{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:11:30Z","timestamp":1784193090246,"version":"3.55.0"},"reference-count":15,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lesions of the pancreas induced by viral infection have drawn relatively little attention because of their low incidence, and the histopathologic features of viral pancreatitis have not been fully elucidated. We report the autopsy findings of 2 patients, a 59-year-old woman with allergic granulomatous angiitis and a 73-year-old man with invasive pulmonary aspergillosis who had a disseminated visceral herpes simplex virus (HSV) infection. In both cases, the liver was the organ most severely affected by the viral infection. The pancreas showed multiple small foci of hemorrhagic necrosis, which were not accompanied by fat necrosis of the surrounding adipose tissue. Histopathologically, Cowdry type A intranuclear inclusions and a ground-glass appearance of the nuclei were found in many degenerated acinar cells around the necrotic foci. The gross appearance and histopathologic features of HSV pancreatitis were characteristic and, in particular, distinct from those of the more common acute hemorrhagic pancreatitis. Immunohistochemistry using an anti-HSV antibody revealed immunoreactivity in the intranuclear inclusions and ground-glass nuclei, and polymerase chain reaction analysis disclosed that the causative virus in these 2 cases was HSV-1. Herpes simplex virus pancreatitis constitutes a rare, but distinct pathologic entity among a group of acute pancreatitis diseases with diverse etiopathogenesis.<\/jats:p>","DOI":"10.5858\/2003-127-231-hs","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T11:46:56Z","timestamp":1611920816000},"page":"231-234","source":"Crossref","is-referenced-by-count":17,"title":["Herpes Simplex Pancreatitis"],"prefix":"10.5858","volume":"127","author":[{"given":"Masayuki","family":"Shintaku","sequence":"first","affiliation":[{"name":"From Departments of Pathology (Dr Shintaku), Internal Medicine (Dr Umehara), Surgery (Dr Iwaisako), and Respiratory Medicine (Dr Tahara), Osaka Red Cross Hospital, Osaka, Japan; and First Department of Pathology, Kansai Medical University, Moriguchi, Japan (Dr Adachi)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Umehara","sequence":"additional","affiliation":[{"name":"From Departments of Pathology (Dr Shintaku), Internal Medicine (Dr Umehara), Surgery (Dr Iwaisako), and Respiratory Medicine (Dr Tahara), Osaka Red Cross Hospital, Osaka, Japan; and First Department of Pathology, Kansai Medical University, Moriguchi, Japan (Dr Adachi)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Iwaisako","sequence":"additional","affiliation":[{"name":"From Departments of Pathology (Dr Shintaku), Internal Medicine (Dr Umehara), Surgery (Dr Iwaisako), and Respiratory Medicine (Dr Tahara), Osaka Red Cross Hospital, Osaka, Japan; and First Department of Pathology, Kansai Medical University, Moriguchi, Japan (Dr Adachi)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Tahara","sequence":"additional","affiliation":[{"name":"From Departments of Pathology (Dr Shintaku), Internal Medicine (Dr Umehara), Surgery (Dr Iwaisako), and Respiratory Medicine (Dr Tahara), Osaka Red Cross Hospital, Osaka, Japan; and First Department of Pathology, Kansai Medical University, Moriguchi, Japan (Dr Adachi)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Adachi","sequence":"additional","affiliation":[{"name":"From Departments of Pathology (Dr Shintaku), Internal Medicine (Dr Umehara), Surgery (Dr Iwaisako), and Respiratory Medicine (Dr Tahara), Osaka Red Cross Hospital, Osaka, Japan; and First Department of Pathology, Kansai Medical University, Moriguchi, Japan (Dr Adachi)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3906","reference":[{"key":"2021012916451687900_i1543-2165-127-2-231-b1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/0002-9343(74)90487-2","article-title":"Fatal disseminated herpesvirus hominis type 2 infection in an adult with associated thymic dysplasia.","volume":"56","author":"Sutton","year":"1974","journal-title":"Am