{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T17:20:26Z","timestamp":1774372826195,"version":"3.50.1"},"reference-count":40,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,6,1]]},"DOI":"10.5858\/134.6.923","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T12:30:56Z","timestamp":1613133056000},"page":"923-929","source":"Crossref","is-referenced-by-count":13,"title":["Protocol for the Examination of Specimens From Patients With Carcinoma of the Penis"],"prefix":"10.5858","volume":"134","author":[{"given":"Elsa F.","family":"Velazquez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahul B.","family":"Amin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan I.","family":"Epstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Grignon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A.","family":"Humphrey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curtis A.","family":"Pettaway","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew A.","family":"Renshaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor E.","family":"Reuter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Srigley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio L.","family":"Cubilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Members of the Cancer Committee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"College of American Pathologists","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","published-online":{"date-parts":[[2010,6,1]]},"reference":[{"key":"2021021103414104900_i1543-2165-134-6-923-b01","volume-title":"AJCC Cancer Staging Manual. 7th ed","author":"Edge","year":"2009"},{"issue":"7","key":"2021021103414104900_i1543-2165-134-6-923-b02","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1097\/00000478-200307000-00015","article-title":"Preputial variability and preferential association of long phimotic foreskins with penile cancer: an anatomic comparative study of types of foreskin in a general population and cancer patients.","volume":"27","author":"Velazquez","year":"2003","journal-title":"Am J Surg Pathol"},{"issue":"4","key":"2021021103414104900_i1543-2165-134-6-923-b03","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/ijc.21009","article-title":"Penile cancer: importance of circumcision, human papillomavirus and smoking in in situ and invasive disease.","volume":"116","author":"Daling","year":"2005","journal-title":"Int J Cancer"},{"issue":"3","key":"2021021103414104900_i1543-2165-134-6-923-b04","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1023\/A:1011266405062","article-title":"Risk factors for penile cancer: results of a population-based case-control study in Los Angeles County (United States).","volume":"12","author":"Tsen","year":"2002","journal-title":"Cancer Causes Control"},{"issue":"10","key":"2021021103414104900_i1543-2165-134-6-923-b05","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1158\/1055-9965.EPI-08-0456","article-title":"Risk factors for squamous cell carcinoma of the penis: population-based case-control study in Denmark.","volume":"17","author":"Madsen","year":"2008","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"3","key":"2021021103414104900_i1543-2165-134-6-923-b06","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.juro.2006.10.060","article-title":"Pelvic lymph node dissection for penile carcinoma: extent of inguinal lymph node involvement as an indicator for pelvic lymph node involvement and survival.","volume":"177","author":"Lont","year":"2007","journal-title":"J Urol"},{"issue":"6","key":"2021021103414104900_i1543-2165-134-6-923-b07","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1016\/j.juro.2009.08.029","article-title":"Association between lymph node density and disease specific survival in patients with penile cancer.","volume":"182","author":"Svatek","year":"2009","journal-title":"J Urol"},{"issue":"2","key":"2021021103414104900_i1543-2165-134-6-923-b08","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/jso.20414","article-title":"Prognostic factors in node-positive carcinoma of the penis.","volume":"93","author":"Pandey","year":"2006","journal-title":"J Surg Oncol"},{"issue":"1","key":"2021021103414104900_i1543-2165-134-6-923-b09","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.urology.2006.01.050","article-title":"Front pattern of invasion in squamous cell carcinoma of the penis: new prognostic factor for predicting risk of lymph node metastases.","volume":"68","author":"Guimar\u00e3es","year":"2006","journal-title":"Urology"},{"key":"2021021103414104900_i1543-2165-134-6-923-b10","volume-title":"Tumors of the Prostate Gland, Seminal Vesicles, Male Urethra, Penis and Scrotum","author":"Epstein"},{"key":"2021021103414104900_i1543-2165-134-6-923-b11","article-title":"Malignant epithelial tumors.","author":"Cubilla","year":"2004","journal-title":"Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs"},{"key":"2021021103414104900_i1543-2165-134-6-923-b12","first-page":"2005","article-title":"Penis.","author":"Velazquez","year":"2009","journal-title":"Sternberg's Diagnostic Surgical Pathology. 