{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:39:11Z","timestamp":1769733551915,"version":"3.49.0"},"reference-count":24,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Context.\u2014Micropapillary urothelial carcinoma (MPUC) is a rare variant of urothelial carcinoma. Most studies of MPUC have focused on the urinary bladder, but MPUC of the upper urinary tract remains to be investigated.<\/jats:p>\n                  <jats:p>Objective.\u2014To investigate the pathologic features and clinical significance of MPUC in the upper urinary tract.<\/jats:p>\n                  <jats:p>Design.\u2014We searched the pathology files at our institution and identified 11 cases of MPUC of the upper urinary tract. The histology slides were reviewed, and the clinical information was obtained by review of medical charts.<\/jats:p>\n                  <jats:p>Results.\u2014The average age of the patients was 64.2 years (range, 22\u201376 years). The tumors were located in the renal pelvis (n = 5), ureter (n = 4), and ureteropelvic junction (n = 2). In all cases, MPUC accounted for an average of 45% (range, 10%\u201380%) of the tumor and was associated with conventional urothelial carcinoma. Lymphovascular invasion was present in all cases, and metastasis to lymph node was present in 4 of 5 patients whose lymph nodes were dissected. Two patients presented with pT2 disease, and both were alive without evidence of disease at 85 and 119 months after surgery. The other 9 patients presented with pT3 or pT4 disease: 4 of them died of disease at an average of 18 months; 4 surviving patients developed distant metastases; and 1 surviving patient with limited follow-up (6 months) showed no evidence of disease.<\/jats:p>\n                  <jats:p>Conclusions.\u2014Micropapillary urothelial carcinoma of the upper urinary tract often presents at an advanced stage with lymphovascular invasion and distant metastasis. The presence of MPUC, even focal, indicates a poor clinical course.<\/jats:p>","DOI":"10.5858\/133.1.62","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T07:49:15Z","timestamp":1613116155000},"page":"62-66","source":"Crossref","is-referenced-by-count":34,"title":["Micropapillary Variant of Urothelial Carcinoma in the Upper Urinary Tract: A Clinicopathologic Study of 11 Cases"],"prefix":"10.5858","volume":"133","author":[{"given":"Charles C.","family":"Guo","sequence":"first","affiliation":[{"name":"From the Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pheroze","family":"Tamboli","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan","family":"Czerniak","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"key":"2021021102002606500_i1543-2165-133-1-62-b1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3322\/CA.2007.0010","article-title":"Cancer statistics, 2008.","volume":"58","author":"Jemal","year":"2008","journal-title":"CA Cancer J Clin"},{"key":"2021021102002606500_i1543-2165-133-1-62-b2","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/S0090-4295(98)00295-7","article-title":"Prognostic factors, recurrence, and survival in transitional cell carcinoma of the upper urinary tract: a 30-year experience in 252 patients.","volume":"52","author":"Hall","year":"1998","journal-title":"Urology"},{"key":"2021021102002606500_i1543-2165-133-1-62-b3","article-title":"Urothelial tumors of the urinary tract.","author":"Messing"},{"key":"2021021102002606500_i1543-2165-133-1-62-b4","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0022-5347(17)55935-2","article-title":"Primary carcinoma of the ureter.","volume":"123","author":"Babaian","year":"1980","journal-title":"J Urol"},{"key":"2021021102002606500_i1543-2165-133-1-62-b5","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1097\/00000478-199412000-00005","article-title":"Micropapillary variant of transitional cell carcinoma of the urinary bladder: histologic pattern resembling ovarian papillary serous carcinoma.","volume":"18","author":"Amin","year":"1994","journal-title":"Am J Surg Pathol"},{"key":"2021021102002606500_i1543-2165-133-1-62-b6","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1016\/S0022-5347(05)68807-6","article-title":"Micropapillary bladder carcinoma: a clinicopathological study of 20 cases.","volume":"161","author":"Johansson","year":"1999","journal-title":"J Urol"},{"key":"2021021102002606500_i1543-2165-133-1-62-b7","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/S0022-5347(05)67796-8","article-title":"Clinical and pathological characteristics of micropapillary transitional cell carcinoma: a highly aggressive variant.","volume":"163","author":"Maranchie","year":"2000","journal-title":"J Urol"},{"key":"2021021102002606500_i1543-2165-133-1-62-b8","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/cncr.22756","article-title":"Micropapillary bladder cancer: a review of the University of Texas M. D. Anderson Cancer Center experience with 100 consecutive patients.","volume":"110","author":"Kamat","year":"2007","journal-title":"Cancer"},{"key":"2021021102002606500_i1543-2165-133-1-62-b9","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1046\/j.1440-1827.2000.00997.x","article-title":"Micropapillary variant of transitional cell carcinoma of the ureter.","volume":"50","author":"Oh","year":"2000","journal-title":"Pathol Int"},{"key":"2021021102002606500_i1543-2165-133-1-62-b10","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1309\/K7MELVFPKQE2RCDL","article-title":"Micropapillary