{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:10:15Z","timestamp":1787314215983,"version":"build-2736575974"},"reference-count":20,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Synchronous occurrence of malignant lymphoma and carcinoma, both located in the intestinal tract, is unusual. We report a unique case of an adenocarcinoma of the cecum and a simultaneous mantle cell lymphoma of the colon, terminal ileum, and regional lymph nodes in an 85-year-old man. Grossly, the adenocarcinoma was identified as a cecal mass. Lymphomatous involvement of the gastrointestinal tract was evident only on microscopic examination. The terminal ileum and colon showed microscopic disseminated multiple mucosal nodules, with involvement of the regional lymph nodes. There was no involvement of distant organs, suggesting that the mantle cell lymphoma was early in its evolution without formation of polyps or a mass lesion. To our knowledge, this is the fourth reported case with this association and the second case that showed early involvement of the gastrointestinal tract with mantle cell lymphoma without polyp formation.<\/jats:p>","DOI":"10.5858\/2003-127-e64-saamcl","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T11:48:01Z","timestamp":1611920881000},"page":"e64-e66","source":"Crossref","is-referenced-by-count":31,"title":["Synchronous Adenocarcinoma and Mantle Cell Lymphoma of the Colon"],"prefix":"10.5858","volume":"127","author":[{"given":"Vijayalakshmi","family":"Padmanabhan","sequence":"first","affiliation":[{"name":"From the Department of Pathology, University of Vermont, Burlington, Vt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas D.","family":"Trainer","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, University of Vermont, Burlington, Vt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3906","reference":[{"key":"i1543-2165-127-2-e64-b1","series-title":"Postgrad Med J","first-page":"443","article-title":"Synchronous multiple lymphomatous polyposis and adenocarcinoma in the large bowel [letter].","volume":"71","author":"Hopster, D.","year":"1995","unstructured":"Hopster, D., P. A.Smith, J. R. G.Nash, K.Elders, and G. J.Poston. Synchronous multiple lymphomatous polyposis and adenocarcinoma in the large bowel [letter].Postgrad Med J1995. 71:443."},{"key":"i1543-2165-127-2-e64-b2","series-title":"Mod Pathol","first-page":"811","article-title":"Early phase of mantle cell lymphoma: a report of two cases associated with advanced colonic adenocarcinoma.","volume":"14","author":"Kanehira, K.","year":"2001","unstructured":"Kanehira, K., R. C.Braylan, and G. Y.Lauwers. Early phase of mantle cell lymphoma: a report of two cases associated with advanced colonic adenocarcinoma.Mod Pathol2001. 14:811\u2013817."},{"key":"i1543-2165-127-2-e64-b3","series-title":"Histopathology","first-page":"235","article-title":"Primary malignant lymphoma of the colon and rectum: a histopathological and immunohistochemical analysis of 45 cases with clinicopathological correlations.","volume":"12","author":"Shepherd, N. A.","year":"1988","unstructured":"Shepherd, N. A., P. A.Hall, P. J.Coated, and D. A.Levison. Primary malignant lymphoma of the colon and rectum: a histopathological and immunohistochemical analysis of 45 cases with clinicopathological correlations.Histopathology1988. 12:235\u2013252."},{"key":"i1543-2165-127-2-e64-b4","series-title":"Mod Pathol","first-page":"151","article-title":"Gastrointestinal lymphomas of T and B-cell types.","volume":"12","author":"Issacson, P. G.","year":"1999","unstructured":"Issacson, P. G.\n          \n          Gastrointestinal lymphomas of T and B-cell types.\n          Mod Pathol\n          1999. 12:151\u2013158."