{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:22:04Z","timestamp":1791591724685,"version":"4.3.4"},"reference-count":48,"publisher":"Korean Stroke Society","issue":"1","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Taiwan National Science and Technology Council","award":["112-2923-B-002-001-MY3"],"award-info":[{"award-number":["112-2923-B-002-001-MY3"]}]},{"name":"Taiwan National Science and Technology Council","award":["113-2628-B-002-013-MY3"],"award-info":[{"award-number":["113-2628-B-002-013-MY3"]}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["113-N0075"],"award-info":[{"award-number":["113-N0075"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["113-X0018"],"award-info":[{"award-number":["113-X0018"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["j-stroke.org"],"crossmark-restriction":true},"short-container-title":["J Stroke"],"published-print":{"date-parts":[[2025,1,31]]},"abstract":"<jats:p>Background and Purpose Although amyloid positron emission tomography (PET) might provide a molecular diagnosis for cerebral amyloid angiopathy (CAA), it does not have sufficient specificity for this condition relative to incipient Alzheimer\u2019s disease (AD). To identify a regional amyloid uptake pattern specific to CAA, we attempted to reduce this overlap by selecting \u201cpure CAA\u201d (i.e., fulfilling the criteria for probable CAA but without tau PET AD signature) and \u201cpure AD\u201d (i.e., positive amyloid PET and presence of tau PET AD signature, but without lobar hemorrhagic lesions). We hypothesized that occipital tracer uptake relative to the whole cortex (WC) would be higher in patients with pure CAA and may serve as a specific diagnostic marker.Methods Patients who fulfilled these criteria were identified. In addition to the occipital region of interest (ROI), we assessed the frontal and posterior cingulate cortex (PCC) ROIs that are sensitive to AD. Amyloid PET uptake was expressed as the absolute standardized uptake value ratio (SUVR) and ROI\/WC ratio. The diagnostic utility of amyloid PET was assessed using the Youden index cutoff.Results Eighteen patients with AD and 42 patients with CAAs of comparable age were eligible. The occipital\/WC was significantly higher in CAA than AD (1.02 [0.97\u20131.06] vs. 0.95 [0.87\u20131.01], P=0.001), with an area under curve of 0.762 (95% confidence interval [CI] 0.635\u20130.889) and a specificity of 72.2% (95% CI 46.5\u201390.3) at Youden cutoff (0.98). The occipital lobe, frontal lobe, PCC and WC SUVRs were significantly lower in CAA than in AD. The frontal\/WC and PCC\/WC ratios did not differ significantly between the groups.Conclusion Using stringent patient selection to minimize between-condition overlap, this study demonstrated the specificity of higher relative occipital amyloid uptake in CAA than in AD.<\/jats:p>","DOI":"10.5853\/jos.2024.02376","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T07:39:28Z","timestamp":1738309168000},"page":"65-74","update-policy":"https:\/\/doi.org\/10.5853\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Differentiating Cerebral Amyloid Angiopathy From Alzheimer\u2019s Disease Using Dual Amyloid and Tau Positron Emission 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