{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:20:01Z","timestamp":1777368001663,"version":"3.51.4"},"reference-count":20,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Primary lung tumors mimicking the salivary gland\u2013type neoplasms are extremely rare. These types of tumors originate from submucosal bronchial glands. Epithelial-myoepithelial carcinoma is an uncommon tumor in this group, and only 7 cases have been reported. It is considered to be a low-grade malignant neoplasm. We report a case of epithelial-myoepithelial carcinoma of bronchial gland origin in a 73-year-old man who presented with coughing and dyspnea. The bronchus of the left lower lobe contained a tumor mass that had a polypoid growth pattern. The tumor also extended into the pulmonary parenchyma, forming a well-circumscribed mass with a pushing margin. The tumor consisted of epithelial and myoepithelial cells. The epithelial cells were positive for cytokeratins and epithelial membrane antigen, while the myoepithelial cells were positive for S100 protein and muscle-specific actin. According to these findings, we diagnosed epithelial-myoepithelial carcinoma. After undergoing pneumonectomy, the patient has been disease free for 34 months.<\/jats:p>","DOI":"10.5858\/2003-127-e177-ecotl","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T11:16:48Z","timestamp":1611919008000},"page":"e177-e180","source":"Crossref","is-referenced-by-count":42,"title":["Epithelial-Myoepithelial Carcinoma of the Lung"],"prefix":"10.5858","volume":"127","author":[{"given":"Latife","family":"Doganay","sequence":"first","affiliation":[{"name":"From the Departments of Pathology (Drs Doganay, Bilgi, Ozdil, Altaner, and Kutlu) and Thoracic Surgery (Dr Yoruk), Trakya University Medical Faculty, Edirne, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selcuk","family":"Bilgi","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Doganay, Bilgi, Ozdil, Altaner, and Kutlu) and Thoracic Surgery (Dr Yoruk), Trakya University Medical Faculty, Edirne, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asli","family":"Ozdil","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Doganay, Bilgi, Ozdil, Altaner, and Kutlu) and Thoracic Surgery (Dr Yoruk), Trakya University Medical Faculty, Edirne, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yener","family":"Yoruk","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Doganay, Bilgi, Ozdil, Altaner, and Kutlu) and Thoracic Surgery (Dr Yoruk), Trakya University Medical Faculty, Edirne, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Semsi","family":"Altaner","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Doganay, Bilgi, Ozdil, Altaner, and Kutlu) and Thoracic Surgery (Dr Yoruk), Trakya University Medical Faculty, Edirne, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kemal","family":"Kutlu","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Doganay, Bilgi, Ozdil, Altaner, and Kutlu) and Thoracic Surgery (Dr Yoruk), Trakya University Medical Faculty, Edirne, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"key":"i1543-2165-127-4-e177-b1","series-title":"Hum Pathol","first-page":"631","article-title":"Epithelial-myoepithelial carcinoma of the lung: immunohistochemical and ultrastructural observations and review of the literature.","volume":"8","author":"Wilson, R. W.","year":"1997","unstructured":"Wilson, R. W. and C. A.Moran. Epithelial-myoepithelial carcinoma of the lung: immunohistochemical and ultrastructural observations and review of the literature.Hum Pathol1997. 8:631\u2013635."},{"key":"i1543-2165-127-4-e177-b2","series-title":"Am J Surg Pathol","first-page":"421","article-title":"Epithelial-myoepithelial tumor of the bronchus.","volume":"18","author":"Nistal, M.","year":"1994","unstructured":"Nistal, M., M.Garcia-Viera, C.Martinez-Garcia, and R.Paniagua. Epithelial-myoepithelial tumor of the bronchus.Am J Surg Pathol1994. 18:421\u2013425."},{"key":"i1543-2165-127-4-e177-b3","series-title":"Am J Surg Pathol","first-page":"1300","article-title":"Myoepithelial carcinoma of the lung arising from bronchial submucosa.","volume":"24","author":"Miura, K.","year":"2000","unstructured":"Miura, K., H.Harada, S.Aiba, and Y.Tsutsui. Myoepithelial carcinoma of the lung arising from bronchial submucosa.Am J Surg Pathol2000. 24:1300\u20131304."},{"key":"i1543-2165-127-4-e177-b4","series-title":"J Clin Pathol","first-page":"185","article-title":"Epithelial-myoepithelial tumor of the tracheal gland.","volume":"46","author":"Horinouchi, H.","year":"1993","unstructured":"Horinouchi, H., T.Ishihara, and M.Kawamura. et al. Epithelial-myoepithelial tumor of the tracheal gland.J Clin Pathol1993. 46:185\u2013187."},{"key":"i1543-2165-127-4-e177-b5","series-title":"Am J Surg Pathol","first-page":"956","article-title":"Adenomyoepithelioma of the lung.","volume":"19","author":"Tsuji, N.","year":"1995","unstructured":"Tsuji, N., R.Tateishi, S.Ishiguro, T.Terao, and M.Higashiyama. Adenomyoepithelioma of the lung.Am J Surg Pathol1995. 19:956\u2013962."},{"key":"i1543-2165-127-4-e177-b6","series-title":"Pathol Res Pract","first-page":"431","article-title":"Epithelial-myoepithelial carcinoma of the bronchus.","volume":"194","author":"Ryska, A.","year":"1998","unstructured":"Ryska, A., Z.Kerekes, E.Hovorkova, and P.Barton. Epithelial-myoepithelial carcinoma of the bronchus.Pathol Res Pract1998. 194:431\u2013435."},{"key":"i1543-2165-127-4-e177-b7","series-title":"Histopathology","first-page":"90","article-title":".","volume":"33","author":"Shanks, J. H.","year":"1998","unstructured":"Shanks, J. H., P. S.Hasleton, A.Curry, A.Rahman, and E. M. C.Bronchial. .Histopathology1998. 33:90\u201391."},{"key":"i1543-2165-127-4-e177-b8","series-title":"Mod Pathol","first-page":"521","article-title":"Pulmonary epithelial-myoepithelial tumor of unproven malignant potential: report of a case and review of the literature.","volume":"14","author":"Pelosi, G.","year":"2001","unstructured":"Pelosi, G., F.Fraggetta, F.Maffini, P.Solli, A.Cavallon, and G.Viale. Pulmonary epithelial-myoepithelial tumor of unproven malignant potential: report of a case and review of the literature.Mod Pathol2001. 14:521\u2013526."},{"key":"i1543-2165-127-4-e177-b9","series-title":"Semin Diagn Pathol","first-page":"106","article-title":"Primary salivary gland-type tumors of the lung.","volume":"12","author":"Moran, C. A.","year":"1995","unstructured":"Moran, C. A.\n          \n          Primary salivary gland-type tumors of the lung.\n          Semin Diagn Pathol\n          1995. 12:106\u2013122."},{"key":"i1543-2165-127-4-e177-b10","series-title":"Am J Clin Pathol","first-page":"432","article-title":"Epithelial-myoepithelial carcinoma of salivary glands: a clinicopathologic, DNA flow cytometric, and immunohistochemical study of Ki-67 and HER-2\/neu oncogene.","volume":"103","author":"Cho, K. J.","year":"1995","unstructured":"Cho, K. J., A. K.El-Naggar, N. G.Ordonez, M. A.Luna, J.Austin, and J. G.Batsakis. 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