{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:05:08Z","timestamp":1770822308768,"version":"3.50.1"},"reference-count":32,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tumors of mixed glioneuronal type are well recognized in the central nervous system. The most common examples of these lesions include gangliogliomas and dysembryoplastic neuroepithelial tumors. Recently, unusual examples of these lesions have been described, including the papillary glioneuronal tumor. This report describes a histologically similar\u2013appearing lesion arising in the left parieto-occipital lobe of an 18-year-old man who presented with headaches and difficulties with vision. Imaging studies noted a large cystic neoplasm marked by a peripheral rim of enhancement. The patient underwent gross total resection of the tumor, which histologically was marked by a mixture of glial (glial fibrillary acidic protein\u2013positive) and neural (synaptophysin-positive) components. Architecturally, the tumor was notable for a focal pseudopapillary pattern. Papillae were lined by predominantly glial cells, with intervening areas occupied by neurally differentiated cells. Mitotic activity, vascular proliferation, and necrosis were not noted. A MIB-1 labeling index of 1.1% was seen. p53 immunoreactivity was not observed. This report adds further evidence supporting the existence of this unusual mixed glioneuronal tumor of the central nervous system.<\/jats:p>","DOI":"10.5858\/2000-124-1820-pgt","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T20:14:29Z","timestamp":1611864869000},"page":"1820-1823","source":"Crossref","is-referenced-by-count":51,"title":["Papillary Glioneuronal Tumor"],"prefix":"10.5858","volume":"124","author":[{"given":"Richard A.","family":"Prayson","sequence":"first","affiliation":[{"name":"Reprints: Richard A. Prayson, MD, Department of Anatomic Pathology (L25), Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195 (e-mail: praysor@cesmtp.ccf.org)."},{"name":"From the Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"key":"i1543-2165-124-12-1820-b1","article-title":"Histological Typing of Tumours of the Central Nervous System: World Health Organization.","author":"Kleihues, P.","year":"1993","unstructured":"Kleihues, P., P. C.Burger, and B. W.Scheithauer. Histological Typing of Tumours of the Central Nervous System: World Health Organization.Berlin, Germany: Springer-Verlag. 1993."},{"key":"i1543-2165-124-12-1820-b2","series-title":"Am J Surg Pathol","first-page":"1171","article-title":"Papillary glioneuronal tumor: a new variant of mixed neuronal-glial neoplasm.","volume":"22","author":"Komori, T.","year":"1998","unstructured":"Komori, T., B. W.Scheithauer, and D. C.Anthony. et al. Papillary glioneuronal tumor: a new variant of mixed neuronal-glial neoplasm.Am J Surg Pathol1998. 22:1171\u20131183."},{"key":"i1543-2165-124-12-1820-b3","series-title":"Semin Diagn Pathol","first-page":"272","article-title":"Immunohistology of lymphoproliferative disorder.","volume":"1","author":"Tubbs, R. R.","year":"1984","unstructured":"Tubbs, R. R. and K.Sheibani. Immunohistology of lymphoproliferative disorder.Semin Diagn Pathol1984. 1:272\u2013284."},{"key":"i1543-2165-124-12-1820-b4","series-title":"Mod Pathol","first-page":"663","article-title":"Immunohistochemical assessment of proliferative activity in adrenocortical neoplasms.","volume":"6","author":"Goldblum, J. R.","year":"1993","unstructured":"Goldblum, J. R., R.Shannon, and E. P.Kaljiam. et al. Immunohistochemical assessment of proliferative activity in adrenocortical neoplasms.Mod Pathol1993. 6:663\u2013668."},{"key":"i1543-2165-124-12-1820-b5","series-title":"Acta Pathol Jpn","first-page":"1009","article-title":"Malignant ganglioglioma of the spinal cord.","volume":"37","author":"Kitano, M.","year":"1987","unstructured":"Kitano, M., S.Takayama, and T.Nagao. et al. Malignant ganglioglioma of the spinal cord.Acta Pathol Jpn1987. 37:1009\u20131018."},{"key":"i1543-2165-124-12-1820-b6","series-title":"J Neuropathol Exp Neurol","first-page":"185","article-title":"Ganglioglioma: a case with a long history and malignant evolution.","volume":"21","author":"Russell, D. S.","year":"1962","unstructured":"Russell, D. S. and L. J.Rubinstein. Ganglioglioma: a case with a long history and malignant evolution.J Neuropathol Exp Neurol1962. 21:185\u2013193."