{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:17:16Z","timestamp":1770823036430,"version":"3.50.1"},"reference-count":30,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Natural killer cell and cytotoxic T-cell lymphomas are frequently difficult to distinguish because they share many common features, and yet it is important to make an accurate diagnosis because their prognoses differ. We report an unusual case of a white man with a CD56-positive T-cell lymphoma in the ileum. The histologic pattern was characterized by angioinvasion and angiodestruction. Immunohistochemical staining showed positive reactions to CD3, CD8, CD43, CD45RO, CD56, and T-cell intracellular antigen-1, but negative reactions to CD4, CD5, CD20, CD23, and CD57. Epstein-Barr virus (EBV) was not detected by EBV\u2013latent membrane protein staining and EBV polymerase chain reaction technique. The T-cell receptor \u03b3 chain gene was rearranged. According to the World Health Organization classification, the absence of EBV excludes the diagnosis of extranodal natural killer\/T-cell lymphoma, nasal type. However, the association of EBV with this lymphoma in white patients is not clear. Therefore, absence of EBV alone does not necessarily exclude nasal-type natural killer\/T-cell lymphoma, particularly because the histologic pattern in this case is highly characteristic of this tumor.<\/jats:p>","DOI":"10.5858\/2005-129-527-aucopt","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T19:16:10Z","timestamp":1612984570000},"page":"527-530","source":"Crossref","is-referenced-by-count":1,"title":["An Unusual Case of Peripheral T-Cell Lymphoma With CD56 Positivity and Angiocentric, Angiodestructive Morphology Arising in the Ileum"],"prefix":"10.5858","volume":"129","author":[{"given":"Matthew C.","family":"Frank","sequence":"first","affiliation":[{"name":"From the Departments of Pathology (Drs Frank and Sun) and Medicine (Dr Bono), University of Colorado Health Sciences Center, Denver; and the Department of Pathology, Veterans Affairs Medical Center, Denver, Colo (Dr Sun)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Bono","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Frank and Sun) and Medicine (Dr Bono), University of Colorado Health Sciences Center, Denver; and the Department of Pathology, Veterans Affairs Medical Center, Denver, Colo (Dr Sun)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsieh","family":"Sun","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Frank and Sun) and Medicine (Dr Bono), University of Colorado Health Sciences Center, Denver; and the Department of Pathology, Veterans Affairs Medical Center, Denver, Colo (Dr Sun)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"key":"i1543-2165-129-4-527-b1","article-title":"Pathology and Genetics of Tumours of the Haematopoietic and Lymphoid Tissues.","author":"Jaffe, E. S.","unstructured":"Jaffe, E. S., N. L.Harris, H.Stein, and J. W.Vardiman. eds. Pathology and Genetics of Tumours of the Haematopoietic and Lymphoid Tissues.Lyon, France: IARC Press; 2001:193, 204\u2013209, 212\u2013213, 227\u2013229. World Health Organization Classification of Tumours; vol 3."},{"key":"i1543-2165-129-4-527-b2","series-title":"Semin Hematol","first-page":"175","article-title":"Classification of cytotoxic T-cell and natural killer cell lymphomas.","volume":"40","author":"Jaffe, E. S.","year":"2003","unstructured":"Jaffe, E. S., L.Krenacs, and M.Raffeld. Classification of cytotoxic T-cell and natural killer cell lymphomas.Semin Hematol2003. 40:175\u2013184."