{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:09:51Z","timestamp":1791263391054,"version":"4.1.0"},"reference-count":20,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The epithelioid trophoblastic tumor is an unusual type of trophoblastic tumor. Herein, we describe a patient with coexisting epithelioid trophoblastic tumor and choriocarcinoma in the uterus. The patient had a history of hydatidiform mole with recurrent elevation of human chorionic gonadotrophin level that is resistant to chemotherapy. Histopathologic and immunohistochemical examination showed distinctive differences between the 2 trophoblastic tumors. The development of epithelioid trophoblastic tumor may be related to the persistence of locally invasive disease, which was unresponsive to chemotherapy. The patient responded well to surgery. The presence of an epithelioid trophoblastic tumor should be considered in chemoresistant gestational trophoblast tumor.<\/jats:p>","DOI":"10.5858\/2003-127-e291-cettac","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T06:44:53Z","timestamp":1611902693000},"page":"e291-e293","source":"Crossref","is-referenced-by-count":36,"title":["Coexisting Epithelioid Trophoblastic Tumor and Choriocarcinoma of the Uterus Following a Chemoresistant Hydatidiform Mole"],"prefix":"10.5858","volume":"127","author":[{"given":"Dan-Hua","family":"Shen","sequence":"first","affiliation":[{"name":"From the Departments of Pathology (Drs Shen, Khoo, Xue, and Cheung), Radiology (Dr Chau), and Obstetrics and Gynaecology (Drs Ngan and Ng), The University of Hong Kong, Queen Mary Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ui Soon","family":"Khoo","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Shen, Khoo, Xue, and Cheung), Radiology (Dr Chau), and Obstetrics and Gynaecology (Drs Ngan and Ng), The University of Hong Kong, Queen Mary Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hextan Y. S.","family":"Ngan","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Shen, Khoo, Xue, and Cheung), Radiology (Dr Chau), and Obstetrics and Gynaecology (Drs Ngan and Ng), The University of Hong Kong, Queen Mary Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tung-Yau","family":"Ng","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Shen, Khoo, Xue, and Cheung), Radiology (Dr Chau), and Obstetrics and Gynaecology (Drs Ngan and Ng), The University of Hong Kong, Queen Mary Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Tak","family":"Chau","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Shen, Khoo, Xue, and Cheung), Radiology (Dr Chau), and Obstetrics and Gynaecology (Drs Ngan and Ng), The University of Hong Kong, Queen Mary Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Cheng","family":"Xue","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Shen, Khoo, Xue, and Cheung), Radiology (Dr Chau), and Obstetrics and Gynaecology (Drs Ngan and Ng), The University of Hong Kong, Queen Mary Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie N. Y.","family":"Cheung","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Shen, Khoo, Xue, and Cheung), Radiology (Dr Chau), and Obstetrics and Gynaecology (Drs Ngan and Ng), The University of Hong Kong, Queen Mary Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3906","reference":[{"key":"i1543-2165-127-7-e291-b1","article-title":"Gestational trophoblastic disease and related lesion.","author":"Mazur, M. T.","unstructured":"Mazur, M. T. and R. J.Kurman. Gestational trophoblastic disease and related lesion.In: Kurman RJ, ed. Blaustein's Pathology of the Female Genital Tract. 4th ed. New York, NY: Springer-Verlag; 1994:1049\u20131093."},{"key":"i1543-2165-127-7-e291-b2","series-title":"Am J Surg Pathol","first-page":"1393","article-title":"Epithelioid trophoblastic tumor: a neoplasm distinct from choriocarcinoma and placental site trophoblastic tumor simulating carcinoma.","volume":"22","author":"Shih, I. M.","year":"1998","unstructured":"Shih, I. M. and R. J.Kurman. Epithelioid trophoblastic tumor: a neoplasm distinct from choriocarcinoma and placental site trophoblastic tumor simulating carcinoma.Am J Surg Pathol1998. 22:1393\u20131403."},{"key":"i1543-2165-127-7-e291-b3","series-title":"Hum Pathol","first-page":"1321","article-title":"Epithelioid trophoblastic tumor: morphological and immunohistochemical study of three lung lesions.","volume":"30","author":"Hamazaki, S.","year":"1999","unstructured":"Hamazaki, S., S.Nakamato, and T.Okino. et al. Epithelioid trophoblastic tumor: morphological and immunohistochemical study of three lung lesions.Hum Pathol1999. 30:1321\u20131327."},{"key":"i1543-2165-127-7-e291-b4","series-title":"Int J Gynecol Pathol","first-page":"381","article-title":"Epithelioid trophoblastic tumor metastatic to the vagina: an immunohistochemical and ultrastructural study.","volume":"19","author":"Ohira, S.","year":"2000","unstructured":"Ohira, S., T.Yamasaki, H.Hatano, O.Harada, T.Toki, and I.Konishi. Epithelioid trophoblastic tumor metastatic to the vagina: an immunohistochemical and ultrastructural study.Int J Gynecol Pathol2000. 