{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T14:43:39Z","timestamp":1785681819025,"version":"3.56.0"},"reference-count":50,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In this short review, we discuss clear cell adenocarcinoma of the urinary bladder, a rare tumor that primarily affects women. The histogenesis of this neoplasm is uncertain; in some tumors the clinicopathologic and histologic features are suggestive of a m\u00fcllerian origin. Clear cell adenocarcinoma consists of cells with abundant clear cytoplasm, arranged in solid, glandular, or tubulocystic patterns. These tumors are positive for pancytokeratin, cytokeratin 7, and CA 125 immunohistochemical stains. Patients typically present with gross hematuria, dysuria, and discharge. The natural history is poorly understood and patient outcomes remain unclear. Currently, surgery is the treatment of choice. Nephrogenic adenoma is the most important differential diagnostic consideration, followed by metastatic clear cell carcinoma.<\/jats:p>","DOI":"10.5858\/133.6.987","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T10:18:05Z","timestamp":1613125085000},"page":"987-991","source":"Crossref","is-referenced-by-count":40,"title":["Clear Cell Adenocarcinoma of the Urinary Bladder: A Short Review"],"prefix":"10.5858","volume":"133","author":[{"given":"Adebowale J.","family":"Adeniran","sequence":"first","affiliation":[{"name":"From the Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pheroze","family":"Tamboli","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3906","reference":[{"key":"i1543-2165-133-6-987-b1","series-title":"Hum Pathol","first-page":"248","article-title":"The histogenesis of clear cell adenocarcinoma of the lower urinary tract: case series and review of the literature.","volume":"27","author":"Drew, P. A.","year":"1996","unstructured":"Drew, P. A., W. M.Murphy, and F.Civantos. et al. The histogenesis of clear cell adenocarcinoma of the lower urinary tract: case series and review of the literature.Hum Pathol1996. 27:248\u2013252."},{"key":"i1543-2165-133-6-987-b2","series-title":"J Urol","first-page":"122","article-title":"Clear cell adenocarcinoma of the urethra: evidence for origin within paraurethral ducts.","volume":"143","author":"Spencer, J. R.","year":"1990","unstructured":"Spencer, J. R., A. G.Brodin, and J. M.Ignatoff. Clear cell adenocarcinoma of the urethra: evidence for origin within paraurethral ducts.J Urol1990. 143:122\u2013125."},{"key":"i1543-2165-133-6-987-b3","series-title":"Mod Pathol","first-page":"513","article-title":"Clear cell adenocarcinoma of the urethra: a clinicopathologic analysis of 19 cases.","volume":"9","author":"Oliva, E.","year":"1996","unstructured":"Oliva, E. and R. H.Young. 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