{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:28:54Z","timestamp":1770823734098,"version":"3.50.1"},"reference-count":38,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Background.<\/jats:italic>\n                    \u2014Elastosis of the prostate may be seen on needle biopsy and radical prostatectomy specimens, but its significance is unknown. Prostatic atrophy (or postatrophic hyperplasia) is one of the most frequent mimics of prostatic adenocarcinoma.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Objective.<\/jats:italic>\n                    \u2014To observe the frequent occurrence of elastosis of the prostate stroma in areas of postatrophic hyperplasia.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Design.<\/jats:italic>\n                    \u2014A step-section method was used to cut the posterior lobe (or peripheral zone) in coronal planes at intervals of 0.3 to 0.5 cm in 100 consecutive autopsy specimens of men older than 40 years. Elastosis was detected because of a basophilic tinge of the stroma on hematoxylin-eosin stain and confirmed using elastic fiber stains. Presence of elastosis correlated with the following variables: age, prostatic atrophy (simple, hyperplastic, or sclerotic), local arteriosclerosis, histologic carcinoma, high-grade prostatic intraepithelial neoplasia, benign or malignant nephrosclerosis, generalized atherosclerosis, nodular prostatic hyperplasia, and acute inflammation. For statistics, a stepwise linear regression method adjusted for age was used.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results and Conclusions.<\/jats:italic>\n                    \u2014Elastosis was found in 65 of the prostates examined and was significantly more frequent with increasing age (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; .001), prostatic atrophy (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; .001), and local arteriosclerosis (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; .02). There was no significant relation to histologic carcinoma, high-grade prostatic intraepithelial neoplasia, benign or malignant nephrosclerosis, generalized atherosclerosis, nodular prostatic hyperplasia, and acute inflammation. The correlation with local arteriosclerosis favors a possible role of ischemia to its etiopathogenesis. The absence of correlation to neoplastic and preneoplastic lesions and the striking spatial relationship of elastosis to prostatic atrophy (or postatrophic hyperplasia) add a new microscopic feature for the diagnosis of this latter lesion, helping in the differential diagnosis with prostate adenocarcinoma.\n                  <\/jats:p>","DOI":"10.5858\/2000-124-1306-pe","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T21:44:57Z","timestamp":1611870297000},"page":"1306-1309","source":"Crossref","is-referenced-by-count":13,"title":["Prostate Elastosis"],"prefix":"10.5858","volume":"124","author":[{"given":"Athanase","family":"Billis","sequence":"first","affiliation":[{"name":"Reprints: Athanase Billis, MD, Department de Anatomia Patol\u00f3gica, Fac. de Ci\u00eancias M\u00e9dicas-UNICAMP, Caixa Postal 6111, CEP 13083\u2013970, Campinas, SP, Brazil (athanase@fcm.unicamp.br)."},{"name":"From the Departments of Anatomic Pathology (Dr Billis) and Medical Genetics (Dr Magna), School of Medicine, State University of Campinas (UNICAMP), Campinas, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis A.","family":"Magna","sequence":"additional","affiliation":[{"name":"From the Departments of Anatomic Pathology (Dr Billis) and Medical Genetics (Dr Magna), School of Medicine, State University of Campinas (UNICAMP), Campinas, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"key":"i1543-2165-124-9-1306-b1","series-title":"Am J Surg Pathol","first-page":"1068","article-title":"Postatrophic hyperplasia of the prostate: a histologic mimic of prostatic adenocarcinoma.","volume":"19","author":"Cheville, J. C.","year":"1995","unstructured":"Cheville, J. C. and D. G.Bostwick. Postatrophic hyperplasia of the prostate: a histologic mimic of prostatic adenocarcinoma.Am J Surg Pathol1995. 