{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T05:52:11Z","timestamp":1770789131923,"version":"3.50.0"},"reference-count":18,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tumoral or nodular melanosis in the skin is considered a variation of completely regressed melanoma, presenting clinically as a suspicious pigmented papule or nodule. Microscopically, the lesion consists of a nodular accumulation of heavily pigmented melanophages in the dermis, staining positive for immunohistochemical markers of histiocytic lineage (CD68) and negative for those of melanocytic lineage (S100, HMB-45, Melan-A). This process is rarely described in lymph nodes. We present a report of a patient with melanosis involving multiple lymph nodes of an axillary dissection, done for metastatic melanoma with an unknown primary, and discuss possible prognostic and treatment factors.<\/jats:p>","DOI":"10.5858\/133.8.1332","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T10:50:44Z","timestamp":1613127044000},"page":"1332-1334","source":"Crossref","is-referenced-by-count":10,"title":["Lymph Node Melanosis in a Patient With Metastatic Melanoma of Unknown Primary"],"prefix":"10.5858","volume":"133","author":[{"given":"Patrick","family":"Malafronte","sequence":"first","affiliation":[{"name":"From the Department of Pathology and Laboratory Services, National Naval Medical Center, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Sorrells","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Laboratory Services, National Naval Medical Center, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"key":"i1543-2165-133-8-1332-b1","article-title":"The Many Faces of Completely Regressed Malignant Melanoma.","author":"Barr, R. J.","unstructured":"Barr, R. J.\n          \n          The Many Faces of Completely Regressed Malignant Melanoma.\n          Philadelphia, PA: Lea & Febiger; 1994:158\u2013159."},{"key":"i1543-2165-133-8-1332-b2","article-title":"Malignant melanoma.","author":"Elder, D.","unstructured":"Elder, D.\n          \n          Malignant melanoma.\n          In: Elder D, ed. Lever's Histopathology of the Skin. 9th ed. Philadelphia, PA: Lippincott-Raven; 2005:778."},{"issue":"2","key":"i1543-2165-133-8-1332-b3","series-title":"Am J Dermatopathol","first-page":"118","article-title":"Nodular melanosis due to epithelial neoplasms: a finding not restricted to regressed melanomas.","volume":"20","author":"Flax, S. H.","year":"1998","unstructured":"Flax, S. H., H. G.Skelton, K. J.Smith, and G. P.Lupton. Nodular melanosis due to epithelial neoplasms: a finding not restricted to regressed melanomas.Am J Dermatopathol1998. 202:118\u2013122."},{"key":"i1543-2165-133-8-1332-b4","article-title":"Malignant melanoma.","author":"Barnhill, R. L.","unstructured":"Barnhill, R. L.\n          \n          Malignant melanoma.\n          In: Barnhill RL, ed. Pathology of Melanocytic Nevi and Malignant Melanoma. 2nd ed. New York, NY: Springer; 2004: 342."},{"issue":"3","key":"i1543-2165-133-8-1332-b5","series-title":"J Cutan Pathol","first-page":"284","article-title":"Tumoral melanosis involving the sentinel lymph nodes: a case report.","volume":"34","author":"Satzger, I.","year":"2007","unstructured":"Satzger, I., B.Volker, A.Kapp, and R.Gutzmer. Tumoral melanosis involving the sentinel lymph nodes: a case report.J Cutan Pathol2007. 343:284\u2013286."},{"issue":"4","key":"i1543-2165-133-8-1332-b6","series-title":"Am J Dermatopathol","first-page":"369","article-title":"Melanosis and its meanings.","volume":"24","author":"LeBoit, P. E.","year":"2002","unstructured":"LeBoit, P. E.\n          \n          Melanosis and its meanings.\n          Am J Dermatopathol\n          2002. 244:369\u2013372."},{"issue":"4","key":"i1543-2165-133-8-1332-b7","series-title":"Australas J Dermatopathol","first-page":"215","article-title":"A blue-black macule of recent onset (tumoral melanosis).","volume":"37","author":"Kossgard, S.","year":"1996","unstructured":"Kossgard, S.\n          \n          A blue-black macule of recent onset (tumoral melanosis).\n          Australas J Dermatopathol\n          1996. 374:215\u2013217."},{"issue":"6","key":"i1543-2165-133-8-1332-b8","series-title":"Cancer","first-page":"1377","article-title":"Regression of primary melanoma with metastasis.","volume":"69","author":"Avril, M. F.","year":"1992","unstructured":"Avril, M. F., P.Charpentier, A.Margulis, and J. C.Guillaume. Regression of primary melanoma with metastasis.Cancer1992. 696:1377\u20131381."