{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:45:34Z","timestamp":1786365934408,"version":"build-2736575974"},"reference-count":34,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A 62-year-old African American woman presented with weight loss and dyspepsia. She did not have any clinical evidence of immunodeficiency. Upper gastrointestinal endoscopy revealed multiple small polypoid lesions in the gastric body and fundus that appeared larger and more erythematous than usual fundic gland polyps. Examination of biopsy specimens revealed an infiltrate of large histiocytes with eosinophilic granular cytoplasm located in the lamina propria and containing Michaelis-Gutmann bodies. These histologic findings were diagnostic of gastric malakoplakia. Gastrointestinal malakoplakia is uncommon, and exclusive gastric involvement is extremely rare. Because occult bacterial infection has been postulated as the underlying cause of malakoplakia, the presence of\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    infection was investigated using immunohistochemical and serologic techniques, and the presence of\n                    <jats:italic>Yersinia enterocolitica<\/jats:italic>\n                    or\n                    <jats:italic>Yersinia pseudotuberculosis<\/jats:italic>\n                    infection was investigated by polymerase chain reaction assay. There was no evidence of\n                    <jats:italic>H pylori<\/jats:italic>\n                    ,\n                    <jats:italic>Y enterocolitica<\/jats:italic>\n                    , or\n                    <jats:italic>Y pseudotuberculosis<\/jats:italic>\n                    in these biopsy specimens, and there was no evidence of malakoplakia or concurrent malignancy at any other site. Follow-up examination 12 months later revealed no endoscopic or histologic improvement.\n                  <\/jats:p>","DOI":"10.5858\/2004-128-e153-igmacr","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T15:17:29Z","timestamp":1612970249000},"page":"e153-e156","source":"Crossref","is-referenced-by-count":18,"title":["Isolated Gastric Malakoplakia: A Case Report and Review of the Literature"],"prefix":"10.5858","volume":"128","author":[{"given":"Lastra-Camacho","family":"Gustavo","sequence":"first","affiliation":[{"name":"From the Departments of Pathology (Drs Gustavo, Robert, and Jain) and Internal Medicine, Section of Digestive Diseases (Dr Lagarde), Yale University School of Medicine, New Haven, Conn; and the Department of Pathology, University of Arkansas Medical Science Center, Little Rock (Ms Lamps). Dr Gustavo is now with the Department of Pathology, Mexico City General Hospital, Mexico DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie E.","family":"Robert","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Gustavo, Robert, and Jain) and Internal Medicine, Section of Digestive Diseases (Dr Lagarde), Yale University School of Medicine, New Haven, Conn; and the Department of Pathology, University of Arkansas Medical Science Center, Little Rock (Ms Lamps). Dr Gustavo is now with the Department of Pathology, Mexico City General Hospital, Mexico DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura W.","family":"Lamps","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Gustavo, Robert, and Jain) and Internal Medicine, Section of Digestive Diseases (Dr Lagarde), Yale University School of Medicine, New Haven, Conn; and the Department of Pathology, University of Arkansas Medical Science Center, Little Rock (Ms Lamps). Dr Gustavo is now with the Department of Pathology, Mexico City General Hospital, Mexico DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne P.","family":"Lagarde","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Gustavo, Robert, and Jain) and Internal Medicine, Section of Digestive Diseases (Dr Lagarde), Yale University School of Medicine, New Haven, Conn; and the Department of Pathology, University of Arkansas Medical Science Center, Little Rock (Ms Lamps). Dr Gustavo is now with the Department of Pathology, Mexico City General Hospital, Mexico DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhanpat","family":"Jain","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Gustavo, Robert, and Jain) and Internal Medicine, Section of Digestive Diseases (Dr Lagarde), Yale University School of Medicine, New Haven, Conn; and the Department of Pathology, University of Arkansas Medical Science Center, Little Rock (Ms Lamps). Dr Gustavo is now with the Department of Pathology, Mexico City General Hospital, Mexico DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3906","reference":[{"key":"i1543-2165-128-11-e153-b1","series-title":"Am J Gastroenterol","first-page":"356","article-title":"Gastrointestinal malakoplakia: report of a case and a review of the literature.","volume":"62","author":"Sanusi, I. D.","year":"1974","unstructured":"Sanusi, I. D. and F. O.Tio. Gastrointestinal malakoplakia: report of a case and a review of the literature.Am J Gastroenterol1974. 62:356\u2013366."},{"key":"i1543-2165-128-11-e153-b2","series-title":"Postgrad Med J","first-page":"95","article-title":"Malakoplakia of the gastrointestinal tract.","volume":"57","author":"McClure, J.","year":"1981","unstructured":"McClure, J.\n          \n          Malakoplakia of the gastrointestinal tract.\n          Postgrad Med J\n          1981. 57:95\u2013103."},{"key":"i1543-2165-128-11-e153-b3","series-title":"Arch Pathol","first-page":"180","article-title":"Malacoplakia: discussion of pathogenesis and report of three cases including one of fatal gastric and colonic involvement.","volume":"83","author":"Yunis, E. J.","year":"1967","unstructured":"Yunis, E. J., J. M.Estevez, and G. J.Pinzon. et al. Malacoplakia: discussion of pathogenesis and report of three cases including one of fatal gastric and colonic involvement.Arch Pathol1967. 83:180\u2013187."},{"key":"i1543-2165-128-11-e153-b4","series-title":"Am J Med","first-page":"74","article-title":"Functional and morphological monocyte abnormalities in a patient with malakoplakia.","volume":"105","author":"van Crevel, R.","year":"1998","unstructured":"van Crevel, R., J.Curfs, A. J.van der Ven, K.Assmann, J. F.Meis, and J. W.van der Meer. Functional and morphological monocyte abnormalities in a patient with malakoplakia.Am J Med1998. 105:74\u201377."},{"key":"i1543-2165-128-11-e153-b5","series-title":"Am J Surg Pathol","first-page":"508","article-title":"The role of Yersinia enterocolitica and Yersinia pseudotuberculosis in granulomatous appendicitis: a histologic and molecular study.","volume":"25","author":"Lamps, L. W.","year":"2001","unstructured":"Lamps, L. W., K. T.Madhusudhan, and J. K.Greenson. et al. The role of Yersinia enterocolitica and Yersinia pseudotuberculosis in granulomatous appendicitis: a histologic and molecular study.Am J Surg Pathol2001. 25:508\u2013515."},{"key":"i1543-2165-128-11-e153-b6","series-title":"Arch Anat Pathol","first-page":"199","article-title":"La malacoplaise: formes anatomo-cliniques, revue de la litt\u00e9rature, \u00e0 propos de 15 observations personelles.","volume":"23","author":"Scheiner, C.","year":"1975","unstructured":"Scheiner, C., A. M.Dor, and D.Basbous. et al. La malacoplaise: formes anatomo-cliniques, revue de la litt\u00e9rature, \u00e0 propos de 15 observations personelles.Arch Anat Pathol1975. 23:199\u2013208."},{"key":"i1543-2165-128-11-e153-b7","series-title":"Arch Pathol Lab Med","first-page":"136","article-title":"Malakoplakia of the stomach: report of a case and review of the literature.","volume":"102","author":"Nakabayashi, H.","year":"1978","unstructured":"Nakabayashi, H., T.Ito, K.Izutsu, R.Yatani, and K.Ishida. Malakoplakia of the stomach: report of a case and review of the literature.Arch Pathol Lab Med1978. 102:136\u2013139."},{"key":"i1543-2165-128-11-e153-b8","series-title":"Rev Clin Esp","first-page":"415","article-title":"Malakoplakia gastrointestinal: revisi\u00f3n a prop\u00f3sito de un caso.","volume":"148","author":"Boixeda, D.","year":"1978","unstructured":"Boixeda, D., F.Hernandez Ranz, and V.Moreira. Malakoplakia gastrointestinal: revisi\u00f3n a prop\u00f3sito de un caso.Rev Clin Esp1978. 148:415."