{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:49:23Z","timestamp":1770814163988,"version":"3.50.1"},"reference-count":34,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We report a case of plasmablastic lymphoma presenting in cervical lymph nodes in an 82-year-old, human immunodeficiency virus\u2013negative man. Cytologic and histologic examinations demonstrated a large cell lymphoma with plasmacytic differentiation. The tumor cells were positive for CD138, CD38, epithelial membrane antigen, CD30, and lysozyme, but lacked expression of leukocyte common antigen, T-cell, and B-cell markers. Abundant Epstein-Barr virus\u2013encoded RNA transcripts were identified by in situ hybridization. A monoclonal rearrangement of \u03ba-light- chain gene was demonstrated. The cytologic, histologic, immunohistochemical, and molecular features of plasmablastic lymphoma are reviewed. The potential diagnostic pitfalls and differential diagnoses, especially in a fine-needle aspiration specimen, are addressed.<\/jats:p>","DOI":"10.5858\/2004-128-581-plotcl","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T17:17:39Z","timestamp":1612977459000},"page":"581-584","source":"Crossref","is-referenced-by-count":52,"title":["Plasmablastic Lymphoma of the Cervical Lymph Nodes in a Human Immunodeficiency Virus\u2013Negative Patient: A Case Report and Review of the Literature"],"prefix":"10.5858","volume":"128","author":[{"given":"Fan","family":"Lin","sequence":"first","affiliation":[{"name":"From the Departments of Laboratory Medicine (Drs Lin, Zhang, Prichard, and Schuerch) and Hematology\/Oncology (Dr Quiery), Geisinger Medical Center, Danville, Pa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Zhang","sequence":"additional","affiliation":[{"name":"From the Departments of Laboratory Medicine (Drs Lin, Zhang, Prichard, and Schuerch) and Hematology\/Oncology (Dr Quiery), Geisinger Medical Center, Danville, Pa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert T.","family":"Quiery","sequence":"additional","affiliation":[{"name":"From the Departments of Laboratory Medicine (Drs Lin, Zhang, Prichard, and Schuerch) and Hematology\/Oncology (Dr Quiery), Geisinger Medical Center, Danville, Pa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Prichard","sequence":"additional","affiliation":[{"name":"From the Departments of Laboratory Medicine (Drs Lin, Zhang, Prichard, and Schuerch) and Hematology\/Oncology (Dr Quiery), Geisinger Medical Center, Danville, Pa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conrad","family":"Schuerch","sequence":"additional","affiliation":[{"name":"From the Departments of Laboratory Medicine (Drs Lin, Zhang, Prichard, and Schuerch) and Hematology\/Oncology (Dr Quiery), Geisinger Medical Center, Danville, Pa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"key":"i1543-2165-128-5-581-b1","series-title":"Blood","first-page":"1413","article-title":"Plasmablastic lymphomas of the oral cavity: a new entity associated with the human immunodeficiency virus infection.","volume":"89","author":"Delecluse, H. J.","year":"1997","unstructured":"Delecluse, H. J., I.Anagnostopoulos, and F.Dallenbach. et al. Plasmablastic lymphomas of the oral cavity: a new entity associated with the human immunodeficiency virus infection.Blood1997. 89:1413\u20131420."},{"key":"i1543-2165-128-5-581-b2","series-title":"Blood","first-page":"744","article-title":"Expression profile of MUM1\/ IRF4, BCL-6, and CD138\/syndecan-1 defines novel histogenetic subsets of human immunodeficiency virus-related lymphomas.","volume":"97","author":"Carbone, A.","year":"2001","unstructured":"Carbone, A., A.Gloghini, and L. M.Larocca. et al. Expression profile of MUM1\/ IRF4, BCL-6, and CD138\/syndecan-1 defines novel histogenetic subsets of human immunodeficiency virus-related lymphomas.Blood2001. 97:744\u2013751."},{"key":"i1543-2165-128-5-581-b3","series-title":"Oral Oncol","first-page":"96","article-title":"Plasmablastic lymphoma: an HIV-associated entity with primary oral manifestations.","volume":"38","author":"Flaitz, C. M.","year":"2002","unstructured":"Flaitz, C. M., C. M.Nichols, D. M.Walling, and M. J.Hicks. Plasmablastic lymphoma: an HIV-associated entity with primary oral manifestations.Oral Oncol2002. 