{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:11:48Z","timestamp":1770822708082,"version":"3.50.1"},"reference-count":28,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A case of pigmented perivascular epithelioid cell tumor of the kidney in a 57-year-old woman with a clinically indicated tuberous sclerosis is presented. The lesion was a 3.0-cm, well-demarcated, black-colored mass. The tumor was histologically characterized by an epithelioid arrangement of round to polygonal cells with round nuclei and clear cytoplasm containing abundant melanin. Tumor cells showed mild atypia and low mitotic activity. A spindle cell proliferation was focally observed. There were no adipose elements or thick-walled vascular vessels. The stroma demonstrated intervening, thin, fibrovascular septa. Immunohistochemically, the tumor cells were strongly positive for HMB-45 but negative for epithelial and muscle markers, vimentin, and S100 protein. The patient had no evidence of disease 3 months after surgery. Pathologists and clinicians should know about the existence of pigmented perivascular epithelioid cell tumor of the kidney. This type of tumor should be differentiated from clear cell renal cell carcinoma or malignant melanoma.<\/jats:p>","DOI":"10.5858\/133.12.1981","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T09:16:02Z","timestamp":1613121362000},"page":"1981-1984","source":"Crossref","is-referenced-by-count":11,"title":["Pigmented Perivascular Epithelioid Cell Tumor of the Kidney"],"prefix":"10.5858","volume":"133","author":[{"given":"Masaharu","family":"Fukunaga","sequence":"first","affiliation":[{"name":"From the Department of Pathology, the Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Harada","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, the Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"issue":"4","key":"i1543-2165-133-12-1981-b1","series-title":"Pathol Int","first-page":"261","article-title":"Heavily melanotic perivascular epithelioid clear cell tumor of the kidney.","volume":"54","author":"Adachi, S.","year":"2004","unstructured":"Adachi, S., M.Hanada, and Y.Kobayashi. et al. Heavily melanotic perivascular epithelioid clear cell tumor of the kidney.Pathol Int2004. 544:261\u2013265."},{"issue":"6","key":"i1543-2165-133-12-1981-b2","series-title":"J Urol","first-page":"1887","article-title":"Solitary renal melanoma?: a case with long survival after initial treatment.","volume":"153","author":"Fujimoto, H.","year":"1995","unstructured":"Fujimoto, H., K.Chitose, K.Bobisu, N.Yamazaki, M.Sakamoto, and T.Kakizoe. Solitary renal melanoma?: a case with long survival after initial treatment.J Urol1995. 1536:1887\u20131889."},{"issue":"3","key":"i1543-2165-133-12-1981-b3","series-title":"Histopathology","first-page":"393","article-title":"Melanotic clear cell epithelioid angiomyolipoma: a rare entity and a mimic of clear cell renal carcinoma.","volume":"50","author":"Goyal, R.","year":"2007","unstructured":"Goyal, R., K.Joshi, S. K.Singh, and B. D.Radotra. Melanotic clear cell epithelioid angiomyolipoma: a rare entity and a mimic of clear cell renal carcinoma.Histopathology2007. 503:393\u2013394."},{"issue":"4","key":"i1543-2165-133-12-1981-b4","series-title":"Hum Pathol","first-page":"516","article-title":"Malignant pigmented clear cell epithelioid tumor of the kidney: clear cell (\u201csugar\u201d) tumor versus malignant melanoma.","volume":"31","author":"Ribalta, T.","year":"2000","unstructured":"Ribalta, T., J.Lloreta, A.Munne, S.Serrano, and A.Cardesa. Malignant pigmented clear cell epithelioid tumor of the kidney: clear cell (\u201csugar\u201d) tumor versus malignant melanoma.Hum Pathol2000. 314:516\u2013519."},{"key":"i1543-2165-133-12-1981-b5","article-title":"Epithelioid angiomyolipoma.","author":"Amin, M. B.","unstructured":"Amin, M. B.