{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:20:51Z","timestamp":1774686051864,"version":"3.50.1"},"reference-count":16,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We present 2 unusual cases of long-standing, extensive reactive lymphadenopathy secondary to\n                    <jats:italic>Actinomyces<\/jats:italic>\n                    infection, 1 of which was also accompanied by\n                    <jats:italic>Actinobacillus actinomycetemcomitans-Actinomyces<\/jats:italic>\n                    complex infection. To our knowledge, histologic features of lymph node involvement by these organisms have not been previously reported in the literature. One patient had extensive cervical, posterior mediastinal, and abdominal lymphadenopathy. The second patient presented with a submandibular mass and cervical lymphadenopathy. Clinical features strongly suggested lymphoma. The histologic examination of the lymph nodes from both patients revealed reactive follicular hyperplasia, marked interfollicular and capsular fibrosis, and multiple interfollicular microabscesses. Characteristic\n                    <jats:italic>Actinomyces<\/jats:italic>\n                    colonies were identified at the center of the microabscesses in deep sections. Cultures were obtained from the lymph nodes of 1 patient, and were positive for\n                    <jats:italic>A actinomycetemcomitans.<\/jats:italic>\n                    Both patients had poor dental hygiene. Lymphadenopathy subsided with antibiotic therapy and appropriate dental care.\n                  <\/jats:p>","DOI":"10.5858\/2000-124-1502-aaaaaa","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T20:09:05Z","timestamp":1611864545000},"page":"1502-1505","source":"Crossref","is-referenced-by-count":9,"title":["Actinomyces and Actinobacillus actinomycetemcomitans-Actinomyces\u2013Associated Lymphadenopathy Mimicking Lymphoma"],"prefix":"10.5858","volume":"124","author":[{"given":"Mojghan","family":"Amrikachi","sequence":"first","affiliation":[{"name":"From the Department of Pathology, Baylor College of Medicine and the Department of Pathology, Veterans Affairs Medical Center, Houston, Tex."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhuvaneswari","family":"Krishnan","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Baylor College of Medicine and the Department of Pathology, Veterans Affairs Medical Center, Houston, Tex."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christie J.","family":"Finch","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Baylor College of Medicine and the Department of Pathology, Veterans Affairs Medical Center, Houston, Tex."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imran","family":"Shahab","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Baylor College of Medicine and the Department of Pathology, Veterans Affairs Medical Center, Houston, Tex."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"key":"i1543-2165-124-10-1502-b1","first-page":"673","article-title":"Lymph nodes. In: Diagnostic Surgical Pathology.","author":"Stephen, S. S.","year":"1994","unstructured":"Stephen, S. S., D. A.Antonioli, D.Carter, S. E.Mills, and H. A,edsOberman. Lymph nodes. In: Diagnostic Surgical Pathology.2nd ed. Philadelphia, Pa: Lippincott-Raven. 1994. 673\u2013734."},{"key":"i1543-2165-124-10-1502-b2","series-title":"Mod Pathol","first-page":"378","article-title":"Reactive states in lymph nodes resembling lymphomas or progressing to lymphomas: a selective review.","volume":"6","author":"Swerdlow, S. H.","year":"1993","unstructured":"Swerdlow, S. H., S.Sukpanichnant, A. D.Glick, and R. D.Collins. Reactive states in lymph nodes resembling lymphomas or progressing to lymphomas: a selective review.Mod Pathol1993. 