},{"key":"i1543-2165-124-12-1820-b7","series-title":"Acta Neuropathol (Berl)","first-page":"365","article-title":"Anaplastic ganglioglioma of the brain stem demonstrating active neurosecretory features of neoplastic neuronal cells.","volume":"83","author":"Hirose, T.","year":"1992","unstructured":"Hirose, T., S.Kannecki, K.Nishida, K.Matsumoto, T.Sano, and K.Hizawa. Anaplastic ganglioglioma of the brain stem demonstrating active neurosecretory features of neoplastic neuronal cells.Acta Neuropathol (Berl)1992. 83:365\u2013370."},{"key":"i1543-2165-124-12-1820-b8","series-title":"Am J Surg Pathol","first-page":"502","article-title":"A distinctive glioneuronal tumor of the adult cerebrum with neuropil-like (including \u201crosetted\u201d) islands.","volume":"23","author":"Teo, J. G. C.","year":"1999","unstructured":"Teo, J. G. C., S. H.Gultekin, M.Bilsky, P.Gutin, and M. K.Rosenblum. A distinctive glioneuronal tumor of the adult cerebrum with neuropil-like (including \u201crosetted\u201d) islands.Am J Surg Pathol1999. 23:502\u2013520."},{"key":"i1543-2165-124-12-1820-b9","series-title":"J Neuropathol Exp Neurol","first-page":"509","article-title":"Glioneuronal tumors with malignant histologic features [abstract].","volume":"58","author":"Tihan, T.","year":"1999","unstructured":"Tihan, T., D. J.Brat, P. T.Goldthwaite, and P. C.Burger. Glioneuronal tumors with malignant histologic features [abstract].J Neuropathol Exp Neurol1999. 58:509."},{"key":"i1543-2165-124-12-1820-b10","series-title":"Acta Neuropathol (Berl)","first-page":"187","article-title":"Pseudopapillary neurocytoma of temporal lobe with glial differentiation.","volume":"94","author":"Kim, D. H.","year":"1997","unstructured":"Kim, D. H. and Y-L.Suh. 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Central nervous system ganglioglioma part 1: pathology.J Neurosurg1993. 79:859\u2013866."},{"key":"i1543-2165-124-12-1820-b15","series-title":"J Child Neurol","first-page":"219","article-title":"Glioneurocytoma: tumor with glial and neuronal differentiation.","volume":"10","author":"Min, K-W.","year":"1995","unstructured":"Min, K-W., R. E.Cashman, and R. A.Brumback. Glioneurocytoma: tumor with glial and neuronal differentiation.J Child Neurol1995. 10:219\u2013226."},{"key":"i1543-2165-124-12-1820-b16","series-title":"Am J Surg Pathol","first-page":"206","article-title":"Extraventricular neoplasms with neurocytoma features: a clinicopathological study of 11 cases.","volume":"21","author":"Giangaspero, F.","year":"1997","unstructured":"Giangaspero, F., G.Cenacchi, L.Losi, S.Cerasoli, M.Bisceglia, and P. C.Burger. 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Papillary glioneuronal tumor: a new variant of mixed neuronal-glial neoplasm.Am J Surg Pathol1998. 22:1171\u20131183."},{"key":"i1543-2165-124-12-1820-b3","series-title":"Semin Diagn Pathol","first-page":"272","article-title":"Immunohistology of lymphoproliferative disorder.","volume":"1","author":"Tubbs, R. R.","year":"1984","unstructured":"Tubbs, R. R. and K.Sheibani. Immunohistology of lymphoproliferative disorder.Semin Diagn Pathol1984. 1:272\u2013284."},{"key":"i1543-2165-124-12-1820-b4","series-title":"Mod Pathol","first-page":"663","article-title":"Immunohistochemical assessment of proliferative activity in adrenocortical neoplasms.","volume":"6","author":"Goldblum, J. R.","year":"1993","unstructured":"Goldblum, J. R., R.Shannon, and E. P.Kaljiam. et al. 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K.Rosenblum. A distinctive glioneuronal tumor of the adult cerebrum with neuropil-like (including \u201crosetted\u201d) islands.Am J Surg Pathol1999. 23:502\u2013520."},{"key":"i1543-2165-124-12-1820-b9","series-title":"J Neuropathol Exp Neurol","first-page":"509","article-title":"Glioneuronal tumors with malignant histologic features [abstract].","volume":"58","author":"Tihan, T.","year":"1999","unstructured":"Tihan, T., D. J.Brat, P. T.Goldthwaite, and P. C.Burger. Glioneuronal tumors with malignant histologic features [abstract].J Neuropathol Exp Neurol1999. 58:509."},{"key":"i1543-2165-124-12-1820-b10","series-title":"Acta Neuropathol (Berl)","first-page":"187","article-title":"Pseudopapillary neurocytoma of temporal lobe with glial differentiation.","volume":"94","author":"Kim, D. H.","year":"1997","unstructured":"Kim, D. H. and Y-L.Suh. 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