{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T19:11:47Z","timestamp":1782587507065,"version":"3.54.5"},"reference-count":22,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Perivascular epithelioid cell tumor (PEComa) is a neoplasm chiefly composed of HMB-45\u2013positive epithelioid cells with clear-to-granular cytoplasm and a perivascular distribution. We describe such a tumor involving the prostate and seminal vesicle in a 46-year-old man. The tumor had characteristic histologic features of PEComa. Immunohistochemically, the tumor cells were positive for HMB-45 but negative for epithelial markers, Melan-A, and S100 protein. The tumor behaved in a malignant fashion, and the patient died of the disease 4 years after diagnosis.<\/jats:p>","DOI":"10.5858\/2003-127-e96-mpecti","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T11:49:11Z","timestamp":1611920951000},"page":"e96-e98","source":"Crossref","is-referenced-by-count":64,"title":["Malignant Perivascular Epithelioid Cell Tumor Involving the Prostate"],"prefix":"10.5858","volume":"127","author":[{"given":"Chin-Chen","family":"Pan","sequence":"first","affiliation":[{"name":"From the Department of Pathology, National Yang-Ming University, and Veterans General Hospital-Taipei, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-Hang","family":"Yang","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, National Yang-Ming University, and Veterans General Hospital-Taipei, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung","family":"Chiang","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, National Yang-Ming University, and Veterans General Hospital-Taipei, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3906","reference":[{"key":"i1543-2165-127-2-e96-b1","series-title":"Am J Surg Pathol","first-page":"307","article-title":"PEC and sugar.","volume":"16","author":"Bonetti, F.","year":"1992","unstructured":"Bonetti, F., M.Pea, G.Martignoni, and G.Zamboni. PEC and sugar.Am J Surg Pathol1992. 16:307\u2013308."},{"key":"i1543-2165-127-2-e96-b2","series-title":"Am J Surg Pathol","first-page":"1239","article-title":"Clear cell myomelanocytic tumor of the falciform ligament\/ligamentum teres: a novel member of the perivascular epithelioid clear cell family of tumors with a predilection for children and young adults.","volume":"24","author":"Folpe, A. L.","year":"2000","unstructured":"Folpe, A. L., Z. D.Goodman, and K. G.Ishak. et al. Clear cell myomelanocytic tumor of the falciform ligament\/ligamentum teres: a novel member of the perivascular epithelioid clear cell family of tumors with a predilection for children and young adults.Am J Surg Pathol2000. 24:1239\u20131246."},{"key":"i1543-2165-127-2-e96-b3","series-title":"Mod Pathol","first-page":"615","article-title":"Primary extrapulmonary sugar tumor (PEST): a report of four cases.","volume":"14","author":"Tazelaar, H. D.","year":"2001","unstructured":"Tazelaar, H. D., K. P.Batts, and J. R.Srigley. Primary extrapulmonary sugar tumor (PEST): a report of four cases.Mod Pathol2001. 14:615\u2013622."},{"key":"i1543-2165-127-2-e96-b4","series-title":"Am J Surg Pathol","first-page":"722","article-title":"Clear cell \u201csugar\u201d tumor of the pancreas: a novel member of the family of lesions characterized by the presence of perivascular epithelioid cells.","volume":"20","author":"Zamboni, G.","year":"1996","unstructured":"Zamboni, G., M.Pea, and G.Martignoni. et al. Clear cell \u201csugar\u201d tumor of the pancreas: a novel member of the family of lesions characterized by the presence of perivascular epithelioid cells.Am J Surg Pathol1996. 20:722\u2013730."},{"key":"i1543-2165-127-2-e96-b5","series-title":"Am J Surg Pathol","first-page":"1","article-title":"Perivascular epithelioid cell tumor (\u2018PEComa\u2019) of the uterus: a subset of HMB-45-positive epithelioid mesenchymal neoplasms with an uncertain relationship to pure smooth muscle tumors.","volume":"26","author":"Vang, R.","year":"2002","unstructured":"Vang, R. and R. L.Kempson. Perivascular epithelioid cell tumor (\u2018PEComa\u2019) of the uterus: a subset of HMB-45-positive epithelioid mesenchymal neoplasms with an uncertain relationship to pure smooth muscle tumors.Am J Surg Pathol2002. 