{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T09:31:34Z","timestamp":1770802294654,"version":"3.50.0"},"reference-count":30,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Crystal-storing histiocytosis is a rare disorder that is typically associated with low-grade B-cell lymphomas and monoclonal gammopathy. We present a 64-year-old man with a prior history of weakness and weight loss and hematologic evaluation that had revealed immunoglobulin G \u03ba monoclonal light chains in the serum and negative bone marrow biopsy. He presented with supraventricular tachyarrhythmia and a right atrial mass seen on echocardiogram and excised surgically. Histologically, the tumor was composed of sheets of macrophages infiltrating the atrial myocardium. The histiocytes were filled with multiple needle-shaped, periodic acid-Schiff\u2013negative crystals. These cells and associated plasma cells failed to show clonal light chain restriction by in situ hybridization or immunohistochemistry, and there was no area of lymphoma in the tumor. Ultrastructural examination showed numerous sticklike, trapezoidal, or polygonal dense crystals in the cytoplasm of histiocytes corroborating the diagnosis of crystal-storing histiocytosis. Although rare, crystal-storing histiocytosis should be included in the differential diagnosis of heart masses in patients with hematologic conditions associated with monoclonal gammopathy.<\/jats:p>","DOI":"10.5858\/133.11.1861","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T08:59:43Z","timestamp":1613120383000},"page":"1861-1864","source":"Crossref","is-referenced-by-count":12,"title":["Crystal-Storing Histiocytosis as a Cause of Symptomatic Cardiac Mass"],"prefix":"10.5858","volume":"133","author":[{"given":"Charles J.","family":"Sailey","sequence":"first","affiliation":[{"name":"From the Departments of Pathology (Drs Sailey, Alexiev, and Burke), Surgery (Dr Gammie), and Cardiology (Drs Pinell-Salles and Stafford), University of Maryland Medical System, Baltimore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borislav A.","family":"Alexiev","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Sailey, Alexiev, and Burke), Surgery (Dr Gammie), and Cardiology (Drs Pinell-Salles and Stafford), University of Maryland Medical System, Baltimore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Gammie","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Sailey, Alexiev, and Burke), Surgery (Dr Gammie), and Cardiology (Drs Pinell-Salles and Stafford), University of Maryland Medical System, Baltimore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Pinell-Salles","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Sailey, Alexiev, and Burke), Surgery (Dr Gammie), and Cardiology (Drs Pinell-Salles and Stafford), University of Maryland Medical System, Baltimore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Lawrence","family":"Stafford","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Sailey, Alexiev, and Burke), Surgery (Dr Gammie), and Cardiology (Drs Pinell-Salles and Stafford), University of Maryland Medical System, Baltimore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen","family":"Burke","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Sailey, Alexiev, and Burke), Surgery (Dr Gammie), and Cardiology (Drs Pinell-Salles and Stafford), University of Maryland Medical System, Baltimore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"key":"i1543-2165-133-11-1861-b1","series-title":"Hum Pathol","first-page":"1441","article-title":"Crystal-storing histiocytosis: a disorder occurring in plasmacytic tumors expressing immunoglobulin kappa light chain.","volume":"30","author":"Jones, D.","year":"1999","unstructured":"Jones, D., V. K.Bhatia, T.Krausz, and G. S.Pinkus. Crystal-storing histiocytosis: a disorder occurring in plasmacytic tumors expressing immunoglobulin kappa light chain.Hum Pathol1999. 