{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:09:23Z","timestamp":1770822563957,"version":"3.50.1"},"reference-count":44,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We report the case of a 30-year-old woman who presented with a subpleural mass in the lower lobe of the right lung, which was found incidentally on a routine chest radiograph. A wedge biopsy followed by lobectomy and lymph node staging revealed an acinic cell carcinoma with involvement of a hilar lymph node. The subcarinal and mediastinal lymph nodes were free of tumor. Perineural invasion was identified at the periphery of the tumor. There was no evidence of origin from salivary gland or involvement of any other organ. The patient was well 12 months postoperatively. To our knowledge, this is the second case report featuring lymph node metastasis in an acinic cell carcinoma of the lung and the first to demonstrate perineural invasion.<\/jats:p>","DOI":"10.5858\/2003-127-e216-paccot","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T11:26:03Z","timestamp":1611919563000},"page":"e216-e219","source":"Crossref","is-referenced-by-count":29,"title":["Primary Acinic Cell Carcinoma of the Lung With Lymph Node Metastasis"],"prefix":"10.5858","volume":"127","author":[{"given":"Hwei-Yee","family":"Lee","sequence":"first","affiliation":[{"name":"From the Department of Pathology, Singapore General Hospital, Singapore (Drs Lee and Mancer); and the Department of Surgical Oncology, National Cancer Center, Singapore (Dr Koong)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kent","family":"Mancer","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Singapore General Hospital, Singapore (Drs Lee and Mancer); and the Department of Surgical Oncology, National Cancer Center, Singapore (Dr Koong)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng-Nung","family":"Koong","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Singapore General Hospital, Singapore (Drs Lee and Mancer); and the Department of Surgical Oncology, National Cancer Center, Singapore (Dr Koong)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"key":"i1543-2165-127-4-e216-b1","article-title":"Tumors of salivary gland type.","author":"Colby, T. V.","unstructured":"Colby, T. V., M. N.Koss, and W. D.Travis. Tumors of salivary gland type.In: Tumors of the Lower Respiratory Tract. Washington, DC: Armed Forces Institute of Pathology; 1995:65\u201387. Atlas of Tumor Pathology; 3rd series, fascicle 13."},{"key":"i1543-2165-127-4-e216-b2","series-title":"Cancer","first-page":"501","article-title":"Acinic cell tumor of the lung: a histologic and ultrastructural study.","volume":"29","author":"Fechner, R. E.","year":"1972","unstructured":"Fechner, R. E., B. R.Bentinck, and J. B.Askew. Acinic cell tumor of the lung: a histologic and ultrastructural study.Cancer1972. 29:501\u2013508."},{"key":"i1543-2165-127-4-e216-b3","series-title":"Chest","first-page":"591","article-title":"Acinic cell carcinoma of the lung with metastases to lymph nodes.","volume":"155","author":"Ukoha, O. O.","year":"1999","unstructured":"Ukoha, O. O., P.Quartararo, D.Carter, M.Kashgarian, and R.Ponn. Acinic cell carcinoma of the lung with metastases to lymph nodes.Chest1999. 155:591\u2013595."},{"key":"i1543-2165-127-4-e216-b4","series-title":"Otolaryngol Head Neck Surg","first-page":"759","article-title":"Acinic cell carcinoma of the nasal cavity.","volume":"120","author":"Von Biberstein, S. E.","year":"1999","unstructured":"Von Biberstein, S. E., J. D.Spiro, and W.Mancoll. Acinic cell carcinoma of the nasal cavity.Otolaryngol Head Neck Surg1999. 120:759\u2013762."},{"key":"i1543-2165-127-4-e216-b5","series-title":"Arch Pathol Lab Med","first-page":"233","article-title":"Acinous cell carcinoma of the larynx.","volume":"102","author":"Crissman, J. D.","year":"1978","unstructured":"Crissman, J. D. and A.Rosenblatt. Acinous cell carcinoma of the larynx.Arch Pathol Lab Med1978. 102:233\u2013236."