{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T22:20:25Z","timestamp":1715984425469},"reference-count":0,"publisher":"The Medical Letter, Inc.","issue":"1670","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Lett Drugs Ther"],"abstract":"<jats:p>The Bruton's tyrosine kinase (BTK) inhibitor pirtobrutinib (Jaypirca \u2013 Lilly) has received accelerated approval from the FDA for treatment of relapsed or refractory mantle cell lymphoma (MCL) in adults who received \u22652 prior lines of systemic therapy, including a BTK inhibitor. Accelerated approval was based on the response rate. The BTK inhibitors ibrutinib (Imbruvica), acalabrutinib (Calquence), and zanubrutinib (Brukinsa) are also approved for treatment of MCL.<\/jats:p>","DOI":"10.58347\/tml.2023.1670f","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T16:04:39Z","timestamp":1678982679000},"page":"e35-e36","source":"Crossref","is-referenced-by-count":1,"title":["Pirtobrutinib (Jaypirca): A Fourth Bruton's Tyrosine Kinase Inhibitor for Mantle Cell Lymphoma"],"prefix":"10.58347","volume":"65","author":[{"name":"Editors from The Medical Letter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"37151","published-online":{"date-parts":[[2023,2,20]]},"container-title":["The Medical Letter on Drugs and Therapeutics"],"original-title":[],"deposited":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T16:04:39Z","timestamp":1678982679000},"score":1,"resource":{"primary":{"URL":"https:\/\/secure.medicalletter.org\/TML-article-1670f"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,20]]},"references-count":0,"journal-issue":{"issue":"1670","published-online":{"date-parts":[[2023,2,20]]}},"URL":"https:\/\/doi.org\/10.58347\/tml.2023.1670f","relation":{},"ISSN":["1523-2859"],"issn-type":[{"value":"1523-2859","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,20]]}}}