{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T05:07:46Z","timestamp":1774328866258,"version":"3.50.1"},"reference-count":24,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 22-year-old man was hospitalized for assessment of thrombocytopenia and fever. Examination showed that he had infectious mononucleosis and moderately severe thrombocytopenia that was asymptomatic. Examination of blood smears revealed that the thrombocytopenia was caused by the clumping of platelets. We made a diagnosis of ethylenediaminetetraacetic acid\u2013dependent pseudothrombocytopenia after excluding other infectious mononucleosis\u2013related mechanisms of thrombocytopenia. When the patient recovered from infectious mononucleosis 2 months later, his thrombocytopenia improved, and no platelet clumping in peripheral blood smears was noted. Ethylenediaminetetraacetic acid\u2013dependent pseudothrombocytopenia should always be considered as a possible cause of reported low platelet counts, even in patients with infectious mononucleosis and splenomegaly.<\/jats:p>","DOI":"10.5858\/2003-127-e17-pawi","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T05:04:52Z","timestamp":1611896692000},"page":"e17-e18","source":"Crossref","is-referenced-by-count":21,"title":["Pseudothrombocytopenia Associated With Infectious Mononucleosis"],"prefix":"10.5858","volume":"127","author":[{"given":"A. T.","family":"Hsieh","sequence":"first","affiliation":[{"name":"From the Division of Hematology\/Oncology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. Y.","family":"Chao","sequence":"additional","affiliation":[{"name":"From the Division of Hematology\/Oncology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. C.","family":"Chen","sequence":"additional","affiliation":[{"name":"From the Division of Hematology\/Oncology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"key":"i1543-2165-127-1-e17-b1","series-title":"J Am Board Fam Pract","first-page":"212","article-title":"EDTA-induced pseudothrombocytopenia.","volume":"9","author":"Allerheiligen, D.","year":"1996","unstructured":"Allerheiligen, D., R.Houston, and B.Vermedahl. EDTA-induced pseudothrombocytopenia.J Am Board Fam Pract1996. 9:212\u2013214."},{"key":"i1543-2165-127-1-e17-b2","series-title":"Blood","first-page":"177","article-title":"Pseudothrombocytopenia caused by platelet agglutinins that are reactive in blood anticoagulated with chelating agents.","volume":"56","author":"Onder, O.","year":"1980","unstructured":"Onder, O., A.Weinstein, and L. W.Hoyer. Pseudothrombocytopenia caused by platelet agglutinins that are reactive in blood anticoagulated with chelating agents.Blood1980. 56:177\u2013182."},{"key":"i1543-2165-127-1-e17-b3","series-title":"Am J Hematol","first-page":"103","article-title":"EDTA-dependent pseudothrombocytopenia: a clinical and epidemiological study of 112 cases, with 10-year follow-up.","volume":"50","author":"Bizzaro, N.","year":"1995","unstructured":"Bizzaro, N.\n          \n          EDTA-dependent pseudothrombocytopenia: a clinical and epidemiological study of 112 cases, with 10-year follow-up.\n          Am J Hematol\n          1995. 50:103\u2013109."},{"key":"i1543-2165-127-1-e17-b4","series-title":"Intensive Care Med","first-page":"218","article-title":"Transient EDTA-dependent pseudothrombocytopenia in a patient with sepsis.","volume":"26","author":"Mori, M.","year":"2000","unstructured":"Mori, M., H.Kudo, S.Yoshitake, K.Ito, C.Shinguu, and T.Noguchi. Transient EDTA-dependent pseudothrombocytopenia in a patient with sepsis.Intensive Care Med2000. 26:218\u2013220."},{"key":"i1543-2165-127-1-e17-b5","series-title":"Mayo Clin Proc","first-page":"123","article-title":"Pseudothrombocytopenia: a laboratory artifact with potentially serious consequences.","volume":"59","author":"Payne, B. A.","year":"1984","unstructured":"Payne, B. A. and R. V.Pierre. Pseudothrombocytopenia: a laboratory artifact with potentially serious consequences.Mayo Clin Proc1984. 59:123\u2013125."