19:1068\u20131076."},{"key":"i1543-2165-124-9-1306-b2","series-title":"Mod Pathol","first-page":"47","article-title":"Prostatic atrophy: an autopsy study of a histologic mimic of adenocarcinoma.","volume":"11","author":"Billis, A.","year":"1998","unstructured":"Billis, A.\n          \n          Prostatic atrophy: an autopsy study of a histologic mimic of adenocarcinoma.\n          Mod Pathol\n          1998. 11:47\u201354."},{"key":"i1543-2165-124-9-1306-b3","series-title":"J Urol","first-page":"224","article-title":"The morphology of small prostatic carcinoma.","volume":"33","author":"Moore, R. A.","year":"1935","unstructured":"Moore, R. A.\n          \n          The morphology of small prostatic carcinoma.\n          J Urol\n          1935. 33:224\u2013234."},{"key":"i1543-2165-124-9-1306-b4","series-title":"Am J Pathol","first-page":"599","article-title":"The evolution and involution of the prostate gland.","volume":"12","author":"Moore, R. A.","year":"1936","unstructured":"Moore, R. A.\n          \n          The evolution and involution of the prostate gland.\n          Am J Pathol\n          1936. 12:599\u2013624."},{"key":"i1543-2165-124-9-1306-b5","series-title":"J Urol","first-page":"557","article-title":"Carcinoma of the prostate gland: a pathologic study.","volume":"41","author":"Kahler, J. E.","year":"1939","unstructured":"Kahler, J. E.\n          \n          Carcinoma of the prostate gland: a pathologic study.\n          J Urol\n          1939. 41:557\u2013574."},{"key":"i1543-2165-124-9-1306-b6","series-title":"J Urol","first-page":"875","article-title":"Carcinoma of the prostate: incidence, origin, pathology.","volume":"89","author":"Strahan, R. W.","year":"1963","unstructured":"Strahan, R. W.\n          \n          Carcinoma of the prostate: incidence, origin, pathology.\n          J Urol\n          1963. 89:875\u2013880."},{"key":"i1543-2165-124-9-1306-b7","series-title":"J Urol","first-page":"1008","article-title":"The prostate and prostatic urethra: a morphological synthesis.","volume":"107","author":"McNeal, J. E.","year":"1972","unstructured":"McNeal, J. E.\n          \n          The prostate and prostatic urethra: a morphological synthesis.\n          J Urol\n          1972. 107:1008\u20131016."},{"key":"i1543-2165-124-9-1306-b8","first-page":"202","article-title":"Tumors of the male genital system.","author":"Mostofi, F. K.","year":"1973","unstructured":"Mostofi, F. K. and E. B. JrPrice. Tumors of the male genital system.In: Firminger HI, ed. Atlas of Tumor Pathology; 2nd series, fascicle 8. Washington, DC: Armed Forces Institute of Pathology. 1973. 202\u2013217."},{"key":"i1543-2165-124-9-1306-b9","first-page":"83","article-title":"Histologic grading of prostatic carcinoma.","author":"Gleason, D. F.","year":"1990","unstructured":"Gleason, D. F.\n          \n          Histologic grading of prostatic carcinoma.\n          In: Bostwick DG, ed. Pathology of the Prostate. New York, NY: Churchill Livingstone. 1990. 83\u201393."},{"key":"i1543-2165-124-9-1306-b10","series-title":"Hum Pathol","first-page":"298","article-title":"Architectural patterns of high-grade prostatic intraepithelial neoplasia.","volume":"24","author":"Bostwick, D. G.","year":"1993","unstructured":"Bostwick, D. G., M. B.Amin, P.Dundore, W.Marsh, and D. S.Schultz. Architectural patterns of high-grade prostatic intraepithelial neoplasia.Hum Pathol1993. 