J Med"},{"key":"2021012916451687900_i1543-2165-127-2-231-b2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1136\/jcp.22.1.60","article-title":"Acute hepatitis due to herpes simplex virus in an adult.","volume":"22","author":"Flewett","year":"1969","journal-title":"J Clin Pathol"},{"key":"2021012916451687900_i1543-2165-127-2-231-b3","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/clinids\/9.2.329","article-title":"Herpes simplex viral hepatitis in adults: two case reports and review of the literature.","volume":"9","author":"Chase","year":"1987","journal-title":"Rev Infect Dis"},{"key":"2021012916451687900_i1543-2165-127-2-231-b4","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1093\/clinids\/24.3.334","article-title":"Herpes simplex virus hepatitis: case report and review.","volume":"24","author":"Kaufman","year":"1997","journal-title":"Clin Infect Dis"},{"key":"2021012916451687900_i1543-2165-127-2-231-b5","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/infdis\/157.3.597","article-title":"Disseminated herpes simplex type 2 and systemic Candida infection in a patient with previous asymptomatic human immunodeficiency virus infection.","volume":"157","author":"Zimmerli","year":"1988","journal-title":"J Infect Dis"},{"key":"2021012916451687900_i1543-2165-127-2-231-b6","first-page":"103","article-title":"Pathology and pathogenesis of diseases of the pancreas.","volume":"107","author":"Longnecker","year":"1982","journal-title":"Am J Pathol"},{"key":"2021012916451687900_i1543-2165-127-2-231-b7","article-title":"Pancreas.","author":"Longnecker"},{"key":"2021012916451687900_i1543-2165-127-2-231-b8","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/00006676-199611000-00005","article-title":"Infectious causes of acute pancreatitis.","volume":"13","author":"Parenti","year":"1996","journal-title":"Pancreas"},{"key":"2021012916451687900_i1543-2165-127-2-231-b9","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/00000658-197407000-00012","article-title":"Acute hemorrhagic pancreatitis and pseudocyst due to mumps.","volume":"180","author":"Feldstein","year":"1974","journal-title":"Ann Surg"},{"key":"2021012916451687900_i1543-2165-127-2-231-b10","first-page":"741","article-title":"An immunofluorescent study of generalized Coxsackie virus B3 infection in a newborn infant.","volume":"35","author":"Iwasaki","year":"1985","journal-title":"Acta Pathol Jpn"},{"key":"2021012916451687900_i1543-2165-127-2-231-b11","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/0046-8177(93)90198-P","article-title":"Disseminated adenoviral infection presenting as acute pancreatitis.","volume":"24","author":"Niemann","year":"1993","journal-title":"Hum Pathol"},{"key":"2021012916451687900_i1543-2165-127-2-231-b12","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0046-8177(81)80053-6","article-title":"Post-transplantation pancreatitis associated with cytomegalovirus: report of a case.","volume":"12","author":"Parham","year":"1981","journal-title":"Hum Pathol"},{"key":"2021012916451687900_i1543-2165-127-2-231-b13","first-page":"1661","article-title":"Acute pancreatitis with cytomegalovirus infection.","volume":"37","author":"Iwasaki","year":"1987","journal-title":"Acta Pathol Jpn"},{"key":"2021012916451687900_i1543-2165-127-2-231-b14","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/S0016-5085(81)80004-2","article-title":"Light microscopic localization of hepatitis B virus antigens in the human pancreas: possibility of multiplication of hepatitis B virus in the human pancreas.","volume":"81","author":"Shimoda","year":"1981","journal-title":"Gastroenterology"},{"key":"2021012916451687900_i1543-2165-127-2-231-b15","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0344-0338(84)80110-7","article-title":"Early histological changes in acute necrotizing hemorrhagic pancreatitis: a retrospective pathological study of 20 total pancreatectomy specimens.","volume":"178","author":"Phat","year":"1984","journal-title":"Pathol Res Pract"}],"container-title":["Archives of Pathology &amp; 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