30:1441\u20131448."},{"key":"i1543-2165-133-11-1861-b2","series-title":"Hum Pathol","first-page":"84","article-title":"Crystal-storing histiocytosis associated with lymphoplasmacytic lymphoma mimicking Weber-Christian disease: immunohistochemical, ultrastructural, and gene-rearrangement studies.","volume":"27","author":"Harada, M.","year":"1996","unstructured":"Harada, M., M.Shimada, M.Fukayama, T.Kaneko, K.Kitazume, and S. W.Weiss. Crystal-storing histiocytosis associated with lymphoplasmacytic lymphoma mimicking Weber-Christian disease: immunohistochemical, ultrastructural, and gene-rearrangement studies.Hum Pathol1996. 27:84\u201387."},{"key":"i1543-2165-133-11-1861-b3","series-title":"Pathol Res Pract","first-page":"1152","article-title":"Gammopathy-related crystal-storing histiocytosis, pseudo- and pseudo-pseudo-Gaucher cells: critical commentary and mini-review.","volume":"192","author":"Schaefer, H. E.","year":"1996","unstructured":"Schaefer, H. E.\n          \n          Gammopathy-related crystal-storing histiocytosis, pseudo- and pseudo-pseudo-Gaucher cells: critical commentary and mini-review.\n          Pathol Res Pract\n          1996. 192:1152\u20131162."},{"key":"i1543-2165-133-11-1861-b4","series-title":"Blood","first-page":"1817","article-title":"Generalized crystal-storing histiocytosis associated with monoclonal gammopathy: molecular analysis of a disorder with rapid clinical course and review of the literature.","volume":"100","author":"Lebeau, A.","year":"2002","unstructured":"Lebeau, A., E.Zeindl-Eberhart, and E. C.Muller. et al. Generalized crystal-storing histiocytosis associated with monoclonal gammopathy: molecular analysis of a disorder with rapid clinical course and review of the literature.Blood2002. 100:1817\u20131827."},{"key":"i1543-2165-133-11-1861-b5","series-title":"Arch Pathol Lab Med","first-page":"1159","article-title":"Pulmonary crystal-storing histiocytoma.","volume":"129","author":"Ionescu, D. N.","year":"2005","unstructured":"Ionescu, D. N., D. M.Pierson, G.Qing, M.Li, T. V.Colby, and K. O.Leslie. Pulmonary crystal-storing histiocytoma.Arch Pathol Lab Med2005. 129:1159\u20131163."},{"key":"i1543-2165-133-11-1861-b6","series-title":"Virchows Arch","first-page":"83","article-title":"Generalized crystal-storing histiocytosis as a presentation of multiple myeloma: a case with a possible pro-aggregation defect in the immunoglobulin heavy chain.","volume":"445","author":"Papla, B.","year":"2004","unstructured":"Papla, B., P.Spolnik, and E.Rzenno. et al. Generalized crystal-storing histiocytosis as a presentation of multiple myeloma: a case with a possible pro-aggregation defect in the immunoglobulin heavy chain.Virchows Arch2004. 445:83\u201389."},{"key":"i1543-2165-133-11-1861-b7","series-title":"Am J Kidney Dis","first-page":"183","article-title":"Crystal-storing histiocytosis involving the kidney in a low-grade B-cell lymphoproliferative disorder.","volume":"39","author":"Sethi, S.","year":"2002","unstructured":"Sethi, S., B. P.Cuiffo, G. S.Pinkus, and H. G.Rennke. Crystal-storing histiocytosis involving the kidney in a low-grade B-cell lymphoproliferative disorder.Am J Kidney Dis2002. 39:183\u2013188."},{"key":"i1543-2165-133-11-1861-b8","series-title":"Bone Marrow Transplant","first-page":"339","article-title":"Clinical and molecular characteristics of patients with non-amyloid light chain deposition disorders, and outcome following treatment with high-dose melphalan and autologous stem cell transplantation.","volume":"38","author":"Weichman, K.","year":"2006","unstructured":"Weichman, K., L. M.Dember, and T.Prokaeva. et al. Clinical and molecular characteristics of patients with non-amyloid light chain deposition disorders, and outcome following treatment with high-dose melphalan and autologous stem cell transplantation.Bone Marrow Transplant2006. 