{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:25:11Z","timestamp":1786112711899,"version":"build-2736575974"},"reference-count":23,"publisher":"Mattioli1885","issue":"Vol. 21 (2026)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,5]]},"abstract":"<jats:p>Background: The overlap between asthma and obesity is becoming an increasing health concern, as overweight and obesity are linked to a higher risk of developing asthma and a greater disease burden. Objective: To assess the association between obesity and hospital-related complications, as well as early readmission rates, in asthmatic patients. Methods: This prospective observational cohort study was conducted at the Department of Chest Diseases, Ain Shams University Hospitals, between January 2024 and January 2026. A total of 75 adult patients were included and classified into three BMI groups: normal weight, overweight, and obese (n = 25 each). Clinical characteristics, pulmonary function tests, and in-hospital outcomes were assessed. Results: Asthma severity increased with BMI, with severe asthma present in 96.0% of obese patients compared with 20.0% of overweight patients and none of the normal-weight patients (p &lt; 0.001). Obese patients had lower pre-FEV\u2081 % predicted (47.5 \u00b1 21.1%) than both overweight (58.5 \u00b1 12.4%) and normal weight patients (65.2 \u00b1 13.5%) (p = 0.003). They also had lower oxygen saturation and longer hospital stay (p &lt; 0.001). ICU admission occurred only in obese patients (40.0%), with 20.0 % requiring mechanical ventilation. BMI correlated with longer hospital stay and lower oxygen saturation (p &lt; 0.001). Predictors of ICU admission included obesity, severe asthma, ventilatory support, lower oxygen saturation, and reduced FEV\u2081. Conclusion: Higher BMI was associated with increased asthma severity, poorer control, impaired lung function, and worse clinical outcomes, including longer hospital stay and greater need for intensive care. These findings highlight the value of weight management and comprehensive care in improving outcomes for obese patients with asthma. \u00a0 \u00a0<\/jats:p>","DOI":"10.5826\/mrm.2026.1116","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:35:08Z","timestamp":1785944108000},"page":"1116","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Obesity on Asthma as Regards In-hospital Complications and Early Readmission"],"prefix":"10.5826","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7408-150X","authenticated-orcid":false,"given":"Dina","family":"Ruby","sequence":"first","affiliation":[{"name":"Department of Chest Diseases, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27750","reference":[{"key":"10.5826\/mrm.2026.1116_ref1","unstructured":"1. Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention. 2024. Available from: https:\/\/ginasthma.org\/gina-reports\/ Accessed 2026"},{"key":"10.5826\/mrm.2026.1116_ref2","doi-asserted-by":"crossref","unstructured":"2. Soriano JB, Abajobir AA, Abate KH, Abera SF, Agrawal A, Ahmed MB, et al. Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990\u20132015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Respir Med 2017;5:691-706. doi:10.1016\/S2213-2600(17)30293-X","DOI":"10.1016\/S2213-2600(17)30293-X"},{"key":"10.5826\/mrm.2026.1116_ref3","unstructured":"3. World Health Organization (WHO). Obesity and overweight. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/obesity-and-overweight Accessed 2026."