{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T22:07:34Z","timestamp":1782252454611,"version":"3.54.5"},"reference-count":20,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Simultaneous involvement of the anterior mediastinum by thymoma and B-cell chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL), to our knowledge, has not been previously reported. We describe a composite tumor composed of thymoma and CLL\/SLL incidentally discovered in a 62-year-old man who had no history of malignant diseases or immunologic disorders. The preoperative peripheral blood specimen showed a normal complete blood cell count and differential count. The diagnosis was established by histologic examination and immunophenotypic studies of the surgically excised anterior mediastinal mass. Postoperatively, bone marrow aspiration and biopsy specimens showed morphologic evidence of CLL\/SLL, and the presence of neoplastic cells in peripheral blood and bone marrow was confirmed by flow cytometry immunophenotypic analysis.<\/jats:p>","DOI":"10.5858\/2003-127-e76-ctacll","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T11:48:35Z","timestamp":1611920915000},"page":"e76-e79","source":"Crossref","is-referenced-by-count":8,"title":["Composite Thymoma and Chronic Lymphocytic Leukemia\/Small Lymphocytic Lymphoma Involving the Anterior Mediastinum"],"prefix":"10.5858","volume":"127","author":[{"given":"Joseph D.","family":"Khoury","sequence":"first","affiliation":[{"name":"From the Division of Pathology and Laboratory Medicine, The University of Texas M. D. Anderson Cancer Center (Drs Khoury, Amin, and Medeiros), and Departments of Pathology (Drs Jorgensen and Ostrowski) and Medicine (Dr Bloom), The Methodist Hospital, Baylor College of Medicine, Houston, Tex"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham M.","family":"Amin","sequence":"additional","affiliation":[{"name":"From the Division of Pathology and Laboratory Medicine, The University of Texas M. D. Anderson Cancer Center (Drs Khoury, Amin, and Medeiros), and Departments of Pathology (Drs Jorgensen and Ostrowski) and Medicine (Dr Bloom), The Methodist Hospital, Baylor College of Medicine, Houston, Tex"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Jorgensen","sequence":"additional","affiliation":[{"name":"From the Division of Pathology and Laboratory Medicine, The University of Texas M. D. Anderson Cancer Center (Drs Khoury, Amin, and Medeiros), and Departments of Pathology (Drs Jorgensen and Ostrowski) and Medicine (Dr Bloom), The Methodist Hospital, Baylor College of Medicine, Houston, Tex"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary L.","family":"Ostrowski","sequence":"additional","affiliation":[{"name":"From the Division of Pathology and Laboratory Medicine, The University of Texas M. D. Anderson Cancer Center (Drs Khoury, Amin, and Medeiros), and Departments of Pathology (Drs Jorgensen and Ostrowski) and Medicine (Dr Bloom), The Methodist Hospital, Baylor College of Medicine, Houston, Tex"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. G. Kim","family":"Bloom","sequence":"additional","affiliation":[{"name":"From the Division of Pathology and Laboratory Medicine, The University of Texas M. D. Anderson Cancer Center (Drs Khoury, Amin, and Medeiros), and Departments of Pathology (Drs Jorgensen and Ostrowski) and Medicine (Dr Bloom), The Methodist Hospital, Baylor College of Medicine, Houston, Tex"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Jeffrey","family":"Medeiros","sequence":"additional","affiliation":[{"name":"From the Division of Pathology and Laboratory Medicine, The University of Texas M. D. Anderson Cancer Center (Drs Khoury, Amin, and Medeiros), and Departments of Pathology (Drs Jorgensen and Ostrowski) and Medicine (Dr Bloom), The Methodist Hospital, Baylor College of Medicine, Houston, Tex"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3906","reference":[{"key":"i1543-2165-127-2-e76-b1","series-title":"Arch Intern Med","first-page":"374","article-title":"The spectrum of diseases associated with thymoma: coincidence or syndrome?","volume":"134","author":"Souadjian, J. V.","year":"1974","unstructured":"Souadjian, J. V., P.Enriquez, M. N.Silverstein, and J. M.Pepin. The spectrum of diseases associated with thymoma: coincidence or syndrome?Arch Intern Med1974. 134:374\u2013379."},{"key":"i1543-2165-127-2-e76-b2","series-title":"Ann Surg","first-page":"562","article-title":"Clinical and pathologic predictors of survival in patients with thymoma.","volume":"230","author":"Wilkins, K. B.","year":"1999","unstructured":"Wilkins, K. B., E.Sheikh, and R.Green. et al. Clinical and pathologic predictors of survival in patients with thymoma.Ann Surg1999. 230:562\u2013572."},{"key":"i1543-2165-127-2-e76-b3","series-title":"Arch Intern Med","first-page":"526","article-title":"Thymoma associated with multiple myeloma.","volume":"122","author":"Lindstrom, F. D.","year":"1968","unstructured":"Lindstrom, F. D., R. C. JrWilliams, and R. D.Brunning. Thymoma associated with multiple myeloma.Arch Intern Med1968. 122:526\u2013531."