},{"key":"i1543-2165-128-11-e153-b9","series-title":"Pathology","first-page":"280","article-title":"Malakoplakia and tuberculosis.","volume":"31","author":"Govender, D.","year":"1999","unstructured":"Govender, D. and A. S.Essa. Malakoplakia and tuberculosis.Pathology1999. 31:280\u2013283."},{"key":"i1543-2165-128-11-e153-b10","series-title":"Clin Infect Dis","first-page":"142","article-title":"Identification of Shigella boydii in colonic malacoplakia by universal bacterial 16S ribosomal DNA\u2013based amplification in a human immunodeficiency virus\u2013infected patient.","volume":"28","author":"Raguin, G.","year":"1999","unstructured":"Raguin, G., J.Nemeth, and M.Wassef. et al. Identification of Shigella boydii in colonic malacoplakia by universal bacterial 16S ribosomal DNA\u2013based amplification in a human immunodeficiency virus\u2013infected patient.Clin Infect Dis1999. 28:142\u2013143."},{"key":"i1543-2165-128-11-e153-b11","series-title":"Arch Pathol Lab Med","first-page":"1828","article-title":"Malakoplakia of the appendix: an unusual association with eggs of Taenia species.","volume":"124","author":"Jain, M.","year":"2000","unstructured":"Jain, M., V. K.Arora, N.Singh, and A.Bhatia. Malakoplakia of the appendix: an unusual association with eggs of Taenia species.Arch Pathol Lab Med2000. 124:1828\u20131829."},{"key":"i1543-2165-128-11-e153-b12","series-title":"Histopathology","first-page":"79","article-title":"Intestinal malakoplakia associated with paracoccidiodomycosis: a new association.","volume":"30","author":"Rocha, N.","year":"1997","unstructured":"Rocha, N., E. H.Suguiama, D.Maia, H.Costa, K. I.Coelho, and M.Franco. Intestinal malakoplakia associated with paracoccidiodomycosis: a new association.Histopathology1997. 30:79\u201383."},{"key":"i1543-2165-128-11-e153-b13","series-title":"Clin Infect Dis","first-page":"1334","article-title":"Pulmonary malacoplakia associated with Rhodococcus equi infection in patients with AIDS: case report and review.","volume":"28","author":"Guerrero, M. F.","year":"1999","unstructured":"Guerrero, M. F., J. M.Ramos, G.Renedo, I.Gadea, and A.Alix. Pulmonary malacoplakia associated with Rhodococcus equi infection in patients with AIDS: case report and review.Clin Infect Dis1999. 28:1334\u20131336."},{"key":"i1543-2165-128-11-e153-b14","series-title":"Mod Pathol","first-page":"1200A","article-title":"Pathogenetic Yersenia enterocolitica DNA is detected in gastrointestinal malokoplakia.","volume":"16","author":"Havens, J. M.","year":"2003","unstructured":"Havens, J. M., E.Motogomery, J. K.Greenson, M. A.Scott, and L. W.Lamps. Pathogenetic Yersenia enterocolitica DNA is detected in gastrointestinal malokoplakia.Mod Pathol2003. 16:1200A."},{"key":"i1543-2165-128-11-e153-b15","series-title":"Gastroenterology","first-page":"28","article-title":"Malacoplakia: an electron-microscopic study: demostration of bacilliform organisms in malacoplakic macrophages.","volume":"66","author":"Lewin, K. J.","year":"1974","unstructured":"Lewin, K. J., G. S.Harell, A. S.Lee, and L. G.Crowley. Malacoplakia: an electron-microscopic study: demostration of bacilliform organisms in malacoplakic macrophages.Gastroenterology1974. 66:28\u201345."},{"key":"i1543-2165-128-11-e153-b16","series-title":"J Pathol","first-page":"13","article-title":"The ultrastructural features of malakoplakia.","volume":"134","author":"McClure, J.","year":"1981","unstructured":"McClure, J., C. H. S.Cameron, and R.Garret. The ultrastructural features of malakoplakia.J Pathol1981. 134:13\u201325."},{"key":"i1543-2165-128-11-e153-b17","series-title":"Transplantation","first-page":"109","article-title":"Malakoplakia: evidence for an acquired disease secondary to immunosupression.","volume":"31","author":"Biggar, W. D.","year":"1981","unstructured":"Biggar, W. D., A.Keating, and R.Bear. Malakoplakia: evidence for an acquired disease secondary to immunosupression.Transplantation1981. 31:109\u2013112."},{"key":"i1543-2165-128-11-e153-b1","series-title":"Am J Gastroenterol","first-page":"356","article-title":"Gastrointestinal malakoplakia: report of a case and a review of the literature.","volume":"62","author":"Sanusi, I. D.","year":"1974","unstructured":"Sanusi, I. D. and F. O.Tio. Gastrointestinal malakoplakia: report of a case and a review of the literature.Am J Gastroenterol1974. 