{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:32:58Z","timestamp":1770823978027,"version":"3.50.1"},"reference-count":32,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Benign fibroblastic polyps of the colon are a recently described entity among mucosal polyps found in the colorectum. These polyps are typically discovered on routine screening colonoscopy within the distal colon. Benign fibroblastic polyps occur most commonly in adult women in the sixth decade of life. Histologically, benign fibroblastic polyps are bland spindle cell lesions that fill the lamina propria and displace the surrounding crypts. The spindle cell proliferation lacks atypia and significant mitotic activity. Hyperplastic changes are frequently present both in the adjacent epithelium and within the lesions. Immunohistochemically, the cells of benign fibroblastic polyps are invariably positive for vimentin with rare focal positivity for CD34 and smooth muscle actin. They are negative for CD117 and S100 protein. Ultrastructurally, benign fibroblastic polyps have features of fibroblastic differentiation. These polyps are benign with no reports, to our knowledge, of recurrence or metastasis.<\/jats:p>","DOI":"10.5858\/133.11.1872","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T09:02:08Z","timestamp":1613120528000},"page":"1872-1876","source":"Crossref","is-referenced-by-count":11,"title":["Benign Fibroblastic Polyps of the Colon"],"prefix":"10.5858","volume":"133","author":[{"given":"Aaron R.","family":"Huber","sequence":"first","affiliation":[{"name":"From the Department of Pathology, Naval Medical Center, San Diego, California (Dr Huber); and the Department of Pathology, Eisenhower Army Medical Center, Fort Gordon, Georgia (Dr Shikle)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Shikle","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Naval Medical Center, San Diego, California (Dr Huber); and the Department of Pathology, Eisenhower Army Medical Center, Fort Gordon, Georgia (Dr Shikle)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"issue":"3","key":"i1543-2165-133-11-1872-b1","series-title":"Am J Surg Pathol","first-page":"374","article-title":"Benign fibroblastic polyps of the colon: a histologic, immunohistochemical, and ultrastructural study.","volume":"28","author":"Eslami-Varzaneh, F.","year":"2004","unstructured":"Eslami-Varzaneh, F., K.Washington, M. E.Robert, M.Kashgarian, J. R.Goldblum, and D.Jain. Benign fibroblastic polyps of the colon: a histologic, immunohistochemical, and ultrastructural study.Am J Surg Pathol2004. 283:374\u2013378."},{"issue":"10","key":"i1543-2165-133-11-1872-b2","series-title":"Am J Surg Pathol","first-page":"1397","article-title":"Fibroblastic polyp of the colon shares features with Vanek tumor.","volume":"28","author":"Zamecnik, M.","year":"2004","unstructured":"Zamecnik, M. and A.Chlumska. Fibroblastic polyp of the colon shares features with Vanek tumor.Am J Surg Pathol2004. 2810:1397\u20131398."},{"issue":"9","key":"i1543-2165-133-11-1872-b3","series-title":"J Clin Gastroenterol","first-page":"778","article-title":"Benign fibroblastic polyp of the colorectum.","volume":"39","author":"Kalof, A. N.","year":"2005","unstructured":"Kalof, A. N., B.Pritt, K.Cooper, N. H.Hyman, and H.Blaszyk. Benign fibroblastic polyp of the colorectum.J Clin Gastroenterol2005. 399:778\u2013781."},{"issue":"4","key":"i1543-2165-133-11-1872-b4","series-title":"Histopathology","first-page":"431","article-title":"Fibroblastic polyp of the colon: clinicopathological analysis of 10 cases with emphasis on its common association with serrated crypts.","volume":"48","author":"Groisman, G. M.","year":"2006","unstructured":"Groisman, G. M., S.Polak-Charcon, and H. D.Appelman. Fibroblastic polyp of the colon: clinicopathological analysis of 10 cases with emphasis on its common association with serrated crypts.Histopathology2006. 