{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:14:45Z","timestamp":1790871285294,"version":"4.1.0"},"reference-count":78,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Context.<\/jats:italic>\n                    \u2014The origin of and relationship between ovarian mucinous and transitional cell (Brenner) neoplasms are enigmatic. The reported association ranges from 1% to 16%, and whether there is an association with Walthard cell nests is unknown.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Objective.<\/jats:italic>\n                    \u2014To clarify the histologic relationship between mucinous and Brenner tumors.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Design.<\/jats:italic>\n                    \u2014A total of 40 mucinous cystadenomas, 67 Brenner tumors, and 13 combined tumors were studied. Peritoneal surfaces were examined for Walthard nests in 83 patients compared with 272 controls.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results.<\/jats:italic>\n                    \u2014A total of 25% of tumors with a mucinous component contained a Brenner component, and 16% of tumors with a Brenner component contained a mucinous component. Most calcifications were spiculated (nonpsammomatous). In 6 combined tumors, the relative volume of the 2 components was less than 1:3000 (transitional-mucinous). Walthard nests were found in 50% of patients with Brenner tumors and 59% of patients with mucinous tumors. This was significantly higher than the 28% found in controls (\n                    <jats:italic>P<\/jats:italic>\n                    = .002 and\n                    <jats:italic>P<\/jats:italic>\n                    &lt; .001, respectively). The number of fallopian tube blocks examined was correlated with the likelihood of finding Walthard nests, and accordingly, sampling accounted for 39% of the increase with Brenner tumors but strengthened the association with mucinous tumors.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions.<\/jats:italic>\n                    \u2014The strong association of mucinous and transitional cell components, similar type of calcification, complementary size distributions, and frequent identification of a transitional component in the face of an exceedingly small estimated proportion of that component suggest that this association has been underestimated. The association of Brenner tumors with Walthard nests, although significant, appears weak and not strongly supportive of a histogenetic relationship. The stronger association of Walthard nests with mucinous tumors remains unexplained.\n                  <\/jats:p>","DOI":"10.5858\/132.11.1753","type":"journal-article","created":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T23:55:51Z","timestamp":1613087751000},"page":"1753-1760","source":"Crossref","is-referenced-by-count":145,"title":["Exploring the Histogenesis of Ovarian Mucinous and Transitional Cell (Brenner) Neoplasms and Their Relationship With Walthard Cell Nests: A Study of 120 Tumors"],"prefix":"10.5858","volume":"132","author":[{"given":"Jeffrey D.","family":"Seidman","sequence":"first","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine, Washington Hospital Center, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Khedmati","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine, Washington Hospital Center, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3906","reference":[{"key":"i1543-2165-132-11-1753-b1","series-title":"Virchows Arch A Pathol Anat Histopathol","first-page":"197","article-title":"Intestinal differentiation in ovarian mucinous tumours.","volume":"417","author":"Ball, N. J.","year":"1990","unstructured":"Ball, N. J., D. I.Robertson, M. A.Duggan, and D. D.Snider. Intestinal differentiation in ovarian mucinous tumours.Virchows Arch A Pathol Anat Histopathol1990. 417:197\u2013201."},{"key":"i1543-2165-132-11-1753-b2","series-title":"Cancer","first-page":"302","article-title":"Mucinous cystadenomas and mucinous cystadenocarcinomas of the ovary: a clinical and pathological study of 355 cases.","volume":"7","author":"Cariker, M.","year":"1954","unstructured":"Cariker, M. and M.Dockerty. Mucinous cystadenomas and mucinous cystadenocarcinomas of the ovary: a clinical and pathological study of 355 cases.Cancer1954. 7:302\u2013310."},{"key":"i1543-2165-132-11-1753-b3","series-title":"Cancer","first-page":"2329","article-title":"Mucinous borderline and malignant tumors of the ovary: a clinicopathologic and DNA ploidy study of 92 cases.","volume":"74","author":"Guerreri, C.","year":"1994","unstructured":"Guerreri, C., T.Hogberg, and S.Wingren. et al. 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I.Robertson, M. A.Duggan, and D. D.Snider. Intestinal differentiation in ovarian mucinous tumours.Virchows Arch A Pathol Anat Histopathol1990. 417:197\u2013201."