urothelial carcinoma of the upper urinary tract: clinicopathologic study of five cases.","volume":"126","author":"Perez-Montiel","year":"2006","journal-title":"Am J Clin Pathol"},{"key":"2021021102002606500_i1543-2165-133-1-62-b11","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0022-5347(05)00153-9","article-title":"Micropapillary carcinoma of the renal pelvis and ureter.","volume":"175","author":"Holm\u00e4ng","year":"2006","journal-title":"J Urol"},{"key":"2021021102002606500_i1543-2165-133-1-62-b12","first-page":"83","article-title":"Use of Ulex europaeus agglutinin I (UEAI) to distinguish vascular and \u201cpseudovascular\u201d invasion in transitional cell carcinoma of bladder with lamina propria invasion.","volume":"3","author":"Larsen","year":"1990","journal-title":"Mod Pathol"},{"key":"2021021102002606500_i1543-2165-133-1-62-b13","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0022-5347(05)00423-4","article-title":"The case for early cystectomy in the treatment of nonmuscle invasive micropapillary bladder carcinoma.","volume":"175","author":"Kamat","year":"2006","journal-title":"J Urol"},{"key":"2021021102002606500_i1543-2165-133-1-62-b14","first-page":"660","article-title":"Invasive micropapillary carcinoma of the breast.","volume":"6","author":"Siriaunkgul","year":"1993","journal-title":"Mod Pathol"},{"key":"2021021102002606500_i1543-2165-133-1-62-b15","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/00000478-200203000-00010","article-title":"Micropapillary component in lung adenocarcinoma: a distinctive histologic feature with possible prognostic significance.","volume":"26","author":"Amin","year":"2002","journal-title":"Am J Surg Pathol"},{"key":"2021021102002606500_i1543-2165-133-1-62-b16","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/00000478-200403000-00004","article-title":"Invasive micropapillary salivary duct carcinoma: a distinct histologic variant with biologic significance.","volume":"28","author":"Nagao","year":"2004","journal-title":"Am J Surg Pathol"},{"key":"2021021102002606500_i1543-2165-133-1-62-b17","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1097\/00000478-199611000-00003","article-title":"Micropapillary serous carcinoma of the ovary: a distinctive low-grade carcinoma related to serous borderline tumors.","volume":"20","author":"Burks","year":"1996","journal-title":"Am J Surg Pathol"},{"key":"2021021102002606500_i1543-2165-133-1-62-b18","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.humpath.2005.10.018","article-title":"Invasive colorectal micropapillary carcinoma: an aggressive variant of adenocarcinoma.","volume":"37","author":"Kim","year":"2006","journal-title":"Hum Pathol"},{"key":"2021021102002606500_i1543-2165-133-1-62-b19","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/modpathol.3800790","article-title":"Colorectal adenocarcinoma with micropapillary pattern and its association with lymph node metastasis.","volume":"20","author":"Haupt","year":"2007","journal-title":"Mod Pathol"},{"key":"2021021102002606500_i1543-2165-133-1-62-b20","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/01.pap.0000138142.26882.fe","article-title":"Carcinomas with micropapillary morphology: clinical significance and current concepts.","volume":"11","author":"Nassar","year":"2004","journal-title":"Adv Anat Pathol"},{"key":"2021021102002606500_i1543-2165-133-1-62-b21","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S1092-9134(02)91216-5","article-title":"Invasive micropapillary carcinoma of the breast metastatic to the urinary bladder and endometrium: diagnostic pitfalls and review of the literature of tumors with micropapillary features.","volume":"7","author":"Ramalingam","year":"2003","journal-title":"Ann Diagn Pathol"},{"key":"2021021102002606500_i1543-2165-133-1-62-b22","first-page":"780A","article-title":"Breast carcinomas with an unexpected inside-out growth pattern: rotation of polarization associated with angioinvasion.","volume":"189","author":"Peterson","year":"1993","journal-title":"Path Res Pract"},{"key":"2021021102002606500_i1543-2165-133-1-62-b23","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/S0344-0338(11)80745-4","article-title":"Invasive micropapillary carcinoma of the breast: a new special type of invasive mammary carcinoma.","volume":"190","author":"Luna-More","year":"1994","journal-title":"Pathol Res Pract"},{"key":"2021021102002606500_i1543-2165-133-1-62-b24","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1038\/modpathol.3800166","article-title":"Pathogenesis of invasive micropapillary carcinoma: role of MUC1 glycoprotein.","volume":"17","author":"Nassar","year":"2004","journal-title":"Mod Pathol"}],"container-title":["Archives of Pathology &amp; Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/133\/1\/62\/2766458\/1543-2165-133_1_62.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/133\/1\/62\/2766458\/1543-2165-133_1_62.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T19:35:59Z","timestamp":1764790559000},"score":1,"resource":{"primary":{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/133\/1\/article-p62.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,1]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1,1]]}},"URL":"https:\/\/doi.org\/10.5858\/133.1.62","relation":{},"ISSN":["1543-2165","0003-9985"],"issn-type":[{"value":"1543-2165","type":"electronic"},{"value":"0003-9985","type":"print"}],"subject":[],"published":{"date-parts":[[2009,1,1]]}}}