5th ed"},{"issue":"2","key":"2021021103414104900_i1543-2165-134-6-923-b13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1177\/106689690100900204","article-title":"Histologic classification of penile carcinoma and its relation to outcome in 61 patients with primary resection.","volume":"9","author":"Cubilla","year":"2001","journal-title":"Int J Surg Pathol"},{"issue":"4","key":"2021021103414104900_i1543-2165-134-6-923-b14","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1097\/00000478-200004000-00004","article-title":"Warty (condylomatous) squamous cell carcinoma of the penis: a report of 11 cases and proposed classification of \u2018verruciform\u2019 penile tumors.","volume":"24","author":"Cubilla","year":"2000","journal-title":"Am J Surg Pathol"},{"issue":"7","key":"2021021103414104900_i1543-2165-134-6-923-b15","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1097\/00000478-200407000-00008","article-title":"Pseudohyperplastic squamous cell carcinoma of the penis associated with lichen sclerosus\u2014an extremely well-differentiated nonverruciform neoplasm that preferentially affects the foreskin and is frequently misdiagnosed: a report of 10 cases of a distinctive clinicopathologic entity.","volume":"28","author":"Cubilla","year":"2004","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"2021021103414104900_i1543-2165-134-6-923-b16","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/01.pas.0000213401.72569.22","article-title":"Carcinoma cuniculatum of the penis\u2014a distinctive variant of penile squamous cell carcinoma: report of 7 cases.","volume":"31","author":"Barreto","year":"2007","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"2021021103414104900_i1543-2165-134-6-923-b17","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1097\/00000478-199806000-00014","article-title":"Basaloid squamous cell carcinoma: a distinctive HPV related penile neoplasm: a report of 20 cases.","volume":"22","author":"Cubilla","year":"1998","journal-title":"Am J Surg Pathol"},{"issue":"9","key":"2021021103414104900_i1543-2165-134-6-923-b18","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1097\/01.pas.0000160440.46394.a8","article-title":"Sarcomatoid carcinoma of the penis: a clinico-pathological study of 14 cases.","volume":"29","author":"Velazquez","year":"2005","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"2021021103414104900_i1543-2165-134-6-923-b19","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/00000478-199602000-00003","article-title":"Surface adenosquamous carcinoma of the penis: a report of three cases.","volume":"20","author":"Cubilla","year":"1996","journal-title":"Am J Surg Pathol"},{"issue":"4","key":"2021021103414104900_i1543-2165-134-6-923-b20","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/S0022-5347(05)66450-6","article-title":"Tumor stage, vascular invasion and the percentage of poorly differentiated cancer: independent prognosticators for inguinal node metastasis in penile squamous cancer.","volume":"165","author":"Slaton","year":"2001","journal-title":"J Urol"},{"key":"2021021103414104900_i1543-2165-134-6-923-b21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/01.pcr.0000153239.13371.58","article-title":"Identification of prognostic pathologic parameters in squamous cell carcinoma of the penis: significance and difficulties.","volume":"10","author":"Cubilla","year":"2005","journal-title":"Pathol Case Rev"},{"issue":"7","key":"2021021103414104900_i1543-2165-134-6-923-b22","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1097\/PAS.0b013e3181641365","article-title":"Histologic grade and perineural invasion are more important than tumor thickness as predictor of nodal metastasis in penile squamous cell carcinoma invading 5 to 10\u00a0mm.","volume":"32","author":"Velazquez","year":"2008","journal-title":"Am J Surg Pathol"},{"key":"2021021103414104900_i1543-2165-134-6-923-b23","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1097\/PAS.0b013e31819aa4c9","article-title":"Histologic grade in penile squamous cell carcinoma: visual estimation versus digital measurement of proportions of grades, adverse prognosis with any proportion of grade 3 and correlation of a Gleason-like system with nodal metastasis.","volume":"33","author":"Chaux","year":"2009","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"2021021103414104900_i1543-2165-134-6-923-b24","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/modpathol.3880419","article-title":"Predicting cancer progression in patients with penile squamous cell carcinoma: the importance of depth of invasion and vascular invasion.","volume":"14","author":"Emerson","year":"2001","journal-title":"Mod Pathol"},{"issue":"2","key":"2021021103414104900_i1543-2165-134-6-923-b25","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.juro.2009.04.028","article-title":"Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases.","volume":"182","author":"Guimaraes","year":"2009","journal-title":"J Urol"},{"issue":"3","key":"2021021103414104900_i1543-2165-134-6-923-b26","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.juro.2008.05.011","article-title":"Evaluation of current TNM classification of penile carcinoma.","volume":"180","author":"Leijte","year":"2008","journal-title":"J Urol"},{"issue":"7","key":"2021021103414104900_i1543-2165-134-6-923-b27","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1097\/PAS.0b013e31819d17eb","article-title":"The prognostic index: a useful pathologic guide for prediction of nodal metastases and survival in penile squamous cell carcinoma.","volume":"33","author":"Chaux","year":"2009","journal-title":"Am J Surg Pathol"},{"issue":"3","key":"2021021103414104900_i1543-2165-134-6-923-b28","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/00000478-200403000-00012","article-title":"Positive