},{"issue":"3","key":"i1543-2165-133-8-1332-b9","series-title":"Br J Dermatopathol","first-page":"627","article-title":"Tumoral melanosis as a manifestation of a completely regressed primary melanoma with metastasis.","volume":"155","author":"Ng, S. H.","year":"2006","unstructured":"Ng, S. H. and T. A.Chave. Tumoral melanosis as a manifestation of a completely regressed primary melanoma with metastasis.Br J Dermatopathol2006. 1553:627\u2013628."},{"key":"i1543-2165-133-8-1332-b1","article-title":"The Many Faces of Completely Regressed Malignant Melanoma.","author":"Barr, R. J.","unstructured":"Barr, R. J.\n          \n          The Many Faces of Completely Regressed Malignant Melanoma.\n          Philadelphia, PA: Lea & Febiger; 1994:158\u2013159."},{"key":"i1543-2165-133-8-1332-b2","article-title":"Malignant melanoma.","author":"Elder, D.","unstructured":"Elder, D.\n          \n          Malignant melanoma.\n          In: Elder D, ed. Lever's Histopathology of the Skin. 9th ed. Philadelphia, PA: Lippincott-Raven; 2005:778."},{"issue":"2","key":"i1543-2165-133-8-1332-b3","series-title":"Am J Dermatopathol","first-page":"118","article-title":"Nodular melanosis due to epithelial neoplasms: a finding not restricted to regressed melanomas.","volume":"20","author":"Flax, S. H.","year":"1998","unstructured":"Flax, S. H., H. G.Skelton, K. J.Smith, and G. P.Lupton. Nodular melanosis due to epithelial neoplasms: a finding not restricted to regressed melanomas.Am J Dermatopathol1998. 202:118\u2013122."},{"key":"i1543-2165-133-8-1332-b4","article-title":"Malignant melanoma.","author":"Barnhill, R. L.","unstructured":"Barnhill, R. L.\n          \n          Malignant melanoma.\n          In: Barnhill RL, ed. Pathology of Melanocytic Nevi and Malignant Melanoma. 2nd ed. New York, NY: Springer; 2004: 342."},{"issue":"3","key":"i1543-2165-133-8-1332-b5","series-title":"J Cutan Pathol","first-page":"284","article-title":"Tumoral melanosis involving the sentinel lymph nodes: a case report.","volume":"34","author":"Satzger, I.","year":"2007","unstructured":"Satzger, I., B.Volker, A.Kapp, and R.Gutzmer. Tumoral melanosis involving the sentinel lymph nodes: a case report.J Cutan Pathol2007. 343:284\u2013286."},{"issue":"4","key":"i1543-2165-133-8-1332-b6","series-title":"Am J Dermatopathol","first-page":"369","article-title":"Melanosis and its meanings.","volume":"24","author":"LeBoit, P. E.","year":"2002","unstructured":"LeBoit, P. E.\n          \n          Melanosis and its meanings.\n          Am J Dermatopathol\n          2002. 244:369\u2013372."},{"issue":"4","key":"i1543-2165-133-8-1332-b7","series-title":"Australas J Dermatopathol","first-page":"215","article-title":"A blue-black macule of recent onset (tumoral melanosis).","volume":"37","author":"Kossgard, S.","year":"1996","unstructured":"Kossgard, S.\n          \n          A blue-black macule of recent onset (tumoral melanosis).\n          Australas J Dermatopathol\n          1996. 374:215\u2013217."},{"issue":"6","key":"i1543-2165-133-8-1332-b8","series-title":"Cancer","first-page":"1377","article-title":"Regression of primary melanoma with metastasis.","volume":"69","author":"Avril, M. F.","year":"1992","unstructured":"Avril, M. F., P.Charpentier, A.Margulis, and J. C.Guillaume. Regression of primary melanoma with metastasis.Cancer1992. 696:1377\u20131381."},{"issue":"3","key":"i1543-2165-133-8-1332-b9","series-title":"Br J Dermatopathol","first-page":"627","article-title":"Tumoral melanosis as a manifestation of a completely regressed primary melanoma with metastasis.","volume":"155","author":"Ng, S. H.","year":"2006","unstructured":"Ng, S. H. and T. A.Chave. Tumoral melanosis as a manifestation of a completely regressed primary melanoma with metastasis.Br J Dermatopathol2006. 1553:627\u2013628."}],"container-title":["Archives of Pathology &amp; Laboratory Medicine"],"original-title":[],"link":[{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/133\/8\/article-p1332.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/133\/8\/1332\/2768106\/1543-2165-133_8_1332.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/133\/8\/article-p1332.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/133\/8\/article-p1332.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T01:06:33Z","timestamp":1770771993000},"score":1,"resource":{"primary":{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/133\/8\/article-p1332.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":18,"journal-issue":{"issue":"8"},"URL":"https:\/\/doi.org\/10.5858\/133.8.1332","relation":{},"ISSN":["1543-2165","0003-9985"],"issn-type":[{"value":"1543-2165","type":"electronic"},{"value":"0003-9985","type":"print"}],"subject":[],"published":{"date-parts":[[2009,8]]}}}