},{"key":"i1543-2165-129-4-527-b3","series-title":"Blood","first-page":"4501","article-title":"Nonnasal lymphoma expressing the natural killer cell marker CD56: a clinicopathologic study of 49 cases of an uncommon aggressive neoplasm.","volume":"89","author":"Chan, J. K.","year":"1997","unstructured":"Chan, J. K., V. C.Sin, and K. F.Wong. et al. Nonnasal lymphoma expressing the natural killer cell marker CD56: a clinicopathologic study of 49 cases of an uncommon aggressive neoplasm.Blood1997. 89:4501\u20134513."},{"key":"i1543-2165-129-4-527-b4","series-title":"Am J Clin Pathol","first-page":"s104","article-title":"The role of morphologic features, phenotype, genotype and anatomic site in defining extranodal T-cell or NK-cell neoplasms.","volume":"111","author":"Kinney, M.","year":"1999","unstructured":"Kinney, M.\n          \n          The role of morphologic features, phenotype, genotype and anatomic site in defining extranodal T-cell or NK-cell neoplasms.\n          Am J Clin Pathol\n          1999. 111:(suppl 1). s104\u2013s118."},{"key":"i1543-2165-129-4-527-b5","series-title":"Ann Oncol","first-page":"849","article-title":"Peripheral T-cell lymphomas: initial features, natural history, and prognostic factors in a series of 174 patients diagnosed according to the R.E.A.L. Classification.","volume":"9","author":"Lopez-Guillermo, A.","year":"1998","unstructured":"Lopez-Guillermo, A., J.Cid, and A.Salar. et al. Peripheral T-cell lymphomas: initial features, natural history, and prognostic factors in a series of 174 patients diagnosed according to the R.E.A.L. Classification.Ann Oncol1998. 9:849\u2013855."},{"key":"i1543-2165-129-4-527-b6","series-title":"Blood","first-page":"2432","article-title":"Neural cell adhesion molecule-positive peripheral T-cell lymphoma: a rare variant with a propensity for unusual sites of involvement.","volume":"79","author":"Kern, D. E.","year":"1992","unstructured":"Kern, D. E., P. G.Kidd, and R.Moe. et al. Neural cell adhesion molecule-positive peripheral T-cell lymphoma: a rare variant with a propensity for unusual sites of involvement.Blood1992. 79:2432\u20132437."},{"key":"i1543-2165-129-4-527-b7","series-title":"Leuk Lymphoma","first-page":"317","article-title":"Expression of cytotoxic proteins in peripheral T-cell and natural killer-cell (NK) lymphomas: association with extranodal site, NK or T-\u03b3\u03b4 phenotype, anaplastic morphology and CD30 expression.","volume":"38","author":"Kanavaros, P.","year":"2000","unstructured":"Kanavaros, P., M. L.Boulland, B.Petit, B.Arnulf, and P. H.Gaulard. Expression of cytotoxic proteins in peripheral T-cell and natural killer-cell (NK) lymphomas: association with extranodal site, NK or T-\u03b3\u03b4 phenotype, anaplastic morphology and CD30 expression.Leuk Lymphoma2000. 38:317\u2013326."},{"key":"i1543-2165-129-4-527-b8","series-title":"Am J Surg Pathol","first-page":"284","article-title":"Clinicopathologic study of CD56 (NCAM)-positive angiocentric lymphoma occurring in sites other than the upper and lower respiratory tract.","volume":"19","author":"Nakamura, S.","year":"1995","unstructured":"Nakamura, S., T.Suchi, and T.Koshikawa. et al. Clinicopathologic study of CD56 (NCAM)-positive angiocentric lymphoma occurring in sites other than the upper and lower respiratory tract.Am J Surg Pathol1995. 19:284\u2013296."},{"key":"i1543-2165-129-4-527-b9","series-title":"Am J Pathol","first-page":"1483","article-title":"Most CD56+ intestinal lymphomas are CD8+CD5\u2212 T-cell lymphomas of monomorphic small to medium size histology.","volume":"153","author":"Chott, A.","year":"1998","unstructured":"Chott, A., W.Haedicke, and I.Mosberger. et al. Most CD56+ intestinal lymphomas are CD8+CD5\u2212 T-cell lymphomas of monomorphic small to medium size histology.Am J Pathol1998. 153:1483\u20131490."