{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:24:39Z","timestamp":1723767879752},"reference-count":0,"publisher":"The Medical Letter, Inc.","issue":"1709","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Lett Drugs Ther"],"abstract":"<jats:p>Efbemalenograstim alfa-vuxw (Ryzneuta \u2013 Evive), a nonpegylated granulocyte colony-stimulating factor (G-CSF) conjugated to an Fc fragment of human IgG2, has been approved by the FDA to decrease the incidence of infection, as manifested by febrile neutropenia, in adults with nonmyeloid malignancies receiving myelosuppressive chemotherapy that can cause clinically significant febrile neutropenia. It is the first nonpegylated, long-acting G-CSF to become available in the US. Two pegylated, long-acting G-CSFs, pegfilgrastim (Neulasta, and biosimilars) and eflapegrastim (Rolvedon), are also available.<\/jats:p>","DOI":"10.58347\/tml.2024.1709d","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T17:02:07Z","timestamp":1723741327000},"page":"134-135","source":"Crossref","is-referenced-by-count":0,"title":["Ryzneuta for Prevention of Febrile Neutropenia"],"prefix":"10.58347","volume":"66","author":[{"name":"Editors from The Medical Letter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"37151","published-online":{"date-parts":[[2024,8,19]]},"container-title":["The Medical Letter on Drugs and Therapeutics"],"original-title":[],"deposited":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T17:02:10Z","timestamp":1723741330000},"score":1,"resource":{"primary":{"URL":"https:\/\/secure.medicalletter.org\/TML-article-1709d"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,19]]},"references-count":0,"journal-issue":{"issue":"1709","published-online":{"date-parts":[[2024,8,19]]}},"URL":"https:\/\/doi.org\/10.58347\/tml.2024.1709d","relation":{},"ISSN":["1523-2859"],"issn-type":[{"value":"1523-2859","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,19]]}}}