26:1\u201313."},{"key":"i1543-2165-127-2-e96-b6","series-title":"Pathology","first-page":"230","article-title":"Clear cell (\u201csugar\u201d) tumor of the lung is a lesion strictly related to angiomyolipoma\u2013the concept of a family of lesions characterized by the presence of the perivascular epithelioid cells (PEC).","volume":"26","author":"Bonetti, F.","year":"1994","unstructured":"Bonetti, F., M.Pea, and G.Martignoni. et al. Clear cell (\u201csugar\u201d) tumor of the lung is a lesion strictly related to angiomyolipoma\u2013the concept of a family of lesions characterized by the presence of the perivascular epithelioid cells (PEC).Pathology1994. 26:230\u2013236."},{"key":"i1543-2165-127-2-e96-b7","series-title":"Mod Pathol","first-page":"563","article-title":"Abdominopelvic sarcoma of perivascular epithelioid cells: report of four cases in young women, one with tuberous sclerosis.","volume":"14","author":"Bonetti, F.","year":"2001","unstructured":"Bonetti, F., G.Martignoni, and C.Colato. et al. Abdominopelvic sarcoma of perivascular epithelioid cells: report of four cases in young women, one with tuberous sclerosis.Mod Pathol2001. 14:563\u2013568."},{"key":"i1543-2165-127-2-e96-b8","series-title":"Am J Surg Pathol","first-page":"889","article-title":"Renal angiomyolipoma with epithelioid sarcomatous transformation and metastases: demonstration of the same genetic defects in the primary and metastatic lesions.","volume":"24","author":"Martignoni, G.","year":"2000","unstructured":"Martignoni, G., M.Pea, and G.Rigaud. et al. Renal angiomyolipoma with epithelioid sarcomatous transformation and metastases: demonstration of the same genetic defects in the primary and metastatic lesions.Am J Surg Pathol2000. 24:889\u2013894."},{"key":"i1543-2165-127-2-e96-b9","series-title":"Histopathology","first-page":"451","article-title":"Monotypic epithelioid angiomyolipoma of the liver.","volume":"36","author":"Yamasaki, S.","year":"2000","unstructured":"Yamasaki, S., S.Tanaka, and H.Fujii. et al. Monotypic epithelioid angiomyolipoma of the liver.Histopathology2000. 36:451\u2013456."},{"key":"i1543-2165-127-2-e96-b10","article-title":"Malignant tumors of the peripheral nerves. Enzinger and Weiss's Soft Tissue Tumors. 4th ed.","author":"Weiss, S. W.","unstructured":"Weiss, S. W. and J. R.Goldrum. Malignant tumors of the peripheral nerves. Enzinger and Weiss's Soft Tissue Tumors. 4th ed.St Louis, Mo: Mosby; 2002:1241\u20131250."},{"key":"i1543-2165-127-2-e96-b11","series-title":"J Urol","first-page":"2062","article-title":"Pelvic clear cell adenocarcinoma in a 14-year-old boy.","volume":"155","author":"Morgan, T. O. Jr","year":"1996","unstructured":"Morgan, T. O. Jr, N. S.Schenkman, D. S.Peppas, E. M.Rueda-Pedraza, C. D.Shriver, and R. A.Costabile. Pelvic clear cell adenocarcinoma in a 14-year-old boy.J Urol1996. 155:2062\u20132063."},{"key":"i1543-2165-127-2-e96-b1","series-title":"Am J Surg Pathol","first-page":"307","article-title":"PEC and sugar.","volume":"16","author":"Bonetti, F.","year":"1992","unstructured":"Bonetti, F., M.Pea, G.Martignoni, and G.Zamboni. PEC and sugar.Am J Surg Pathol1992. 16:307\u2013308."},{"key":"i1543-2165-127-2-e96-b2","series-title":"Am J Surg Pathol","first-page":"1239","article-title":"Clear cell myomelanocytic tumor of the falciform ligament\/ligamentum teres: a novel member of the perivascular epithelioid clear cell family of tumors with a predilection for children and young adults.","volume":"24","author":"Folpe, A. L.","year":"2000","unstructured":"Folpe, A. L., Z. D.Goodman, and K. G.Ishak. et al. Clear cell myomelanocytic tumor of the falciform ligament\/ligamentum teres: a novel member of the perivascular epithelioid clear cell family of tumors with a predilection for children and young adults.Am J Surg Pathol2000. 