},{"key":"i1543-2165-127-1-e17-b6","series-title":"Am J Clin Pathol","first-page":"178","article-title":"IgG platelet antibodies in EDTA-dependent pseudothrombocytopenia bind to platelet membrane glycoprotein IIb.","volume":"110","author":"Fiorin, F.","year":"1998","unstructured":"Fiorin, F., A.Steffan, P.Pradella, N.Bizzaro, R.Potenza, and V.De Angelis. IgG platelet antibodies in EDTA-dependent pseudothrombocytopenia bind to platelet membrane glycoprotein IIb.Am J Clin Pathol1998. 110:178\u2013183."},{"key":"i1543-2165-127-1-e17-b7","series-title":"J Clin Pathol","first-page":"625","article-title":"EDTA dependent pseudothrombocytopenia caused by antibodies against the cytoadhesive receptor of platelet gpIIB-IIIA.","volume":"47","author":"Casonato, A.","year":"1994","unstructured":"Casonato, A., A.Bertomoro, E.Pontara, D.Dannhauser, A. R.Lazzaro, and A.Girolami. EDTA dependent pseudothrombocytopenia caused by antibodies against the cytoadhesive receptor of platelet gpIIB-IIIA.J Clin Pathol1994. 47:625\u2013630."},{"key":"i1543-2165-127-1-e17-b8","series-title":"Haematologia","first-page":"117","article-title":"The incidence of pseudothrombocytopenia in automatic blood analyzers.","volume":"30","author":"Cohen, A. M.","year":"2000","unstructured":"Cohen, A. M., Z.Cycowitz, M.Mittelman, U. H.Lewinski, and J.Gardyn. The incidence of pseudothrombocytopenia in automatic blood analyzers.Haematologia2000. 30:117\u2013121."},{"key":"i1543-2165-127-1-e17-b9","series-title":"Vox Sang","first-page":"35","article-title":"Incidence and diagnosis of EDTA-dependent pseudothrombocytopenia in a consecutive outpatient population referred for isolated thrombocytopenia.","volume":"68","author":"Silvestri, F.","year":"1995","unstructured":"Silvestri, F., L.Virgolini, C.Savignano, F.Zaja, M.Velisig, and M.Baccarani. Incidence and diagnosis of EDTA-dependent pseudothrombocytopenia in a consecutive outpatient population referred for isolated thrombocytopenia.Vox Sang1995. 68:35\u201339."},{"key":"i1543-2165-127-1-e17-b10","series-title":"Curr Opin Pediatr","first-page":"263","article-title":"Acute complications of Epstein-Barr virus infectious mononucleosis.","volume":"12","author":"Jenson, H. B.","year":"2000","unstructured":"Jenson, H. B.\n          \n          Acute complications of Epstein-Barr virus infectious mononucleosis.\n          Curr Opin Pediatr\n          2000. 12:263\u2013268."},{"key":"i1543-2165-127-1-e17-b11","series-title":"Blood","first-page":"157","article-title":"Pseudothrombocytopenia: an immunologic study on platelet antibodies dependent on ethylene diamine tetra-acetate.","volume":"59","author":"Pegels, J. G.","year":"1982","unstructured":"Pegels, J. G., E. C.Bruynes, C. P.Engelfriet, and A. E.Borne. Pseudothrombocytopenia: an immunologic study on platelet antibodies dependent on ethylene diamine tetra-acetate.Blood1982. 59:157\u2013161."},{"key":"i1543-2165-127-1-e17-b12","series-title":"Am J Clin Pathol","first-page":"1005","article-title":"Pseudothrombocytopenia due to agglutinins.","volume":"72","author":"Veenhoven, W. A.","year":"1979","unstructured":"Veenhoven, W. A., G. S.van der Schans, W.Huiges, H. E.Metting-Scherphuis, M. R.Halie, and H. O.Nieweg. Pseudothrombocytopenia due to agglutinins.Am J Clin Pathol1979. 72:1005\u20131008."},{"key":"i1543-2165-127-1-e17-b1","series-title":"J Am Board Fam Pract","first-page":"212","article-title":"EDTA-induced pseudothrombocytopenia.","volume":"9","author":"Allerheiligen, D.","year":"1996","unstructured":"Allerheiligen, D., R.Houston, and B.Vermedahl. EDTA-induced pseudothrombocytopenia.J Am Board Fam Pract1996. 9:212\u2013214."},{"key":"i1543-2165-127-1-e17-b2","series-title":"Blood","first-page":"177","article-title":"Pseudothrombocytopenia caused by platelet agglutinins that are reactive in blood anticoagulated with chelating agents.","volume":"56","author":"Onder, O.","year":"1980","unstructured":"Onder, O., A.Weinstein, and L. W.Hoyer. Pseudothrombocytopenia caused by platelet agglutinins that are reactive in blood anticoagulated with chelating agents.Blood1980. 56:177\u2013182."},{"key":"i1543-2165-127-1-e17-b3","series-title":"Am J Hematol","first-page":"103","article-title":"EDTA-dependent pseudothrombocytopenia: a clinical and epidemiological study of 112 cases, with 10-year follow-up.","volume":"50","author":"Bizzaro, N.","year":"1995","unstructured":"Bizzaro, N.