{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T10:29:42Z","timestamp":1794652182350,"version":"4.9.1"},"reference-count":38,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Renal medullary carcinoma is a recently described aggressive neoplasm of the kidney. With the exception of 2 patients, all other reported cases have been associated with sickle cell hemoglobinopathies, mainly sickle cell trait and hemoglobin SC disease. Renal medullary carcinoma is a highly malignant tumor with evidence of angiolymphatic and distant metastasis at the time of diagnosis. No specific genetic abnormality has been identified in this neoplasm despite its close association with a genetic disease. We describe 2 cases of renal medullary carcinoma, one associated with hemoglobin SC disease, and the other with what we believe to be the first reported case associated with sickle cell disease.<\/jats:p>","DOI":"10.5858\/2003-127-e135-rmcaro","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T11:38:16Z","timestamp":1611920296000},"page":"e135-e138","source":"Crossref","is-referenced-by-count":53,"title":["Renal Medullary Carcinoma: A Report of 2 Cases and Review of the Literature"],"prefix":"10.5858","volume":"127","author":[{"given":"Haytham","family":"Dimashkieh","sequence":"first","affiliation":[{"name":"From the Departments of Pathology and Laboratory Medicine (Drs Dimashkieh and Mutema) and Urology (Dr Choe), University of Cincinnati, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong","family":"Choe","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology and Laboratory Medicine (Drs Dimashkieh and Mutema) and Urology (Dr Choe), University of Cincinnati, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Mutema","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology and Laboratory Medicine (Drs Dimashkieh and Mutema) and Urology (Dr Choe), University of Cincinnati, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3906","reference":[{"key":"i1543-2165-127-3-e135-b1","series-title":"Am J Surg Pathol","first-page":"1","article-title":"Renal medullary carcinoma: the seventh sickle cell nephropathy.","volume":"19","author":"Davis, C. J. Jr","year":"1995","unstructured":"Davis, C. J. Jr, F. K.Mostofi, and I. A.Sesterhenn. Renal medullary carcinoma: the seventh sickle cell nephropathy.Am J Surg Pathol1995. 19:1\u201311."},{"key":"i1543-2165-127-3-e135-b2","series-title":"J Urol","first-page":"711","article-title":"Renal medullary carcinoma.","volume":"159","author":"Figenshau, R. S.","year":"1998","unstructured":"Figenshau, R. S., J. W.Basler, J. H.Ritter, C. L.Siegel, J. A.Simon, and S. M.Dierks. Renal medullary carcinoma.J Urol1998. 159:711\u2013713."},{"key":"i1543-2165-127-3-e135-b3","series-title":"J Urol","first-page":"2246","article-title":"Renal medullary carcinoma: a recently described highly aggressive renal tumor in young black patients.","volume":"157","author":"Herring, J. C.","year":"1997","unstructured":"Herring, J. C., M. A.Schmetz, A. B.Digan, S. T.Young, and N. B.Kalloo. Renal medullary carcinoma: a recently described highly aggressive renal tumor in young black patients.J Urol1997. 157:2246\u20132247."},{"key":"i1543-2165-127-3-e135-b4","series-title":"J Urol","first-page":"1349","article-title":"Renal medullary carcinoma and sickle cell trait.","volume":"157","author":"Friedrichs, P.","year":"1997","unstructured":"Friedrichs, P., P.Lassen, E.Canby, and C.Graham. Renal medullary carcinoma and sickle cell trait.J Urol1997. 157:1349."},{"key":"i1543-2165-127-3-e135-b5","series-title":"Am J Roentgenol","first-page":"1037","article-title":"Renal medulla carcinoma in a white adolescent.","volume":"169","author":"Kalyanpur, A.","year":"1997","unstructured":"Kalyanpur, A., D. S.Schwartz, J. M.Fields, M.Rayes-Mugica, M. S.Keller, and J.Gosche. Renal medulla carcinoma in a white adolescent.Am J Roentgenol1997. 169:1037\u20131038."},{"key":"i1543-2165-127-3-e135-b6","series-title":"Am J Surg Pathol","first-page":"260","article-title":"Cancer as a marker of genetic medical disease: an unusual case of medullary carcinoma of the kidney.","volume":"22","author":"Adsay, N. V.","year":"1998","unstructured":"Adsay, N. V., S. J.deRoux, W.Sakr, and D.Grignon. Cancer as a marker of genetic medical disease: an unusual case of medullary carcinoma of the kidney.Am J Surg Pathol1998. 22:260\u2013264."},{"key":"i1543-2165-127-3-e135-b7","series-title":"Pediatrics","first-page":"22","article-title":"Renal medullary carcinoma in an adolescent with sickle cell trait.","volume":"103","author":"Warren, K. E.","year":"1999","unstructured":"Warren, K. E., V.Gidvani-Diaz, and B.Duval-Arnould. Renal medullary carcinoma in an adolescent with sickle cell trait.Pediatrics1999. 103: E. 22."},{"key":"i1543-2165-127-3-e135-b8","series-title":"J Pediatr Hematol Oncol","first-page":"67","article-title":"Prolonged survival of a patient with sickle cell trait and metastatic renal medullary carcinoma.","volume":"21","author":"Pirich, L. M.","year":"1999","unstructured":"Pirich, L. M., P.Chou, and D. O.Walterhouse. Prolonged survival of a patient with sickle cell trait and metastatic renal medullary carcinoma.J Pediatr Hematol Oncol1999. 