24:298\u2013310."},{"key":"i1543-2165-124-9-1306-b11","first-page":"341","article-title":"Degenerative diseases and perforating disorders.","author":"Heilman, E. R.","year":"1997","unstructured":"Heilman, E. R. and R. J.Friedman. Degenerative diseases and perforating disorders.In: Elder D, Elenitsas R, Jaworsky C, Johnson B Jr, eds. Lever's Histopathology of the Skin. 8th ed. Philadelphia, Pa: Lippincott-Raven. 1997. 341\u2013351."},{"key":"i1543-2165-124-9-1306-b12","series-title":"Acta Pathol Jpn","first-page":"13","article-title":"A morphologic study on human conduction system of heart considering influences of some disorders of individuals.","volume":"31","author":"Sugai, M.","year":"1981","unstructured":"Sugai, M., R.Kono, and Y.Kunita. A morphologic study on human conduction system of heart considering influences of some disorders of individuals.Acta Pathol Jpn1981. 31:13\u201325."},{"issue":"Suppl 1","key":"i1543-2165-124-9-1306-b13","series-title":"Cardiologia","first-page":"197","article-title":"Microcirculation and remodelling.","volume":"39","author":"Camici, P. G.","year":"1994","unstructured":"Camici, P. G. and R.Lorenzoni. Microcirculation and remodelling.Cardiologia1994. 39 (Suppl 1):197\u2013201."},{"key":"i1543-2165-124-9-1306-b14","series-title":"J Cell Physiol","first-page":"137","article-title":"Extracellular matrix regulation of metalloproteinase and antiproteinase in human heart fibroblast cells.","volume":"167","author":"Tyagi, S. C.","year":"1996","unstructured":"Tyagi, S. C., S. G.Kumar, S. R.Alla, H. K.Reddy, D. J.Voelker, and J. S.Janicki. Extracellular matrix regulation of metalloproteinase and antiproteinase in human heart fibroblast cells.J Cell Physiol1996. 167:137\u2013147."},{"key":"i1543-2165-124-9-1306-b15","series-title":"Hum Pathol","first-page":"1161","article-title":"Role of arterial occlusion in pulmonary scar cancers.","volume":"19","author":"Kolin, A.","year":"1988","unstructured":"Kolin, A. and T.Koutoulakis. Role of arterial occlusion in pulmonary scar cancers.Hum Pathol1988. 19:1161\u20131167."},{"key":"i1543-2165-124-9-1306-b16","series-title":"Connect Tissue Res","first-page":"255","article-title":"Desmosine radioimmunoassay as a means of studying elastogenesis in cell culture.","volume":"8","author":"Starcher, B. C.","year":"1981","unstructured":"Starcher, B. C. and R. P.Mecham. Desmosine radioimmunoassay as a means of studying elastogenesis in cell culture.Connect Tissue Res1981. 8:255\u2013258."},{"key":"i1543-2165-124-9-1306-b17","first-page":"107","article-title":"Prostate biopsy interpretation.","author":"Epstein, J. I.","year":"1995","unstructured":"Epstein, J. I.\n          \n          Prostate biopsy interpretation.\n          In: Silverberg SG, ed. Biopsy Interpretation Series. 2nd ed. New York, NY: Raven Press. 1995. 107\u2013109."},{"key":"i1543-2165-124-9-1306-b18","first-page":"52","article-title":"Biopsy pathology of the prostate.","author":"Bostwick, D. G.","year":"1997","unstructured":"Bostwick, D. G. and P. A.Dundore. Biopsy pathology of the prostate.In: Neville AM, Walker F, Taylor CR, ed. Biopsy Pathology Series 20. London, England: Chapman & Hall. 1997. 52\u201356."},{"key":"i1543-2165-124-9-1306-b19","series-title":"J Urol Pathol","first-page":"31","article-title":"Minimal diagnostic criteria for adenocarcinoma of the prostate.","volume":"8","author":"Grignon, D. J.","year":"1998","unstructured":"Grignon, D. J.\n          \n          Minimal diagnostic criteria for adenocarcinoma of the prostate.