{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:46:05Z","timestamp":1790628365384,"version":"4.1.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["RSPD2025R757"],"award-info":[{"award-number":["RSPD2025R757"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.kosfaj.org"],"crossmark-restriction":true},"short-container-title":["Food Sci Anim Resour"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.5851\/kosfa.2024.e62","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T01:22:05Z","timestamp":1721352125000},"page":"807-820","update-policy":"https:\/\/doi.org\/10.5851\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Green Solvent-Based Extraction of Lipids and Proteins from\n                        Tenebrio molitor: A Sustainable Approach and Cytotoxic\n                    Activity"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1887-7789","authenticated-orcid":false,"given":"Nael","family":"Abutaha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8190-7901","authenticated-orcid":false,"given":"Fahd A","family":"Al-Mekhlafi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,1]]},"reference":[{"key":"key2.0250516080538e+13_B1","doi-asserted-by":"crossref","first-page":"102525","DOI":"10.1016\/j.jksus.2022.102525","article-title":"Phytochemical screening and GC-MS chemical profiling of an\n                        innovative anti-cancer herbal formula (PHF6)","volume":"35","author":"Al-Zharani","year":"2023","journal-title":"J King Saud Univ Sci"},{"key":"key2.0250516080538e+13_B2","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/1748-5967.12363","article-title":"Effects of processing methods on nutritional composition and\n                        antioxidant activity of mealworm (Tenebrio molitor)\n                        larvae","volume":"49","author":"Baek","year":"2019","journal-title":"Entomol Res"},{"key":"key2.0250516080538e+13_B3","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram\n                        quantities of protein utilizing the principle of protein-dye\n                        binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"key2.0250516080538e+13_B4","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.fbp.2018.03.001","article-title":"New perspective in extraction of plant biologically active\n                        compounds by green solvents","volume":"109","author":"Bubalo","year":"2018","journal-title":"Food Bioprod Process"},{"key":"key2.0250516080538e+13_B5","first-page":"178","article-title":"Studies on antioxidant activity, volatile compound and fatty acid\n                        composition of different parts of Glycyrrhiza echinata\n                        L","volume":"11","author":"\u00c7akmak","year":"2012","journal-title":"EXCLI J"},{"key":"key2.0250516080538e+13_B6","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.3390\/molecules24163007","article-title":"Review of alternative solvents for green extraction of food and\n                        natural products: Panorama, principles, applications and\n                        prospects","volume":"24","author":"Chemat","year":"2019","journal-title":"Molecules"},{"key":"key2.0250516080538e+13_B7","doi-asserted-by":"crossref","first-page":"8615","DOI":"10.3390\/ijms13078615","article-title":"Green extraction of natural products: Concept and\n                        principles","volume":"13","author":"Chemat","year":"2012","journal-title":"Int J Mol Sci"},{"key":"key2.0250516080538e+13_B8","first-page":"955","article-title":"Defatting and sonication enhances protein extraction from edible\n                        insects","volume":"37","author":"Choi","year":"2017","journal-title":"Korean J Food Sci Anim Resour"},{"key":"key2.0250516080538e+13_B9","doi-asserted-by":"crossref","first-page":"125742","DOI":"10.1016\/j.foodchem.2019.125742","article-title":"Characterization, antioxidant activity, and inhibitory effect on\n                        pancreatic lipase of extracts from the edible insects Acheta\n                            domesticus and Tenebrio\n                        molitor","volume":"309","author":"del Hierro","year":"2020","journal-title":"Food Chem"},{"key":"key2.0250516080538e+13_B10","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.plefa.2011.07.005","article-title":"Pro- and anti-oxidant effects of polyunsaturated fatty acid\n                        