{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T05:29:47Z","timestamp":1770787787027,"version":"3.50.0"},"reference-count":28,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We report 2 cases of nonspecific postvaccinial dermatitis following smallpox vaccination. The patients presented with diffuse, pruritic, erythematous macules and papules 11 days (case 1) and 7 days (case 2) following routine smallpox vaccination. Biopsies of the lesions demonstrated spongiotic dermatitis without evidence of viral cytopathic changes. One case showed a pityriasis rosea\u2013like histologic pattern. The exanthema resolved without sequelae with symptomatic treatment (case 1). Review of historical literature demonstrated the association of a variety of nonspecific cutaneous complications with vaccinia inoculation, including erythema multiforme, urticaria, and pityriasis rosea. The association of these various dermatitides with smallpox immunization is not well known and is likely underreported.<\/jats:p>","DOI":"10.5858\/2004-128-1173-psdosv","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T15:03:09Z","timestamp":1612969389000},"page":"1173-1175","source":"Crossref","is-referenced-by-count":7,"title":["Papular Spongiotic Dermatitis of Smallpox Vaccination: Report of 2 Cases With Review of the Literature"],"prefix":"10.5858","volume":"128","author":[{"given":"Erich M.","family":"Gaertner","sequence":"first","affiliation":[{"name":"From the Departments of Pathology (Drs Gaertner and Groo) and Dermatology (Dr Kim), Madigan Army Medical Center, Tacoma, Wash"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Groo","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Gaertner and Groo) and Dermatology (Dr Kim), Madigan Army Medical Center, Tacoma, Wash"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Gaertner and Groo) and Dermatology (Dr Kim), Madigan Army Medical Center, Tacoma, Wash"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"key":"i1543-2165-128-10-1173-b1","series-title":"N Engl J Med","first-page":"1201","article-title":"Complications of smallpox vaccination: national surveillance in the United States, 1968.","volume":"281","author":"Lane, J. M.","year":"1969","unstructured":"Lane, J. M., F. L.Ruben, L. M.Neff, and J. D.Millar. Complications of smallpox vaccination: national surveillance in the United States, 1968.N Engl J Med1969. 281:1201\u20131207."},{"key":"i1543-2165-128-10-1173-b2","series-title":"MMWR Morbid Mortal Wkly Rep","first-page":"1","article-title":"Smallpox vaccination and adverse reactions: guidance for clinicians.","volume":"52(RR4)","year":"2003","unstructured":"Centers for Disease Control and Prevention.\n          \n          Smallpox vaccination and adverse reactions: guidance for clinicians.\n          MMWR Morbid Mortal Wkly Rep\n          2003. 52(RR4):1\u201327."},{"key":"i1543-2165-128-10-1173-b3","series-title":"JAMA","first-page":"141","article-title":"Smallpox immunization in the United States.","volume":"194","author":"Kempe, C. H.","year":"1965","unstructured":"Kempe, C. H. and A.Benenson. Smallpox immunization in the United States.JAMA1965. 194:141\u2013166."},{"key":"i1543-2165-128-10-1173-b4","series-title":"Trans St John Dermatol Soc","first-page":"163","article-title":"Cutaneous complications of smallpox vaccination.","volume":"48","author":"Sarkany, I.","year":"1962","unstructured":"Sarkany, I. and G. A.Caron. Cutaneous complications of smallpox vaccination.Trans St John Dermatol Soc1962. 48:163\u2013170."},{"key":"i1543-2165-128-10-1173-b5","series-title":"J Invest Dermatol","first-page":"197","article-title":"Cutaneous complications of mass vaccinations in New York City, 1947.","volume":"10","author":"Curth, O. H.","year":"1948","unstructured":"Curth, O. H., W.Curth, and J.Garb. Cutaneous complications of mass vaccinations in New York City, 1947.J Invest Dermatol1948. 10:197\u2013204."},{"key":"i1543-2165-128-10-1173-b6","series-title":"J Invest Dermatol","first-page":"167","article-title":"Cutaneous complications of mass vaccinations in New York City, 1947, part II.","volume":"11","author":"Curth, O. H.","year":"1948","unstructured":"Curth, O. H., W.Curth, and J.Garb. Cutaneous complications of mass vaccinations in New York City, 1947, part II.J Invest Dermatol1948. 11:167\u2013188."},{"key":"i1543-2165-128-10-1173-b7","series-title":"MMWR Morbid Mortal Wkly Rep","first-page":"136","article-title":"Smallpox vaccine adverse events among civilians: United States, January 24\u2013February 18, 2003.","volume":"52","year":"2003","unstructured":"Centers for Disease Control and Prevention.\n          \n          Smallpox vaccine adverse events among civilians: United States, January 24\u2013February 18, 2003.\n          MMWR Morbid Mortal Wkly Rep\n          2003. 