6:378\u2013384."},{"key":"i1543-2165-124-10-1502-b3","article-title":"Principles and Practice of Infectious Disease.","author":"Mandell, G. L.","year":"1995","unstructured":"Mandell, G. L., J. E.Bennett, and R.Dolin. Principles and Practice of Infectious Disease.4th ed. New York, NY: Churchill Livingstone Inc. 1995."},{"key":"i1543-2165-124-10-1502-b4","article-title":"Color Atlas and Textbook of Diagnostic Microbiology.","author":"Koneman, E. W.","year":"1997","unstructured":"Koneman, E. W., S. D.Allen, W. M.Janda, P. C.Schreckenberger, and W. C.Winn. Color Atlas and Textbook of Diagnostic Microbiology.5th ed. Philadelphia, Pa: Lippincott-Raven. 1997."},{"key":"i1543-2165-124-10-1502-b5","first-page":"467","article-title":"Miscellaneous pathogenic organisms. In: Clinical and Pathogenic Microbiology.","author":"Howard, B. J.","year":"1994","unstructured":"Howard, B. J., J. F.Keiser, T. F.Smith, A. S.Weissfeld, and R. C,edsTilton. Miscellaneous pathogenic organisms. In: Clinical and Pathogenic Microbiology.2th ed. St Louis, Mo: Mosby-Yearbook Inc. 1994. 467\u2013469."},{"key":"i1543-2165-124-10-1502-b6","series-title":"Actinobacillus actinomycetemcomitans. Res Med","first-page":"341","article-title":"Thoracic actinomycosis complicated by.","volume":"86","author":"Tyrrel, J.","year":"1992","unstructured":"Tyrrel, J., P.Noone, and J. S.Prichard. Thoracic actinomycosis complicated by.Actinobacillus actinomycetemcomitans. Res Med1992. 86:341\u2013343."},{"key":"i1543-2165-124-10-1502-b7","series-title":"Trends Microbiol","first-page":"224","article-title":"The role of Actinobacillus actinomycetemcomitans in the pathogenesis of periodontal disease.","volume":"5","author":"Meyer, D. H.","year":"1997","unstructured":"Meyer, D. H. and P. M.Fives-Taylor. The role of Actinobacillus actinomycetemcomitans in the pathogenesis of periodontal disease.Trends Microbiol1997. 5:224\u2013228."},{"key":"i1543-2165-124-10-1502-b8","series-title":"Chest","first-page":"1109","article-title":"Actinomyces odontolyticus thoracopulmonary infection: two cases in lung and heart-lung transplant recipient and a review of literature.","volume":"109","author":"Bassiri, A. G.","year":"1996","unstructured":"Bassiri, A. G., R. E.Girgis, and J.Theodore. Actinomyces odontolyticus thoracopulmonary infection: two cases in lung and heart-lung transplant recipient and a review of literature.Chest1996. 109:1109\u20131111."},{"key":"i1543-2165-124-10-1502-b1","first-page":"673","article-title":"Lymph nodes. In: Diagnostic Surgical Pathology.","author":"Stephen, S. S.","year":"1994","unstructured":"Stephen, S. S., D. A.Antonioli, D.Carter, S. E.Mills, and H. A,edsOberman. Lymph nodes. In: Diagnostic Surgical Pathology.2nd ed. Philadelphia, Pa: Lippincott-Raven. 1994. 673\u2013734."},{"key":"i1543-2165-124-10-1502-b2","series-title":"Mod Pathol","first-page":"378","article-title":"Reactive states in lymph nodes resembling lymphomas or progressing to lymphomas: a selective review.","volume":"6","author":"Swerdlow, S. H.","year":"1993","unstructured":"Swerdlow, S. H., S.Sukpanichnant, A. D.Glick, and R. D.Collins. Reactive states in lymph nodes resembling lymphomas or progressing to lymphomas: a selective review.Mod Pathol1993. 6:378\u2013384."},{"key":"i1543-2165-124-10-1502-b3","article-title":"Principles and Practice of Infectious Disease.","author":"Mandell, G. L.","year":"1995","unstructured":"Mandell, G. L., J. E.Bennett, and R.Dolin. Principles and Practice of Infectious Disease.4th ed. New York, NY: Churchill Livingstone Inc. 1995."},{"key":"i1543-2165-124-10-1502-b4","article-title":"Color Atlas and Textbook of Diagnostic Microbiology.","author":"Koneman, E. 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