{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T04:54:17Z","timestamp":1770785657892,"version":"3.50.0"},"reference-count":30,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We report a case of multiple lymphoepithelial cysts of the thyroid gland in a patient with severe chronic lymphocytic thyroiditis. Lymphoepithelial cysts of the thyroid gland are rare lesions that are histologically similar to branchial cleft cysts found in the lateral neck. The cysts have an epithelial lining that is usually stratified squamous epithelium but may be focally respiratory-type epithelium. Abundant lymphoid tissue is present beneath the epithelium, and lymphoid follicles with reactive germinal centers are common features in the walls of the cysts. Because of their similarity to branchial cleft cysts and the presence of intrathyroidal branchiae-derived structures such as thymus and parathyroid gland tissue in the vicinity of some cysts, lymphoepithelial cysts of the thyroid have been postulated to arise from remnants of branchial derivatives; origination from solid cell nest remnants of the ultimobranchial bodies has been raised as a possibility. A definitive origin, however, has not been established. An association with chronic thyroiditis has been noted in 8 of the previously reported 16 cases occurring in a background of Hashimoto or chronic lymphocytic thyroiditis.<\/jats:p>","DOI":"10.5858\/2003-127-e205-lcottg","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T11:25:45Z","timestamp":1611919545000},"page":"e205-e208","source":"Crossref","is-referenced-by-count":21,"title":["Lymphoepithelial Cysts of the Thyroid Gland"],"prefix":"10.5858","volume":"127","author":[{"given":"Elliot","family":"Carter","sequence":"first","affiliation":[{"name":"From the Department of Pathology, University of South Alabama Medical Center, Mobile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozlem","family":"Ulusarac","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, University of South Alabama Medical Center, Mobile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"key":"i1543-2165-127-4-e205-b1","series-title":"Am J Surg Pathol","first-page":"45","article-title":"Multiple branchial cleft-like cysts in Hashimoto's thyroiditis.","volume":"13","author":"Louis, D. N.","year":"1989","unstructured":"Louis, D. N., A. L.Vickery, and J.Rosai. et al. Multiple branchial cleft-like cysts in Hashimoto's thyroiditis.Am J Surg Pathol1989. 13:45\u201349."},{"key":"i1543-2165-127-4-e205-b2","series-title":"Hum Pathol","first-page":"1238","article-title":"Intrathyroidal lymphoepithelial cysts of probable branchial origin.","volume":"25","author":"Apel, R. L.","year":"1994","unstructured":"Apel, R. L., S. L.Asa, and A.Chalvardjian. et al. Intrathyroidal lymphoepithelial cysts of probable branchial origin.Hum Pathol1994. 25:1238\u20131242."},{"key":"i1543-2165-127-4-e205-b3","series-title":"Am J Surg Pathol","first-page":"1072","article-title":"Thyroid cysts.","volume":"13","author":"Carney, J. A.","year":"1989","unstructured":"Carney, J. A.\n          \n          Thyroid cysts.\n          Am J Surg Pathol\n          1989. 13:1072\u20131074."},{"key":"i1543-2165-127-4-e205-b4","series-title":"Am J Surg Pathol","first-page":"1165","article-title":"Branchial cleft like cysts of the thyroid.","volume":"14","author":"Delabie, J.","year":"1990","unstructured":"Delabie, J., C.De Wolf-Peeters, and L.Cappelle. et al. Branchial cleft like cysts of the thyroid.Am J Surg Pathol1990. 14:1165\u20131171."},{"key":"i1543-2165-127-4-e205-b5","series-title":"Pathol Int","first-page":"897","article-title":"Intrathyroidal branchial cleft-like cyst in chronic thyroiditis.","volume":"50","author":"Haba, R.","year":"November 2000","unstructured":"Haba, R., H.Miki, and S.Kobayashi. et al. Intrathyroidal branchial cleft-like cyst in chronic thyroiditis.Pathol IntNovember 2000. 