{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:18:51Z","timestamp":1792790331725,"version":"4.5.0"},"reference-count":28,"publisher":"Korean Stroke Society","issue":"3","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Patient-Centered Clinical Research Coordinating Center","id":[{"id":"https:\/\/ror.org\/00fzvsb30","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["RS-2021-KH120281"],"award-info":[{"award-number":["RS-2021-KH120281"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["j-stroke.org"],"crossmark-restriction":true},"short-container-title":["J Stroke"],"published-print":{"date-parts":[[2026,9,30]]},"abstract":"<jats:p>Background and Purpose Admission hyperglycemia is associated with poor outcomes after endovascular thrombectomy (EVT) for acute ischemic stroke, but whether post-EVT glycemic pattern determines functional outcome remains unknown.Methods A Retrospective Study for the Prediction of Clinical Outcomes in Acute Ischemic Stroke Patients with Thrombectomy study was a hybrid prospective-retrospective multicenter cohort study nested within the Rescue on Reperfusion Damage in Cerebral Infarction by Nelonemdaz trial (NCT05041010) across 24 tertiary stroke centers in South Korea. Patients with \u226580% measurements within 80\u2013140 mg\/dL and no value \u2265200 mg\/dL were classified as normoglycemic (Group 1); the remainder were classified by group-based trajectory modeling into persistently elevated (Group 2) and variable hyperglycemia (Group 3). The primary outcome was 3-month modified Rankin Scale (mRS) distribution.Results Among 457 patients, 319 were included (mean age 73.6\u00b112.2 years; 53.6% male): 97 (30.4%) in Group 1, 159 (49.8%) in Group 2, and 63 (19.7%) in Group 3. Groups 2 and 3 had more diabetes and higher hemoglobin A1c; stroke severity, Alberta Stroke Program Early Computed Tomography Scores, and reperfusion status were comparable. Both hyperglycemic groups had lower odds of a favorable mRS shift than Group 1 (adjusted common odds ratio [OR] 0.35, 95% confidence interval [CI] 0.20\u20130.61 and 0.49, 0.25\u20130.94). Functional independence (mRS 0\u20132) was achieved in 63.9% of Group 1 versus 36.5% and 38.1% in Groups 2 and 3 (adjusted OR 0.26, 95% CI 0.13\u20130.53 and 0.31, 0.13\u20130.73). No significant difference was observed between Groups 2 and 3.Conclusions Five-day post-EVT hyperglycemic status was independently associated with worse 3-month functional outcomes beyond chronic glycemic burden, supporting re-evaluation of targeted glycemic interventions during this vulnerable window.<\/jats:p>","DOI":"10.5853\/jos.2026.03867","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:49:47Z","timestamp":1791265787000},"page":"462-474","update-policy":"https:\/\/doi.org\/10.5853\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Five-Day Glycemic Patterns and 3-Month Functional Outcomes After Endovascular Thrombectomy"],"prefix":"10.5853","volume":"28","author":[{"given":"Kwanju","family":"Song","sequence":"first","affiliation":[{"name":"Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea"},{"name":"Bonghwa-Gun Public Health Center, Bonghwa, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Sung","family":"Lee","sequence":"additional","affiliation":[{"name":"Clinical Research Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Goo","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Hwan","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chosun University Hospital, Chosun University College of Medicine, Gwangju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Jin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Ick","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Joon","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Hun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Hyuk","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Soo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ajou University School of Medicine, Ajou University Medical Center, Suwon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Kwan","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dong-A University Hospital, College of Medicine, Dong-A University, Busan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong Bae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eung Gyu","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Busan Paik Hospital, College of Medicine, Inje University, Busan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man Seok","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chonnam National University Medical School, Chonnam National University Hospital, Gwangju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Kwon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology, Inha University Hospital, Inha University College of Medicine, Incheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinkwon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungwook","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Korea University Anam Hospital, Korea University Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heejung","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Il","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee Hyun","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Guk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Daejeon Eulji Medical Center, Eulji University School of Medicine, Daejeon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Seo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Wonkwang University Hospital, School of Medicine, Wonkwang University, Iksan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay Chol","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jeju National University Hospital, Jeju National University College of Medicine, Jeju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang-Ha","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keun Hwa","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo-Kyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Keun","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Hwa","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dong-A University Hospital, College of 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Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bum Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2247-3039","authenticated-orcid":true,"given":"Sun U.","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3882","reference":[{"key":"ref1","first-page":"e316","type":"journal-article","volume-title":"2026 guideline for the early management of patients with acute ischemic stroke: a guideline from the American Heart Association\/American Stroke 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