{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T06:05:16Z","timestamp":1770789916415,"version":"3.50.0"},"reference-count":20,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Patients with Gaucher disease have an increased risk of malignancies, especially the lymphoreticular type. To our knowledge, this is the first reported case of Gaucher disease diagnosed during the workup and diagnosis of a splenic marginal-zone lymphoma with progression to diffuse large B-cell lymphoma. There are several theories as to how Gaucher disease leads to malignancies. The accumulated glucocerebroside in the reticuloendothelial organs, histologically visible as Gaucher cells, is thought to provide chronic antigenic stimulus to the immune system. Polyclonal hypergammaglobulinemia develops, and monoclonal populations of lymphocytes and plasma cells may arise from this premalignant proliferative state. How Gaucher disease is related to nonlymphoid malignancies remains unclear.<\/jats:p>","DOI":"10.5858\/2003-127-e242-slaiap","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T11:06:29Z","timestamp":1611918389000},"page":"e242-e245","source":"Crossref","is-referenced-by-count":15,"title":["Splenic Lymphoma Arising in a Patient With Gaucher Disease"],"prefix":"10.5858","volume":"127","author":[{"given":"Heidi C.","family":"Bertram","sequence":"first","affiliation":[{"name":"From Evanston Northwestern Healthcare, Departments of Pathology and Laboratory Medicine (Drs Bertram, Eldibany, and Padgett) and Internal Medicine, Hematology\/Oncology Division (Dr Dragon), Northwestern University Medical School, Evanston, Ill"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Eldibany","sequence":"additional","affiliation":[{"name":"From Evanston Northwestern Healthcare, Departments of Pathology and Laboratory Medicine (Drs Bertram, Eldibany, and Padgett) and Internal Medicine, Hematology\/Oncology Division (Dr Dragon), Northwestern University Medical School, Evanston, Ill"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Padgett","sequence":"additional","affiliation":[{"name":"From Evanston Northwestern Healthcare, Departments of Pathology and Laboratory Medicine (Drs Bertram, Eldibany, and Padgett) and Internal Medicine, Hematology\/Oncology Division (Dr Dragon), Northwestern University Medical School, Evanston, Ill"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon H.","family":"Dragon","sequence":"additional","affiliation":[{"name":"From Evanston Northwestern Healthcare, Departments of Pathology and Laboratory Medicine (Drs Bertram, Eldibany, and Padgett) and Internal Medicine, Hematology\/Oncology Division (Dr Dragon), Northwestern University Medical School, Evanston, Ill"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"key":"i1543-2165-127-5-e242-b1","series-title":"Cancer","first-page":"219","article-title":"Increased risk of cancer in patients with Gaucher disease.","volume":"72","author":"Shiran, A.","year":"1993","unstructured":"Shiran, A., B.Brenner, A.Laor, and I.Tatarsky. Increased risk of cancer in patients with Gaucher disease.Cancer1993. 72:219\u2013224."},{"key":"i1543-2165-127-5-e242-b2","series-title":"Leuk Lymphoma","first-page":"609","article-title":"Non-Hodgkin's lymphoma associated with Gaucher disease.","volume":"31","author":"Perales, M.","year":"1998","unstructured":"Perales, M., F.Cervantes, F.Cobo, and E.Montserrat. Non-Hodgkin's lymphoma associated with Gaucher disease.Leuk Lymphoma1998. 31:609\u2013612."},{"key":"i1543-2165-127-5-e242-b3","series-title":"Am J Clin Pathol","first-page":"103","article-title":"Coexistence of Hodgkin's disease and Gaucher disease.","volume":"65","author":"Cho, S. Y.","year":"1976","unstructured":"Cho, S. Y. and M.Sastre. Coexistence of Hodgkin's disease and Gaucher disease.Am J Clin Pathol1976. 65:103\u2013108."},{"key":"i1543-2165-127-5-e242-b4","series-title":"Hematol Pathol","first-page":"91","article-title":"Richter's transformation of lymphoma complicating Gaucher disease.","volume":"3","author":"Paulson, J. A.","year":"1989","unstructured":"Paulson, J. A., G. E.Marti, J. K.Fink, N.Sato, M.Schoen, and D. S.Karcher. Richter's transformation of lymphoma complicating Gaucher disease.Hematol Pathol1989. 