484:431\u2013437."},{"issue":"3","key":"i1543-2165-133-11-1872-b5","series-title":"Am J Surg Pathol","first-page":"374","article-title":"Benign fibroblastic polyps of the colon: a histologic, immunohistochemical, and ultrastructural study.","volume":"28","author":"Jain, D.","year":"2004","unstructured":"Jain, D., F.Eslami-Varzaneh, K.Washington, M. E.Robert, M.Kashgarian, and J. R.Goldblum. Benign fibroblastic polyps of the colon: a histologic, immunohistochemical, and ultrastructural study.Am J Surg Pathol2004. 283:374\u2013378."},{"issue":"7","key":"i1543-2165-133-11-1872-b6","series-title":"Ann Diagn Pathol","first-page":"7337","article-title":"Vanek's tumor (inflammatory fibroid polyp): report of 18 cases and comparison with three cases of original Vanek's series.","volume":"7","author":"Daum, O.","year":"2003","unstructured":"Daum, O., O.Hes, and T.Vanecek. et al. Vanek's tumor (inflammatory fibroid polyp): report of 18 cases and comparison with three cases of original Vanek's series.Ann Diagn Pathol2003. 77:7337\u20137347."},{"issue":"1","key":"i1543-2165-133-11-1872-b7","series-title":"Am J Surg Pathol","first-page":"107","article-title":"Inflammatory fibroid polyps of the gastrointestinal tract: evidence for a dendritic cell origin.","volume":"28","author":"Pantanowitz, L.","year":"2004","unstructured":"Pantanowitz, L., D. A.Antonioli, G. S.Pinkus, A.Shahsafaei, and R. D.Odze. Inflammatory fibroid polyps of the gastrointestinal tract: evidence for a dendritic cell origin.Am J Surg Pathol2004. 281:107\u2013114."},{"issue":"4","key":"i1543-2165-133-11-1872-b8","series-title":"Mod Pathol","first-page":"366","article-title":"Gastrointestinal stromal tumors and other mesenchymal lesions of the gut.","volume":"16","author":"Greenson, J. K.","year":"2003","unstructured":"Greenson, J. K.\n          \n          Gastrointestinal stromal tumors and other mesenchymal lesions of the gut.\n          Mod Pathol\n          2003. 164:366\u2013375."},{"issue":"10","key":"i1543-2165-133-11-1872-b9","series-title":"Am J Surg Pathol","first-page":"1339","article-title":"Gastrointestinal stromal tumors and leiomyosarcomas in the colon: a clinicopathologic, immunohistochemical, and molecular genetic study of 44 cases.","volume":"24","author":"Miettinen, M.","year":"2000","unstructured":"Miettinen, M., M.Sarlomo-Rikala, L. H.Sobin, and J.Lasota. Gastrointestinal stromal tumors and leiomyosarcomas in the colon: a clinicopathologic, immunohistochemical, and molecular genetic study of 44 cases.Am J Surg Pathol2000. 2410:1339\u20131352."},{"issue":"7","key":"i1543-2165-133-11-1872-b10","series-title":"Am J Surg Pathol","first-page":"846","article-title":"Schwannomas in the colon and rectum: a clinicopathologic and immunohistochemical study of 20 cases.","volume":"25","author":"Miettinen, M.","year":"2001","unstructured":"Miettinen, M., K. M.Shekitka, and L. H.Sobin. Schwannomas in the colon and rectum: a clinicopathologic and immunohistochemical study of 20 cases.Am J Surg Pathol2001. 257:846\u2013855."},{"issue":"3","key":"i1543-2165-133-11-1872-b11","series-title":"Hum Pathol","first-page":"276","article-title":"Intestinal ganglioneuromatosis: mucosal and transmural types\u2014a clinicopathologic and immunohistochemical study of six cases.","volume":"22","author":"d'Amore, E. S.","year":"1991","unstructured":"d'Amore, E. S., J. C.Manivel, G.Pettinato, G. A.Niehans, and D. C.Snover. Intestinal ganglioneuromatosis: mucosal and transmural types\u2014a clinicopathologic and immunohistochemical study of six cases.Hum Pathol1991. 