},{"key":"i1543-2165-129-4-527-b10","series-title":"Virchows Arch","first-page":"425","article-title":"Classification of cell lineage and anatomical site, and prognosis of extranodal T-cell lymphoma-natural killer cell, cytotoxic T lymphocyte, and no-NK\/CTL types.","volume":"440","author":"Ohshima, K.","year":"2002","unstructured":"Ohshima, K., L.Qiang, and K.Tetsuya. et al. Classification of cell lineage and anatomical site, and prognosis of extranodal T-cell lymphoma-natural killer cell, cytotoxic T lymphocyte, and no-NK\/CTL types.Virchows Arch2002. 440:425\u2013435."},{"key":"i1543-2165-129-4-527-b11","series-title":"Arch Pathol Lab Med","first-page":"2142","article-title":"Natural killer-like T-cell lymphoma of the small intestine with a distinct immunophenotype and lack of association with gluten-sensitive enteropathy.","volume":"127","author":"Yuan, C.","year":"2003","unstructured":"Yuan, C., S.Stein, and J.Glick. et al. Natural killer-like T-cell lymphoma of the small intestine with a distinct immunophenotype and lack of association with gluten-sensitive enteropathy.Arch Pathol Lab Med2003. 127:2142\u20132146."},{"key":"i1543-2165-129-4-527-b12","series-title":"Leuk Lymphoma","first-page":"201","article-title":"Natural killer cell lymphoma in the duodenum.","volume":"44","author":"Sumi, M.","year":"2003","unstructured":"Sumi, M., T.Tauchi, and G.Sahida. et al. Natural killer cell lymphoma in the duodenum.Leuk Lymphoma2003. 44:201\u2013204."},{"key":"i1543-2165-129-4-527-b13","series-title":"Mod Pathol","first-page":"467","article-title":"Aggressive natural killer cell lymphoma of the small intestine.","volume":"8","author":"Martin, A.","year":"1995","unstructured":"Martin, A., W.Chan, and D.Perry. et al. Aggressive natural killer cell lymphoma of the small intestine.Mod Pathol1995. 8:467\u2013472."},{"key":"i1543-2165-129-4-527-b14","series-title":"Am J Surg Pathol","first-page":"17","article-title":"T-cell lymphoma involving subcutaneous tissue: a clinicopathologic entity commonly associated with hemophagocytic syndrome.","volume":"15","author":"Gonzales, C. L.","year":"1991","unstructured":"Gonzales, C. L., L. J.Medeiros, R. M.Braziel, and E. S.Jaffe. T-cell lymphoma involving subcutaneous tissue: a clinicopathologic entity commonly associated with hemophagocytic syndrome.Am J Surg Pathol1991. 15:17\u201327."},{"key":"i1543-2165-129-4-527-b15","series-title":"Ann Oncol","first-page":"717","article-title":"Epidemiology of the non-Hodgkin lymphomas: distributions of the major subtypes differ by geographic locations.","volume":"9","year":"1998","unstructured":"for the Non-Hodgkin Lymphoma Classification Project.\n          \n          Epidemiology of the non-Hodgkin lymphomas: distributions of the major subtypes differ by geographic locations.\n          Ann Oncol\n          1998. 9:717\u2013720."},{"key":"i1543-2165-129-4-527-b1","article-title":"Pathology and Genetics of Tumours of the Haematopoietic and Lymphoid Tissues.","author":"Jaffe, E. S.","unstructured":"Jaffe, E. S., N. L.Harris, H.Stein, and J. W.Vardiman. eds. Pathology and Genetics of Tumours of the Haematopoietic and Lymphoid Tissues.Lyon, France: IARC Press; 2001:193, 204\u2013209, 212\u2013213, 227\u2013229. World Health Organization Classification of Tumours; vol 3."},{"key":"i1543-2165-129-4-527-b2","series-title":"Semin Hematol","first-page":"175","article-title":"Classification of cytotoxic T-cell and natural killer cell lymphomas.","volume":"40","author":"Jaffe, E. S.","year":"2003","unstructured":"Jaffe, E. S., L.Krenacs, and M.Raffeld. Classification of cytotoxic T-cell and natural killer cell lymphomas.Semin Hematol2003. 40:175\u2013184."