},{"key":"10.5826\/mrm.2026.1116_ref4","doi-asserted-by":"crossref","unstructured":"4. NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults. Lancet 2024;403:1027-50. doi:10.1016\/S0140-6736(23)02750-2","DOI":"10.1016\/S0140-6736(23)02750-2"},{"key":"10.5826\/mrm.2026.1116_ref5","doi-asserted-by":"crossref","unstructured":"5. Reyes-Angel J, Kaviany P, Rastogi D, Forno E. Obesity-related asthma in children and adolescents. Lancet Child Adolesc Health 2022;6:713-24. doi:10.1016\/S2352-4642(22)00185-7","DOI":"10.1016\/S2352-4642(22)00185-7"},{"key":"10.5826\/mrm.2026.1116_ref6","doi-asserted-by":"crossref","unstructured":"6. Miethe S, Karsonova A, Karaulov A, Renz H. Obesity and asthma. J Allergy Clin Immunol 2020;146:685-93. doi:10.1016\/j.jaci.2020.08.011","DOI":"10.1016\/j.jaci.2020.08.011"},{"key":"10.5826\/mrm.2026.1116_ref7","doi-asserted-by":"crossref","unstructured":"7. Dixon AE, Que LG. Obesity and asthma. Semin Respir Crit Care Med 2022;43:662-74. doi:10.1055\/s-0042-1742384","DOI":"10.1055\/s-0042-1742384"},{"key":"10.5826\/mrm.2026.1116_ref8","doi-asserted-by":"crossref","unstructured":"8. Camargo CA Jr, Weiss ST, Zhang S, Willett WC, Speizer FE. Prospective study of body mass index, weight change, and risk of adult-onset asthma in women. Arch Intern Med 1999;159:2582-8. doi:10.1001\/archinte.159.21.2582","DOI":"10.1001\/archinte.159.21.2582"},{"key":"10.5826\/mrm.2026.1116_ref9","doi-asserted-by":"crossref","unstructured":"9. Nystad W, Meyer HE, Nafstad P, Tverdal A, Engeland A. Body mass index in relation to adult asthma among 135,000 Norwegian men and women. Am J Epidemiol 2004;160:969-76. doi:10.1093\/aje\/kwh303","DOI":"10.1093\/aje\/kwh303"},{"key":"10.5826\/mrm.2026.1116_ref10","doi-asserted-by":"crossref","unstructured":"10. Tay TR, Radhakrishna N, Hore-Lacy F, Smith C, Hoy R, Dabscheck E, et al. Comorbidities in difficult asthma are independent risk factors for frequent exacerbations, poor control and diminished quality of life. Respirology 2016;21:1384-90. doi:10.1111\/resp.12838","DOI":"10.1111\/resp.12838"},{"key":"10.5826\/mrm.2026.1116_ref11","doi-asserted-by":"crossref","unstructured":"11. Clerisme-Beaty E, Karam S, Rand C, Patino C, Bilderback A, Riekert K, et al. Does higher body mass index contribute to worse asthma control in an urban population? J Allergy Clin Immunol 2009;124:207-12. doi:10.1016\/j.jaci.2009.05.034","DOI":"10.1016\/j.jaci.2009.05.034"},{"key":"10.5826\/mrm.2026.1116_ref12","doi-asserted-by":"crossref","unstructured":"12. Yeh KH, Skowronski ME, Coreno AJ, Seitz RE, Villalba KD, Dickey-White H, et al. Impact of obesity on the severity and therapeutic responsiveness of acute episodes of asthma. J Asthma. 2011 Aug;48(6):546-52. doi: 10.3109\/02770903.2011.581733.","DOI":"10.3109\/02770903.2011.581733"},{"key":"10.5826\/mrm.2026.1116_ref13","doi-asserted-by":"crossref","unstructured":"13. Martin A, Bauer V, Datta A, Masi C, Mosnaim G, Solomonides A, et al. Development and Validation of an Asthma Exacerbation Prediction Model using Electronic Health Record (EHR) Data. J Asthma 2020;57(12):1\u201313. doi:10.1080\/02770903.2019.1648505","DOI":"10.1080\/02770903.2019.1648505"},{"key":"10.5826\/mrm.2026.1116_ref14","doi-asserted-by":"crossref","unstructured":"14. Luthe SK, Hirayama A, Goto T, Faridi MK, Camargo CA Jr, Hasegawa K. Association between obesity and acute severity among patients hospitalized for asthma exacerbation. J Allergy Clin Immunol Pract 2018;6:1936-41.e4. doi:10.1016\/j.jaip.2018.04.021","DOI":"10.1016\/j.jaip.2018.02.001"},{"key":"10.5826\/mrm.2026.1116_ref15","doi-asserted-by":"crossref","unstructured":"15. Gangu K, Sharma E, Bobba A, Patel T, Holliday Z. In-hospital