},{"key":"i1543-2165-127-2-e64-b5","series-title":"Recent Results Cancer Res","first-page":"33","article-title":"Pathology of intestinal lymphomas.","volume":"156","author":"Foss, H. D.","year":"2000","unstructured":"Foss, H. D. and H.Stein. Pathology of intestinal lymphomas.Recent Results Cancer Res2000. 156:33\u201341."},{"key":"i1543-2165-127-2-e64-b6","series-title":"Cancer","first-page":"249","article-title":"Multiple lymphomatous polyposis of the gastrointestinal tract.","volume":"14","author":"Cornes, J. S.","year":"1961","unstructured":"Cornes, J. S.\n          \n          Multiple lymphomatous polyposis of the gastrointestinal tract.\n          Cancer\n          1961. 14:249\u2013257."},{"key":"i1543-2165-127-2-e64-b7","series-title":"Histopathology","first-page":"641","article-title":"Multiple lymphomatoid polyposis of the gastrointestinal tract.","volume":"8","author":"Issacson, P. G.","year":"1984","unstructured":"Issacson, P. G., K. M.MacLennan, and S. G.Subbuswamy. Multiple lymphomatoid polyposis of the gastrointestinal tract.Histopathology1984. 8:641\u2013656."},{"key":"i1543-2165-127-2-e64-b8","series-title":"Am J Clin Pathol","first-page":"737","article-title":"Bcl-1 rearrangement and cyclin D1 protein expression in multiple lymphomatous polyposis.","volume":"105","author":"Kumar, S.","year":"1996","unstructured":"Kumar, S., L.Krenacs, and T.Otsuki. et al. Bcl-1 rearrangement and cyclin D1 protein expression in multiple lymphomatous polyposis.Am J Clin Pathol1996. 105:737\u2013743."},{"key":"i1543-2165-127-2-e64-b9","series-title":"Hum Pathol","first-page":"1282","article-title":"Molecular evidence links lymphomatous polyposis of the gastrointestinal tract with mantle cell lymphoma.","volume":"26","author":"Smir, B. N.","year":"1995","unstructured":"Smir, B. N., C. A.Ramaika, and C. G.Cho. et al. Molecular evidence links lymphomatous polyposis of the gastrointestinal tract with mantle cell lymphoma.Hum Pathol1995. 26:1282\u20131298."},{"key":"i1543-2165-127-2-e64-b10","series-title":"Arch Pathol Lab Med","first-page":"1182","article-title":"Mantle cell lymphoma: molecular and immunophenotypic diagnostic aids.","volume":"123","author":"Hankin, R. C.","year":"1999","unstructured":"Hankin, R. C. and S. V.Hunter. Mantle cell lymphoma: molecular and immunophenotypic diagnostic aids.Arch Pathol Lab Med1999. 123:1182\u20131188."},{"key":"i1543-2165-127-2-e64-b1","series-title":"Postgrad Med J","first-page":"443","article-title":"Synchronous multiple lymphomatous polyposis and adenocarcinoma in the large bowel [letter].","volume":"71","author":"Hopster, D.","year":"1995","unstructured":"Hopster, D., P. A.Smith, J. R. G.Nash, K.Elders, and G. J.Poston. Synchronous multiple lymphomatous polyposis and adenocarcinoma in the large bowel [letter].Postgrad Med J1995. 71:443."},{"key":"i1543-2165-127-2-e64-b2","series-title":"Mod Pathol","first-page":"811","article-title":"Early phase of mantle cell lymphoma: a report of two cases associated with advanced colonic adenocarcinoma.","volume":"14","author":"Kanehira, K.","year":"2001","unstructured":"Kanehira, K., R. C.Braylan, and G. Y.Lauwers. Early phase of mantle cell lymphoma: a report of two cases associated with advanced colonic adenocarcinoma.Mod Pathol2001. 14:811\u2013817."},{"key":"i1543-2165-127-2-e64-b3","series-title":"Histopathology","first-page":"235","article-title":"Primary malignant lymphoma of the colon and rectum: a histopathological and immunohistochemical analysis of 45 cases with clinicopathological correlations.","volume":"12","author":"Shepherd, N. A.","year":"1988","unstructured":"Shepherd, N. A., P. A.Hall, P. J.Coated, and D. A.Levison. Primary malignant lymphoma of the colon and rectum: a histopathological and immunohistochemical analysis of 45 cases with clinicopathological correlations.Histopathology1988. 12:235\u2013252."