{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T11:33:03Z","timestamp":1775043183008,"version":"3.50.1"},"reference-count":22,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We describe an unusual case of metastatic disease to the thyroid, characterized by massive intra-arterial embolization and clinical presentation as acute thyroiditis. The patient, a 37-year-old woman with a history of breast carcinoma, presented clinically with acute thyroiditis. No nodules were palpable, and fine-needle aspiration cytology of the left lobe was performed. It showed a pleomorphic carcinoma and was followed by total thyroidectomy. Histology disclosed a pleomorphic carcinoma diffusely affecting the thyroid gland. It was characterized by an extensive intra-arterial tumoral embolization. Immunohistochemistry confirmed the metastatic nature of the neoplasm. This is a very uncommon form of metastatic disease to the thyroid. The ischemia and necrosis associated with the embolic process were most probably responsible for this clinical presentation. This atypical clinical and cytologic presentation may induce confusion with a primary neoplasm, mainly anaplastic thyroid carcinoma.<\/jats:p>","DOI":"10.5858\/2004-128-804-mttefa","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T17:41:15Z","timestamp":1612978875000},"page":"804-806","source":"Crossref","is-referenced-by-count":10,"title":["Massive Thyroid Tumoral Embolism From a Breast Carcinoma Presenting as Acute Thyroiditis"],"prefix":"10.5858","volume":"128","author":[{"given":"Jose A.","family":"Jim\u00e9nez-Heffernan","sequence":"first","affiliation":[{"name":"From the Department of Pathology, Hospital La Zarzuela, Madrid, Spain (Drs Jim\u00e9nez-Heffernan, Perez, and Perna); Department of Oncology, Hospital La Luz, Madrid, Spain (Dr Hornedo); and Department of Surgery, Hospital Montepr\u00edncipe, Madrid, Spain (Dr Lapuente)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Perez","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Hospital La Zarzuela, Madrid, Spain (Drs Jim\u00e9nez-Heffernan, Perez, and Perna); Department of Oncology, Hospital La Luz, Madrid, Spain (Dr Hornedo); and Department of Surgery, Hospital Montepr\u00edncipe, Madrid, Spain (Dr Lapuente)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Hornedo","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Hospital La Zarzuela, Madrid, Spain (Drs Jim\u00e9nez-Heffernan, Perez, and Perna); Department of Oncology, Hospital La Luz, Madrid, Spain (Dr Hornedo); and Department of Surgery, Hospital Montepr\u00edncipe, Madrid, Spain (Dr Lapuente)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian","family":"Perna","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Hospital La Zarzuela, Madrid, Spain (Drs Jim\u00e9nez-Heffernan, Perez, and Perna); Department of Oncology, Hospital La Luz, Madrid, Spain (Dr Hornedo); and Department of Surgery, Hospital Montepr\u00edncipe, Madrid, Spain (Dr Lapuente)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Lapuente","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Hospital La Zarzuela, Madrid, Spain (Drs Jim\u00e9nez-Heffernan, Perez, and Perna); Department of Oncology, Hospital La Luz, Madrid, Spain (Dr Hornedo); and Department of Surgery, Hospital Montepr\u00edncipe, Madrid, Spain (Dr Lapuente)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"key":"i1543-2165-128-7-804-b1","article-title":"Tumors of the Lower Respiratory Tract.","author":"Colby, T. V.","unstructured":"Colby, T. V., M. N.Koss, and W. D.Travis. Tumors of the Lower Respiratory Tract.Washington, DC: Armed Forces Institute of Pathology; 1995:526\u2013530. Atlas of Tumor Pathology; 3rd series, fascicle 13."