62:356\u2013366."},{"key":"i1543-2165-128-11-e153-b2","series-title":"Postgrad Med J","first-page":"95","article-title":"Malakoplakia of the gastrointestinal tract.","volume":"57","author":"McClure, J.","year":"1981","unstructured":"McClure, J.\n          \n          Malakoplakia of the gastrointestinal tract.\n          Postgrad Med J\n          1981. 57:95\u2013103."},{"key":"i1543-2165-128-11-e153-b3","series-title":"Arch Pathol","first-page":"180","article-title":"Malacoplakia: discussion of pathogenesis and report of three cases including one of fatal gastric and colonic involvement.","volume":"83","author":"Yunis, E. J.","year":"1967","unstructured":"Yunis, E. J., J. M.Estevez, and G. J.Pinzon. et al. Malacoplakia: discussion of pathogenesis and report of three cases including one of fatal gastric and colonic involvement.Arch Pathol1967. 83:180\u2013187."},{"key":"i1543-2165-128-11-e153-b4","series-title":"Am J Med","first-page":"74","article-title":"Functional and morphological monocyte abnormalities in a patient with malakoplakia.","volume":"105","author":"van Crevel, R.","year":"1998","unstructured":"van Crevel, R., J.Curfs, A. J.van der Ven, K.Assmann, J. F.Meis, and J. W.van der Meer. Functional and morphological monocyte abnormalities in a patient with malakoplakia.Am J Med1998. 105:74\u201377."},{"key":"i1543-2165-128-11-e153-b5","series-title":"Am J Surg Pathol","first-page":"508","article-title":"The role of Yersinia enterocolitica and Yersinia pseudotuberculosis in granulomatous appendicitis: a histologic and molecular study.","volume":"25","author":"Lamps, L. W.","year":"2001","unstructured":"Lamps, L. W., K. T.Madhusudhan, and J. K.Greenson. et al. The role of Yersinia enterocolitica and Yersinia pseudotuberculosis in granulomatous appendicitis: a histologic and molecular study.Am J Surg Pathol2001. 25:508\u2013515."},{"key":"i1543-2165-128-11-e153-b6","series-title":"Arch Anat Pathol","first-page":"199","article-title":"La malacoplaise: formes anatomo-cliniques, revue de la litt\u00e9rature, \u00e0 propos de 15 observations personelles.","volume":"23","author":"Scheiner, C.","year":"1975","unstructured":"Scheiner, C., A. M.Dor, and D.Basbous. et al. La malacoplaise: formes anatomo-cliniques, revue de la litt\u00e9rature, \u00e0 propos de 15 observations personelles.Arch Anat Pathol1975. 23:199\u2013208."},{"key":"i1543-2165-128-11-e153-b7","series-title":"Arch Pathol Lab Med","first-page":"136","article-title":"Malakoplakia of the stomach: report of a case and review of the literature.","volume":"102","author":"Nakabayashi, H.","year":"1978","unstructured":"Nakabayashi, H., T.Ito, K.Izutsu, R.Yatani, and K.Ishida. Malakoplakia of the stomach: report of a case and review of the literature.Arch Pathol Lab Med1978. 102:136\u2013139."},{"key":"i1543-2165-128-11-e153-b8","series-title":"Rev Clin Esp","first-page":"415","article-title":"Malakoplakia gastrointestinal: revisi\u00f3n a prop\u00f3sito de un caso.","volume":"148","author":"Boixeda, D.","year":"1978","unstructured":"Boixeda, D., F.Hernandez Ranz, and V.Moreira. Malakoplakia gastrointestinal: revisi\u00f3n a prop\u00f3sito de un caso.Rev Clin Esp1978. 148:415."},{"key":"i1543-2165-128-11-e153-b9","series-title":"Pathology","first-page":"280","article-title":"Malakoplakia and tuberculosis.","volume":"31","author":"Govender, D.","year":"1999","unstructured":"Govender, D. and A. S.Essa. Malakoplakia and tuberculosis.Pathology1999. 31:280\u2013283."},{"key":"i1543-2165-128-11-e153-b10","series-title":"Clin Infect Dis","first-page":"142","article-title":"Identification of Shigella boydii in colonic malacoplakia by universal bacterial 16S ribosomal DNA\u2013based amplification in a human immunodeficiency virus\u2013infected patient.","volume":"28","author":"Raguin, G.","year":"1999","unstructured":"Raguin, G., J.Nemeth, and M.Wassef. et al. Identification of Shigella boydii in colonic malacoplakia by universal bacterial 16S ribosomal DNA\u2013based amplification in a human immunodeficiency virus\u2013infected patient.Clin Infect Dis1999. 