{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T04:40:24Z","timestamp":1776314424295,"version":"3.50.1"},"reference-count":24,"publisher":"Korean Stroke Society","issue":"1","license":[{"start":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T00:00:00Z","timestamp":1639699200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["j-stroke.org"],"crossmark-restriction":true},"short-container-title":["J Stroke"],"published-print":{"date-parts":[[2022,1,31]]},"abstract":"<jats:p>Background and Purpose Prolonged electrocardiography (ECG)-monitoring in stroke patients improves the detection of paroxysmal atrial fibrillation (pAF). However, most randomized studies only had short follow-up. We aimed to provide 3-year follow-up data for AF detection and stroke recurrence risk.Methods We randomized 402 patients aged \u226560 years with acute ischemic strokes without AF to either enhanced and prolonged monitoring (EPM; 3\u00d710-day Holter-ECG-monitoring) or standard-of-care (\u226524 hours ECG-monitoring). The endpoint of the current analysis was AF within 36 months analyzed by intention to treat. Long-term follow-up was performed for 36 months.Results Two hundred and seventy-four patients (80%) participated in the extended follow-up (median duration of follow-up was 36 months [interquartile range, 12 to 36]). During the first 6 months, more AF was documented in the EPM arm compared to the control arm (13.5% vs. 5.1%; 95% confidence interval, 2.9% to 14.4%; P=0.004). During months 6 to 36, AF was less detected in the EPM intervention arm than in the control arm (2.0% vs. 7.3%; 95% confidence interval, 0.7% to 9.9%; P=0.028). Overall, the detection rate of AF within 36 months was numerically higher within the EPM group (15.0% vs. 11.1%, P=0.30). Numerically less patients in the EPM arm had recurrent ischemic strokes (5.5% vs. 9.1%, P=0.18), transient ischemic attacks (3.0% vs. 4.5%, P=0.44) or died (4.5% vs. 6.6%, P=0.37).Conclusions Enhanced and prolonged ECG monitoring increased AF detection during the first six months, but there was significantly more clinical AF during months 6 to 36 observed in the usual-care arm. This suggests that EPM leads to an earlier detection of clinically relevant AF.<\/jats:p>","DOI":"10.5853\/jos.2021.01207","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T07:07:16Z","timestamp":1639638436000},"page":"98-107","update-policy":"https:\/\/doi.org\/10.5853\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Long-Term Follow-up of Enhanced Holter-Electrocardiography Monitoring in Acute Ischemic Stroke"],"prefix":"10.5853","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2231-2200","authenticated-orcid":true,"given":"Rolf","family":"Wachter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Weber-Kr\u00fcger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard F.","family":"Hamann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawel","family":"Kermer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Liman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meinhard","family":"Mende","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Seegers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Wasser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja","family":"Gr\u00f6schel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Uphaus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Poppert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"K\u00f6hrmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Zabel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Laufs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter U.","family":"Heuschmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Conen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Gr\u00f6schel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on Behalf of the Find-AFRANDOMISED Investigators and Coordinators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3882","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12007"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161\/hs1201.100209"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(16)31257-0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1311376"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1313600"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(17)30002-9"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2017.3180"},{"key":"ref8","volume-title":"","author":"Wilson","year":"1968"},{"key":"ref9","first-page":"438","volume-title":"Finding atrial fibrillation in stroke patients: randomized evaluation of enhanced and prolonged Holter monitoring: Find-AF(RANDOMISED). Rationale and design","author":"Weber-Kr\u00fcger","year":"2014"},{"key":"ref10","first-page":"2369","volume-title":"Guidelines for the management of atrial fibrillation: the task force for the management of atrial fibrillation of the European Society of Cardiology (ESC)","author":"Camm","year":"2010"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176350951"},{"key":"ref12","first-page":"e003333","volume-title":"Uncovering atrial fibrillation beyond short-term monitoring in cryptogenic stroke patients: three-year results from the cryptogenic stroke and underlying atrial fibrillation trial","author":"Brachmann","year":"2016"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000004487"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx042"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2018.10.009"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1813959"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.119.025169"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-6935-x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.111.632836"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067602"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034351"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.119.026496"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-018-1256-9"},{"key":"ref24","first-page":"129","volume-title":"Use of vitamin K antagonists for secondary stroke prevention depends on the treating healthcare provider in Germany: results from the German AFNET registry","author":"Haeusler","year":"2015"}],"container-title":["Journal of Stroke"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/j-stroke.org\/upload\/pdf\/jos-2021-01207.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/j-stroke.org\/journal\/view.php?doi=10.5853\/jos.2021.01207","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/j-stroke.org\/upload\/pdf\/jos-2021-01207.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T08:06:20Z","timestamp":1644307580000},"score":1,"resource":{"primary":{"URL":"http:\/\/j-stroke.org\/journal\/view.php?doi=10.5853\/jos.2021.01207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,31]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"URL":"https:\/\/doi.org\/10.5853\/jos.2021.01207","relation":{},"ISSN":["2287-6391","2287-6405"],"issn-type":[{"value":"2287-6391","type":"print"},{"value":"2287-6405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,31]]},"assertion":[{"value":"2021-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-17","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-31","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}