223:276\u2013286."},{"issue":"2","key":"i1543-2165-133-11-1872-b12","series-title":"Am J Gastroenterol","first-page":"370","article-title":"Prolapsing mucosal polyps: an underrecognized form of colonic polyp\u2014a clinicopathological study of 15 cases.","volume":"97","author":"Tendler, D. A.","year":"2002","unstructured":"Tendler, D. A., S.Aboudola, J. F.Zacks, M. J.O'Brien, and C. P.Kelly. Prolapsing mucosal polyps: an underrecognized form of colonic polyp\u2014a clinicopathological study of 15 cases.Am J Gastroenterol2002. 972:370\u2013376."},{"issue":"10","key":"i1543-2165-133-11-1872-b13","series-title":"Mod Pathol","first-page":"950","article-title":"Mesenchymal tumors of muscularis mucosae of colon and rectum are benign leiomyomas that should be separated from gastrointestinal stromal tumors\u2014a clinicopathologic and immunohistochemical study of eighty-eight cases.","volume":"14","author":"Miettinen, M.","year":"2001","unstructured":"Miettinen, M., M.Sarlomo-Rikala, and L. H.Sobin. Mesenchymal tumors of muscularis mucosae of colon and rectum are benign leiomyomas that should be separated from gastrointestinal stromal tumors\u2014a clinicopathologic and immunohistochemical study of eighty-eight cases.Mod Pathol2001. 1410:950\u2013958."},{"issue":"7","key":"i1543-2165-133-11-1872-b14","series-title":"Am J Surg Pathol","first-page":"859","article-title":"Intestinal perineuriomas: clinicopathologic definition of a new anatomic subset in a series of 10 cases.","volume":"29","author":"Hornick, J. L.","year":"2005","unstructured":"Hornick, J. L. and C. D.Fletcher. Intestinal perineuriomas: clinicopathologic definition of a new anatomic subset in a series of 10 cases.Am J Surg Pathol2005. 297:859\u2013865."},{"issue":"7","key":"i1543-2165-133-11-1872-b15","series-title":"Am J Surg Pathol","first-page":"1088","article-title":"Fibroblastic polyp of the colon and colonic perineurioma: 2 names for a single entity?","volume":"32","author":"Groisman, G. M.","year":"2008","unstructured":"Groisman, G. M. and S.Polak-Charcon. Fibroblastic polyp of the colon and colonic perineurioma: 2 names for a single entity?Am J Surg Pathol2008. 327:1088\u20131094."},{"issue":"10","key":"i1543-2165-133-11-1872-b16","series-title":"Am J Surg Pathol","first-page":"1337","article-title":"Perineurioma versus fibroblastic polyp of the colon.","volume":"30","author":"Zamecnik, M.","year":"2006","unstructured":"Zamecnik, M. and A.Chlumska. Perineurioma versus fibroblastic polyp of the colon.Am J Surg Pathol2006. 3010:1337\u20131339."},{"issue":"3","key":"i1543-2165-133-11-1872-b1","series-title":"Am J Surg Pathol","first-page":"374","article-title":"Benign fibroblastic polyps of the colon: a histologic, immunohistochemical, and ultrastructural study.","volume":"28","author":"Eslami-Varzaneh, F.","year":"2004","unstructured":"Eslami-Varzaneh, F., K.Washington, M. E.Robert, M.Kashgarian, J. R.Goldblum, and D.Jain. 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E.Robert, M.Kashgarian, and J. R.Goldblum. Benign fibroblastic polyps of the colon: a histologic, immunohistochemical, and ultrastructural study.Am J Surg Pathol2004. 283:374\u2013378."},{"issue":"7","key":"i1543-2165-133-11-1872-b6","series-title":"Ann Diagn Pathol","first-page":"7337","article-title":"Vanek's tumor (inflammatory fibroid polyp): report of 18 cases and comparison with three cases of original Vanek's series.","volume":"7","author":"Daum, O.","year":"2003","unstructured":"Daum, O., O.Hes, and T.Vanecek. et al. 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K.\n          \n          Gastrointestinal stromal tumors and other mesenchymal lesions of the gut.