},{"key":"i1543-2165-127-4-e216-b6","article-title":"Salivary and lacrimal glands.","author":"Gnepp, D. G.","unstructured":"Gnepp, D. G., M. S.Brandwein, and J. D.Henley. Salivary and lacrimal glands.In: Gnepp DG, ed. Diagnostic Surgical Pathology of the Head and Neck. Philadelphia, Pa: WB Saunders; 2001:325\u2013430."},{"key":"i1543-2165-127-4-e216-b7","series-title":"Histopathology","first-page":"286","article-title":"Primary acinic cell-like carcinoma of the breast: a variant with a good prognosis?","volume":"36","author":"Schmitt, F. C.","year":"2000","unstructured":"Schmitt, F. C., C. A.Ribeiro, S.Alvarenga, and J. M.Lopes. Primary acinic cell-like carcinoma of the breast: a variant with a good prognosis?Histopathology2000. 36:286\u2013289."},{"key":"i1543-2165-127-4-e216-b8","series-title":"Int J Oral Maxillofac Surg","first-page":"289","article-title":"Acinic cell carcinoma arising in a parotid lymph node.","volume":"22","author":"Minic, A. J.","year":"1993","unstructured":"Minic, A. J.\n          \n          Acinic cell carcinoma arising in a parotid lymph node.\n          Int J Oral Maxillofac Surg\n          1993. 22:289\u2013291."},{"key":"i1543-2165-127-4-e216-b9","series-title":"Thorax","first-page":"97","article-title":"One very rare and one new tracheal tumor found by electron microscopy: glomus tumor and acinic cell tumor resembling carcinoid tumors by light microscopy.","volume":"37","author":"Heard, B. E.","year":"1982","unstructured":"Heard, B. E., A.Dewar, and R. K.Firmin. et al. One very rare and one new tracheal tumor found by electron microscopy: glomus tumor and acinic cell tumor resembling carcinoid tumors by light microscopy.Thorax1982. 37:97\u2013103."},{"key":"i1543-2165-127-4-e216-b10","series-title":"Auris Nasus Larynx","first-page":"193","article-title":"Acinic cell carcinoma of the trachea.","volume":"21","author":"Horowitz, Z.","year":"1994","unstructured":"Horowitz, Z. and J.Kronenberg. Acinic cell carcinoma of the trachea.Auris Nasus Larynx1994. 21:193\u2013195."},{"key":"i1543-2165-127-4-e216-b11","series-title":"Zentralbl Allg Pathol","first-page":"751","article-title":"Predominantly mucous-differentiated acinic cell adenocarcinoma of the trachea.","volume":"135","author":"Martin, H.","year":"1989","unstructured":"Martin, H., A.Abboud, and T.Nawka. Predominantly mucous-differentiated acinic cell adenocarcinoma of the trachea.Zentralbl Allg Pathol1989. 135:751\u2013756."},{"key":"i1543-2165-127-4-e216-b12","series-title":"Gan No Rinsho","first-page":"1412","article-title":"Acinic cell carcinoma of the trachea: a case report.","volume":"30","author":"Murakami, M.","year":"1984","unstructured":"Murakami, M., T.Ochi, and H.Tokunaga. et al. Acinic cell carcinoma of the trachea: a case report.Gan No Rinsho1984. 30:1412\u20131416."},{"key":"i1543-2165-127-4-e216-b13","series-title":"Chest","first-page":"1120","article-title":"Upper airway obstruction secondary to acinic cell carcinoma of the trachea: use of Nd:YAG laser.","volume":"110","author":"Ansari, M. A.","year":"1996","unstructured":"Ansari, M. A., A.Marchevsky, and L.Strick. et al. Upper airway obstruction secondary to acinic cell carcinoma of the trachea: use of Nd:YAG laser.Chest1996. 110:1120\u20131122."},{"key":"i1543-2165-127-4-e216-b14","series-title":"Am J Surg Pathol","first-page":"1039","article-title":"Acinic cell carcinoma of the lung (\u201cFechner tumor\u201d): a clinicopathologic, immunohistochemical, and ultrastructural study of five cases.","volume":"16","author":"Moran, C. A.","year":"1992","unstructured":"Moran, C. A., S.Suster, and M. N.Koss. Acinic cell carcinoma of the lung (\u201cFechner tumor\u201d): a clinicopathologic, immunohistochemical, and ultrastructural study of five cases.Am J Surg Pathol1992. 16:1039\u20131050."},{"key":"i1543-2165-127-4-e216-b15","series-title":"Cancer","first-page":"830","article-title":"Acinic cell tumor of the bronchus.","volume":"38","author":"Kantz, D. R.","year":"1976","unstructured":"Kantz, D. R. and J. J.Bubis. Acinic cell tumor of the bronchus.Cancer1976. 38:830\u2013832."