\n          \n          EDTA-dependent pseudothrombocytopenia: a clinical and epidemiological study of 112 cases, with 10-year follow-up.\n          Am J Hematol\n          1995. 50:103\u2013109."},{"key":"i1543-2165-127-1-e17-b4","series-title":"Intensive Care Med","first-page":"218","article-title":"Transient EDTA-dependent pseudothrombocytopenia in a patient with sepsis.","volume":"26","author":"Mori, M.","year":"2000","unstructured":"Mori, M., H.Kudo, S.Yoshitake, K.Ito, C.Shinguu, and T.Noguchi. Transient EDTA-dependent pseudothrombocytopenia in a patient with sepsis.Intensive Care Med2000. 26:218\u2013220."},{"key":"i1543-2165-127-1-e17-b5","series-title":"Mayo Clin Proc","first-page":"123","article-title":"Pseudothrombocytopenia: a laboratory artifact with potentially serious consequences.","volume":"59","author":"Payne, B. A.","year":"1984","unstructured":"Payne, B. A. and R. V.Pierre. Pseudothrombocytopenia: a laboratory artifact with potentially serious consequences.Mayo Clin Proc1984. 59:123\u2013125."},{"key":"i1543-2165-127-1-e17-b6","series-title":"Am J Clin Pathol","first-page":"178","article-title":"IgG platelet antibodies in EDTA-dependent pseudothrombocytopenia bind to platelet membrane glycoprotein IIb.","volume":"110","author":"Fiorin, F.","year":"1998","unstructured":"Fiorin, F., A.Steffan, P.Pradella, N.Bizzaro, R.Potenza, and V.De Angelis. IgG platelet antibodies in EDTA-dependent pseudothrombocytopenia bind to platelet membrane glycoprotein IIb.Am J Clin Pathol1998. 110:178\u2013183."},{"key":"i1543-2165-127-1-e17-b7","series-title":"J Clin Pathol","first-page":"625","article-title":"EDTA dependent pseudothrombocytopenia caused by antibodies against the cytoadhesive receptor of platelet gpIIB-IIIA.","volume":"47","author":"Casonato, A.","year":"1994","unstructured":"Casonato, A., A.Bertomoro, E.Pontara, D.Dannhauser, A. R.Lazzaro, and A.Girolami. EDTA dependent pseudothrombocytopenia caused by antibodies against the cytoadhesive receptor of platelet gpIIB-IIIA.J Clin Pathol1994. 47:625\u2013630."},{"key":"i1543-2165-127-1-e17-b8","series-title":"Haematologia","first-page":"117","article-title":"The incidence of pseudothrombocytopenia in automatic blood analyzers.","volume":"30","author":"Cohen, A. M.","year":"2000","unstructured":"Cohen, A. M., Z.Cycowitz, M.Mittelman, U. H.Lewinski, and J.Gardyn. The incidence of pseudothrombocytopenia in automatic blood analyzers.Haematologia2000. 30:117\u2013121."},{"key":"i1543-2165-127-1-e17-b9","series-title":"Vox Sang","first-page":"35","article-title":"Incidence and diagnosis of EDTA-dependent pseudothrombocytopenia in a consecutive outpatient population referred for isolated thrombocytopenia.","volume":"68","author":"Silvestri, F.","year":"1995","unstructured":"Silvestri, F., L.Virgolini, C.Savignano, F.Zaja, M.Velisig, and M.Baccarani. Incidence and diagnosis of EDTA-dependent pseudothrombocytopenia in a consecutive outpatient population referred for isolated thrombocytopenia.Vox Sang1995. 68:35\u201339."},{"key":"i1543-2165-127-1-e17-b10","series-title":"Curr Opin Pediatr","first-page":"263","article-title":"Acute complications of Epstein-Barr virus infectious mononucleosis.","volume":"12","author":"Jenson, H. B.","year":"2000","unstructured":"Jenson, H. B.\n          \n          Acute complications of Epstein-Barr virus infectious mononucleosis.\n          Curr Opin Pediatr\n          2000. 12:263\u2013268."},{"key":"i1543-2165-127-1-e17-b11","series-title":"Blood","first-page":"157","article-title":"Pseudothrombocytopenia: an immunologic study on platelet antibodies dependent on ethylene diamine tetra-acetate.","volume":"59","author":"Pegels, J. G.","year":"1982","unstructured":"Pegels, J. G., E. C.Bruynes, C. P.Engelfriet, and A. E.Borne. Pseudothrombocytopenia: an immunologic study on platelet antibodies dependent on ethylene diamine tetra-acetate.Blood1982. 59:157\u2013161."},{"key":"i1543-2165-127-1-e17-b12","series-title":"Am J Clin Pathol","first-page":"1005","article-title":"Pseudothrombocytopenia due to agglutinins.","volume":"72","author":"Veenhoven, W. A.","year":"1979","unstructured":"Veenhoven, W. A., G. S.van der Schans, W.Huiges, H. E.Metting-Scherphuis, M. R.Halie, and H. O.Nieweg. 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