{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:39:46Z","timestamp":1790739586006,"version":"4.1.0"},"reference-count":60,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Follicular lymphoma, although common in adults, is rare in children. Pediatric follicular lymphoma has a more favorable prognosis than adult follicular lymphoma, even though it is often of higher grade. Children with follicular lymphomas are generally at a lower clinical stage, respond well to less aggressive therapy, and have a better survival than adults. Follicular lymphoma must be distinguished from reactive follicular hyperplasia, which it may mimic. Immunohistochemical and molecular markers serve to facilitate this distinction, as well as careful attention to clinical and morphologic details. It is important to recognize pediatric follicular lymphoma as a unique clinicopathologic entity to properly diagnose and manage these patients. It may represent a subset of follicular lymphoma with a particularly good prognosis.<\/jats:p>","DOI":"10.5858\/133.1.142","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T07:05:15Z","timestamp":1613113515000},"page":"142-146","source":"Crossref","is-referenced-by-count":36,"title":["Pediatric Follicular Lymphoma: A Rare Clinicopathologic Entity"],"prefix":"10.5858","volume":"133","author":[{"given":"Renuka","family":"Agrawal","sequence":"first","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine, Loma Linda University Medical Center, Loma Linda, Calif"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine, Loma Linda University Medical Center, Loma Linda, Calif"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3906","reference":[{"key":"i1543-2165-133-1-142-b1","series-title":"Arch Pathol Lab Med","first-page":"551","article-title":"Primary follicular large cell lymphoma of the testis in a child.","volume":"125","author":"Lu, D.","year":"2001","unstructured":"Lu, D., L. 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BCL-6 gene product, a 92- to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counterparts.Blood1995. 86:28\u201337."},{"key":"i1543-2165-133-1-142-b24","series-title":"Am J Surg Pathol","first-page":"846","article-title":"CD10 and BCL-6 expression in paraffin sections of normal lymphoid tissue and B-cell lymphomas.","volume":"24","author":"Dogan, A.","year":"2000","unstructured":"Dogan, A., E.Bagdi, P.Munson, and P. G.Isaacson. CD10 and BCL-6 expression in paraffin sections of normal lymphoid tissue and B-cell lymphomas.Am J Surg Pathol2000. 24:846\u2013852."},{"key":"i1543-2165-133-1-142-b25","series-title":"Histopathology","first-page":"505","article-title":"Ki67 staining pattern as a diagnostic tool in the evaluation of lymphoproliferative disorders.","volume":"48","author":"Bryant, R. J.","year":"2006","unstructured":"Bryant, R. J., P. M.Banks, and D. P.O'Malley. Ki67 staining pattern as a diagnostic tool in the evaluation of lymphoproliferative disorders.Histopathology2006. 48:505\u2013515."},{"key":"i1543-2165-133-1-142-b26","series-title":"Am J Clin Pathol","first-page":"538","article-title":"Immunohistochemical detection of p53, bcl-2 and retinoblastoma proteins in follicular lymphoma.","volume":"105","author":"Nguyen, P. L.","year":"1996","unstructured":"Nguyen, P. L., L. R.Zukerberg, W. F.Benedict, and N. L.Harris. Immunohistochemical detection of p53, bcl-2 and retinoblastoma proteins in follicular lymphoma.Am J Clin Pathol1996. 105:538\u2013543."},{"key":"i1543-2165-133-1-142-b27","series-title":"Blood","first-page":"1994","article-title":"p53 mutation is associated with progression in follicular lymphomas.","volume":"82","author":"Sander, C. A.","year":"1993","unstructured":"Sander, C. A., T.Yano, and H. M.Clark. et al. p53 mutation is associated with progression in follicular lymphomas.Blood1993. 82:1994\u20132004."},{"key":"i1543-2165-133-1-142-b28","series-title":"Blood","first-page":"2289","article-title":"p53 mutations are associated with histologic transformation of follicular lymphoma.","volume":"82","author":"Lo Coco, F.","year":"1993","unstructured":"Lo Coco, F., G.Gaidano, D. C.Louie, K.Offit, R. S.Chaganti, and R.Dalla-Favera. p53 mutations are associated with histologic transformation of follicular lymphoma.Blood1993. 82:2289\u20132295."},{"key":"i1543-2165-133-1-142-b29","series-title":"Semin Hematol","first-page":"323","article-title":"The child with lymphadenopathy.","volume":"12","author":"Zuelzer, W. W.","year":"1975","unstructured":"Zuelzer, W. W. and J.Kaplan. The child with lymphadenopathy.Semin Hematol1975. 12:323\u2013334."},{"key":"i1543-2165-133-1-142-b30","series-title":"Am J Surg Pathol","first-page":"522","article-title":"Marginal zone B-cell lymphoma in children and young adults.","volume":"27","author":"Taddesse-Heath, L.","year":"2003","unstructured":"Taddesse-Heath, L., S.Pittaluga, L.Sorbara, M.Bussey, M.Raffeld, and E. S.Jaffe. Marginal zone B-cell lymphoma in children and young adults.Am J Surg Pathol2003. 27:522\u2013531."}],"container-title":["Archives of Pathology &amp; Laboratory Medicine"],"original-title":[],"link":[{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/133\/1\/article-p142.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/133\/1\/142\/2766312\/1543-2165-133_1_142.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/133\/1\/article-p142.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/133\/1\/article-p142.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T01:04:47Z","timestamp":1770771887000},"score":1,"resource":{"primary":{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/133\/1\/article-p142.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":60,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.5858\/133.1.142","relation":{},"ISSN":["1543-2165","0003-9985"],"issn-type":[{"value":"1543-2165","type":"electronic"},{"value":"0003-9985","type":"print"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}