},{"key":"i1543-2165-127-4-e216-b16","series-title":"Indian J Cancer","first-page":"152","article-title":"Acinic cell tumor of the bronchus (a case report).","volume":"22","author":"Gharpure, K. J.","year":"1985","unstructured":"Gharpure, K. J., R. K.Deshpande, and R. N.Vishweshvara. et al. Acinic cell tumor of the bronchus (a case report).Indian J Cancer1985. 22:152\u2013156."},{"key":"i1543-2165-127-4-e216-b17","series-title":"Nippon Geka Gakkai Zasshi","first-page":"1810","article-title":"Acinic cell carcinoma of the bronchial gland.","volume":"90","author":"Yoshida, K.","year":"1989","unstructured":"Yoshida, K., I.Koyama, and T.Matsui. et al. Acinic cell carcinoma of the bronchial gland.Nippon Geka Gakkai Zasshi1989. 90:1810\u20131813."},{"key":"i1543-2165-127-4-e216-b18","series-title":"Cancer","first-page":"172","article-title":"Acinic cell carcinoma: clinicopathologic review.","volume":"67","author":"Lewis, J. E.","year":"1991","unstructured":"Lewis, J. E., K. D.Olen, and L. H.Weiland. Acinic cell carcinoma: clinicopathologic review.Cancer1991. 67:172\u2013179."},{"key":"i1543-2165-127-4-e216-b19","series-title":"J Pathol","first-page":"307","article-title":"Histogenesis of acinic cell carcinoma of the major and minor salivary glands: an ultrastructural study.","volume":"148","author":"Chaudhry, A. P.","year":"1986","unstructured":"Chaudhry, A. P., L. S.Cutler, C.Leifer, S.Satchidanand, G.Labay, and G.Yamane. Histogenesis of acinic cell carcinoma of the major and minor salivary glands: an ultrastructural study.J Pathol1986. 148:307\u2013320."},{"key":"i1543-2165-127-4-e216-b20","article-title":"Malignant epithelial tumors.","author":"Ellis, G. L.","unstructured":"Ellis, G. L. and P. L.Auclair. Malignant epithelial tumors.In: Tumors of the Salivary Glands. Washington, DC: Armed Forces Institute of Pathology; 1996:155\u2013349. Atlas of Tumor Pathology; 3rd series, fascicle 17."},{"key":"i1543-2165-127-4-e216-b21","series-title":"Am J Surg Pathol","first-page":"644","article-title":"Clear cell tumor of the lung: immunohistochemical and ultrastructural evidence of melanogenesis.","volume":"15","author":"Gaffey, M. J.","year":"1991","unstructured":"Gaffey, M. J., S. E.Mills, R. J.Zarbo, L. M.Weiss, and A. M.Gown. Clear cell tumor of the lung: immunohistochemical and ultrastructural evidence of melanogenesis.Am J Surg Pathol1991. 15:644\u2013653."},{"key":"i1543-2165-127-4-e216-b22","article-title":"Glycogen.","unstructured":"Glycogen.\n          In: Dardick I, ed. Handbook of Diagnostic Electron Microscopy for Pathologists-in-Training. New York, NY: Igaku-Shoin Medical Publishers; 1996:3.32\u20133.33."},{"key":"i1543-2165-127-4-e216-b1","article-title":"Tumors of salivary gland type.","author":"Colby, T. V.","unstructured":"Colby, T. V., M. N.Koss, and W. D.Travis. Tumors of salivary gland type.In: Tumors of the Lower Respiratory Tract. Washington, DC: Armed Forces Institute of Pathology; 1995:65\u201387. Atlas of Tumor Pathology; 3rd series, fascicle 13."},{"key":"i1543-2165-127-4-e216-b2","series-title":"Cancer","first-page":"501","article-title":"Acinic cell tumor of the lung: a histologic and ultrastructural study.","volume":"29","author":"Fechner, R. E.","year":"1972","unstructured":"Fechner, R. E., B. R.Bentinck, and J. B.Askew. Acinic cell tumor of the lung: a histologic and ultrastructural study.Cancer1972. 29:501\u2013508."},{"key":"i1543-2165-127-4-e216-b3","series-title":"Chest","first-page":"591","article-title":"Acinic cell carcinoma of the lung with metastases to lymph nodes.","volume":"155","author":"Ukoha, O. O.","year":"1999","unstructured":"Ukoha, O. O., P.Quartararo, D.Carter, M.Kashgarian, and R.Ponn. Acinic cell carcinoma of the lung with metastases to lymph nodes.Chest1999. 155:591\u2013595."},{"key":"i1543-2165-127-4-e216-b4","series-title":"Otolaryngol Head Neck Surg","first-page":"759","article-title":"Acinic cell carcinoma of the nasal cavity.","volume":"120","author":"Von Biberstein, S. E.","year":"1999","unstructured":"Von Biberstein, S. E., J. D.Spiro, and W.Mancoll. Acinic cell carcinoma of the nasal cavity.Otolaryngol Head Neck Surg1999. 