outcomes in patients with obesity and acute asthma exacerbation. Chest 2021;160. doi:10.1016\/j.chest.2021.07.1646","DOI":"10.1016\/j.chest.2021.07.1646"},{"key":"10.5826\/mrm.2026.1116_ref16","doi-asserted-by":"crossref","unstructured":"16. Gonzalez-Barcala FJ, Nieto-Fontarigo JJ, Lourido-Cebreiro T, Rodr\u00edguez-Garc\u00eda C, San-Jose P, Carreira JM, et al. Obesity does not increase the risk of asthma readmissions. J Clin Med 2020;9:221. doi:10.3390\/jcm9010221","DOI":"10.3390\/jcm9010221"},{"key":"10.5826\/mrm.2026.1116_ref17","doi-asserted-by":"crossref","unstructured":"17. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, et al. Standardisation of spirometry. Eur Respir J 2005;26:319-38. doi:10.1183\/09031936.05.00034805","DOI":"10.1183\/09031936.05.00034805"},{"key":"10.5826\/mrm.2026.1116_ref18","doi-asserted-by":"crossref","unstructured":"18. Gonzalez-Barcala FJ, Calvo-Alvarez U, Garcia-Sanz MT, Boudin A, Pose-Reino A, Carreira JM, et al. Characteristics and prognosis of near-fatal asthma exacerbations. Am J Med Sci 2015;350:98-102. doi:10.1097\/MAJ.0000000000000518","DOI":"10.1097\/MAJ.0000000000000518"},{"key":"10.5826\/mrm.2026.1116_ref19","doi-asserted-by":"crossref","unstructured":"19. Lee DS, Gross E, Hotz A, Ngo KC, Rastogi D. Impact of obesity on asthma morbidity during a hospitalization. Hosp Pediatr 2018;8:538-46. doi:10.1542\/hpeds.2017-0265","DOI":"10.1542\/hpeds.2017-0265"},{"key":"10.5826\/mrm.2026.1116_ref20","doi-asserted-by":"crossref","unstructured":"20. Russjan E. The role of peptides in asthma\u2013obesity phenotype. Int J Mol Sci 2024;25:3213. doi:10.3390\/ijms25063213","DOI":"10.3390\/ijms25063213"},{"key":"10.5826\/mrm.2026.1116_ref21","doi-asserted-by":"crossref","unstructured":"21.Alqarni AA, Aldhahir AM, Siraj RA, Alqahtani JS, Alshehri HH, Alshamrani AM, et al. Prevalence of overweight and obesity and their impact on spirometry parameters in patients with asthma: a multicentre, retrospective study. J Clin Med 2023;12:1843. doi:10.3390\/jcm12051843","DOI":"10.3390\/jcm12051843"},{"key":"10.5826\/mrm.2026.1116_ref22","doi-asserted-by":"crossref","unstructured":"22. Sin DD, Jones RL, Man SFP. Obesity is a risk factor for dyspnea but not for airflow obstruction. Arch Intern Med 2002;162:1477-81. doi:10.1001\/archinte.162.13.1477","DOI":"10.1001\/archinte.162.13.1477"},{"key":"10.5826\/mrm.2026.1116_ref23","doi-asserted-by":"crossref","unstructured":"23. Sharma V, Cowan DC. Obesity, inflammation, and severe asthma: an update. Curr Allergy Asthma Rep 2021;21:46. doi:10.1007\/s11882-021-01024-9.","DOI":"10.1007\/s11882-021-01024-9"}],"container-title":["Multidisciplinary Respiratory Medicine"],"original-title":[],"link":[{"URL":"https:\/\/mrmjournal.org\/index.php\/mrm\/article\/download\/1116\/1603","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/mrmjournal.org\/index.php\/mrm\/article\/download\/1116\/1603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:35:12Z","timestamp":1785944112000},"score":1,"resource":{"primary":{"URL":"https:\/\/mrmjournal.org\/index.php\/mrm\/article\/view\/1116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,5]]},"references-count":23,"journal-issue":{"issue":"Vol. 21 (2026)"},"URL":"https:\/\/doi.org\/10.5826\/mrm.2026.1116","relation":{"has-manifestation":[{"id-type":"other","id":"1-44-1116-g1603","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-44","asserted-by":"subject"}]},"ISSN":["2049-6958","1828-695X"],"issn-type":[{"value":"2049-6958","type":"electronic"},{"value":"1828-695X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,5]]}}}