{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T07:36:45Z","timestamp":1757576205876},"reference-count":0,"publisher":"The Medical Letter, Inc.","issue":"1704","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Lett Drugs Ther"],"abstract":"<jats:p>Fidanacogene elaparvovec-dzkt (Beqvez \u2013 Pfizer), an adeno-associated virus (AAV) vector-based gene therapy, has been approved by the FDA for treatment of adults with moderate to severe hemophilia B who do not have neutralizing antibodies to AAV serotype Rh74var and currently receive factor IX prophylaxis therapy or have had life-threatening hemorrhage or repeated, serious, spontaneous bleeding episodes. Beqvez is the second single-dose gene therapy to be approved in the US for treatment of hemophilia B; Hemgenix was the first.<\/jats:p>","DOI":"10.58347\/tml.2024.1704d","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T22:07:11Z","timestamp":1718662031000},"page":"95-96","source":"Crossref","is-referenced-by-count":1,"title":["Beqvez \u2014 Another Gene Therapy for Hemophilia B"],"prefix":"10.58347","volume":"66","member":"37151","published-online":{"date-parts":[[2024,6,10]]},"container-title":["The Medical Letter on Drugs and Therapeutics"],"original-title":[],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T22:07:12Z","timestamp":1718662032000},"score":1,"resource":{"primary":{"URL":"https:\/\/secure.medicalletter.org\/TML-article-1704d"}},"subtitle":[],"editor":[{"name":"Editors from The Medical Letter","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,6,10]]},"references-count":0,"journal-issue":{"issue":"1704","published-online":{"date-parts":[[2024,6,10]]}},"URL":"https:\/\/doi.org\/10.58347\/tml.2024.1704d","relation":{},"ISSN":["1523-2859"],"issn-type":[{"value":"1523-2859","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,10]]}}}