{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T19:56:35Z","timestamp":1764791795764,"version":"3.46.0"},"reference-count":39,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Context.\u2014The behavior of adrenocortical tumors (ACTs) is usually difficult to establish in childhood, and the role of immunomarkers in predicting outcome has not yet been elucidated.<\/jats:p>\n                  <jats:p>Objective.\u2014To investigate the relationship between clinical, pathologic, and immunohistochemical findings and prognosis in a series of children with ACTs.<\/jats:p>\n                  <jats:p>Patients and Methods.\u2014Clinical data were evaluated retrospectively in 33 children with ACTs, including age at diagnosis, sex, time between first symptoms and diagnosis, clinical signs and symptoms, tumor position, and follow-up. Histologic sections were reviewed, each tumor was classified, and staging was performed according to previously published criteria. Immunohistochemical analysis of p53, Ki-67, c-Erb-B2, and Bcl-2 was performed according to previously published techniques.<\/jats:p>\n                  <jats:p>Results.\u2014Sixty-four percent (n = 21) of the patients were female, and the age at diagnosis in the cohort ranged from 2 to 96 months. Virilization alone affected 70% (n = 23) of the patients, and 18 patients had stage 1 disease, 9 had stage 2 disease, and 3 each had stage 3 and stage 4 disease. Female sex and stage 1 and stage 2 disease were associated with good outcome. None of the histopathologic criteria evaluated correctly predicted outcome. Only tumors with a volume exceeding 200 mL were associated with malignant behavior. Because only a small number of tumors expressed the antigens, results of these immunohistochemical tests were considered inconclusive.<\/jats:p>\n                  <jats:p>Conclusion.\u2014In this sample of pediatric ACTs, the clinical and surgical parameters are the most important prognostic factors, while the immunohistochemical markers evaluated were not predictive of outcome.<\/jats:p>","DOI":"10.5858\/2005-129-1127-atibci","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T19:50:08Z","timestamp":1612986608000},"page":"1127-1131","source":"Crossref","is-referenced-by-count":34,"title":["Adrenocortical Tumors in Brazilian Children: Immunohistochemical Markers and Prognostic Factors"],"prefix":"10.5858","volume":"129","author":[{"given":"Lourenco","family":"Sbragia","sequence":"first","affiliation":[{"name":"From the Division of Pediatric Surgery, Department of Surgery (Drs Sbragia, Oliveira-Filho, and Bustorff-Silva), Department of Pathology (Dr Vassallo and Mr Pinto), and Pediatric Endocrinology, Department of Pediatrics (Dr Guerra-Junior), School of Medical Sciences, State University of Campinas, UNICAMP, Campinas, Sao Paulo, Brazil; and Department of Surgery, Boldrini Children's Cancer Center (Dr"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Goncalves","family":"Oliveira-Filho","sequence":"additional","affiliation":[{"name":"From the Division of Pediatric Surgery, Department of Surgery (Drs Sbragia, Oliveira-Filho, and Bustorff-Silva), Department of Pathology (Dr Vassallo and Mr Pinto), and Pediatric Endocrinology, Department of Pediatrics (Dr Guerra-Junior), School of Medical Sciences, State University of Campinas, UNICAMP, Campinas, Sao Paulo, Brazil; and Department of Surgery, Boldrini Children's Cancer Center (Dr"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Vassallo","sequence":"additional","affiliation":[{"name":"From the Division of Pediatric Surgery, Department of Surgery (Drs Sbragia, Oliveira-Filho, and Bustorff-Silva), Department of Pathology (Dr Vassallo and Mr Pinto), and Pediatric Endocrinology, Department of Pediatrics (Dr Guerra-Junior), School of Medical Sciences, State University of Campinas, UNICAMP, Campinas, Sao Paulo, Brazil; and Department of Surgery, Boldrini Children's Cancer Center (Dr"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glauce Aparecida","family":"Pinto","sequence":"additional","affiliation":[{"name":"From the Division of Pediatric Surgery, Department of Surgery (Drs Sbragia, Oliveira-Filho, and Bustorff-Silva), Department of Pathology (Dr Vassallo and Mr Pinto), and Pediatric Endocrinology, Department of Pediatrics (Dr Guerra-Junior), School of Medical Sciences, State University of Campinas, UNICAMP, Campinas, Sao Paulo, Brazil; and Department of Surgery, Boldrini Children's Cancer Center (Dr"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gil","family":"Guerra-Junior","sequence":"additional","affiliation":[{"name":"From the Division of Pediatric Surgery, Department of Surgery (Drs Sbragia, Oliveira-Filho, and Bustorff-Silva), Department of Pathology (Dr Vassallo and Mr Pinto), and Pediatric Endocrinology, Department of Pediatrics (Dr Guerra-Junior), School of Medical Sciences, State University of Campinas, UNICAMP, Campinas, Sao Paulo, Brazil; and Department of Surgery, Boldrini Children's Cancer Center (Dr"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaquim","family":"Bustorff-Silva","sequence":"additional","affiliation":[{"name":"From the Division of Pediatric Surgery, Department of Surgery (Drs Sbragia, Oliveira-Filho, and Bustorff-Silva), Department of Pathology (Dr Vassallo and Mr Pinto), and Pediatric Endocrinology, Department of Pediatrics (Dr Guerra-Junior), School of Medical Sciences, State University of Campinas, UNICAMP, 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