resection margins in partial penectomies: sites of involvement and proposal of local routes of spread of penile squamous cell carcinoma.","volume":"28","author":"Velazquez","year":"2004","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"2021021103414104900_i1543-2165-134-6-923-b29","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/S0022-5347(01)65471-5","article-title":"Prognostic factors in carcinoma of the penis: multivariate analysis of 145 patients treated with amputation and lymphadenectomy.","volume":"156","author":"Lopes","year":"1996","journal-title":"J Urol"},{"issue":"12","key":"2021021103414104900_i1543-2165-134-6-923-b30","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1002\/cncr.21076","article-title":"Lymphatic and vascular embolizations are independent predictive variables of inguinal node involvement in patients with squamous cell carcinoma of the penis: Gruppo Uro-Oncologico del Nord Est (Northeast Uro-Oncological Group) Penile Cancer data base data.","volume":"103","author":"Ficarra","year":"2005","journal-title":"Cancer"},{"issue":"6","key":"2021021103414104900_i1543-2165-134-6-923-b31","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/S0022-5347(05)01003-7","article-title":"Nomogram predictive of pathological inguinal lymph node involvement in patients with squamous cell carcinoma of the penis.","volume":"175","author":"Ficarra","year":"2006","journal-title":"J Urol"},{"issue":"6","key":"2021021103414104900_i1543-2165-134-6-923-b32","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1016\/S0022-5347(06)00313-2","article-title":"Nomogram predictive of cancer specific survival in patients undergoing partial or total amputation for squamous cell carcinoma of the penis.","volume":"175","author":"Kattan","year":"2006","journal-title":"J Urol"},{"issue":"3","key":"2021021103414104900_i1543-2165-134-6-923-b33","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/ncpuro0751","article-title":"Prognostic factors in squamous cell carcinoma of the penis.","volume":"4","author":"Novara","year":"2007","journal-title":"Nat Clin Pract Urol"},{"issue":"1","key":"2021021103414104900_i1543-2165-134-6-923-b34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eururo.2004.03.007","article-title":"EAU guidelines on penile cancer.","volume":"46","author":"Solsona","year":"2004","journal-title":"Eur Urol"},{"issue":"5","key":"2021021103414104900_i1543-2165-134-6-923-b35","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1016\/S0022-5347(05)66337-9","article-title":"Prospective validation of the association of local tumor stage and grade as a predictive factor for occult lymph node micrometastasis in patients with penile carcinoma and clinically negative inguinal lymph nodes.","volume":"165","author":"Solsona","year":"2001","journal-title":"J Urol"},{"issue":"3","key":"2021021103414104900_i1543-2165-134-6-923-b36","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.urology.2006.03.052","article-title":"Risk stratification in penile carcinoma: 25-year experience with surgical inguinal lymph node staging.","volume":"68","author":"Hungerhuber","year":"2006","journal-title":"Urology"},{"issue":"4","key":"2021021103414104900_i1543-2165-134-6-923-b37","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.juro.2008.06.028","article-title":"Prognostic factors in invasive squamous cell carcinoma of the penis: analysis of 196 patients treated at the Brazilian National Cancer Institute.","volume":"180","author":"Ornellas","year":"2008","journal-title":"J Urol"},{"key":"2021021103414104900_i1543-2165-134-6-923-b38","first-page":"696(A)","article-title":"Morphological characterization and distribution of penile precancerous lesions using a simplified nomenclature: a study of 198 lesions in 115 patients.","volume":"88","author":"Cubilla","year":"2008","journal-title":"Lab Invest"},{"key":"2021021103414104900_i1543-2165-134-6-923-b39","first-page":"807(A)","article-title":"Expression of p53 and p16 in differentiated and warty\/basaloid penile intraepithelial neoplasia (PeIN).","volume":"88","author":"Pfannl","year":"2008","journal-title":"Lab Invest"},{"key":"2021021103414104900_i1543-2165-134-6-923-b40","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1097\/00000478-200108000-00016","article-title":"Anatomic levels: important landmarks in penectomy specimens; a detailed anatomic and histologic study based on the examination of 44 specimens.","volume":"25","author":"Cubilla","year":"2001","journal-title":"Am J Surg Pathol"}],"container-title":["Archives of Pathology & Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/134\/6\/923\/2769818\/1543-2165-134_6_923.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/134\/6\/923\/2769818\/1543-2165-134_6_923.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T19:38:40Z","timestamp":1764790720000},"score":1,"resource":{"primary":{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/134\/6\/article-p923.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,1]]},"references-count":40,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2010,6,1]]},"published-print":{"date-parts":[[2010,6,1]]}},"URL":"https:\/\/doi.org\/10.5858\/134.6.923","relation":{},"ISSN":["1543-2165","0003-9985"],"issn-type":[{"value":"1543-2165","type":"electronic"},{"value":"0003-9985","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6,1]]}}}