38:96\u2013102."},{"key":"i1543-2165-128-5-581-b4","series-title":"Br J Haematol","first-page":"622","article-title":"Molecular histogenesis of plasmablastic lymphoma of the oral cavity.","volume":"119","author":"Gaidano, G.","year":"2002","unstructured":"Gaidano, G., M.Cerri, and D.Capello. et al. Molecular histogenesis of plasmablastic lymphoma of the oral cavity.Br J Haematol2002. 119:622\u2013628."},{"key":"i1543-2165-128-5-581-b5","series-title":"Clin Oncol","first-page":"327","article-title":"Plasmablastic lymphoma: a new subcategory of human immunodeficiency virus\u2013related non- Hodgkin's lymphoma.","volume":"10","author":"Brown, R. S.","year":"1998","unstructured":"Brown, R. S., C.Campbell, S. C.Lishman, M. F.Spittle, and R. F.Miller. Plasmablastic lymphoma: a new subcategory of human immunodeficiency virus\u2013related non- Hodgkin's lymphoma.Clin Oncol1998. 10:327\u2013329."},{"key":"i1543-2165-128-5-581-b6","series-title":"Blood","first-page":"1406","article-title":"HIV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HIV-8-positive plasmablastic lymphoma.","volume":"95","author":"Dupin, N.","year":"2000","unstructured":"Dupin, N., T. L.Diss, and P.Kellam. et al. HIV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HIV-8-positive plasmablastic lymphoma.Blood2000. 95:1406\u20131412."},{"key":"i1543-2165-128-5-581-b7","series-title":"Haematologica","first-page":"87","article-title":"Plasmablastic lymphoma of the stomach: a case report.","volume":"83","author":"Pruneri, G.","year":"1998","unstructured":"Pruneri, G., G.Graziadei, L.Ermellino, L.Baldini, A.Neri, and R.Buffa. Plasmablastic lymphoma of the stomach: a case report.Haematologica1998. 83:87\u201389."},{"key":"i1543-2165-128-5-581-b8","series-title":"Arch Pathol Lab Med","first-page":"282","article-title":"Plasmablastic lymphoma of the lung: a report of a unique case and review of the literature.","volume":"125","author":"Lin, Y.","year":"2001","unstructured":"Lin, Y., G. D.Rodrigues, J. F.Turner, and M. A.Vasef. Plasmablastic lymphoma of the lung: a report of a unique case and review of the literature.Arch Pathol Lab Med2001. 125:282\u2013285."},{"key":"i1543-2165-128-5-581-b9","series-title":"Eur J Haematol","first-page":"322","article-title":"Plasmablastic lymphoma in a patient with chronic lymphocytic leukemia heavily pretreated with cladribine (2-CdA): an unusual variant of Richter's syndrome.","volume":"67","author":"Robak, T.","year":"2001","unstructured":"Robak, T., H.Urbanska-Rys, and B.Strzelecka. et al. Plasmablastic lymphoma in a patient with chronic lymphocytic leukemia heavily pretreated with cladribine (2-CdA): an unusual variant of Richter's syndrome.Eur J Haematol2001. 67:322\u2013327."},{"key":"i1543-2165-128-5-581-b10","series-title":"Ann Hematol","first-page":"521","article-title":"Plasmablastic lymphoma presenting in a human immunodeficiency virus\u2013negative patient: a case report.","volume":"82","author":"Nguyen, D. D.","year":"2003","unstructured":"Nguyen, D. D., B. W.Loo, and G.Tillman. et al. Plasmablastic lymphoma presenting in a human immunodeficiency virus\u2013negative patient: a case report.Ann Hematol2003. 82:521\u2013525."},{"key":"i1543-2165-128-5-581-b11","series-title":"Am J Pathol","first-page":"1461","article-title":"Abundant expression of EBER1 small nuclear RNA in nasopharyngeal carcinoma: a morphologically distinctive target for detection of Epstein-Barr virus in formalin-fixed paraffin-embedded carcinoma specimens.","volume":"138","author":"Wu, T-C.","year":"1991","unstructured":"Wu, T-C., R. B.Mann, J. I.Epstein, and E.MacMahon. et al. Abundant expression of EBER1 small nuclear RNA in nasopharyngeal carcinoma: a morphologically distinctive target for detection of Epstein-Barr virus in formalin-fixed paraffin-embedded carcinoma specimens.Am J Pathol1991. 138:1461\u20131469."