\n          J Urol Pathol\n          1998. 8:31\u201343."},{"key":"i1543-2165-124-9-1306-b1","series-title":"Am J Surg Pathol","first-page":"1068","article-title":"Postatrophic hyperplasia of the prostate: a histologic mimic of prostatic adenocarcinoma.","volume":"19","author":"Cheville, J. C.","year":"1995","unstructured":"Cheville, J. C. and D. G.Bostwick. Postatrophic hyperplasia of the prostate: a histologic mimic of prostatic adenocarcinoma.Am J Surg Pathol1995. 19:1068\u20131076."},{"key":"i1543-2165-124-9-1306-b2","series-title":"Mod Pathol","first-page":"47","article-title":"Prostatic atrophy: an autopsy study of a histologic mimic of adenocarcinoma.","volume":"11","author":"Billis, A.","year":"1998","unstructured":"Billis, A.\n          \n          Prostatic atrophy: an autopsy study of a histologic mimic of adenocarcinoma.\n          Mod Pathol\n          1998. 11:47\u201354."},{"key":"i1543-2165-124-9-1306-b3","series-title":"J Urol","first-page":"224","article-title":"The morphology of small prostatic carcinoma.","volume":"33","author":"Moore, R. A.","year":"1935","unstructured":"Moore, R. A.\n          \n          The morphology of small prostatic carcinoma.\n          J Urol\n          1935. 33:224\u2013234."},{"key":"i1543-2165-124-9-1306-b4","series-title":"Am J Pathol","first-page":"599","article-title":"The evolution and involution of the prostate gland.","volume":"12","author":"Moore, R. A.","year":"1936","unstructured":"Moore, R. A.\n          \n          The evolution and involution of the prostate gland.\n          Am J Pathol\n          1936. 12:599\u2013624."},{"key":"i1543-2165-124-9-1306-b5","series-title":"J Urol","first-page":"557","article-title":"Carcinoma of the prostate gland: a pathologic study.","volume":"41","author":"Kahler, J. E.","year":"1939","unstructured":"Kahler, J. E.\n          \n          Carcinoma of the prostate gland: a pathologic study.\n          J Urol\n          1939. 41:557\u2013574."},{"key":"i1543-2165-124-9-1306-b6","series-title":"J Urol","first-page":"875","article-title":"Carcinoma of the prostate: incidence, origin, pathology.","volume":"89","author":"Strahan, R. W.","year":"1963","unstructured":"Strahan, R. W.\n          \n          Carcinoma of the prostate: incidence, origin, pathology.\n          J Urol\n          1963. 89:875\u2013880."},{"key":"i1543-2165-124-9-1306-b7","series-title":"J Urol","first-page":"1008","article-title":"The prostate and prostatic urethra: a morphological synthesis.","volume":"107","author":"McNeal, J. E.","year":"1972","unstructured":"McNeal, J. E.\n          \n          The prostate and prostatic urethra: a morphological synthesis.\n          J Urol\n          1972. 107:1008\u20131016."},{"key":"i1543-2165-124-9-1306-b8","first-page":"202","article-title":"Tumors of the male genital system.","author":"Mostofi, F. K.","year":"1973","unstructured":"Mostofi, F. K. and E. B. JrPrice. Tumors of the male genital system.In: Firminger HI, ed. Atlas of Tumor Pathology; 2nd series, fascicle 8. Washington, DC: Armed Forces Institute of Pathology. 1973. 202\u2013217."},{"key":"i1543-2165-124-9-1306-b9","first-page":"83","article-title":"Histologic grading of prostatic carcinoma.","author":"Gleason, D. F.","year":"1990","unstructured":"Gleason, D. F.\n          \n          Histologic grading of prostatic carcinoma.\n          In: Bostwick DG, ed. Pathology of the Prostate. New York, NY: Churchill Livingstone. 1990. 83\u201393."},{"key":"i1543-2165-124-9-1306-b10","series-title":"Hum Pathol","first-page":"298","article-title":"Architectural patterns of high-grade prostatic intraepithelial neoplasia.","volume":"24","author":"Bostwick, D. G.","year":"1993","unstructured":"Bostwick, D. G., M. B.Amin, P.Dundore, W.Marsh, and D. S.Schultz. Architectural patterns of high-grade prostatic intraepithelial neoplasia.Hum Pathol1993. 