19:381\u2013386."},{"key":"i1543-2165-127-7-e291-b5","series-title":"Am J Surg Pathol","first-page":"1558","article-title":"Epithelioid trophoblastic tumor of the uterus in a postmenopausal woman: a case report and review of the literature.","volume":"24","author":"Coulson, L. E.","year":"2000","unstructured":"Coulson, L. E., C. S.Kong, and C.Zaloudek. Epithelioid trophoblastic tumor of the uterus in a postmenopausal woman: a case report and review of the literature.Am J Surg Pathol2000. 24:1558\u20131562."},{"key":"i1543-2165-127-7-e291-b6","series-title":"Pathol Int","first-page":"75","article-title":"Epithelioid trophoblastic tumor of the uterus: cytological and immunohistochemical observation of a case.","volume":"52","author":"Kamoi, S.","year":"2002","unstructured":"Kamoi, S., Y.Ohaki, and O.Mori. et al. Epithelioid trophoblastic tumor of the uterus: cytological and immunohistochemical observation of a case.Pathol Int2002. 52:75\u201381."},{"key":"i1543-2165-127-7-e291-b7","series-title":"Gynecol Oncol","first-page":"204","article-title":"Choriocarcinoma and epithelial trophoblastic tumor: successful treatment of relapse with hysterectomy and high-dose chemotherapy with peripheral stem cell support: a case report.","volume":"85","author":"Knox, S.","year":"2002","unstructured":"Knox, S., S. E.Brooks, J.Wong-You-Cheong, O.Ioffe, B.Meisenberg, and D. P.Goldstein. Choriocarcinoma and epithelial trophoblastic tumor: successful treatment of relapse with hysterectomy and high-dose chemotherapy with peripheral stem cell support: a case report.Gynecol Oncol2002. 85:204\u2013208."},{"key":"i1543-2165-127-7-e291-b8","series-title":"Int J Gynecol Pathol","first-page":"31","article-title":"The pathology of intermediate trophoblastic tumors and tumor-like lesions.","volume":"20","author":"Shih, I. M.","year":"2001","unstructured":"Shih, I. M. and R. J.Kurman. The pathology of intermediate trophoblastic tumors and tumor-like lesions.Int J Gynecol Pathol2001. 20:31\u201347."},{"key":"i1543-2165-127-7-e291-b9","series-title":"Proc R Soc Med","first-page":"381","article-title":"Hydatidiform mole and chorion epithelioma: the problem of the borderline case.","volume":"49","author":"King, G.","year":"1956","unstructured":"King, G.\n          \n          Hydatidiform mole and chorion epithelioma: the problem of the borderline case.\n          Proc R Soc Med\n          1956. 49:381\u2013390."},{"key":"i1543-2165-127-7-e291-b10","article-title":"Gestational trophoblastic diseases.","author":"Cheung, A. N. Y.","unstructured":"Cheung, A. N. Y.\n          \n          Gestational trophoblastic diseases.\n          In: Ho FCS, Wu PC, eds. Topics in Pathology for Hong Kong. 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Epithelioid trophoblastic tumor: a neoplasm distinct from choriocarcinoma and placental site trophoblastic tumor simulating carcinoma.Am J Surg Pathol1998. 22:1393\u20131403."},{"key":"i1543-2165-127-7-e291-b3","series-title":"Hum Pathol","first-page":"1321","article-title":"Epithelioid trophoblastic tumor: morphological and immunohistochemical study of three lung lesions.","volume":"30","author":"Hamazaki, S.","year":"1999","unstructured":"Hamazaki, S., S.Nakamato, and T.Okino. et al. Epithelioid trophoblastic tumor: morphological and immunohistochemical study of three lung lesions.Hum Pathol1999. 30:1321\u20131327."},{"key":"i1543-2165-127-7-e291-b4","series-title":"Int J Gynecol Pathol","first-page":"381","article-title":"Epithelioid trophoblastic tumor metastatic to the vagina: an immunohistochemical and ultrastructural study.","volume":"19","author":"Ohira, S.","year":"2000","unstructured":"Ohira, S., T.Yamasaki, H.Hatano, O.Harada, T.Toki, and I.Konishi. 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Epithelioid trophoblastic tumor of the uterus: cytological and immunohistochemical observation of a case.Pathol Int2002. 52:75\u201381."},{"key":"i1543-2165-127-7-e291-b7","series-title":"Gynecol Oncol","first-page":"204","article-title":"Choriocarcinoma and epithelial trophoblastic tumor: successful treatment of relapse with hysterectomy and high-dose chemotherapy with peripheral stem cell support: a case report.","volume":"85","author":"Knox, S.","year":"2002","unstructured":"Knox, S., S. E.Brooks, J.Wong-You-Cheong, O.Ioffe, B.Meisenberg, and D. P.Goldstein. Choriocarcinoma and epithelial trophoblastic tumor: successful treatment of relapse with hysterectomy and high-dose chemotherapy with peripheral stem cell support: a case report.Gynecol Oncol2002. 85:204\u2013208."},{"key":"i1543-2165-127-7-e291-b8","series-title":"Int J Gynecol Pathol","first-page":"31","article-title":"The pathology of intermediate trophoblastic tumors and tumor-like lesions.","volume":"20","author":"Shih, I. 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