},{"key":"i1543-2165-127-2-e64-b4","series-title":"Mod Pathol","first-page":"151","article-title":"Gastrointestinal lymphomas of T and B-cell types.","volume":"12","author":"Issacson, P. G.","year":"1999","unstructured":"Issacson, P. G.\n          \n          Gastrointestinal lymphomas of T and B-cell types.\n          Mod Pathol\n          1999. 12:151\u2013158."},{"key":"i1543-2165-127-2-e64-b5","series-title":"Recent Results Cancer Res","first-page":"33","article-title":"Pathology of intestinal lymphomas.","volume":"156","author":"Foss, H. D.","year":"2000","unstructured":"Foss, H. D. and H.Stein. Pathology of intestinal lymphomas.Recent Results Cancer Res2000. 156:33\u201341."},{"key":"i1543-2165-127-2-e64-b6","series-title":"Cancer","first-page":"249","article-title":"Multiple lymphomatous polyposis of the gastrointestinal tract.","volume":"14","author":"Cornes, J. S.","year":"1961","unstructured":"Cornes, J. S.\n          \n          Multiple lymphomatous polyposis of the gastrointestinal tract.\n          Cancer\n          1961. 14:249\u2013257."},{"key":"i1543-2165-127-2-e64-b7","series-title":"Histopathology","first-page":"641","article-title":"Multiple lymphomatoid polyposis of the gastrointestinal tract.","volume":"8","author":"Issacson, P. G.","year":"1984","unstructured":"Issacson, P. G., K. M.MacLennan, and S. G.Subbuswamy. Multiple lymphomatoid polyposis of the gastrointestinal tract.Histopathology1984. 8:641\u2013656."},{"key":"i1543-2165-127-2-e64-b8","series-title":"Am J Clin Pathol","first-page":"737","article-title":"Bcl-1 rearrangement and cyclin D1 protein expression in multiple lymphomatous polyposis.","volume":"105","author":"Kumar, S.","year":"1996","unstructured":"Kumar, S., L.Krenacs, and T.Otsuki. et al. Bcl-1 rearrangement and cyclin D1 protein expression in multiple lymphomatous polyposis.Am J Clin Pathol1996. 105:737\u2013743."},{"key":"i1543-2165-127-2-e64-b9","series-title":"Hum Pathol","first-page":"1282","article-title":"Molecular evidence links lymphomatous polyposis of the gastrointestinal tract with mantle cell lymphoma.","volume":"26","author":"Smir, B. N.","year":"1995","unstructured":"Smir, B. N., C. A.Ramaika, and C. G.Cho. et al. Molecular evidence links lymphomatous polyposis of the gastrointestinal tract with mantle cell lymphoma.Hum Pathol1995. 26:1282\u20131298."},{"key":"i1543-2165-127-2-e64-b10","series-title":"Arch Pathol Lab Med","first-page":"1182","article-title":"Mantle cell lymphoma: molecular and immunophenotypic diagnostic aids.","volume":"123","author":"Hankin, R. C.","year":"1999","unstructured":"Hankin, R. C. and S. V.Hunter. Mantle cell lymphoma: molecular and immunophenotypic diagnostic aids.Arch Pathol Lab Med1999. 123:1182\u20131188."}],"container-title":["Archives of Pathology &amp; Laboratory Medicine"],"original-title":[],"link":[{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/127\/2\/article-pe64.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/127\/2\/e64\/2730014\/0003-9985(2003)127_e64_saamcl_2_0_co_2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/127\/2\/article-pe64.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/127\/2\/article-pe64.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T01:06:18Z","timestamp":1770771978000},"score":1,"resource":{"primary":{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/127\/2\/article-pe64.xml"}},"subtitle":["A Case Report and Review of the Literature"],"short-title":[],"issued":{"date-parts":[[2003,2]]},"references-count":20,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.5858\/2003-127-e64-saamcl","relation":{},"ISSN":["1543-2165","0003-9985"],"issn-type":[{"value":"1543-2165","type":"electronic"},{"value":"0003-9985","type":"print"}],"subject":[],"published":{"date-parts":[[2003,2]]}}}