{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T18:33:09Z","timestamp":1780511589545,"version":"3.54.1"},"reference-count":14,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Context.<\/jats:italic>\n                    \u2014The size of ductal carcinoma in situ (DCIS) is a significant predictor of local tumor recurrence and is used for selection of patients for conservative versus aggressive therapy. A standardized method for size assessment is lacking.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Objective.<\/jats:italic>\n                    \u2014To evaluate 2 commonly used methods for measurement of DCIS extent: one based on the distribution of the lesion in sequential series of sections (mapping method) and the other on the number of sections with DCIS (block method).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Design.<\/jats:italic>\n                    \u2014Ninety-eight consecutive cases of DCIS, measuring at least 1.0 cm, were retrieved from our files. All specimens were serially sectioned along the long axis. The size of DCIS was calculated for each case by 2 different methods: (1) mapping method (average thickness of each slice \u00d7 number of consecutive slices with DCIS) and (2) block method (number of blocks with DCIS \u00d7 0.3 cm). Additional calculations were performed by using 0.35, 0.4, and 0.5 cm as multiplication factors for the block method in order to improve concordance.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results.<\/jats:italic>\n                    \u2014The block method underestimated the size in 71 cases (72%) by 4.5% to 81.3% (mean, 33%). Using 0.4 cm as the multiplication factor improved concordance, while multiplying by 0.5 cm led to an overestimation of size.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions.<\/jats:italic>\n                    \u2014Assessment of DCIS size by the block method is inaccurate and underestimates size in most cases (72%), with an average reduction of 33%. Using 0.4 cm as the multiplication factor improves concordance. A standardized method for size estimation is necessary for effective patient management.\n                  <\/jats:p>","DOI":"10.5858\/133.1.26","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T07:07:44Z","timestamp":1613113664000},"page":"26-30","source":"Crossref","is-referenced-by-count":27,"title":["Comparative Analysis of Size Estimation by Mapping and Counting Number of Blocks With Ductal Carcinoma In Situ in Breast Excision Specimens"],"prefix":"10.5858","volume":"133","author":[{"given":"Farnaz","family":"Dadmanesh","sequence":"first","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemo","family":"Fan","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Dastane","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahul B.","family":"Amin","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikha","family":"Bose","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3906","reference":[{"key":"i1543-2165-133-1-26-b1","series-title":"Cancer","first-page":"2317","article-title":"The prognostic significance of multiple morphologic features and biologic markers in ductal carcinoma in situ of the breast.","volume":"100","author":"Cornfield, D. B.","year":"2004","unstructured":"Cornfield, D. B., J. P.Palazzo, and G. F.Schwartz. et al. The prognostic significance of multiple morphologic features and biologic markers in ductal carcinoma in situ of the breast.Cancer2004. 100:2317\u20132327."},{"key":"i1543-2165-133-1-26-b2","series-title":"Cancer","first-page":"2267","article-title":"A prognostic index for ductal carcinoma in situ of the breast.","volume":"77","author":"Silverstein, M. J.","year":"1996","unstructured":"Silverstein, M. J., M. D.Lagios, and P. H.Craig. et al. A prognostic index for ductal carcinoma in situ of the breast.Cancer1996. 77:2267\u20132274."},{"key":"i1543-2165-133-1-26-b3","series-title":"Lancet","first-page":"519","article-title":"Extent, distribution, and mammographic\/histological correlations of breast ductal carcinoma in situ.","volume":"335","author":"Holland, R.","year":"1990","unstructured":"Holland, R., J. H.Hendriks, A. L.Vebeek, M.Mravunac, and J. H.Schuurmans Stekhoven. Extent, distribution, and mammographic\/histological correlations of breast ductal carcinoma in situ.Lancet1990. 335:519\u2013522."},{"key":"i1543-2165-133-1-26-b4","series-title":"Semin Diagn Pathol","first-page":"181","article-title":"Microcalcifications associated with ductal carcinoma in situ: mammographic-pathologic correlation.","volume":"11","author":"Holland, R.","year":"1994","unstructured":"Holland, R. and J. H.Hendriks. Microcalcifications associated with ductal carcinoma in situ: mammographic-pathologic correlation.Semin Diagn Pathol1994. 11:181\u2013192."},{"key":"i1543-2165-133-1-26-b5","series-title":"Cancer","first-page":"2189","article-title":"Developing a prognostic index for ductal carcinoma in situ of the breast: are we there yet?","volume":"77","author":"Schnitt, S. J.","year":"1996","unstructured":"Schnitt, S. J., J. R.Harris, and B. L.Smith. Developing a prognostic index for ductal carcinoma in situ of the breast: are we there yet?Cancer1996. 77:2189\u20132192."