120:759\u2013762."},{"key":"i1543-2165-127-4-e216-b5","series-title":"Arch Pathol Lab Med","first-page":"233","article-title":"Acinous cell carcinoma of the larynx.","volume":"102","author":"Crissman, J. D.","year":"1978","unstructured":"Crissman, J. D. and A.Rosenblatt. Acinous cell carcinoma of the larynx.Arch Pathol Lab Med1978. 102:233\u2013236."},{"key":"i1543-2165-127-4-e216-b6","article-title":"Salivary and lacrimal glands.","author":"Gnepp, D. G.","unstructured":"Gnepp, D. G., M. S.Brandwein, and J. D.Henley. Salivary and lacrimal glands.In: Gnepp DG, ed. Diagnostic Surgical Pathology of the Head and Neck. Philadelphia, Pa: WB Saunders; 2001:325\u2013430."},{"key":"i1543-2165-127-4-e216-b7","series-title":"Histopathology","first-page":"286","article-title":"Primary acinic cell-like carcinoma of the breast: a variant with a good prognosis?","volume":"36","author":"Schmitt, F. C.","year":"2000","unstructured":"Schmitt, F. C., C. A.Ribeiro, S.Alvarenga, and J. M.Lopes. Primary acinic cell-like carcinoma of the breast: a variant with a good prognosis?Histopathology2000. 36:286\u2013289."},{"key":"i1543-2165-127-4-e216-b8","series-title":"Int J Oral Maxillofac Surg","first-page":"289","article-title":"Acinic cell carcinoma arising in a parotid lymph node.","volume":"22","author":"Minic, A. J.","year":"1993","unstructured":"Minic, A. J.\n          \n          Acinic cell carcinoma arising in a parotid lymph node.\n          Int J Oral Maxillofac Surg\n          1993. 22:289\u2013291."},{"key":"i1543-2165-127-4-e216-b9","series-title":"Thorax","first-page":"97","article-title":"One very rare and one new tracheal tumor found by electron microscopy: glomus tumor and acinic cell tumor resembling carcinoid tumors by light microscopy.","volume":"37","author":"Heard, B. E.","year":"1982","unstructured":"Heard, B. E., A.Dewar, and R. K.Firmin. et al. One very rare and one new tracheal tumor found by electron microscopy: glomus tumor and acinic cell tumor resembling carcinoid tumors by light microscopy.Thorax1982. 37:97\u2013103."},{"key":"i1543-2165-127-4-e216-b10","series-title":"Auris Nasus Larynx","first-page":"193","article-title":"Acinic cell carcinoma of the trachea.","volume":"21","author":"Horowitz, Z.","year":"1994","unstructured":"Horowitz, Z. and J.Kronenberg. Acinic cell carcinoma of the trachea.Auris Nasus Larynx1994. 21:193\u2013195."},{"key":"i1543-2165-127-4-e216-b11","series-title":"Zentralbl Allg Pathol","first-page":"751","article-title":"Predominantly mucous-differentiated acinic cell adenocarcinoma of the trachea.","volume":"135","author":"Martin, H.","year":"1989","unstructured":"Martin, H., A.Abboud, and T.Nawka. Predominantly mucous-differentiated acinic cell adenocarcinoma of the trachea.Zentralbl Allg Pathol1989. 135:751\u2013756."},{"key":"i1543-2165-127-4-e216-b12","series-title":"Gan No Rinsho","first-page":"1412","article-title":"Acinic cell carcinoma of the trachea: a case report.","volume":"30","author":"Murakami, M.","year":"1984","unstructured":"Murakami, M., T.Ochi, and H.Tokunaga. et al. Acinic cell carcinoma of the trachea: a case report.Gan No Rinsho1984. 30:1412\u20131416."},{"key":"i1543-2165-127-4-e216-b13","series-title":"Chest","first-page":"1120","article-title":"Upper airway obstruction secondary to acinic cell carcinoma of the trachea: use of Nd:YAG laser.","volume":"110","author":"Ansari, M. A.","year":"1996","unstructured":"Ansari, M. A., A.Marchevsky, and L.Strick. et al. Upper airway obstruction secondary to acinic cell carcinoma of the trachea: use of Nd:YAG laser.Chest1996. 110:1120\u20131122."},{"key":"i1543-2165-127-4-e216-b14","series-title":"Am J Surg Pathol","first-page":"1039","article-title":"Acinic cell carcinoma of the lung (\u201cFechner tumor\u201d): a clinicopathologic, immunohistochemical, and ultrastructural study of five cases.","volume":"16","author":"Moran, C. A.","year":"1992","unstructured":"Moran, C. A., S.Suster, and M. N.Koss. Acinic cell carcinoma of the lung (\u201cFechner tumor\u201d): a clinicopathologic, immunohistochemical, and ultrastructural study of five cases.Am J Surg Pathol1992. 