{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:56:00Z","timestamp":1790873760080,"version":"4.1.0"},"reference-count":0,"publisher":"The Medical Letter, Inc.","issue":"1765","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Lett Drugs Ther"],"abstract":"<jats:p>The kinase inhibitor gedatolisib (Revtorpyk \u2013 Celcuity) has been approved by the FDA for use in combination with fulvestrant, with or without the cyclin-dependent kinase (CDK) 4\/6 inhibitor palbociclib (Ibrance), for treatment of hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer without a PIK3CA mutation in adults who had disease progression on or after at least one prior line of endocrine therapy for metastatic disease.<\/jats:p>","DOI":"10.58347\/tml.2026.1765c","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:59:38Z","timestamp":1790870378000},"page":"e167-e168","source":"Crossref","is-referenced-by-count":0,"title":["Gedatolisib (Revtorpyk) for Breast Cancer"],"prefix":"10.58347","volume":"68","member":"37151","published-online":{"date-parts":[[2026,10,12]]},"container-title":["The Medical Letter on Drugs and Therapeutics"],"original-title":[],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:59:38Z","timestamp":1790870378000},"score":1,"resource":{"primary":{"URL":"https:\/\/secure.medicalletter.org\/TML-article-1765c"}},"subtitle":[],"editor":[{"name":"Editors from The Medical Letter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,10,12]]},"references-count":0,"journal-issue":{"issue":"1765","published-online":{"date-parts":[[2026,10,12]]}},"URL":"https:\/\/doi.org\/10.58347\/tml.2026.1765c","relation":{},"ISSN":["1523-2859"],"issn-type":[{"value":"1523-2859","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,12]]}}}