24:298\u2013310."},{"key":"i1543-2165-124-9-1306-b11","first-page":"341","article-title":"Degenerative diseases and perforating disorders.","author":"Heilman, E. R.","year":"1997","unstructured":"Heilman, E. R. and R. J.Friedman. Degenerative diseases and perforating disorders.In: Elder D, Elenitsas R, Jaworsky C, Johnson B Jr, eds. Lever's Histopathology of the Skin. 8th ed. Philadelphia, Pa: Lippincott-Raven. 1997. 341\u2013351."},{"key":"i1543-2165-124-9-1306-b12","series-title":"Acta Pathol Jpn","first-page":"13","article-title":"A morphologic study on human conduction system of heart considering influences of some disorders of individuals.","volume":"31","author":"Sugai, M.","year":"1981","unstructured":"Sugai, M., R.Kono, and Y.Kunita. A morphologic study on human conduction system of heart considering influences of some disorders of individuals.Acta Pathol Jpn1981. 31:13\u201325."},{"issue":"Suppl 1","key":"i1543-2165-124-9-1306-b13","series-title":"Cardiologia","first-page":"197","article-title":"Microcirculation and remodelling.","volume":"39","author":"Camici, P. G.","year":"1994","unstructured":"Camici, P. G. and R.Lorenzoni. Microcirculation and remodelling.Cardiologia1994. 39 (Suppl 1):197\u2013201."},{"key":"i1543-2165-124-9-1306-b14","series-title":"J Cell Physiol","first-page":"137","article-title":"Extracellular matrix regulation of metalloproteinase and antiproteinase in human heart fibroblast cells.","volume":"167","author":"Tyagi, S. C.","year":"1996","unstructured":"Tyagi, S. C., S. G.Kumar, S. R.Alla, H. K.Reddy, D. J.Voelker, and J. S.Janicki. Extracellular matrix regulation of metalloproteinase and antiproteinase in human heart fibroblast cells.J Cell Physiol1996. 167:137\u2013147."},{"key":"i1543-2165-124-9-1306-b15","series-title":"Hum Pathol","first-page":"1161","article-title":"Role of arterial occlusion in pulmonary scar cancers.","volume":"19","author":"Kolin, A.","year":"1988","unstructured":"Kolin, A. and T.Koutoulakis. Role of arterial occlusion in pulmonary scar cancers.Hum Pathol1988. 19:1161\u20131167."},{"key":"i1543-2165-124-9-1306-b16","series-title":"Connect Tissue Res","first-page":"255","article-title":"Desmosine radioimmunoassay as a means of studying elastogenesis in cell culture.","volume":"8","author":"Starcher, B. C.","year":"1981","unstructured":"Starcher, B. C. and R. P.Mecham. Desmosine radioimmunoassay as a means of studying elastogenesis in cell culture.Connect Tissue Res1981. 8:255\u2013258."},{"key":"i1543-2165-124-9-1306-b17","first-page":"107","article-title":"Prostate biopsy interpretation.","author":"Epstein, J. I.","year":"1995","unstructured":"Epstein, J. I.\n          \n          Prostate biopsy interpretation.\n          In: Silverberg SG, ed. Biopsy Interpretation Series. 2nd ed. New York, NY: Raven Press. 1995. 107\u2013109."},{"key":"i1543-2165-124-9-1306-b18","first-page":"52","article-title":"Biopsy pathology of the prostate.","author":"Bostwick, D. G.","year":"1997","unstructured":"Bostwick, D. G. and P. A.Dundore. Biopsy pathology of the prostate.In: Neville AM, Walker F, Taylor CR, ed. Biopsy Pathology Series 20. London, England: Chapman & Hall. 1997. 52\u201356."},{"key":"i1543-2165-124-9-1306-b19","series-title":"J Urol Pathol","first-page":"31","article-title":"Minimal diagnostic criteria for adenocarcinoma of the prostate.","volume":"8","author":"Grignon, D. J.","year":"1998","unstructured":"Grignon, D. 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