38:339\u2013343."},{"key":"i1543-2165-133-11-1861-b9","series-title":"Br J Haematol","first-page":"412","article-title":"Crystal-storing histiocytosis in a patient with IgG kappa multiple myeloma.","volume":"128","author":"Tholouli, E.","year":"2005","unstructured":"Tholouli, E., M.Krebs, R.Reeve, and J. B.Houghton. Crystal-storing histiocytosis in a patient with IgG kappa multiple myeloma.Br J Haematol2005. 128:412."},{"key":"i1543-2165-133-11-1861-b10","series-title":"Klin Wochenschr","first-page":"365","article-title":"Weber-Christian panniculitis with systemic cytophagic histiocytosis.","volume":"66","author":"Steininger, H.","year":"1988","unstructured":"Steininger, H. and M.Missmahl. Weber-Christian panniculitis with systemic cytophagic histiocytosis.Klin Wochenschr1988. 66:365\u2013372."},{"key":"i1543-2165-133-11-1861-b11","series-title":"Chest","first-page":"1217","article-title":"Cardiac rhabdomyoma in an adult patient presenting with ventricular arrhythmia.","volume":"118","author":"Krasuski, R. A.","year":"2000","unstructured":"Krasuski, R. A., A. B.Hesselson, K. P.Landolfo, K. J.Ellington, and T. M.Bashore. Cardiac rhabdomyoma in an adult patient presenting with ventricular arrhythmia.Chest2000. 118:1217\u20131221."},{"key":"i1543-2165-133-11-1861-b12","article-title":"Langerhans cell histiocytosis.","author":"Jaffe, E.","unstructured":"Jaffe, E., N.Harris, H.Stein, and J.Vardiman. Langerhans cell histiocytosis.In: Weiss LM, Grogan TM, Muller-Hermelink HK, eds. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, France: IARC Press; 2003. World Health Organization Classification of Tumours; vol 3."},{"key":"i1543-2165-133-11-1861-b13","series-title":"Pathologe","first-page":"222","article-title":"Extranodal Rosai Dorfman disease (sinus histiocytosis with massive lymphadenopathy): report of 5 cases.","volume":"25","author":"Hindermann, W.","year":"2004","unstructured":"Hindermann, W. and D.Katenkamp. Extranodal Rosai Dorfman disease (sinus histiocytosis with massive lymphadenopathy): report of 5 cases.Pathologe2004. 25:222\u2013228."},{"key":"i1543-2165-133-11-1861-b14","series-title":"Arch Pathol Lab Med","first-page":"682","article-title":"Myocardial involvement in Erdheim-Chester disease.","volume":"128","author":"Loeffler, A.","year":"2004","unstructured":"Loeffler, A. and V.Memoli. Myocardial involvement in Erdheim-Chester disease.Arch Pathol Lab Med2004. 128:682\u2013685."},{"key":"i1543-2165-133-11-1861-b15","series-title":"Am J Surg Pathol","first-page":"1115","article-title":"Cardiac inflammatory myofibroblastic tumor: a \u201cbenign\u201d neoplasm that may result in syncope, myocardial infarction, and sudden death.","volume":"31","author":"Burke, A.","year":"2007","unstructured":"Burke, A., L.Li, E.Kling, R.Kutys, R.Virmani, and M.Miettinen. Cardiac inflammatory myofibroblastic tumor: a \u201cbenign\u201d neoplasm that may result in syncope, myocardial infarction, and sudden death.Am J Surg Pathol2007. 31:1115\u20131122."},{"key":"i1543-2165-133-11-1861-b1","series-title":"Hum Pathol","first-page":"1441","article-title":"Crystal-storing histiocytosis: a disorder occurring in plasmacytic tumors expressing immunoglobulin kappa light chain.","volume":"30","author":"Jones, D.","year":"1999","unstructured":"Jones, D., V. K.Bhatia, T.Krausz, and G. S.Pinkus. Crystal-storing histiocytosis: a disorder occurring in plasmacytic tumors expressing immunoglobulin kappa light chain.Hum Pathol1999. 30:1441\u20131448."