52:136."},{"key":"i1543-2165-128-10-1173-b8","article-title":"Armed Forces Institute of Pathology Laboratory Methods in Histotechnology.","author":"Prophet, E. R.","unstructured":"Prophet, E. R., B.Mills, J. B.Arrington, and L. H.Sobin. Armed Forces Institute of Pathology Laboratory Methods in Histotechnology.Washington, DC: American Registry of Pathology; 1992:225."},{"key":"i1543-2165-128-10-1173-b9","series-title":"Lancet","first-page":"504","article-title":"Postvaccinial eruptions.","volume":"2","author":"Bloch, E.","year":"1942","unstructured":"Bloch, E. and M. D.Glasg. Postvaccinial eruptions.Lancet1942. 2:504\u2013507."},{"key":"i1543-2165-128-10-1173-b10","series-title":"J Infect Dis","first-page":"303","article-title":"Complications of smallpox vaccination, 1968: results of ten statewide surveys.","volume":"122","author":"Lane, J. M.","year":"1970","unstructured":"Lane, J. M., F. L.Ruben, J. M.Neff, and J. D.Millar. Complications of smallpox vaccination, 1968: results of ten statewide surveys.J Infect Dis1970. 122:303\u2013309."},{"key":"i1543-2165-128-10-1173-b11","series-title":"Clin Exp Rheumatol","first-page":"81","article-title":"Immune-mediated pathology following hepatitis B vaccination: two cases of polyarteritis nodosa and one case of pityriasis rosea\u2013like drug eruption.","volume":"18","author":"De Keyser, F.","year":"2000","unstructured":"De Keyser, F., J. M.Naeyaert, and P.Hindryckx. et al. Immune-mediated pathology following hepatitis B vaccination: two cases of polyarteritis nodosa and one case of pityriasis rosea\u2013like drug eruption.Clin Exp Rheumatol2000. 18:81\u201385."},{"key":"i1543-2165-128-10-1173-b12","series-title":"Br J Dermatol","first-page":"215","article-title":"Malignant fibrous histiocytoma arising in a smallpox vaccination scar.","volume":"105","author":"Slater, D. N.","year":"1981","unstructured":"Slater, D. N., M. A.Parsons, and I. V.Fussey. Malignant fibrous histiocytoma arising in a smallpox vaccination scar.Br J Dermatol1981. 105:215\u2013217."},{"key":"i1543-2165-128-10-1173-b13","series-title":"Arch Dermatol","first-page":"400","article-title":"Malignant tumors in smallpox vaccination scars: a report of 24 cases.","volume":"97","author":"Marmelzat, W. L.","year":"1968","unstructured":"Marmelzat, W. L.\n          \n          Malignant tumors in smallpox vaccination scars: a report of 24 cases.\n          Arch Dermatol\n          1968. 97:400\u2013406."},{"key":"i1543-2165-128-10-1173-b14","series-title":"J Am Acad Dermatol","first-page":"688","article-title":"Discoid lupus erythematosus occurring in a smallpox vaccination scar.","volume":"17","author":"Lupton, G. P.","year":"1987","unstructured":"Lupton, G. P.\n          \n          Discoid lupus erythematosus occurring in a smallpox vaccination scar.\n          J Am Acad Dermatol\n          1987. 17:688\u2013690."},{"key":"i1543-2165-128-10-1173-b1","series-title":"N Engl J Med","first-page":"1201","article-title":"Complications of smallpox vaccination: national surveillance in the United States, 1968.","volume":"281","author":"Lane, J. M.","year":"1969","unstructured":"Lane, J. M., F. L.Ruben, L. M.Neff, and J. D.Millar. Complications of smallpox vaccination: national surveillance in the United States, 1968.N Engl J Med1969. 281:1201\u20131207."},{"key":"i1543-2165-128-10-1173-b2","series-title":"MMWR Morbid Mortal Wkly Rep","first-page":"1","article-title":"Smallpox vaccination and adverse reactions: guidance for clinicians.","volume":"52(RR4)","year":"2003","unstructured":"Centers for Disease Control and Prevention.\n          \n          Smallpox vaccination and adverse reactions: guidance for clinicians.\n          MMWR Morbid Mortal Wkly Rep\n          2003. 52(RR4):1\u201327."},{"key":"i1543-2165-128-10-1173-b3","series-title":"JAMA","first-page":"141","article-title":"Smallpox immunization in the United States.","volume":"194","author":"Kempe, C. H.","year":"1965","unstructured":"Kempe, C. H. and A.Benenson. Smallpox immunization in the United States.JAMA1965. 194:141\u2013166."},{"key":"i1543-2165-128-10-1173-b4","series-title":"Trans St John Dermatol Soc","first-page":"163","article-title":"Cutaneous complications of smallpox vaccination.","volume":"48","author":"Sarkany, I.","year":"1962","unstructured":"Sarkany, I. and G. A.Caron. Cutaneous complications of smallpox vaccination.Trans St John Dermatol Soc1962. 48:163\u2013170."},{"key":"i1543-2165-128-10-1173-b5","series-title":"J Invest Dermatol","first-page":"197","article-title":"Cutaneous complications of mass vaccinations in New York City, 1947.","volume":"10","author":"Curth, O. H.","year":"1948","unstructured":"Curth, O. H., W.Curth, and J.Garb. Cutaneous complications of mass vaccinations in New York City, 1947.J Invest Dermatol1948. 