supplementation in HepG2 cells","volume":"85","author":"Di Nunzio","year":"2011","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"key2.0250516080538e+13_B11","doi-asserted-by":"crossref","first-page":"131918","DOI":"10.1016\/j.foodchem.2021.131918","article-title":"Influence of the extraction method on the recovery of bioactive\n                        phenolic compounds from food industry by-products","volume":"378","author":"Gil-Mart\u00edn","year":"2022","journal-title":"Food Chem"},{"key":"key2.0250516080538e+13_B12","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1039\/c0gc00918k","article-title":"Expanding GSK\u2019s solvent selection guide: Embedding\n                        sustainability into solvent selection starting at medicinal\n                        chemistry","volume":"13","author":"Henderson","year":"2011","journal-title":"Green Chem"},{"key":"key2.0250516080538e+13_B13","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2298\/BAH2002167J","article-title":"Fatty and amino acid profile of mealworm larvae (Tenebrio\n                            molitor L.)","volume":"36","author":"Jaji\u0107","year":"2020","journal-title":"Biotechnol Anim Husb"},{"key":"key2.0250516080538e+13_B14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9734\/jpri\/2019\/v28i330203","article-title":"An overview on common organic solvents and their\n                        toxicity","volume":"28","author":"Joshi","year":"2019","journal-title":"J Pharm Res Int"},{"key":"key2.0250516080538e+13_B15","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.3390\/molecules23092340","article-title":"Optimization of antioxidant and skin-whitening compounds\n                        extraction condition from Tenebrio molitor larvae\n                        (mealworm)","volume":"23","author":"Kim","year":"2018","journal-title":"Molecules"},{"key":"key2.0250516080538e+13_B16","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.3390\/foods13071027","article-title":"Exploiting agri-food waste as feed for Tenebrio\n                            molitor larvae rearing: A review","volume":"13","author":"Kotsou","year":"2024","journal-title":"Foods"},{"key":"key2.0250516080538e+13_B17","doi-asserted-by":"crossref","first-page":"107868","DOI":"10.1016\/j.cep.2020.107868","article-title":"Current insights in yeast cell disruption technologies for oil\n                        recovery: A review","volume":"150","author":"Koubaa","year":"2020","journal-title":"Chem Eng Process Process Intensif"},{"key":"key2.0250516080538e+13_B18","doi-asserted-by":"crossref","first-page":"106595","DOI":"10.1016\/j.foodhyd.2021.106595","article-title":"Advances in the plant protein extraction: Mechanism and\n                        recommendations","volume":"115","author":"Kumar","year":"2021","journal-title":"Food Hydrocoll"},{"key":"key2.0250516080538e+13_B19","doi-asserted-by":"crossref","first-page":"572","DOI":"10.3390\/foods8110572","article-title":"Comparison of conventional and sustainable lipid extraction\n                        methods for the production of oil and protein isolate from edible insect\n                        meal","volume":"8","author":"Laroche","year":"2019","journal-title":"Foods"},{"key":"key2.0250516080538e+13_B20","doi-asserted-by":"crossref","first-page":"131782","DOI":"10.1016\/j.cej.2021.131782","article-title":"Direct conversion of yellow mealworm larvae into biodiesel via a\n                        non-catalytic transesterification platform","volume":"427","author":"Lee","year":"2022","journal-title":"Chem Eng J"},{"key":"key2.0250516080538e+13_B21","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3746\/jkfn.2015.44.2.200","article-title":"Cytotoxic effects of Tenebrio molitor larval\n                        extracts against hepatocellular carcinoma","volume":"44","author":"Lee","year":"2015","journal-title":"J Korean Soc Food Sci Nutr"},{"key":"key2.0250516080538e+13_B22","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s40104-021-00565-3","article-title":"Phenolic compounds as natural feed additives in poultry and swine\n                        diets: A review","volume":"12","author":"Mahfuz","year":"2021","journal-title":"J Anim Sci Biotechnol"},{"key":"key2.0250516080538e+13_B23","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3920\/JIFF2018.0034","article-title":"Effects of different blanching