16:1039\u20131050."},{"key":"i1543-2165-127-4-e216-b15","series-title":"Cancer","first-page":"830","article-title":"Acinic cell tumor of the bronchus.","volume":"38","author":"Kantz, D. R.","year":"1976","unstructured":"Kantz, D. R. and J. J.Bubis. Acinic cell tumor of the bronchus.Cancer1976. 38:830\u2013832."},{"key":"i1543-2165-127-4-e216-b16","series-title":"Indian J Cancer","first-page":"152","article-title":"Acinic cell tumor of the bronchus (a case report).","volume":"22","author":"Gharpure, K. J.","year":"1985","unstructured":"Gharpure, K. J., R. K.Deshpande, and R. N.Vishweshvara. et al. Acinic cell tumor of the bronchus (a case report).Indian J Cancer1985. 22:152\u2013156."},{"key":"i1543-2165-127-4-e216-b17","series-title":"Nippon Geka Gakkai Zasshi","first-page":"1810","article-title":"Acinic cell carcinoma of the bronchial gland.","volume":"90","author":"Yoshida, K.","year":"1989","unstructured":"Yoshida, K., I.Koyama, and T.Matsui. et al. Acinic cell carcinoma of the bronchial gland.Nippon Geka Gakkai Zasshi1989. 90:1810\u20131813."},{"key":"i1543-2165-127-4-e216-b18","series-title":"Cancer","first-page":"172","article-title":"Acinic cell carcinoma: clinicopathologic review.","volume":"67","author":"Lewis, J. E.","year":"1991","unstructured":"Lewis, J. E., K. D.Olen, and L. H.Weiland. Acinic cell carcinoma: clinicopathologic review.Cancer1991. 67:172\u2013179."},{"key":"i1543-2165-127-4-e216-b19","series-title":"J Pathol","first-page":"307","article-title":"Histogenesis of acinic cell carcinoma of the major and minor salivary glands: an ultrastructural study.","volume":"148","author":"Chaudhry, A. P.","year":"1986","unstructured":"Chaudhry, A. P., L. S.Cutler, C.Leifer, S.Satchidanand, G.Labay, and G.Yamane. Histogenesis of acinic cell carcinoma of the major and minor salivary glands: an ultrastructural study.J Pathol1986. 148:307\u2013320."},{"key":"i1543-2165-127-4-e216-b20","article-title":"Malignant epithelial tumors.","author":"Ellis, G. L.","unstructured":"Ellis, G. L. and P. L.Auclair. Malignant epithelial tumors.In: Tumors of the Salivary Glands. Washington, DC: Armed Forces Institute of Pathology; 1996:155\u2013349. Atlas of Tumor Pathology; 3rd series, fascicle 17."},{"key":"i1543-2165-127-4-e216-b21","series-title":"Am J Surg Pathol","first-page":"644","article-title":"Clear cell tumor of the lung: immunohistochemical and ultrastructural evidence of melanogenesis.","volume":"15","author":"Gaffey, M. J.","year":"1991","unstructured":"Gaffey, M. J., S. E.Mills, R. J.Zarbo, L. M.Weiss, and A. M.Gown. Clear cell tumor of the lung: immunohistochemical and ultrastructural evidence of melanogenesis.Am J Surg Pathol1991. 15:644\u2013653."},{"key":"i1543-2165-127-4-e216-b22","article-title":"Glycogen.","unstructured":"Glycogen.\n          In: Dardick I, ed. Handbook of Diagnostic Electron Microscopy for Pathologists-in-Training. New York, NY: Igaku-Shoin Medical Publishers; 1996:3.32\u20133.33."}],"container-title":["Archives of Pathology &amp; Laboratory Medicine"],"original-title":[],"link":[{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/127\/4\/article-pe216.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/127\/4\/e216\/2730537\/0003-9985(2003)127_e216_paccot_2_0_co_2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/127\/4\/article-pe216.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/127\/4\/article-pe216.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T01:06:44Z","timestamp":1770772004000},"score":1,"resource":{"primary":{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/127\/4\/article-pe216.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4]]},"references-count":44,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.5858\/2003-127-e216-paccot","relation":{},"ISSN":["1543-2165","0003-9985"],"issn-type":[{"value":"1543-2165","type":"electronic"},{"value":"0003-9985","type":"print"}],"subject":[],"published":{"date-parts":[[2003,4]]}}}