28:142\u2013143."},{"key":"i1543-2165-128-11-e153-b11","series-title":"Arch Pathol Lab Med","first-page":"1828","article-title":"Malakoplakia of the appendix: an unusual association with eggs of Taenia species.","volume":"124","author":"Jain, M.","year":"2000","unstructured":"Jain, M., V. K.Arora, N.Singh, and A.Bhatia. Malakoplakia of the appendix: an unusual association with eggs of Taenia species.Arch Pathol Lab Med2000. 124:1828\u20131829."},{"key":"i1543-2165-128-11-e153-b12","series-title":"Histopathology","first-page":"79","article-title":"Intestinal malakoplakia associated with paracoccidiodomycosis: a new association.","volume":"30","author":"Rocha, N.","year":"1997","unstructured":"Rocha, N., E. H.Suguiama, D.Maia, H.Costa, K. I.Coelho, and M.Franco. Intestinal malakoplakia associated with paracoccidiodomycosis: a new association.Histopathology1997. 30:79\u201383."},{"key":"i1543-2165-128-11-e153-b13","series-title":"Clin Infect Dis","first-page":"1334","article-title":"Pulmonary malacoplakia associated with Rhodococcus equi infection in patients with AIDS: case report and review.","volume":"28","author":"Guerrero, M. F.","year":"1999","unstructured":"Guerrero, M. F., J. M.Ramos, G.Renedo, I.Gadea, and A.Alix. Pulmonary malacoplakia associated with Rhodococcus equi infection in patients with AIDS: case report and review.Clin Infect Dis1999. 28:1334\u20131336."},{"key":"i1543-2165-128-11-e153-b14","series-title":"Mod Pathol","first-page":"1200A","article-title":"Pathogenetic Yersenia enterocolitica DNA is detected in gastrointestinal malokoplakia.","volume":"16","author":"Havens, J. M.","year":"2003","unstructured":"Havens, J. M., E.Motogomery, J. K.Greenson, M. A.Scott, and L. W.Lamps. Pathogenetic Yersenia enterocolitica DNA is detected in gastrointestinal malokoplakia.Mod Pathol2003. 16:1200A."},{"key":"i1543-2165-128-11-e153-b15","series-title":"Gastroenterology","first-page":"28","article-title":"Malacoplakia: an electron-microscopic study: demostration of bacilliform organisms in malacoplakic macrophages.","volume":"66","author":"Lewin, K. J.","year":"1974","unstructured":"Lewin, K. J., G. S.Harell, A. S.Lee, and L. G.Crowley. Malacoplakia: an electron-microscopic study: demostration of bacilliform organisms in malacoplakic macrophages.Gastroenterology1974. 66:28\u201345."},{"key":"i1543-2165-128-11-e153-b16","series-title":"J Pathol","first-page":"13","article-title":"The ultrastructural features of malakoplakia.","volume":"134","author":"McClure, J.","year":"1981","unstructured":"McClure, J., C. H. S.Cameron, and R.Garret. The ultrastructural features of malakoplakia.J Pathol1981. 134:13\u201325."},{"key":"i1543-2165-128-11-e153-b17","series-title":"Transplantation","first-page":"109","article-title":"Malakoplakia: evidence for an acquired disease secondary to immunosupression.","volume":"31","author":"Biggar, W. D.","year":"1981","unstructured":"Biggar, W. D., A.Keating, and R.Bear. Malakoplakia: evidence for an acquired disease secondary to immunosupression.Transplantation1981. 31:109\u2013112."}],"container-title":["Archives of Pathology &amp; Laboratory Medicine"],"original-title":[],"link":[{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/128\/11\/article-pe153.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/128\/11\/e153\/2753239\/1543-2165(2004)128_e153_igmacr_2_0_co_2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/128\/11\/article-pe153.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/128\/11\/article-pe153.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T01:09:28Z","timestamp":1770772168000},"score":1,"resource":{"primary":{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/128\/11\/article-pe153.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":34,"journal-issue":{"issue":"11"},"URL":"https:\/\/doi.org\/10.5858\/2004-128-e153-igmacr","relation":{},"ISSN":["1543-2165","0003-9985"],"issn-type":[{"value":"1543-2165","type":"electronic"},{"value":"0003-9985","type":"print"}],"subject":[],"published":{"date-parts":[[2004,11]]}}}