},{"key":"i1543-2165-133-11-1861-b2","series-title":"Hum Pathol","first-page":"84","article-title":"Crystal-storing histiocytosis associated with lymphoplasmacytic lymphoma mimicking Weber-Christian disease: immunohistochemical, ultrastructural, and gene-rearrangement studies.","volume":"27","author":"Harada, M.","year":"1996","unstructured":"Harada, M., M.Shimada, M.Fukayama, T.Kaneko, K.Kitazume, and S. W.Weiss. Crystal-storing histiocytosis associated with lymphoplasmacytic lymphoma mimicking Weber-Christian disease: immunohistochemical, ultrastructural, and gene-rearrangement studies.Hum Pathol1996. 27:84\u201387."},{"key":"i1543-2165-133-11-1861-b3","series-title":"Pathol Res Pract","first-page":"1152","article-title":"Gammopathy-related crystal-storing histiocytosis, pseudo- and pseudo-pseudo-Gaucher cells: critical commentary and mini-review.","volume":"192","author":"Schaefer, H. E.","year":"1996","unstructured":"Schaefer, H. E.\n          \n          Gammopathy-related crystal-storing histiocytosis, pseudo- and pseudo-pseudo-Gaucher cells: critical commentary and mini-review.\n          Pathol Res Pract\n          1996. 192:1152\u20131162."},{"key":"i1543-2165-133-11-1861-b4","series-title":"Blood","first-page":"1817","article-title":"Generalized crystal-storing histiocytosis associated with monoclonal gammopathy: molecular analysis of a disorder with rapid clinical course and review of the literature.","volume":"100","author":"Lebeau, A.","year":"2002","unstructured":"Lebeau, A., E.Zeindl-Eberhart, and E. C.Muller. et al. Generalized crystal-storing histiocytosis associated with monoclonal gammopathy: molecular analysis of a disorder with rapid clinical course and review of the literature.Blood2002. 100:1817\u20131827."},{"key":"i1543-2165-133-11-1861-b5","series-title":"Arch Pathol Lab Med","first-page":"1159","article-title":"Pulmonary crystal-storing histiocytoma.","volume":"129","author":"Ionescu, D. N.","year":"2005","unstructured":"Ionescu, D. N., D. M.Pierson, G.Qing, M.Li, T. V.Colby, and K. O.Leslie. Pulmonary crystal-storing histiocytoma.Arch Pathol Lab Med2005. 129:1159\u20131163."},{"key":"i1543-2165-133-11-1861-b6","series-title":"Virchows Arch","first-page":"83","article-title":"Generalized crystal-storing histiocytosis as a presentation of multiple myeloma: a case with a possible pro-aggregation defect in the immunoglobulin heavy chain.","volume":"445","author":"Papla, B.","year":"2004","unstructured":"Papla, B., P.Spolnik, and E.Rzenno. et al. Generalized crystal-storing histiocytosis as a presentation of multiple myeloma: a case with a possible pro-aggregation defect in the immunoglobulin heavy chain.Virchows Arch2004. 445:83\u201389."},{"key":"i1543-2165-133-11-1861-b7","series-title":"Am J Kidney Dis","first-page":"183","article-title":"Crystal-storing histiocytosis involving the kidney in a low-grade B-cell lymphoproliferative disorder.","volume":"39","author":"Sethi, S.","year":"2002","unstructured":"Sethi, S., B. P.Cuiffo, G. S.Pinkus, and H. G.Rennke. Crystal-storing histiocytosis involving the kidney in a low-grade B-cell lymphoproliferative disorder.Am J Kidney Dis2002. 39:183\u2013188."},{"key":"i1543-2165-133-11-1861-b8","series-title":"Bone Marrow Transplant","first-page":"339","article-title":"Clinical and molecular characteristics of patients with non-amyloid light chain deposition disorders, and outcome following treatment with high-dose melphalan and autologous stem cell transplantation.","volume":"38","author":"Weichman, K.","year":"2006","unstructured":"Weichman, K., L. M.Dember, and T.Prokaeva. et al. Clinical and molecular characteristics of patients with non-amyloid light chain deposition disorders, and outcome following treatment with high-dose melphalan and autologous stem cell transplantation.Bone Marrow Transplant2006. 38:339\u2013343."},{"key":"i1543-2165-133-11-1861-b9","series-title":"Br J Haematol","first-page":"412","article-title":"Crystal-storing histiocytosis in a patient with IgG kappa multiple myeloma.","volume":"128","author":"Tholouli, E.","year":"2005","unstructured":"Tholouli, E., M.Krebs, R.Reeve, and J. B.Houghton. Crystal-storing histiocytosis in a patient with IgG kappa multiple myeloma.Br J Haematol2005. 