{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:51:05Z","timestamp":1767829865408,"version":"3.49.0"},"reference-count":0,"publisher":"The Medical Letter, Inc.","issue":"1719","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Lett Drugs Ther"],"abstract":"<jats:p>The FDA has approved pilocarpine 0.4% preservative-free ophthalmic solution (Qlosi \u2013 Orasis) for treatment of presbyopia in adults. Pilocarpine 1.25% ophthalmic solution (Vuity) was approved in 2021 for the same indication.1 Pilocarpine 1%, 2%, and 4% ophthalmic solutions (Isopto Carpine, and others) have been available for years for treatment of glaucoma, but local (e.g., blurry vision and instillation-site pain) and systemic (e.g., sweating and GI disturbances) adverse effects have limited their use.<\/jats:p>","DOI":"10.58347\/tml.2025.1719b","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T01:25:41Z","timestamp":1736385941000},"page":"5-6","source":"Crossref","is-referenced-by-count":1,"title":["Qlosi \u2014 Pilocarpine 0.4% Ophthalmic Solution for Presbyopia"],"prefix":"10.58347","volume":"67","author":[{"name":"Editors from The Medical Letter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"37151","published-online":{"date-parts":[[2025,1,6]]},"container-title":["The Medical Letter on Drugs and Therapeutics"],"original-title":[],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T01:25:41Z","timestamp":1736385941000},"score":1,"resource":{"primary":{"URL":"https:\/\/secure.medicalletter.org\/TML-article-1719b"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,6]]},"references-count":0,"journal-issue":{"issue":"1719","published-online":{"date-parts":[[2025,1,6]]}},"URL":"https:\/\/doi.org\/10.58347\/tml.2025.1719b","relation":{},"ISSN":["1523-2859"],"issn-type":[{"value":"1523-2859","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,6]]}}}