},{"key":"i1543-2165-129-4-527-b3","series-title":"Blood","first-page":"4501","article-title":"Nonnasal lymphoma expressing the natural killer cell marker CD56: a clinicopathologic study of 49 cases of an uncommon aggressive neoplasm.","volume":"89","author":"Chan, J. K.","year":"1997","unstructured":"Chan, J. K., V. C.Sin, and K. F.Wong. et al. Nonnasal lymphoma expressing the natural killer cell marker CD56: a clinicopathologic study of 49 cases of an uncommon aggressive neoplasm.Blood1997. 89:4501\u20134513."},{"key":"i1543-2165-129-4-527-b4","series-title":"Am J Clin Pathol","first-page":"s104","article-title":"The role of morphologic features, phenotype, genotype and anatomic site in defining extranodal T-cell or NK-cell neoplasms.","volume":"111","author":"Kinney, M.","year":"1999","unstructured":"Kinney, M.\n          \n          The role of morphologic features, phenotype, genotype and anatomic site in defining extranodal T-cell or NK-cell neoplasms.\n          Am J Clin Pathol\n          1999. 111:(suppl 1). s104\u2013s118."},{"key":"i1543-2165-129-4-527-b5","series-title":"Ann Oncol","first-page":"849","article-title":"Peripheral T-cell lymphomas: initial features, natural history, and prognostic factors in a series of 174 patients diagnosed according to the R.E.A.L. Classification.","volume":"9","author":"Lopez-Guillermo, A.","year":"1998","unstructured":"Lopez-Guillermo, A., J.Cid, and A.Salar. et al. Peripheral T-cell lymphomas: initial features, natural history, and prognostic factors in a series of 174 patients diagnosed according to the R.E.A.L. Classification.Ann Oncol1998. 9:849\u2013855."},{"key":"i1543-2165-129-4-527-b6","series-title":"Blood","first-page":"2432","article-title":"Neural cell adhesion molecule-positive peripheral T-cell lymphoma: a rare variant with a propensity for unusual sites of involvement.","volume":"79","author":"Kern, D. E.","year":"1992","unstructured":"Kern, D. E., P. G.Kidd, and R.Moe. et al. Neural cell adhesion molecule-positive peripheral T-cell lymphoma: a rare variant with a propensity for unusual sites of involvement.Blood1992. 79:2432\u20132437."},{"key":"i1543-2165-129-4-527-b7","series-title":"Leuk Lymphoma","first-page":"317","article-title":"Expression of cytotoxic proteins in peripheral T-cell and natural killer-cell (NK) lymphomas: association with extranodal site, NK or T-\u03b3\u03b4 phenotype, anaplastic morphology and CD30 expression.","volume":"38","author":"Kanavaros, P.","year":"2000","unstructured":"Kanavaros, P., M. L.Boulland, B.Petit, B.Arnulf, and P. H.Gaulard. Expression of cytotoxic proteins in peripheral T-cell and natural killer-cell (NK) lymphomas: association with extranodal site, NK or T-\u03b3\u03b4 phenotype, anaplastic morphology and CD30 expression.Leuk Lymphoma2000. 38:317\u2013326."},{"key":"i1543-2165-129-4-527-b8","series-title":"Am J Surg Pathol","first-page":"284","article-title":"Clinicopathologic study of CD56 (NCAM)-positive angiocentric lymphoma occurring in sites other than the upper and lower respiratory tract.","volume":"19","author":"Nakamura, S.","year":"1995","unstructured":"Nakamura, S., T.Suchi, and T.Koshikawa. et al. Clinicopathologic study of CD56 (NCAM)-positive angiocentric lymphoma occurring in sites other than the upper and lower respiratory tract.Am J Surg Pathol1995. 19:284\u2013296."},{"key":"i1543-2165-129-4-527-b9","series-title":"Am J Pathol","first-page":"1483","article-title":"Most CD56+ intestinal lymphomas are CD8+CD5\u2212 T-cell lymphomas of monomorphic small to medium size histology.","volume":"153","author":"Chott, A.","year":"1998","unstructured":"Chott, A., W.Haedicke, and I.Mosberger. et al. Most CD56+ intestinal lymphomas are CD8+CD5\u2212 T-cell lymphomas of monomorphic small to medium size histology.Am J Pathol1998. 153:1483\u20131490."