\n          \n          Epithelioid angiomyolipoma.\n          In: Eble JN, Sauter G, Epstein JI, eds. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs. Lyon, France: IARC Press; 2005:68\u201369. World Health Organization Classification of Tumours.."},{"issue":"2","key":"i1543-2165-133-12-1981-b6","series-title":"Am J Surg Pathol","first-page":"180","article-title":"Apparent renal cell carcinomas in tuberous sclerosis are heterogeneous: the identification of malignant epithelioid angiomyolipoma.","volume":"22","author":"Pea, M.","year":"1998","unstructured":"Pea, M., F.Bonetti, and G.Martignoni. et al. Apparent renal cell carcinomas in tuberous sclerosis are heterogeneous: the identification of malignant epithelioid angiomyolipoma.Am J Surg Pathol1998. 222:180\u2013187."},{"issue":"2","key":"i1543-2165-133-12-1981-b7","series-title":"Int J Urol","first-page":"204","article-title":"Epithelioid angiomyolipoma.","volume":"12","author":"Acikalin, M. F.","year":"2005","unstructured":"Acikalin, M. F., N.Tel, U.Oner, O.Pasaoglu, and T.D\u00f5nmez. Epithelioid angiomyolipoma.Int J Urol2005. 122:204\u2013207."},{"issue":"6","key":"i1543-2165-133-12-1981-b8","series-title":"Am J Surg Pathol","first-page":"663","article-title":"Carcinomalike monotypic epithelioid angiomyolipoma in patients without evidence of tuberous sclerosis: a clinicopathologic and genetic study.","volume":"22","author":"Martignoni, G.","year":"1998","unstructured":"Martignoni, G., M.Pea, and F.Bonetti. et al. Carcinomalike monotypic epithelioid angiomyolipoma in patients without evidence of tuberous sclerosis: a clinicopathologic and genetic study.Am J Surg Pathol1998. 226:663\u2013672."},{"issue":"1","key":"i1543-2165-133-12-1981-b9","series-title":"Urology","first-page":"66","article-title":"Malignant melanoma presenting as renal tumor.","volume":"19","author":"Wirtshafter, A.","year":"1982","unstructured":"Wirtshafter, A., M.Bondhus, V. A.Politano, and C. M.Lynne. 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Pigmented renal cell carcinoma.Am J Surg Pathol1995. 193:350\u2013356."},{"issue":"3","key":"i1543-2165-133-12-1981-b12","series-title":"Am J Surg Pathol","first-page":"356","article-title":"Malignant epithelioid angiomyolipoma.","volume":"23","author":"Mai, K. T.","year":"1999","unstructured":"Mai, K. T. and D. G.Perkins. Malignant epithelioid angiomyolipoma.Am J Surg Pathol1999. 233:356\u2013357."},{"issue":"6","key":"i1543-2165-133-12-1981-b13","series-title":"J Urol","first-page":"2533","article-title":"Malignant clear cell \u201csugar\u201d tumor of the kidney: clear cell variant of epithelioid angiomyolipoma.","volume":"168","author":"Saito, K.","year":"2002","unstructured":"Saito, K., Y.Fujii, F.Kasahara, N.Kobayashi, T.Kasuga, and K.Kihar. 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Lyon, France: IARC Press; 2005:68\u201369. World Health Organization Classification of Tumours.."},{"issue":"2","key":"i1543-2165-133-12-1981-b6","series-title":"Am J Surg Pathol","first-page":"180","article-title":"Apparent renal cell carcinomas in tuberous sclerosis are heterogeneous: the identification of malignant epithelioid angiomyolipoma.","volume":"22","author":"Pea, M.","year":"1998","unstructured":"Pea, M., F.Bonetti, and G.Martignoni. et al. Apparent renal cell carcinomas in tuberous sclerosis are heterogeneous: the identification of malignant epithelioid angiomyolipoma.Am J Surg Pathol1998. 222:180\u2013187."},{"issue":"2","key":"i1543-2165-133-12-1981-b7","series-title":"Int J Urol","first-page":"204","article-title":"Epithelioid angiomyolipoma.","volume":"12","author":"Acikalin, M. F.","year":"2005","unstructured":"Acikalin, M. F., N.Tel, U.Oner, O.Pasaoglu, and T.D\u00f5nmez. 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