50:897\u2013900."},{"key":"i1543-2165-127-4-e205-b6","series-title":"Aust N Z J Surg","first-page":"826","article-title":"An intra-thyroidal branchial cyst: a case report.","volume":"62","author":"Lim-Tio, S. W.","year":"1992","unstructured":"Lim-Tio, S. W., R.Judson, and I.Busmanis. et al. An intra-thyroidal branchial cyst: a case report.Aust N Z J Surg1992. 62:826\u2013828."},{"key":"i1543-2165-127-4-e205-b7","series-title":"Pathol Res Pract","first-page":"777","article-title":"Intrathyroidal epithelial cyst: a report of two cases not associated with Hashimoto's thyroiditis.","volume":"193","author":"Ryska, A.","year":"1997","unstructured":"Ryska, A., J.Vokurka, and M.Michal. et al. Intrathyroidal epithelial cyst: a report of two cases not associated with Hashimoto's thyroiditis.Pathol Res Pract1997. 193:777\u2013781."},{"key":"i1543-2165-127-4-e205-b8","series-title":"Pathol Int. December","first-page":"965","article-title":"Multilocular lymphoepithelial cyst in the thyroid accompanied with a minute thyroid carcinoma.","volume":"45","author":"Watanabe, I.","year":"1995","unstructured":"Watanabe, I., K.Kobayashi, and M.Yamaguchi. et al. Multilocular lymphoepithelial cyst in the thyroid accompanied with a minute thyroid carcinoma.Pathol Int. December1995. 45:965\u2013970."},{"key":"i1543-2165-127-4-e205-b9","series-title":"Oral Surg","first-page":"77","article-title":"Lymphoepithelial cysts of the oral mucosa.","volume":"35","author":"Guinta, J.","year":"1973","unstructured":"Guinta, J. and E.Cataldo. Lymphoepithelial cysts of the oral mucosa.Oral Surg1973. 35:77\u201384."},{"key":"i1543-2165-127-4-e205-b10","series-title":"Am J Clin Pathol","first-page":"395","article-title":"Benign lymphoepithelial cysts of the parotid gland: a histologic, cytologic, and ultrastructural study.","volume":"85","author":"Weidner, N.","year":"1986","unstructured":"Weidner, N., K. R.Geisenger, and R. T.Sterling. et al. Benign lymphoepithelial cysts of the parotid gland: a histologic, cytologic, and ultrastructural study.Am J Clin Pathol1986. 85:395\u2013401."},{"key":"i1543-2165-127-4-e205-b11","series-title":"Am J Clin Pathol","first-page":"348","article-title":"Parathyroiditis associated with hyperparathyroidism and branchial cysts.","volume":"96","author":"Chetty, R.","year":"1991","unstructured":"Chetty, R. and M. D.Forder. Parathyroiditis associated with hyperparathyroidism and branchial cysts.Am J Clin Pathol1991. 96:348\u2013350."},{"key":"i1543-2165-127-4-e205-b12","series-title":"Am J Surg Pathol","first-page":"899","article-title":"Lymphoepithelial cyst of the pancreas.","volume":"11","author":"Truong, L. D.","year":"1987","unstructured":"Truong, L. D., S.Rangdaeng, and P. H.Jordan. Lymphoepithelial cyst of the pancreas.Am J Surg Pathol1987. 11:899\u2013903."},{"key":"i1543-2165-127-4-e205-b13","series-title":"Arch Pathol Lab Med","first-page":"1049","article-title":"Solid and cystic ultimobranchial body remnants in the thyroid.","volume":"114","author":"Becker, M. E.","year":"1990","unstructured":"Becker, M. E., J. J.Shultz, and T.Richardson. Solid and cystic ultimobranchial body remnants in the thyroid.Arch Pathol Lab Med1990. 114:1049\u20131052."},{"key":"i1543-2165-127-4-e205-b14","series-title":"J Pathol","first-page":"191","article-title":"Solid cell nests of the thyroid.","volume":"155","author":"Harach, H. R.","year":"1988","unstructured":"Harach, H. R.\n          \n          Solid cell nests of the thyroid.\n          J Pathol\n          1988. 155:191\u2013200."