treatments on microbiological\n                        profile and quality of the mealworm (Tenebrio\n                        molitor)","volume":"5","author":"Mancini","year":"2019","journal-title":"J Insects Food Feed"},{"key":"key2.0250516080538e+13_B24","doi-asserted-by":"crossref","first-page":"247","DOI":"10.31883\/pjfns\/109666","article-title":"Fat from Tenebrionidae bugs: Sterols content, fatty acid\n                        profiles, and cardiovascular risk indexes","volume":"69","author":"Ml\u010dek","year":"2019","journal-title":"Pol J Food Nutr Sci"},{"key":"key2.0250516080538e+13_B25","doi-asserted-by":"crossref","first-page":"45","DOI":"10.15171\/ijb.1168","article-title":"The effects of organic solvents on the physicochemical properties\n                        of human serum albumin nanoparticles","volume":"14","author":"Mohammad-Beigi","year":"2016","journal-title":"Iran J Biotechnol"},{"key":"key2.0250516080538e+13_B26","doi-asserted-by":"crossref","first-page":"7827","DOI":"10.1111\/ijfs.17037","article-title":"Comparative analysis of process intensification technologies\n                        (PIT) for improved cell disruption and lipid recovery in\n                            Aurantiochytrium sp. SW1 microalgae","volume":"59","author":"Mokhtar","year":"2024","journal-title":"Int J Food Sci Technol"},{"key":"key2.0250516080538e+13_B27","doi-asserted-by":"crossref","first-page":"896","DOI":"10.3390\/insects13100896","article-title":"Effects of a mealworm (Tenebrio molitor) extract\n                        on metabolic syndrome-related pathologies: In vitro insulin\n                        sensitivity, inflammatory response, hypolipidemic activity and oxidative\n                        stress","volume":"13","author":"Navarro del Hierro","year":"2022","journal-title":"Insects"},{"key":"key2.0250516080538e+13_B28","doi-asserted-by":"crossref","first-page":"119925","DOI":"10.1016\/j.renene.2023.119925","article-title":"RSM optimization of ultrasound-assisted melia dubia oil\n                        extraction with green solvents and their suitability for diesel engine\n                        applications","volume":"222","author":"Paneerselvam","year":"2024","journal-title":"Renew Energy"},{"key":"key2.0250516080538e+13_B29","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.foodres.2018.07.014","article-title":"Essential oils as natural additives to prevent oxidation\n                        reactions in meat and meat products: A review","volume":"113","author":"Pateiro","year":"2018","journal-title":"Food Res Int"},{"key":"key2.0250516080538e+13_B30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0233788","article-title":"Antihypertensive, cardio- and neuro-protective effects of\n                            Tenebrio molitor (Coleoptera: Tenebrionidae) defatted\n                        larvae in spontaneously hypertensive rats","volume":"15","author":"Pessina","year":"2020","journal-title":"PLOS ONE"},{"key":"key2.0250516080538e+13_B31","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1039\/C4GC01149J","article-title":"A survey of solvent selection guides","volume":"16","author":"Prat","year":"2014","journal-title":"Green Chem"},{"key":"key2.0250516080538e+13_B32","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1021\/op4002565","article-title":"Sanofi\u2019s solvent selection guide: A step toward more\n                        sustainable processes","volume":"17","author":"Prat","year":"2013","journal-title":"Org Process Res Dev"},{"key":"key2.0250516080538e+13_B33","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/B978-0-323-95594-2.00014-8","article-title":"Insect processing for chitin production","volume-title":"Insects as food and food ingredients: Technological improvements\n                        sustainability and safety aspects","author":"Psarianos","year":"2024"},{"key":"key2.0250516080538e+13_B34","doi-asserted-by":"crossref","first-page":"6961","DOI":"10.1021\/jf0346713","article-title":"Radical scavenging activity of black cumin (Nigella\n                            sativa L.), coriander (Coriandrum sativum L.),\n                        and niger (Guizotia abyssinica Cass.) crude seed oils and\n                        oil fractions","volume":"51","author":"Ramadan","year":"2003","journal-title":"J Agric Food