},{"key":"i1543-2165-129-4-527-b10","series-title":"Virchows Arch","first-page":"425","article-title":"Classification of cell lineage and anatomical site, and prognosis of extranodal T-cell lymphoma-natural killer cell, cytotoxic T lymphocyte, and no-NK\/CTL types.","volume":"440","author":"Ohshima, K.","year":"2002","unstructured":"Ohshima, K., L.Qiang, and K.Tetsuya. et al. Classification of cell lineage and anatomical site, and prognosis of extranodal T-cell lymphoma-natural killer cell, cytotoxic T lymphocyte, and no-NK\/CTL types.Virchows Arch2002. 440:425\u2013435."},{"key":"i1543-2165-129-4-527-b11","series-title":"Arch Pathol Lab Med","first-page":"2142","article-title":"Natural killer-like T-cell lymphoma of the small intestine with a distinct immunophenotype and lack of association with gluten-sensitive enteropathy.","volume":"127","author":"Yuan, C.","year":"2003","unstructured":"Yuan, C., S.Stein, and J.Glick. et al. Natural killer-like T-cell lymphoma of the small intestine with a distinct immunophenotype and lack of association with gluten-sensitive enteropathy.Arch Pathol Lab Med2003. 127:2142\u20132146."},{"key":"i1543-2165-129-4-527-b12","series-title":"Leuk Lymphoma","first-page":"201","article-title":"Natural killer cell lymphoma in the duodenum.","volume":"44","author":"Sumi, M.","year":"2003","unstructured":"Sumi, M., T.Tauchi, and G.Sahida. et al. Natural killer cell lymphoma in the duodenum.Leuk Lymphoma2003. 44:201\u2013204."},{"key":"i1543-2165-129-4-527-b13","series-title":"Mod Pathol","first-page":"467","article-title":"Aggressive natural killer cell lymphoma of the small intestine.","volume":"8","author":"Martin, A.","year":"1995","unstructured":"Martin, A., W.Chan, and D.Perry. et al. Aggressive natural killer cell lymphoma of the small intestine.Mod Pathol1995. 8:467\u2013472."},{"key":"i1543-2165-129-4-527-b14","series-title":"Am J Surg Pathol","first-page":"17","article-title":"T-cell lymphoma involving subcutaneous tissue: a clinicopathologic entity commonly associated with hemophagocytic syndrome.","volume":"15","author":"Gonzales, C. L.","year":"1991","unstructured":"Gonzales, C. L., L. J.Medeiros, R. M.Braziel, and E. S.Jaffe. T-cell lymphoma involving subcutaneous tissue: a clinicopathologic entity commonly associated with hemophagocytic syndrome.Am J Surg Pathol1991. 15:17\u201327."},{"key":"i1543-2165-129-4-527-b15","series-title":"Ann Oncol","first-page":"717","article-title":"Epidemiology of the non-Hodgkin lymphomas: distributions of the major subtypes differ by geographic locations.","volume":"9","year":"1998","unstructured":"for the Non-Hodgkin Lymphoma Classification Project.\n          \n          Epidemiology of the non-Hodgkin lymphomas: distributions of the major subtypes differ by geographic locations.\n          Ann Oncol\n          1998. 9:717\u2013720."}],"container-title":["Archives of Pathology &amp; Laboratory Medicine"],"original-title":[],"link":[{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/129\/4\/article-p527.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/aplm\/article-pdf\/129\/4\/527\/2756128\/1543-2165(2005)129_527_aucopt_2_0_co_2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/129\/4\/article-p527.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aplm.kglmeridian.com\/downloadpdf\/journals\/arpa\/129\/4\/article-p527.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T01:12:35Z","timestamp":1770772355000},"score":1,"resource":{"primary":{"URL":"https:\/\/aplm.kglmeridian.com\/view\/journals\/arpa\/129\/4\/article-p527.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":30,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.5858\/2005-129-527-aucopt","relation":{},"ISSN":["1543-2165","0003-9985"],"issn-type":[{"value":"1543-2165","type":"electronic"},{"value":"0003-9985","type":"print"}],"subject":[],"published":{"date-parts":[[2005,4]]}}}