128:412."},{"key":"i1543-2165-133-11-1861-b10","series-title":"Klin Wochenschr","first-page":"365","article-title":"Weber-Christian panniculitis with systemic cytophagic histiocytosis.","volume":"66","author":"Steininger, H.","year":"1988","unstructured":"Steininger, H. and M.Missmahl. Weber-Christian panniculitis with systemic cytophagic histiocytosis.Klin Wochenschr1988. 66:365\u2013372."},{"key":"i1543-2165-133-11-1861-b11","series-title":"Chest","first-page":"1217","article-title":"Cardiac rhabdomyoma in an adult patient presenting with ventricular arrhythmia.","volume":"118","author":"Krasuski, R. A.","year":"2000","unstructured":"Krasuski, R. A., A. B.Hesselson, K. P.Landolfo, K. J.Ellington, and T. M.Bashore. Cardiac rhabdomyoma in an adult patient presenting with ventricular arrhythmia.Chest2000. 118:1217\u20131221."},{"key":"i1543-2165-133-11-1861-b12","article-title":"Langerhans cell histiocytosis.","author":"Jaffe, E.","unstructured":"Jaffe, E., N.Harris, H.Stein, and J.Vardiman. Langerhans cell histiocytosis.In: Weiss LM, Grogan TM, Muller-Hermelink HK, eds. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, France: IARC Press; 2003. World Health Organization Classification of Tumours; vol 3."},{"key":"i1543-2165-133-11-1861-b13","series-title":"Pathologe","first-page":"222","article-title":"Extranodal Rosai Dorfman disease (sinus histiocytosis with massive lymphadenopathy): report of 5 cases.","volume":"25","author":"Hindermann, W.","year":"2004","unstructured":"Hindermann, W. and D.Katenkamp. Extranodal Rosai Dorfman disease (sinus histiocytosis with massive lymphadenopathy): report of 5 cases.Pathologe2004. 25:222\u2013228."},{"key":"i1543-2165-133-11-1861-b14","series-title":"Arch Pathol Lab Med","first-page":"682","article-title":"Myocardial involvement in Erdheim-Chester disease.","volume":"128","author":"Loeffler, A.","year":"2004","unstructured":"Loeffler, A. and V.Memoli. Myocardial involvement in Erdheim-Chester disease.Arch Pathol Lab Med2004. 128:682\u2013685."},{"key":"i1543-2165-133-11-1861-b15","series-title":"Am J Surg Pathol","first-page":"1115","article-title":"Cardiac inflammatory myofibroblastic tumor: a \u201cbenign\u201d neoplasm that may result in syncope, myocardial infarction, and sudden death.","volume":"31","author":"Burke, A.","year":"2007","unstructured":"Burke, A., L.Li, E.Kling, R.Kutys, R.Virmani, and M.Miettinen. Cardiac inflammatory myofibroblastic tumor: a \u201cbenign\u201d neoplasm that may result in syncope, myocardial infarction, and sudden death.Am J Surg Pathol2007. 31:1115\u20131122."}],"container-title":["Archives of Pathology &amp; Laboratory Medicine"],"original-title":[],"link":[{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/133\/11\/article-p1861.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/133\/11\/1861\/2767032\/1543-2165-133_11_1861.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/133\/11\/article-p1861.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/133\/11\/article-p1861.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T01:04:59Z","timestamp":1770771899000},"score":1,"resource":{"primary":{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/133\/11\/article-p1861.xml"}},"subtitle":["Histologic, Immunohistochemical, and Electron Microscopic Findings"],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":30,"journal-issue":{"issue":"11"},"URL":"https:\/\/doi.org\/10.5858\/133.11.1861","relation":{},"ISSN":["1543-2165","0003-9985"],"issn-type":[{"value":"1543-2165","type":"electronic"},{"value":"0003-9985","type":"print"}],"subject":[],"published":{"date-parts":[[2009,11]]}}}