Collins S, Li YC, Lina I, et al. Characterizing the macrophage population in patients with idiopathic subglottic stenosis. Laryngoscope 2023;133(9):2308-16. doi: 10.1002\/lary.30524","DOI":"10.1002\/lary.30524"},{"key":"10.5826\/mrm.2026.1076_ref55","doi-asserted-by":"crossref","unstructured":"55. Motz KM, Yin LX, Samad I, Ding D, Murphy MK, Duvvuri M, et al. Quantification of inflammatory markers in laryngotracheal stenosis. Otolaryngol Head Neck Surg 2017;157(3):466-72. doi: 10.1177\/0194599817706930","DOI":"10.1177\/0194599817706930"},{"key":"10.5826\/mrm.2026.1076_ref56","doi-asserted-by":"crossref","unstructured":"56. Dorris ER, Russell J, Murphy M. Post-intubation subglottic stenosis: aetiology at the cellular and molecular level. Eur Respir Rev 2021;30(159):200218. doi: 10.1183\/16000617.0218-2020","DOI":"10.1183\/16000617.0218-2020"},{"key":"10.5826\/mrm.2026.1076_ref57","doi-asserted-by":"crossref","unstructured":"57. Martins RS, Weber J, Poulikidis K, Shetawi AHA, Latif MJ, Razi SS, et al. Gene expression profiles in COVID-19-associated tracheal stenosis indicate persistent anti-viral response and dysregulated retinol metabolism. BMC Res Notes 2024;17(1):140. doi: 10.1186\/s13104-024-06775-y","DOI":"10.1186\/s13104-024-06775-y"},{"key":"10.5826\/mrm.2026.1076_ref58","doi-asserted-by":"crossref","unstructured":"58. Liu MM, Motz KM, Murphy MK, Yin LX, Ding D, Gelbard A, et al. Laryngotracheal mucosal surface expression of candidate biomarkers in idiopathic subglottic stenosis. Laryngoscope 2021;131(2):342-9. doi: 10.1002\/lary.28712","DOI":"10.1002\/lary.28712"},{"key":"10.5826\/mrm.2026.1076_ref59","doi-asserted-by":"crossref","unstructured":"59. Clark EA, Talatala ERR, Ye W, Davis RJ, Collins SL, Hillel AT, et al. Characterizing the T cell repertoire in the proximal airway in health and disease. Laryngoscope 2024;134(4):1757-64. doi: 10.1002\/lary.31088","DOI":"10.1002\/lary.31088"},{"key":"10.5826\/mrm.2026.1076_ref60","doi-asserted-by":"crossref","unstructured":"60. Schoeff S, Hoffman MR, Zhang Y, Yang Q, Dailey SH. Long-term follow-up of 64 patients with idiopathic subglottic stenosis: treatment pathways, outcomes, and impact of serial intralesional steroid injections. Ann Otol Rhinol Laryngol 2023;132(11):1341-8. doi: 10.1177\/00034894231156122","DOI":"10.1177\/00034894231156122"},{"key":"10.5826\/mrm.2026.1076_ref61","doi-asserted-by":"crossref","unstructured":"61. Fan Y, Li X, Fang X, Liu Y, Zhao S, Yu Z, et al. Antifibrotic role of nintedanib in tracheal stenosis after a tracheal wound. Laryngoscope 2021;131(9):E2496-505. doi: 10.1002\/lary.29618","DOI":"10.1002\/lary.29618"},{"key":"10.5826\/mrm.2026.1076_ref62","doi-asserted-by":"crossref","unstructured":"62. Li X, Pan J, Qian H, Ma Y, Gao B. Treatment of scarring central airway stenosis with pirfenidone: case report. Medicine (Baltimore) 2022;101(43):e31354. doi: 10.1097\/MD.0000000000031354","DOI":"10.1097\/MD.0000000000031354"},{"key":"10.5826\/mrm.2026.1076_ref63","doi-asserted-by":"crossref","unstructured":"63. Katsouli O, Lainis V, Goules AV, Vlachoyiannopoulos PG. The pathophysiological significance of dual inhibition of IL-17A and IL-17F in psoriatic arthritis and axial spondyloarthritis. Mediterr J Rheumatol 2026;37(Suppl 1):21-36. doi: 10.31138\/mjr.020925.aar","DOI":"10.31138\/mjr.020925.aar"},{"key":"10.5826\/mrm.2026.1076_ref64","doi-asserted-by":"crossref","unstructured":"64. Zhang T, Meng F, He J, Li C, Zhao Z. Temporarily induced facial eczema by IL-17 inhibitors: a case report and literature review. Front Allergy 2025;6:1672897. doi: 10.3389\/falgy.2025.1672897","DOI":"10.3389\/falgy.2025.1672897"},{"key":"10.5826\/mrm.2026.1076_ref65","doi-asserted-by":"crossref","unstructured":"65. Kraik K, Tota M, Laska J, \u0141acwik J, Paz\u0301dzierz \u0141, Se\u02dbdek \u0141, Gomu\u0142ka K. The role of transforming growth factor-\u03b2(TGF-\u03b2) in asthma and chronic obstructive pulmonary disease (COPD). Cells 2024;13(15):1271. doi: 10.3390 \/cells13151271","DOI":"10.3390\/cells13151271"},{"key":"10.5826\/mrm.2026.1076_ref66","doi-asserted-by":"crossref","unstructured":"66. Mafla L, So RJ, Collins SL, Chan-Li Y, Lina I, Motz KM, et al. An ovine model yields histology and gene expression changes consistent with laryngotracheal stenosis. Laryngoscope 2024;134(10):4239-45. doi: 10.1002\/lary .31499","DOI":"10.1002\/lary.31499"},{"key":"10.5826\/mrm.2026.1076_ref67","doi-asserted-by":"crossref","unstructured":"67. Chen W, Wang Q, Xu H, Xie Y, Zhang L, Li Y, et al. Establishment of a survival rabbit model for laryngotracheal stenosis: a prospective randomized study. 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