},{"key":"i1543-2165-127-4-e205-b15","series-title":"J Pathol","first-page":"135","article-title":"The ultimobranchial gland and congenital thyroid abnormalities in man.","volume":"159","author":"Williams, E. D.","year":"1989","unstructured":"Williams, E. D., C. E.Toyn, and H. R.Harach. The ultimobranchial gland and congenital thyroid abnormalities in man.J Pathol1989. 159:135\u2013141."},{"key":"i1543-2165-127-4-e205-b1","series-title":"Am J Surg Pathol","first-page":"45","article-title":"Multiple branchial cleft-like cysts in Hashimoto's thyroiditis.","volume":"13","author":"Louis, D. N.","year":"1989","unstructured":"Louis, D. N., A. L.Vickery, and J.Rosai. et al. 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Intrathyroidal branchial cleft-like cyst in chronic thyroiditis.Pathol IntNovember 2000. 50:897\u2013900."},{"key":"i1543-2165-127-4-e205-b6","series-title":"Aust N Z J Surg","first-page":"826","article-title":"An intra-thyroidal branchial cyst: a case report.","volume":"62","author":"Lim-Tio, S. W.","year":"1992","unstructured":"Lim-Tio, S. W., R.Judson, and I.Busmanis. et al. An intra-thyroidal branchial cyst: a case report.Aust N Z J Surg1992. 62:826\u2013828."},{"key":"i1543-2165-127-4-e205-b7","series-title":"Pathol Res Pract","first-page":"777","article-title":"Intrathyroidal epithelial cyst: a report of two cases not associated with Hashimoto's thyroiditis.","volume":"193","author":"Ryska, A.","year":"1997","unstructured":"Ryska, A., J.Vokurka, and M.Michal. et al. Intrathyroidal epithelial cyst: a report of two cases not associated with Hashimoto's thyroiditis.Pathol Res Pract1997. 193:777\u2013781."},{"key":"i1543-2165-127-4-e205-b8","series-title":"Pathol Int. 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R.Geisenger, and R. T.Sterling. et al. Benign lymphoepithelial cysts of the parotid gland: a histologic, cytologic, and ultrastructural study.Am J Clin Pathol1986. 85:395\u2013401."},{"key":"i1543-2165-127-4-e205-b11","series-title":"Am J Clin Pathol","first-page":"348","article-title":"Parathyroiditis associated with hyperparathyroidism and branchial cysts.","volume":"96","author":"Chetty, R.","year":"1991","unstructured":"Chetty, R. and M. D.Forder. Parathyroiditis associated with hyperparathyroidism and branchial cysts.Am J Clin Pathol1991. 96:348\u2013350."},{"key":"i1543-2165-127-4-e205-b12","series-title":"Am J Surg Pathol","first-page":"899","article-title":"Lymphoepithelial cyst of the pancreas.","volume":"11","author":"Truong, L. D.","year":"1987","unstructured":"Truong, L. D., S.Rangdaeng, and P. H.Jordan. 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The ultimobranchial gland and congenital thyroid abnormalities in man.J Pathol1989. 159:135\u2013141."}],"container-title":["Archives of Pathology &amp; Laboratory Medicine"],"original-title":[],"link":[{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/127\/4\/article-pe205.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/127\/4\/e205\/2730528\/0003-9985(2003)127_e205_lcottg_2_0_co_2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/127\/4\/article-pe205.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/127\/4\/article-pe205.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T01:06:42Z","timestamp":1770772002000},"score":1,"resource":{"primary":{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/127\/4\/article-pe205.xml"}},"subtitle":["A Case Report and Review of the Literature"],"short-title":[],"issued":{"date-parts":[[2003,4]]},"references-count":30,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.5858\/2003-127-e205-lcottg","relation":{},"ISSN":["1543-2165","0003-9985"],"issn-type":[{"value":"1543-2165","type":"electronic"},{"value":"0003-9985","type":"print"}],"subject":[],"published":{"date-parts":[[2003,4]]}}}