Chem"},{"key":"key2.0250516080538e+13_B35","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.3390\/plants12061217","article-title":"Recent developments in polyphenol applications on human health: A\n                        review with current knowledge","volume":"12","author":"Rathod","year":"2023","journal-title":"Plants"},{"key":"key2.0250516080538e+13_B36","doi-asserted-by":"crossref","first-page":"117861","DOI":"10.1016\/j.jclepro.2019.117861","article-title":"Alternative solvents for lipid extraction and their effect on\n                        protein quality in black soldier fly (Hermetia illucens)\n                        larvae","volume":"238","author":"Ravi","year":"2019","journal-title":"J Clean Prod"},{"key":"key2.0250516080538e+13_B37","first-page":"1","article-title":"Extraction, isolation and characterization of bioactive compounds\n                        from plants\u2019 extracts","volume":"8","author":"Sasidharan","year":"2011","journal-title":"Afr J Tradit Complement Altern Med"},{"key":"key2.0250516080538e+13_B38","volume-title":"Handbook of organic solvent properties","author":"Smallwood","year":"1997"},{"key":"key2.0250516080538e+13_B39","doi-asserted-by":"crossref","first-page":"5852","DOI":"10.3390\/en16155852","article-title":"Evaluating green solvents for bio-oil extraction: Advancements,\n                        challenges, and future perspectives","volume":"16","author":"Usman","year":"2023","journal-title":"Energies"},{"key":"key2.0250516080538e+13_B40","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.3390\/ani12111450","article-title":"Insects as feed for companion and exotic pets: A current\n                        trend","volume":"12","author":"Vald\u00e9s","year":"2022","journal-title":"Animals"},{"key":"key2.0250516080538e+13_B41","doi-asserted-by":"crossref","first-page":"112438","DOI":"10.1016\/j.jep.2019.112438","article-title":"Caspase 3-mediated cytotoxicity of mealworm larvae\n                            (Tenebrio molitor) oil extract against human\n                        hepatocellular carcinoma and colorectal adenocarcinoma","volume":"250","author":"Wu","year":"2020","journal-title":"J Ethnopharmacol"},{"key":"key2.0250516080538e+13_B42","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.3390\/molecules23051065","article-title":"Greening reversed-phase liquid chromatography methods using\n                        alternative solvents for pharmaceutical analysis","volume":"23","author":"Yabr\u00e9","year":"2018","journal-title":"Molecules"},{"key":"key2.0250516080538e+13_B43","doi-asserted-by":"crossref","first-page":"120935","DOI":"10.1016\/j.saa.2022.120935","article-title":"Investigation of protective effect of ethanol on the natural\n                        structure of protein with infrared spectroscopy","volume":"271","author":"Yang","year":"2022","journal-title":"Spectrochim Acta A Mol Biomol Spectrosc"},{"key":"key2.0250516080538e+13_B44","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ijbiomac.2014.04.041","article-title":"Dependence of ethanol effects on protein charges","volume":"68","author":"Yoshizawa","year":"2014","journal-title":"Int J Biol Macromol"},{"key":"key2.0250516080538e+13_B45","first-page":"890","article-title":"Antioxidant capacity and Raw 264.7 macrophage anti-inflammatory\n                        effect of the Tenebrio molitor","volume":"23","author":"Yu","year":"2016","journal-title":"Food Sci Preserv"}],"container-title":["Food Science of Animal Resources"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.kosfaj.org\/download\/download_pdf?doi=10.5851\/kosfa.2024.e62","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.kosfaj.org\/download\/download_pdf?doi=10.5851\/kosfa.2024.e62","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T12:57:22Z","timestamp":1764593842000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.kosfaj.org\/archive\/view_article?doi=10.5851\/kosfa.2024.e62"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":45,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,5,1]]},"published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.5851\/kosfa.2024.e62"],"URL":"https:\/\/doi.org\/10.5851\/kosfa.2024.e62","relation":{},"ISSN":["2636-0772","2636-0780"],"issn-type":[{"value":"2636-0772","type":"print"},{"value":"2636-0780","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2024-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}