\n          Mod Pathol\n          2003. 164:366\u2013375."},{"issue":"10","key":"i1543-2165-133-11-1872-b9","series-title":"Am J Surg Pathol","first-page":"1339","article-title":"Gastrointestinal stromal tumors and leiomyosarcomas in the colon: a clinicopathologic, immunohistochemical, and molecular genetic study of 44 cases.","volume":"24","author":"Miettinen, M.","year":"2000","unstructured":"Miettinen, M., M.Sarlomo-Rikala, L. H.Sobin, and J.Lasota. Gastrointestinal stromal tumors and leiomyosarcomas in the colon: a clinicopathologic, immunohistochemical, and molecular genetic study of 44 cases.Am J Surg Pathol2000. 2410:1339\u20131352."},{"issue":"7","key":"i1543-2165-133-11-1872-b10","series-title":"Am J Surg Pathol","first-page":"846","article-title":"Schwannomas in the colon and rectum: a clinicopathologic and immunohistochemical study of 20 cases.","volume":"25","author":"Miettinen, M.","year":"2001","unstructured":"Miettinen, M., K. M.Shekitka, and L. H.Sobin. Schwannomas in the colon and rectum: a clinicopathologic and immunohistochemical study of 20 cases.Am J Surg Pathol2001. 257:846\u2013855."},{"issue":"3","key":"i1543-2165-133-11-1872-b11","series-title":"Hum Pathol","first-page":"276","article-title":"Intestinal ganglioneuromatosis: mucosal and transmural types\u2014a clinicopathologic and immunohistochemical study of six cases.","volume":"22","author":"d'Amore, E. S.","year":"1991","unstructured":"d'Amore, E. S., J. C.Manivel, G.Pettinato, G. A.Niehans, and D. C.Snover. Intestinal ganglioneuromatosis: mucosal and transmural types\u2014a clinicopathologic and immunohistochemical study of six cases.Hum Pathol1991. 223:276\u2013286."},{"issue":"2","key":"i1543-2165-133-11-1872-b12","series-title":"Am J Gastroenterol","first-page":"370","article-title":"Prolapsing mucosal polyps: an underrecognized form of colonic polyp\u2014a clinicopathological study of 15 cases.","volume":"97","author":"Tendler, D. A.","year":"2002","unstructured":"Tendler, D. A., S.Aboudola, J. F.Zacks, M. J.O'Brien, and C. P.Kelly. Prolapsing mucosal polyps: an underrecognized form of colonic polyp\u2014a clinicopathological study of 15 cases.Am J Gastroenterol2002. 972:370\u2013376."},{"issue":"10","key":"i1543-2165-133-11-1872-b13","series-title":"Mod Pathol","first-page":"950","article-title":"Mesenchymal tumors of muscularis mucosae of colon and rectum are benign leiomyomas that should be separated from gastrointestinal stromal tumors\u2014a clinicopathologic and immunohistochemical study of eighty-eight cases.","volume":"14","author":"Miettinen, M.","year":"2001","unstructured":"Miettinen, M., M.Sarlomo-Rikala, and L. H.Sobin. Mesenchymal tumors of muscularis mucosae of colon and rectum are benign leiomyomas that should be separated from gastrointestinal stromal tumors\u2014a clinicopathologic and immunohistochemical study of eighty-eight cases.Mod Pathol2001. 1410:950\u2013958."},{"issue":"7","key":"i1543-2165-133-11-1872-b14","series-title":"Am J Surg Pathol","first-page":"859","article-title":"Intestinal perineuriomas: clinicopathologic definition of a new anatomic subset in a series of 10 cases.","volume":"29","author":"Hornick, J. L.","year":"2005","unstructured":"Hornick, J. L. and C. D.Fletcher. Intestinal perineuriomas: clinicopathologic definition of a new anatomic subset in a series of 10 cases.Am J Surg Pathol2005. 297:859\u2013865."},{"issue":"7","key":"i1543-2165-133-11-1872-b15","series-title":"Am J Surg Pathol","first-page":"1088","article-title":"Fibroblastic polyp of the colon and colonic perineurioma: 2 names for a single entity?","volume":"32","author":"Groisman, G. 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