},{"key":"i1543-2165-133-1-26-b6","series-title":"Breast J","first-page":"359","article-title":"The value of the Van Nuys Prognostic Index in ductal carcinoma in situ of the breast: a retrospective analysis.","volume":"13","author":"Asjoe, F. T.","year":"2007","unstructured":"Asjoe, F. T., S.Altinas, C.Colpaert, E. V.Marck, J. B.Vermorken, and W. A.Tjalma. The value of the Van Nuys Prognostic Index in ductal carcinoma in situ of the breast: a retrospective analysis.Breast J2007. 13:359\u2013367."},{"key":"i1543-2165-133-1-26-b7","series-title":"Breast Cancer Res Treat","first-page":"405","article-title":"259 patients with DCIS of the breast applying USC\/Van Nuys prognostic index: a retrospective review with long term follow up.","volume":"109","author":"Di Saverio, S.","year":"2008","unstructured":"Di Saverio, S., F.Catena, and D.Santini. et al. 259 patients with DCIS of the breast applying USC\/Van Nuys prognostic index: a retrospective review with long term follow up.Breast Cancer Res Treat2008. 109:405\u2013416."},{"key":"i1543-2165-133-1-26-b1","series-title":"Cancer","first-page":"2317","article-title":"The prognostic significance of multiple morphologic features and biologic markers in ductal carcinoma in situ of the breast.","volume":"100","author":"Cornfield, D. B.","year":"2004","unstructured":"Cornfield, D. B., J. P.Palazzo, and G. F.Schwartz. et al. The prognostic significance of multiple morphologic features and biologic markers in ductal carcinoma in situ of the breast.Cancer2004. 100:2317\u20132327."},{"key":"i1543-2165-133-1-26-b2","series-title":"Cancer","first-page":"2267","article-title":"A prognostic index for ductal carcinoma in situ of the breast.","volume":"77","author":"Silverstein, M. J.","year":"1996","unstructured":"Silverstein, M. J., M. D.Lagios, and P. H.Craig. et al. A prognostic index for ductal carcinoma in situ of the breast.Cancer1996. 77:2267\u20132274."},{"key":"i1543-2165-133-1-26-b3","series-title":"Lancet","first-page":"519","article-title":"Extent, distribution, and mammographic\/histological correlations of breast ductal carcinoma in situ.","volume":"335","author":"Holland, R.","year":"1990","unstructured":"Holland, R., J. H.Hendriks, A. L.Vebeek, M.Mravunac, and J. H.Schuurmans Stekhoven. Extent, distribution, and mammographic\/histological correlations of breast ductal carcinoma in situ.Lancet1990. 335:519\u2013522."},{"key":"i1543-2165-133-1-26-b4","series-title":"Semin Diagn Pathol","first-page":"181","article-title":"Microcalcifications associated with ductal carcinoma in situ: mammographic-pathologic correlation.","volume":"11","author":"Holland, R.","year":"1994","unstructured":"Holland, R. and J. H.Hendriks. Microcalcifications associated with ductal carcinoma in situ: mammographic-pathologic correlation.Semin Diagn Pathol1994. 11:181\u2013192."},{"key":"i1543-2165-133-1-26-b5","series-title":"Cancer","first-page":"2189","article-title":"Developing a prognostic index for ductal carcinoma in situ of the breast: are we there yet?","volume":"77","author":"Schnitt, S. J.","year":"1996","unstructured":"Schnitt, S. J., J. R.Harris, and B. L.Smith. Developing a prognostic index for ductal carcinoma in situ of the breast: are we there yet?Cancer1996. 77:2189\u20132192."},{"key":"i1543-2165-133-1-26-b6","series-title":"Breast J","first-page":"359","article-title":"The value of the Van Nuys Prognostic Index in ductal carcinoma in situ of the breast: a retrospective analysis.","volume":"13","author":"Asjoe, F. T.","year":"2007","unstructured":"Asjoe, F. T., S.Altinas, C.Colpaert, E. V.Marck, J. B.Vermorken, and W. A.Tjalma. The value of the Van Nuys Prognostic Index in ductal carcinoma in situ of the breast: a retrospective analysis.Breast J2007. 13:359\u2013367."},{"key":"i1543-2165-133-1-26-b7","series-title":"Breast Cancer Res Treat","first-page":"405","article-title":"259 patients with DCIS of the breast applying USC\/Van Nuys prognostic index: a retrospective review with long term follow up.","volume":"109","author":"Di Saverio, S.","year":"2008","unstructured":"Di Saverio, S., F.Catena, and D.Santini. et al. 259 patients with DCIS of the breast applying USC\/Van Nuys prognostic index: a retrospective review with long term follow up.Breast Cancer Res Treat2008. 109:405\u2013416."}],"container-title":["Archives of Pathology &amp; Laboratory Medicine"],"original-title":[],"link":[{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/133\/1\/article-p26.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/133\/1\/26\/2766385\/1543-2165-133_1_26.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/133\/1\/article-p26.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/133\/1\/article-p26.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T01:04:49Z","timestamp":1770771889000},"score":1,"resource":{"primary":{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/133\/1\/article-p26.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":14,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.5858\/133.1.26","relation":{},"ISSN":["1543-2165","0003-9985"],"issn-type":[{"value":"1543-2165","type":"electronic"},{"value":"0003-9985","type":"print"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}