10:197\u2013204."},{"key":"i1543-2165-128-10-1173-b6","series-title":"J Invest Dermatol","first-page":"167","article-title":"Cutaneous complications of mass vaccinations in New York City, 1947, part II.","volume":"11","author":"Curth, O. H.","year":"1948","unstructured":"Curth, O. H., W.Curth, and J.Garb. Cutaneous complications of mass vaccinations in New York City, 1947, part II.J Invest Dermatol1948. 11:167\u2013188."},{"key":"i1543-2165-128-10-1173-b7","series-title":"MMWR Morbid Mortal Wkly Rep","first-page":"136","article-title":"Smallpox vaccine adverse events among civilians: United States, January 24\u2013February 18, 2003.","volume":"52","year":"2003","unstructured":"Centers for Disease Control and Prevention.\n          \n          Smallpox vaccine adverse events among civilians: United States, January 24\u2013February 18, 2003.\n          MMWR Morbid Mortal Wkly Rep\n          2003. 52:136."},{"key":"i1543-2165-128-10-1173-b8","article-title":"Armed Forces Institute of Pathology Laboratory Methods in Histotechnology.","author":"Prophet, E. R.","unstructured":"Prophet, E. R., B.Mills, J. B.Arrington, and L. H.Sobin. Armed Forces Institute of Pathology Laboratory Methods in Histotechnology.Washington, DC: American Registry of Pathology; 1992:225."},{"key":"i1543-2165-128-10-1173-b9","series-title":"Lancet","first-page":"504","article-title":"Postvaccinial eruptions.","volume":"2","author":"Bloch, E.","year":"1942","unstructured":"Bloch, E. and M. D.Glasg. Postvaccinial eruptions.Lancet1942. 2:504\u2013507."},{"key":"i1543-2165-128-10-1173-b10","series-title":"J Infect Dis","first-page":"303","article-title":"Complications of smallpox vaccination, 1968: results of ten statewide surveys.","volume":"122","author":"Lane, J. M.","year":"1970","unstructured":"Lane, J. M., F. L.Ruben, J. M.Neff, and J. D.Millar. Complications of smallpox vaccination, 1968: results of ten statewide surveys.J Infect Dis1970. 122:303\u2013309."},{"key":"i1543-2165-128-10-1173-b11","series-title":"Clin Exp Rheumatol","first-page":"81","article-title":"Immune-mediated pathology following hepatitis B vaccination: two cases of polyarteritis nodosa and one case of pityriasis rosea\u2013like drug eruption.","volume":"18","author":"De Keyser, F.","year":"2000","unstructured":"De Keyser, F., J. M.Naeyaert, and P.Hindryckx. et al. Immune-mediated pathology following hepatitis B vaccination: two cases of polyarteritis nodosa and one case of pityriasis rosea\u2013like drug eruption.Clin Exp Rheumatol2000. 18:81\u201385."},{"key":"i1543-2165-128-10-1173-b12","series-title":"Br J Dermatol","first-page":"215","article-title":"Malignant fibrous histiocytoma arising in a smallpox vaccination scar.","volume":"105","author":"Slater, D. N.","year":"1981","unstructured":"Slater, D. N., M. A.Parsons, and I. V.Fussey. Malignant fibrous histiocytoma arising in a smallpox vaccination scar.Br J Dermatol1981. 105:215\u2013217."},{"key":"i1543-2165-128-10-1173-b13","series-title":"Arch Dermatol","first-page":"400","article-title":"Malignant tumors in smallpox vaccination scars: a report of 24 cases.","volume":"97","author":"Marmelzat, W. L.","year":"1968","unstructured":"Marmelzat, W. L.\n          \n          Malignant tumors in smallpox vaccination scars: a report of 24 cases.\n          Arch Dermatol\n          1968. 97:400\u2013406."},{"key":"i1543-2165-128-10-1173-b14","series-title":"J Am Acad Dermatol","first-page":"688","article-title":"Discoid lupus erythematosus occurring in a smallpox vaccination scar.","volume":"17","author":"Lupton, G. P.","year":"1987","unstructured":"Lupton, G. P.\n          \n          Discoid lupus erythematosus occurring in a smallpox vaccination scar.\n          J Am Acad Dermatol\n          1987. 17:688\u2013690."}],"container-title":["Archives of Pathology &amp; Laboratory Medicine"],"original-title":[],"link":[{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/128\/10\/article-p1173.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/128\/10\/1173\/2753109\/1543-2165(2004)128_1173_psdosv_2_0_co_2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/128\/10\/article-p1173.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/128\/10\/article-p1173.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T01:09:17Z","timestamp":1770772157000},"score":1,"resource":{"primary":{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/128\/10\/article-p1173.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":28,"journal-issue":{"issue":"10"},"URL":"https:\/\/doi.org\/10.5858\/2004-128-1173-psdosv","relation":{},"ISSN":["1543-2165","0003-9985"],"issn-type":[{"value":"1543-2165","type":"electronic"},{"value":"0003-9985","type":"print"}],"subject":[],"published":{"date-parts":[[2004,10]]}}}