24:1239\u20131246."},{"key":"i1543-2165-127-2-e96-b3","series-title":"Mod Pathol","first-page":"615","article-title":"Primary extrapulmonary sugar tumor (PEST): a report of four cases.","volume":"14","author":"Tazelaar, H. D.","year":"2001","unstructured":"Tazelaar, H. D., K. P.Batts, and J. R.Srigley. Primary extrapulmonary sugar tumor (PEST): a report of four cases.Mod Pathol2001. 14:615\u2013622."},{"key":"i1543-2165-127-2-e96-b4","series-title":"Am J Surg Pathol","first-page":"722","article-title":"Clear cell \u201csugar\u201d tumor of the pancreas: a novel member of the family of lesions characterized by the presence of perivascular epithelioid cells.","volume":"20","author":"Zamboni, G.","year":"1996","unstructured":"Zamboni, G., M.Pea, and G.Martignoni. et al. Clear cell \u201csugar\u201d tumor of the pancreas: a novel member of the family of lesions characterized by the presence of perivascular epithelioid cells.Am J Surg Pathol1996. 20:722\u2013730."},{"key":"i1543-2165-127-2-e96-b5","series-title":"Am J Surg Pathol","first-page":"1","article-title":"Perivascular epithelioid cell tumor (\u2018PEComa\u2019) of the uterus: a subset of HMB-45-positive epithelioid mesenchymal neoplasms with an uncertain relationship to pure smooth muscle tumors.","volume":"26","author":"Vang, R.","year":"2002","unstructured":"Vang, R. and R. L.Kempson. Perivascular epithelioid cell tumor (\u2018PEComa\u2019) of the uterus: a subset of HMB-45-positive epithelioid mesenchymal neoplasms with an uncertain relationship to pure smooth muscle tumors.Am J Surg Pathol2002. 26:1\u201313."},{"key":"i1543-2165-127-2-e96-b6","series-title":"Pathology","first-page":"230","article-title":"Clear cell (\u201csugar\u201d) tumor of the lung is a lesion strictly related to angiomyolipoma\u2013the concept of a family of lesions characterized by the presence of the perivascular epithelioid cells (PEC).","volume":"26","author":"Bonetti, F.","year":"1994","unstructured":"Bonetti, F., M.Pea, and G.Martignoni. et al. Clear cell (\u201csugar\u201d) tumor of the lung is a lesion strictly related to angiomyolipoma\u2013the concept of a family of lesions characterized by the presence of the perivascular epithelioid cells (PEC).Pathology1994. 26:230\u2013236."},{"key":"i1543-2165-127-2-e96-b7","series-title":"Mod Pathol","first-page":"563","article-title":"Abdominopelvic sarcoma of perivascular epithelioid cells: report of four cases in young women, one with tuberous sclerosis.","volume":"14","author":"Bonetti, F.","year":"2001","unstructured":"Bonetti, F., G.Martignoni, and C.Colato. et al. Abdominopelvic sarcoma of perivascular epithelioid cells: report of four cases in young women, one with tuberous sclerosis.Mod Pathol2001. 14:563\u2013568."},{"key":"i1543-2165-127-2-e96-b8","series-title":"Am J Surg Pathol","first-page":"889","article-title":"Renal angiomyolipoma with epithelioid sarcomatous transformation and metastases: demonstration of the same genetic defects in the primary and metastatic lesions.","volume":"24","author":"Martignoni, G.","year":"2000","unstructured":"Martignoni, G., M.Pea, and G.Rigaud. et al. Renal angiomyolipoma with epithelioid sarcomatous transformation and metastases: demonstration of the same genetic defects in the primary and metastatic lesions.Am J Surg Pathol2000. 24:889\u2013894."},{"key":"i1543-2165-127-2-e96-b9","series-title":"Histopathology","first-page":"451","article-title":"Monotypic epithelioid angiomyolipoma of the liver.","volume":"36","author":"Yamasaki, S.","year":"2000","unstructured":"Yamasaki, S., S.Tanaka, and H.Fujii. et al. Monotypic epithelioid angiomyolipoma of the liver.Histopathology2000. 36:451\u2013456."},{"key":"i1543-2165-127-2-e96-b10","article-title":"Malignant tumors of the peripheral nerves. Enzinger and Weiss's Soft Tissue Tumors. 4th ed.","author":"Weiss, S. W.","unstructured":"Weiss, S. W. and J. R.Goldrum. Malignant tumors of the peripheral nerves. 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