{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T19:48:17Z","timestamp":1764791297780,"version":"3.46.0"},"reference-count":10,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Paragangliomas are neuroendocrine tumors arising from extra-adrenal autonomic ganglia. We present what is to our knowledge the first immunohistochemically documented case of a paraganglioma of the tongue, a 2.5-cm benign tumor growing in the position of the foramen cecum. The patient was an elderly woman who presented with throat irritation. The histologic profile and ultrastructural appearance of this lesion were classic for paraganglioma, and cells stained strongly for neurosecretory granules by immunohistochemistry. Carcinoid, ectopic thyroid neoplasm, and other tumors that mimic paraganglioma were ruled out on immunohistochemical grounds. To our knowledge, paraganglia have not been previously documented in the tongue; this tumor may have arisen from a branch of cranial nerve VII or IX, or from an embryologic remnant of the thyroid or thyroid capsule.<\/jats:p>","DOI":"10.5858\/2000-124-0877-pott","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T10:10:42Z","timestamp":1612951842000},"page":"877-879","source":"Crossref","is-referenced-by-count":10,"title":["Paraganglioma of the Tongue"],"prefix":"10.5858","volume":"124","author":[{"given":"Torsten O.","family":"Nielsen","sequence":"first","affiliation":[{"name":"From the Department of Pathology, Vancouver Hospital & Health Sciences Centre and the University of British Columbia, Vancouver, Canada (Dr Nielsen); and the Departments of Otolaryngology (Dr S\u00e9jean) and Pathology (Dr Onerheim), St Mary's Hospital and McGill University, Montr\u00e9al, Qu\u00e9bec, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georges","family":"S\u00e9jean","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Vancouver Hospital & Health Sciences Centre and the University of British Columbia, Vancouver, Canada (Dr Nielsen); and the Departments of Otolaryngology (Dr S\u00e9jean) and Pathology (Dr Onerheim), St Mary's Hospital and McGill University, Montr\u00e9al, Qu\u00e9bec, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald M.","family":"Onerheim","sequence":"additional","affiliation":[{"name":"Reprints: Ronald Onerheim, MD, Department of Pathology, St Mary's Hospital Center, 3830 Ave Lacombe, Montr\u00e9al, Qu\u00e9bec, Canada H3T 1M5."},{"name":"From the Department of Pathology, Vancouver Hospital & Health Sciences Centre and the University of British Columbia, Vancouver, Canada (Dr Nielsen); and the Departments of Otolaryngology (Dr S\u00e9jean) and Pathology (Dr Onerheim), St Mary's Hospital and McGill University, Montr\u00e9al, Qu\u00e9bec, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"key":"2021020915005068800_i1543-2165-124-6-877-b1","first-page":"1209","article-title":"A review of the histology, ultrastructure, immunohistology, and molecular biology of extra-adrenal paragangliomas.","volume":"113","author":"Kliewer","year":"1989","journal-title":"Arch Pathol Lab Med"},{"article-title":"Pathology of Adrenal and Extra-Adrenal Paraganglia.","year":"1994","author":"Lack","key":"2021020915005068800_i1543-2165-124-6-877-b2"},{"key":"2021020915005068800_i1543-2165-124-6-877-b3","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/0278-2391(90)90539-E","article-title":"Firm mass of the tongue.","volume":"48","author":"Moore","year":"1990","journal-title":"J Oral Maxillofac Surg"},{"key":"2021020915005068800_i1543-2165-124-6-877-b4","first-page":"1041","article-title":"Medullary carcinoma of the thyroid gland with sustentacular cell-like cells in a patient with multiple endocrine neoplasia, type IIA: report of a case with ultrastructural and immunohistochemical studies.","volume":"118","author":"Collina","year":"1994","journal-title":"Arch Pathol Lab Med"},{"key":"2021020915005068800_i1543-2165-124-6-877-b5","first-page":"82","article-title":"Glomic (paragangliomic) tissue in the larynx and capsule of the thyroid gland.","volume":"39","author":"Zak","year":"1972","journal-title":"Mt Sinai J Med"},{"key":"2021020915005068800_i1543-2165-124-6-877-b6","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1097\/00000478-199707000-00002","article-title":"Thyroid paraganglioma: a clinicopathologic and immunohistochemical study of three cases.","volume":"21","author":"LaGuette","year":"1997","journal-title":"Am J Surg Pathol"},{"key":"2021020915005068800_i1543-2165-124-6-877-b7","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000181879","article-title":"Papillary carcinoma in an ectopic thyroid.","volume":"35","author":"Zink","year":"1991","journal-title":"Hormone Res"},{"key":"2021020915005068800_i1543-2165-124-6-877-b8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0278-2391(89)90132-8","article-title":"Squamous cell carcinoma arising in a thyroglossal duct cyst in the tongue.","volume":"47","author":"Lustmann","year":"1989","journal-title":"J Oral Maxillofac Surg"},{"key":"2021020915005068800_i1543-2165-124-6-877-b9","first-page":"819","article-title":"Chemodectoma della lingua: criteri diagnostico-differenziali ed istogenetici.","volume":"19","author":"Scopelliti","year":"1970","journal-title":"Ann Stomatol"},{"key":"2021020915005068800_i1543-2165-124-6-877-b10","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/0266-4356(92)90210-A","article-title":"Glomus tumour of the palate: case report and review of the literature.","volume":"30","author":"Geraghty","year":"1992","journal-title":"Br J Oral Maxillofac Surg"}],"container-title":["Archives of Pathology &amp; Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/124\/6\/877\/2751297\/0003-9985(2000)124_0877_pott_2_0_co_2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/124\/6\/877\/2751297\/0003-9985(2000)124_0877_pott_2_0_co_2.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T19:37:48Z","timestamp":1764790668000},"score":1,"resource":{"primary":{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/124\/6\/article-p877.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6,1]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,6,1]]}},"URL":"https:\/\/doi.org\/10.5858\/2000-124-0877-pott","relation":{},"ISSN":["1543-2165","0003-9985"],"issn-type":[{"type":"electronic","value":"1543-2165"},{"type":"print","value":"0003-9985"}],"subject":[],"published":{"date-parts":[[2000,6,1]]}}}