},{"key":"i1543-2165-127-2-e76-b4","series-title":"Hum Pathol","first-page":"163","article-title":"Concurrent thymoma and lymphoma: a report of two cases.","volume":"13","author":"Skinnider, L. F.","year":"1982","unstructured":"Skinnider, L. F., S.Alexander, and D.Horsman. Concurrent thymoma and lymphoma: a report of two cases.Hum Pathol1982. 13:163\u2013166."},{"key":"i1543-2165-127-2-e76-b5","series-title":"Cancer","first-page":"1414","article-title":"Thymoma and chronic myelogenous leukemia: a case report.","volume":"38","author":"Knowles, D. M.","year":"1976","unstructured":"Knowles, D. M.\n          \n          Thymoma and chronic myelogenous leukemia: a case report.\n          Cancer\n          1976. 38:1414\u20131419."},{"key":"i1543-2165-127-2-e76-b6","series-title":"Acta Pathol Jpn","first-page":"1505","article-title":"Hodgkin's disease accompanied with thymoma.","volume":"37","author":"Nemoto, K.","year":"1987","unstructured":"Nemoto, K., H.Ishikawa, Y.Ohnishi, T.Nakamura, and N.Ohsaki. Hodgkin's disease accompanied with thymoma.Acta Pathol Jpn1987. 37:1505\u20131512."},{"key":"i1543-2165-127-2-e76-b7","series-title":"Hum Pathol","first-page":"1211","article-title":"Thymoma associated with CD4+ lymphopenia, cytomegalovirus infection, and Kaposi's sarcoma.","volume":"28","author":"Moysset, I.","year":"1997","unstructured":"Moysset, I., J.Lloreta, and A.Miguel. et al. Thymoma associated with CD4+ lymphopenia, cytomegalovirus infection, and Kaposi's sarcoma.Hum Pathol1997. 28:1211\u20131213."},{"key":"i1543-2165-127-2-e76-b8","series-title":"Am J Pathol","first-page":"1435","article-title":"Primary thymic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type exhibits distinctive clinicopathologic and molecular features.","volume":"160","author":"Inagaki, H.","year":"2002","unstructured":"Inagaki, H., J. K.Chan, and J. W.Ng. et al. Primary thymic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type exhibits distinctive clinicopathologic and molecular features.Am J Pathol2002. 160:1435\u20131443."},{"key":"i1543-2165-127-2-e76-b9","series-title":"Genes Chromosomes Cancer","first-page":"11","article-title":"Clinical significance of Y chromosome loss in hematologic disease.","volume":"27","author":"Wiktor, A.","year":"2000","unstructured":"Wiktor, A., B. A.Rybicki, and Z. S.Piao. et al. Clinical significance of Y chromosome loss in hematologic disease.Genes Chromosomes Cancer2000. 27:11\u201316."},{"key":"i1543-2165-127-2-e76-b10","series-title":"Arch Pathol Lab Med","first-page":"279","article-title":"Malignant thymoma associated with T-cell lymphocytosis: a case report with immunophenotypic and gene rearrangement analysis.","volume":"117","author":"Medeiros, L. J.","year":"1993","unstructured":"Medeiros, L. J., S. K. M.Bhagat, P.Naylor, D.Fowler, E. S.Jaffe, and M.Stetler-Stevenson. Malignant thymoma associated with T-cell lymphocytosis: a case report with immunophenotypic and gene rearrangement analysis.Arch Pathol Lab Med1993. 117:279\u2013283."},{"key":"i1543-2165-127-2-e76-b1","series-title":"Arch Intern Med","first-page":"374","article-title":"The spectrum of diseases associated with thymoma: coincidence or syndrome?","volume":"134","author":"Souadjian, J. V.","year":"1974","unstructured":"Souadjian, J. V., P.Enriquez, M. N.Silverstein, and J. M.Pepin. The spectrum of diseases associated with thymoma: coincidence or syndrome?Arch Intern Med1974. 134:374\u2013379."},{"key":"i1543-2165-127-2-e76-b2","series-title":"Ann Surg","first-page":"562","article-title":"Clinical and pathologic predictors of survival in patients with thymoma.","volume":"230","author":"Wilkins, K. B.","year":"1999","unstructured":"Wilkins, K. B., E.Sheikh, and R.Green. et al. Clinical and pathologic predictors of survival in patients with thymoma.Ann Surg1999. 230:562\u2013572."},{"key":"i1543-2165-127-2-e76-b3","series-title":"Arch Intern Med","first-page":"526","article-title":"Thymoma associated with multiple myeloma.","volume":"122","author":"Lindstrom, F. D.","year":"1968","unstructured":"Lindstrom, F. D., R. C. JrWilliams, and R. D.Brunning. 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Thymoma associated with CD4+ lymphopenia, cytomegalovirus infection, and Kaposi's sarcoma.Hum Pathol1997. 28:1211\u20131213."},{"key":"i1543-2165-127-2-e76-b8","series-title":"Am J Pathol","first-page":"1435","article-title":"Primary thymic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type exhibits distinctive clinicopathologic and molecular features.","volume":"160","author":"Inagaki, H.","year":"2002","unstructured":"Inagaki, H., J. K.Chan, and J. W.Ng. et al. Primary thymic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type exhibits distinctive clinicopathologic and molecular features.Am J Pathol2002. 160:1435\u20131443."},{"key":"i1543-2165-127-2-e76-b9","series-title":"Genes Chromosomes Cancer","first-page":"11","article-title":"Clinical significance of Y chromosome loss in hematologic disease.","volume":"27","author":"Wiktor, A.","year":"2000","unstructured":"Wiktor, A., B. A.Rybicki, and Z. S.Piao. et al. 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