21:67\u201369."},{"key":"i1543-2165-127-3-e135-b9","series-title":"Pediatr Pathol Lab Med","first-page":"97","article-title":"Renal medullary carcinoma: a potential sickle cell nephropathy of children and adolescents.","volume":"18","author":"Wesche, W. A.","year":"1998","unstructured":"Wesche, W. A., J.Wilimas, V.Khare, and D. M.Parham. Renal medullary carcinoma: a potential sickle cell nephropathy of children and adolescents.Pediatr Pathol Lab Med1998. 18:97\u2013113."},{"key":"i1543-2165-127-3-e135-b10","series-title":"Urology","first-page":"1049","article-title":"Renal medullary carcinoma in patients with sickle cell trait.","volume":"51","author":"Coogan, C. L.","year":"1998","unstructured":"Coogan, C. L., C. F. JrMcKiel, M. J.Flanagan, T. P.Bormes, and T. G.Matkov. Renal medullary carcinoma in patients with sickle cell trait.Urology1998. 51:1049\u20131050."},{"key":"i1543-2165-127-3-e135-b11","series-title":"Arch Pathol Lab Med","first-page":"1561","article-title":"Pathologic quiz case: a 33-year-old man with an abdominal mass.","volume":"124","author":"Mathur, S. C.","year":"2000","unstructured":"Mathur, S. C. and A. M.Schwartz. Pathologic quiz case: a 33-year-old man with an abdominal mass.Arch Pathol Lab Med2000. 124:1561\u20131563."},{"key":"i1543-2165-127-3-e135-b12","series-title":"Acta Cytol","first-page":"735","article-title":"Fine needle aspiration cytology diagnosis of renal medullary carcinoma: a case report.","volume":"45","author":"Qi, J.","year":"2001","unstructured":"Qi, J., P. U.Shen, W. N.Rezuke, A. A.Currier, P. K.Westfall, and S. R.Mandavilli. Fine needle aspiration cytology diagnosis of renal medullary carcinoma: a case report.Acta Cytol2001. 45:735\u2013739."},{"key":"i1543-2165-127-3-e135-b13","series-title":"Eur J Radiol","first-page":"1","article-title":"Renal medullary carcinoma: sonographic, computed tomography, magnetic resonance and angiographic findings.","volume":"35","author":"Khan, A.","year":"2000","unstructured":"Khan, A., N.Thomas, and B.Costello. et al. Renal medullary carcinoma: sonographic, computed tomography, magnetic resonance and angiographic findings.Eur J Radiol2000. 35:1\u20137."},{"key":"i1543-2165-127-3-e135-b14","series-title":"J Urol","first-page":"1238","article-title":"Renal medullary carcinoma: can early diagnosis lead to long-term survival?","volume":"163","author":"Selby, D. M.","year":"2000","unstructured":"Selby, D. M., C.Simon, J. P.Foley, I. M.Thompson, and R. T.Baddour. Renal medullary carcinoma: can early diagnosis lead to long-term survival?J Urol2000. 163:1238."},{"key":"i1543-2165-127-3-e135-b15","series-title":"Diagn Cytopathol","first-page":"276","article-title":"Renal medullary carcinoma: report of a case with positive urinary cytology.","volume":"18","author":"Larson, D. M.","year":"1998","unstructured":"Larson, D. M., C. W.Gilstad, G. W.Manson, and M. R.Henry. Renal medullary carcinoma: report of a case with positive urinary cytology.Diagn Cytopathol1998. 18:276\u2013279."},{"key":"i1543-2165-127-3-e135-b16","series-title":"J Urol Pathol","first-page":"191","article-title":"Renal medullary carcinoma. Immunohistochemical and ultrastructural observations.","volume":"4","author":"Rodriguez-Jurado, R.","year":"1996","unstructured":"Rodriguez-Jurado, R. and F.Gonzalez-Crussi. Renal medullary carcinoma. Immunohistochemical and ultrastructural observations.J Urol Pathol1996. 4:191\u2013203."},{"key":"i1543-2165-127-3-e135-b17","series-title":"Med Pediatr Oncol","first-page":"551","article-title":"Renal medullary carcinoma: prolonged remission with chemotherapy, immunohistochemical characterization and evidence of bcr\/abl rearrangement.","volume":"33","author":"Stahlschmidt, J.","year":"1999","unstructured":"Stahlschmidt, J., C.Cullilane, P.Roberts, and S.Picton. 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Prolonged survival of a patient with sickle cell trait and metastatic renal medullary carcinoma.J Pediatr Hematol Oncol1999. 21:67\u201369."},{"key":"i1543-2165-127-3-e135-b9","series-title":"Pediatr Pathol Lab Med","first-page":"97","article-title":"Renal medullary carcinoma: a potential sickle cell nephropathy of children and adolescents.","volume":"18","author":"Wesche, W. A.","year":"1998","unstructured":"Wesche, W. A., J.Wilimas, V.Khare, and D. M.Parham. Renal medullary carcinoma: a potential sickle cell nephropathy of children and adolescents.Pediatr Pathol Lab Med1998. 18:97\u2013113."},{"key":"i1543-2165-127-3-e135-b10","series-title":"Urology","first-page":"1049","article-title":"Renal medullary carcinoma in patients with sickle cell trait.","volume":"51","author":"Coogan, C. L.","year":"1998","unstructured":"Coogan, C. L., C. F. JrMcKiel, M. J.Flanagan, T. P.Bormes, and T. G.Matkov. 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