3:91\u201396."},{"key":"i1543-2165-127-5-e242-b5","series-title":"Am J Hematol","first-page":"189","article-title":"Polyclonal B-cell lymphocytosis and hypergammaglobulinemia in pateints with Gaucher disease.","volume":"29","author":"Marti, G. E.","year":"1988","unstructured":"Marti, G. E., E. T.Ryan, N. M.Papdopoulos, M.Filling-Katz, and N.Barton. Polyclonal B-cell lymphocytosis and hypergammaglobulinemia in pateints with Gaucher disease.Am J Hematol1988. 29:189\u2013194."},{"key":"i1543-2165-127-5-e242-b6","series-title":"Arch Pathol Lab Med","first-page":"388","article-title":"Gaucher disease: a disease with chronic stimulation of the immune system.","volume":"106","author":"Shoenfeld, Y.","year":"1982","unstructured":"Shoenfeld, Y., L. A.Gallant, M.Skaklai, E.Livni, M.Djaldetti, and J.Pinkhas. Gaucher disease: a disease with chronic stimulation of the immune system.Arch Pathol Lab Med1982. 106:388\u2013391."},{"key":"i1543-2165-127-5-e242-b7","series-title":"Medicine","first-page":"337","article-title":"Gaucher disease: clinical, laboratory, radiologic and genetic features of 53 patients.","volume":"71","author":"Zimran, A.","year":"1992","unstructured":"Zimran, A., A.Kay, and T.Gelbart. et al. Gaucher disease: clinical, laboratory, radiologic and genetic features of 53 patients.Medicine1992. 71:337\u2013353."},{"key":"i1543-2165-127-5-e242-b8","series-title":"Blood","first-page":"1950","article-title":"Non-MALT marginal zone B-cell lymphomas: a description of clinical presentation and outcome in 124 patients.","volume":"95","author":"Berger, F.","year":"2000","unstructured":"Berger, F., P.Felman, and C.Thieblemont. et al. Non-MALT marginal zone B-cell lymphomas: a description of clinical presentation and outcome in 124 patients.Blood2000. 95:1950\u20131956."},{"key":"i1543-2165-127-5-e242-b9","series-title":"Histopathology","first-page":"230","article-title":"A marginal zone pattern may be found in different varieties of non-Hodgkin's lymphoma: the morphology and immunohistochemistry of splenic involvement by B-cell lymphomas simulating splenic marginal zone lymphoma.","volume":"33","author":"Piris, M. A.","year":"1998","unstructured":"Piris, M. A., M.Moolejo, E.Campo, J.Menarguez, T.Flores, and P. G.Isaacson. A marginal zone pattern may be found in different varieties of non-Hodgkin's lymphoma: the morphology and immunohistochemistry of splenic involvement by B-cell lymphomas simulating splenic marginal zone lymphoma.Histopathology1998. 33:230\u2013239."},{"key":"i1543-2165-127-5-e242-b10","series-title":"Am J Surg Pathol","first-page":"1268","article-title":"Progression to large B-cell lymphoma in splenic marginal zone lymphoma.","volume":"25","author":"Camacho, F. I.","year":"2001","unstructured":"Camacho, F. I., M.Manuela, and M.Mateo. et al. Progression to large B-cell lymphoma in splenic marginal zone lymphoma.Am J Surg Pathol2001. 25:1268\u20131276."},{"key":"i1543-2165-127-5-e242-b1","series-title":"Cancer","first-page":"219","article-title":"Increased risk of cancer in patients with Gaucher disease.","volume":"72","author":"Shiran, A.","year":"1993","unstructured":"Shiran, A., B.Brenner, A.Laor, and I.Tatarsky. 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A., M.Moolejo, E.Campo, J.Menarguez, T.Flores, and P. G.Isaacson. A marginal zone pattern may be found in different varieties of non-Hodgkin's lymphoma: the morphology and immunohistochemistry of splenic involvement by B-cell lymphomas simulating splenic marginal zone lymphoma.Histopathology1998. 33:230\u2013239."},{"key":"i1543-2165-127-5-e242-b10","series-title":"Am J Surg Pathol","first-page":"1268","article-title":"Progression to large B-cell lymphoma in splenic marginal zone lymphoma.","volume":"25","author":"Camacho, F. I.","year":"2001","unstructured":"Camacho, F. I., M.Manuela, and M.Mateo. et al. 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