},{"key":"i1543-2165-128-7-804-b2","series-title":"Am J Surg","first-page":"519","article-title":"Clinical and pathologic correlations in disease metastatic to the thyroid gland.","volume":"150","author":"McCabe, D. P.","year":"1985","unstructured":"McCabe, D. P., W. B.Farrar, T. M.Petkov, W.Finkelmeier, P.O'Dwyer, and A.James. Clinical and pathologic correlations in disease metastatic to the thyroid gland.Am J Surg1985. 150:519\u2013523."},{"key":"i1543-2165-128-7-804-b3","series-title":"Cancer","first-page":"574","article-title":"Metastasis to the thyroid gland: a report of 43 cases.","volume":"79","author":"Nakhjavani, M. K.","year":"1997","unstructured":"Nakhjavani, M. K., H.Gharib, J. R.Goellner, and J. A.van Heerden. Metastasis to the thyroid gland: a report of 43 cases.Cancer1997. 79:574\u2013578."},{"key":"i1543-2165-128-7-804-b4","series-title":"Arch Pathol Lab Med","first-page":"37","article-title":"Metastatic tumors of the thyroid gland: a study of 79 cases in Chinese patients.","volume":"122","author":"Lam, K. Y.","year":"1998","unstructured":"Lam, K. Y. and C. Y.Lo. Metastatic tumors of the thyroid gland: a study of 79 cases in Chinese patients.Arch Pathol Lab Med1998. 122:37\u201341."},{"key":"i1543-2165-128-7-804-b5","series-title":"Mayo Clin Proc","first-page":"399","article-title":"Thyroiditis mimicked by metastatic carcinoma to the thyroid.","volume":"61","author":"Tibaldi, J. M.","year":"1986","unstructured":"Tibaldi, J. M., L. E.Shapiro, and P. S.Mahadevia. Thyroiditis mimicked by metastatic carcinoma to the thyroid.Mayo Clin Proc1986. 61:399\u2013400."},{"key":"i1543-2165-128-7-804-b6","series-title":"Tumori","first-page":"783","article-title":"Thyroid metastases from a ductal carcinoma of the breast: a case report.","volume":"83","author":"Ferrara, G.","year":"1997","unstructured":"Ferrara, G., G. P.Ianniello, and O.Nappi. Thyroid metastases from a ductal carcinoma of the breast: a case report.Tumori1997. 83:783\u2013787."},{"key":"i1543-2165-128-7-804-b7","series-title":"Thyroid","first-page":"1029","article-title":"Destructive thyroiditis secondary to a metastasis.","volume":"12","author":"Lo, C. Y.","year":"2002","unstructured":"Lo, C. Y. and K. Y.Lam. Destructive thyroiditis secondary to a metastasis.Thyroid2002. 12:1029."},{"key":"i1543-2165-128-7-804-b8","series-title":"Arch Intern Med","first-page":"311","article-title":"Fine-needle aspiration: usefulness for diagnosis and management of metastatic carcinoma of the thyroid.","volume":"147","author":"Smith, S. A.","year":"1987","unstructured":"Smith, S. A., H.Gharib, and J. R.Goellner. Fine-needle aspiration: usefulness for diagnosis and management of metastatic carcinoma of the thyroid.Arch Intern Med1987. 147:311\u2013312."},{"key":"i1543-2165-128-7-804-b9","series-title":"Diagn Cytopathol","first-page":"209","article-title":"Metastases to the thyroid gland: diagnosis by aspiration cytology.","volume":"13","author":"Michelow, P. M.","year":"1995","unstructured":"Michelow, P. M. and G.Leiman. Metastases to the thyroid gland: diagnosis by aspiration cytology.Diagn Cytopathol1995. 13:209\u2013213."},{"key":"i1543-2165-128-7-804-b10","series-title":"Acta Cytol","first-page":"687","article-title":"Cytomorphologic aspects of thyroiditis: a study of 541 cases with functional, immunologic and ultrasonographic data.","volume":"31","author":"Jayaram, G.","year":"1987","unstructured":"Jayaram, G., R.Marsaha, and R.Gupta. Cytomorphologic aspects of thyroiditis: a study of 541 cases with functional, immunologic and ultrasonographic data.Acta Cytol1987. 31:687\u2013693."},{"key":"i1543-2165-128-7-804-b11","article-title":"Modern Cytopathology.","author":"Geisinger, K. R.","unstructured":"Geisinger, K. R., M. W.Stanley, S. S.Raab, J. F.Silverman, and A.Abati. eds. Modern Cytopathology.Philadelphia, Pa: Churchill Livingstone; 2004:740\u2013746."},{"key":"i1543-2165-128-7-804-b1","article-title":"Tumors of the Lower Respiratory Tract.","author":"Colby, T. V.","unstructured":"Colby, T. 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