},{"key":"i1543-2165-132-11-1753-b2","series-title":"Cancer","first-page":"302","article-title":"Mucinous cystadenomas and mucinous cystadenocarcinomas of the ovary: a clinical and pathological study of 355 cases.","volume":"7","author":"Cariker, M.","year":"1954","unstructured":"Cariker, M. and M.Dockerty. Mucinous cystadenomas and mucinous cystadenocarcinomas of the ovary: a clinical and pathological study of 355 cases.Cancer1954. 7:302\u2013310."},{"key":"i1543-2165-132-11-1753-b3","series-title":"Cancer","first-page":"2329","article-title":"Mucinous borderline and malignant tumors of the ovary: a clinicopathologic and DNA ploidy study of 92 cases.","volume":"74","author":"Guerreri, C.","year":"1994","unstructured":"Guerreri, C., T.Hogberg, and S.Wingren. et al. Mucinous borderline and malignant tumors of the ovary: a clinicopathologic and DNA ploidy study of 92 cases.Cancer1994. 74:2329\u20132340."},{"key":"i1543-2165-132-11-1753-b4","series-title":"Cancer","first-page":"1031","article-title":"Borderline and malignant mucinous tumors of the ovary: histologic criteria and clinical behavior.","volume":"31","author":"Hart, W. R.","year":"1973","unstructured":"Hart, W. R. and H. J.Norris. Borderline and malignant mucinous tumors of the ovary: histologic criteria and clinical behavior.Cancer1973. 31:1031\u20131045."},{"key":"i1543-2165-132-11-1753-b5","article-title":"Tumors of the Female Sex Organs, Part 3.","author":"Hertig, A. T.","unstructured":"Hertig, A. T. and H.Gore. Tumors of the Female Sex Organs, Part 3.Washington, DC: Armed Forces Institute of Pathology; 1961."},{"key":"i1543-2165-132-11-1753-b6","series-title":"Am J Surg Pathol","first-page":"1449","article-title":"Primary ovarian mucinous cystadenocarcinomas: a clinicopathologic study of 49 cases with long-term follow-up.","volume":"22","author":"Hoerl, H. D.","year":"1998","unstructured":"Hoerl, H. D. and W. R.Hart. Primary ovarian mucinous cystadenocarcinomas: a clinicopathologic study of 49 cases with long-term follow-up.Am J Surg Pathol1998. 22:1449\u20131462."},{"key":"i1543-2165-132-11-1753-b7","series-title":"Am J Surg Pathol","first-page":"1447","article-title":"Mucinous tumors of the ovary: a clinicopathologic study of 196 borderline tumors (of intestinal type) and carcinomas, including an evaluation of 11 cases with \u2018pseudomyxoma peritonei.\u2019.","volume":"24","author":"Lee, K. R.","year":"2000","unstructured":"Lee, K. R. and R. E.Scully. Mucinous tumors of the ovary: a clinicopathologic study of 196 borderline tumors (of intestinal type) and carcinomas, including an evaluation of 11 cases with \u2018pseudomyxoma peritonei.\u2019.Am J Surg Pathol2000. 24:1447\u20131464."},{"key":"i1543-2165-132-11-1753-b8","series-title":"Pathol Int","first-page":"862","article-title":"A histogenetic consideration of ovarian mucinous tumors based on an analysis of lesions associated with teratomas or Brenner tumors.","volume":"47","author":"Nomura, K.","year":"1997","unstructured":"Nomura, K. and S.Aizawa. A histogenetic consideration of ovarian mucinous tumors based on an analysis of lesions associated with teratomas or Brenner tumors.Pathol Int1997. 47:862\u2013865."},{"key":"i1543-2165-132-11-1753-b9","series-title":"Am J Surg Pathol","first-page":"617","article-title":"Evaluation of diagnostic criteria and behavior of ovarian intestinal-type mucinous tumors: atypical proliferative (borderline) tumors and intraepithelial, microinvasive, invasive, and metastatic carcinomas.","volume":"23","author":"Riopel, M. A.","year":"1999","unstructured":"Riopel, M. A., B. M.Ronnett, and R. J.Kurman. Evaluation of diagnostic criteria and behavior of ovarian intestinal-type mucinous tumors: atypical proliferative (borderline) tumors and intraepithelial, microinvasive, invasive, and metastatic carcinomas.Am J Surg Pathol1999. 23:617\u2013635."},{"key":"i1543-2165-132-11-1753-b10","series-title":"Am J Surg Pathol","first-page":"139","article-title":"Mucinous tumors of the ovary: a clinicopathologic analysis of 75 borderline tumors (of intestinal type) and carcinomas.","volume":"26","author":"Rodriguez, I. M.","year":"2002","unstructured":"Rodriguez, I. M. and J.Prat. Mucinous tumors of the ovary: a clinicopathologic analysis of 75 borderline tumors (of intestinal type) and carcinomas.Am J Surg Pathol2002. 26:139\u2013152."},{"key":"i1543-2165-132-11-1753-b11","series-title":"Pathology","first-page":"5","article-title":"The pathological assessment of ovarian neoplasms, I: introduction to the common \u2018epithelial\u2019 tumours and analysis of benign \u2018epithelial\u2019 tumours.","volume":"11","author":"Russell, P.","year":"1979","unstructured":"Russell, P.\n          \n          The pathological assessment of ovarian neoplasms, I: introduction to the common \u2018epithelial\u2019 tumours and analysis of benign \u2018epithelial\u2019 tumours.\n          Pathology\n          1979. 11:5\u201326."},{"key":"i1543-2165-132-11-1753-b12","series-title":"Obstet Gynecol","first-page":"699","article-title":"Mucinous tumors of the ovary.","volume":"16","author":"Woodruff, J. D.","year":"1960","unstructured":"Woodruff, J. D., L. S.Bie, and R. J.Sherman. 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