{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:31:38Z","timestamp":1770823898635,"version":"3.50.1"},"reference-count":44,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Context.\u2014Reflex human papillomavirus (HPV) testing has been designated in consensus guidelines as \u201cpreferred\u201d for women with atypical squamous cells of undetermined significance (ASC-US) liquid-based cytology (LBC) results, and colposcopy is currently recommended for patients with HPV-positive ASC-US results. Data from large clinical practices using newer screening methods and current cytology terminology are limited.<\/jats:p>\n                  <jats:p>Objectives.\u2014We analyzed data from patients with ASC-US LBC and positive HPV test results. We also assessed the impact of the presence or absence of an endocervical cell\/ transformation zone sample (EC\/TZS) on biopsy diagnoses.<\/jats:p>\n                  <jats:p>Design.\u2014The information system of a large women's hospital serving an older-than-average population was searched over a 21-month period between July 1, 2005, and March 31, 2007, for HPV-positive cases interpreted as ASC-US (Bethesda System 2001) using computer-imaged LBC. Histologic diagnoses, patient ages, and presence or absence of an EC\/TZS were analyzed. The average follow-up period was 7.5 months.<\/jats:p>\n                  <jats:p>Results.\u2014Among 4273 women with HPV-positive ASC-US results, the cumulative cervical intraepithelial neoplasia 2 or 3 (CIN 2\/3) and CIN 1 rates for 2192 women with available biopsies were 5.1% and 43.6%, respectively. Cervical intraepithelial neoplasia 2\/3 and CIN 1 rates for women with HPV-positive ASC-US results were not significantly different for women with and without an EC\/TZS.<\/jats:p>\n                  <jats:p>Conclusions.\u2014The risk of CIN 2\/3 in the study population was significantly lower than reported in widely cited trial data. Neither presence nor absence of an EC\/TZS, nor the age of the patient, had a statistically significant impact on the likelihood of biopsy diagnoses of CIN 2\/3 and CIN 1 for patients with HPV-positive ASC-US test results.<\/jats:p>","DOI":"10.5858\/133.9.1426","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T10:59:24Z","timestamp":1613127564000},"page":"1426-1430","source":"Crossref","is-referenced-by-count":20,"title":["Follow-up Findings for Women With Human Papillomavirus\u2013Positive and Atypical Squamous Cells of Undetermined Significance Screening Test Results in a Large Women's Hospital Practice"],"prefix":"10.5858","volume":"133","author":[{"given":"Henry","family":"Armah","sequence":"first","affiliation":[{"name":"From the Department of Pathology, Magee-Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Marshall","family":"Austin","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Magee-Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Dabbs","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Magee-Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengquan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Reprints: Chengquan Zhao, MD, Department of Pathology, Magee-Womens Hospital of University of Pittsburgh Medical Center, 300 Halket St, Pittsburgh, PA 15213 (zhaoc@upmc.edu)."},{"name":"From the Department of Pathology, Magee-Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"key":"2021021103010399700_i1543-2165-133-9-1426-b1","article-title":"An Atlas of Exfoliative Cytology.","author":"Papanicolaou"},{"key":"2021021103010399700_i1543-2165-133-9-1426-b2","doi-asserted-by":"crossref","article-title":"The Bethesda System for Reporting Cervical\/Vaginal Cytologic Diagnoses.","author":"Kurman","DOI":"10.1007\/978-1-4684-0201-8"},{"key":"2021021103010399700_i1543-2165-133-9-1426-b3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/cncr.22423","article-title":"The Bethesda Interobserver Reproducibility Study (BIRST).","volume":"111","author":"Sherman","year":"2007","journal-title":"Cancer Cytopathol"},{"key":"2021021103010399700_i1543-2165-133-9-1426-b4","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/00128360-200504000-00010","article-title":"Cytopathology update on atypical squamous cells.","volume":"9","author":"Davey","year":"2005","journal-title":"J Low Genital Tract Dis"},{"key":"2021021103010399700_i1543-2165-133-9-1426-b5","first-page":"973","article-title":"Where's the high-grade cervical neoplasia: the importance of minimally abnormal Papanicolaou diagnoses.","volume":"91","author":"Kinney","year":"1998","journal-title":"Obstet Gyynecol"},{"key":"2021021103010399700_i1543-2165-133-9-1426-b6","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1006\/gyno.2001.6370","article-title":"Shanxi Province Cervical Cancer Screening Study: a cross-sectional comparative trial of multiple techniques to detect cervical neoplasia.","volume":"83","author":"Belinson","year":"2001","journal-title":"Gynecol Oncol"},{"key":"2021021103010399700_i1543-2165-133-9-1426-b7","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/cncr.21940","article-title":"ALTS Group. 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