},{"key":"i1543-2165-128-5-581-b12","article-title":"Molecular Cloning: A Laboratory Manual. 2nd ed.","author":"Sambrook, J.","unstructured":"Sambrook, J., E. F.Fritsch, and T.Maniatis. Molecular Cloning: A Laboratory Manual. 2nd ed.Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 1989."},{"key":"i1543-2165-128-5-581-b13","series-title":"Blood","first-page":"2642","article-title":"ALK-positive B-cell lymphoma with expression of the NPM-ALK fusion transcript: report of 2 cases.","volume":"102","author":"Onciu, M.","year":"2003","unstructured":"Onciu, M., F. G.Behm, and J. R.Downing. et al. ALK-positive B-cell lymphoma with expression of the NPM-ALK fusion transcript: report of 2 cases.Blood2003. 102:2642\u20132644."},{"key":"i1543-2165-128-5-581-b14","series-title":"Am J Surg Pathol","first-page":"1473","article-title":"A case of a diffuse large B- cell lymphoma of plasmablastic type associated with the t(2;5)(p23;q35) chromosomal translocation.","volume":"27","author":"Adam, P.","year":"2003","unstructured":"Adam, P., T.Katzenberger, and H.Seeberger. et al. A case of a diffuse large B- cell lymphoma of plasmablastic type associated with the t(2;5)(p23;q35) chromosomal translocation.Am J Surg Pathol2003. 27:1473\u20131476."},{"key":"i1543-2165-128-5-581-b15","series-title":"Acta Cytol","first-page":"359","article-title":"Fine needle aspiration cytology and immunocytochemistry of large cell lymphoma expressing the Ki-1 antigen.","volume":"33","author":"Tani, E. M.","year":"1989","unstructured":"Tani, E. M., T.Lowhagen, and K.Nasiell. et al. Fine needle aspiration cytology and immunocytochemistry of large cell lymphoma expressing the Ki-1 antigen.Acta Cytol1989. 33:359\u2013362."},{"key":"i1543-2165-128-5-581-b16","series-title":"Blood","first-page":"3517","article-title":"Transcripts of the npm-alk fusion gene in anaplastic large cell lymphoma, Hodgkin's lymphoma, and reactive lymphoid lesions.","volume":"86","author":"Elmberger, P. G.","year":"1995","unstructured":"Elmberger, P. G., M. D.Loeano, and D. D.Weisenburger. et al. 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M., C. M.Nichols, D. M.Walling, and M. J.Hicks. Plasmablastic lymphoma: an HIV-associated entity with primary oral manifestations.Oral Oncol2002. 38:96\u2013102."},{"key":"i1543-2165-128-5-581-b4","series-title":"Br J Haematol","first-page":"622","article-title":"Molecular histogenesis of plasmablastic lymphoma of the oral cavity.","volume":"119","author":"Gaidano, G.","year":"2002","unstructured":"Gaidano, G., M.Cerri, and D.Capello. et al. Molecular histogenesis of plasmablastic lymphoma of the oral cavity.Br J Haematol2002. 119:622\u2013628."},{"key":"i1543-2165-128-5-581-b5","series-title":"Clin Oncol","first-page":"327","article-title":"Plasmablastic lymphoma: a new subcategory of human immunodeficiency virus\u2013related non- Hodgkin's lymphoma.","volume":"10","author":"Brown, R. S.","year":"1998","unstructured":"Brown, R. S., C.Campbell, S. C.Lishman, M. F.Spittle, and R. F.Miller. 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A case of a diffuse large B- cell lymphoma of plasmablastic type associated with the t(2;5)(p23;q35) chromosomal translocation.Am J Surg Pathol2003. 27:1473\u20131476."},{"key":"i1543-2165-128-5-581-b15","series-title":"Acta Cytol","first-page":"359","article-title":"Fine needle aspiration cytology and immunocytochemistry of large cell lymphoma expressing the Ki-1 antigen.","volume":"33","author":"Tani, E. M.","year":"1989","unstructured":"Tani, E. M., T.Lowhagen, and K.Nasiell. et al. Fine needle aspiration cytology and immunocytochemistry of large cell lymphoma expressing the Ki-1 antigen.Acta Cytol1989. 33:359\u2013362."},{"key":"i1543-2165-128-5-581-b16","series-title":"Blood","first-page":"3517","article-title":"Transcripts of the npm-alk fusion gene in anaplastic large cell lymphoma, Hodgkin's lymphoma, and reactive lymphoid lesions.","volume":"86","author":"Elmberger, P. G.","year":"1995","unstructured":"Elmberger, P. G., M. D.Loeano, and D. D.Weisenburger. et al. 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