{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T19:24:23Z","timestamp":1787599463123,"version":"build-2736575974"},"reference-count":0,"publisher":"The Medical Letter, Inc.","issue":"1759","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Lett Drugs Ther"],"abstract":"<jats:p>The FDA has granted accelerated approval to the B-cell lymphoma 2 (BCL-2) inhibitor sonrotoclax (Beqalzi \u2013 BeOne Medicines) for treatment of relapsed or refractory mantle cell lymphoma (MCL) in adults who received \u22652 prior lines of systemic therapy, including a Bruton's tyrosine kinase (BTK) inhibitor (e.g., pirtobrutinib [Jaypirca]), acalabrutinib [Calquence], or zanubrutinib [Brukinsa]).1 Sonrotoclax is the first BCL-2 inhibitor to be approved in the US for this indication. The BCL-2 inhibitor venetoclax (Venclexta) has been used off label for third-line treatment of MCL.<\/jats:p>","DOI":"10.58347\/tml.2026.1759f","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:58:12Z","timestamp":1787597892000},"page":"e119-e120","source":"Crossref","is-referenced-by-count":0,"title":["Sonrotoclax (Beqalzi) for Mantle Cell Lymphoma"],"prefix":"10.58347","volume":"68","member":"37151","published-online":{"date-parts":[[2026,7,20]]},"container-title":["The Medical Letter on Drugs and Therapeutics"],"original-title":[],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:58:12Z","timestamp":1787597892000},"score":1,"resource":{"primary":{"URL":"https:\/\/secure.medicalletter.org\/TML-article-1759f"}},"subtitle":[],"editor":[{"name":"Editors from The Medical Letter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,7,20]]},"references-count":0,"journal-issue":{"issue":"1759","published-online":{"date-parts":[[2026,7,20]]}},"URL":"https:\/\/doi.org\/10.58347\/tml.2026.1759f","relation":{},"ISSN":["1523-2859"],"issn-type":[{"value":"1523-2859","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,20]]}}}