{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:22:49Z","timestamp":1788200569676,"version":"build-2803163510"},"reference-count":22,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Clear cell hidradenoma is a benign skin appendage tumor that may mimic conventional-type renal cell carcinoma. Histologically, clear cell hidradenoma contains small ductular lumens, focal apocrine and squamoid change, and a less prominent vascular pattern than renal cell carcinoma. Furthermore, immunohistochemical studies can aid in distinguishing the 2 tumors. Knowing the cytologic features of primary skin adnexal neoplasms helps distinguish them from cutaneous metastases, which are more commonly referred for fine-needle aspiration biopsy evaluation. Detailed clinical history, physical findings, and ancillary studies are essential for correct diagnosis and categorization of these tumors. We report the rare case of a patient with renal cell carcinoma who underwent excision of an axillary clear cell hidradenoma, which was clinically suggestive of cutaneous metastatic disease.<\/jats:p>","DOI":"10.5858\/2005-129-e113-cchamo","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T19:25:50Z","timestamp":1612985150000},"page":"e113-e116","source":"Crossref","is-referenced-by-count":37,"title":["Clear Cell Hidradenoma: A Mimic of Metastatic Clear Cell Tumors"],"prefix":"10.5858","volume":"129","author":[{"given":"Keith E.","family":"Volmar","sequence":"first","affiliation":[{"name":"From the Departments of Pathology (Drs Volmar, Cummings, Wang, Creager, and Xie) and Surgery (Dr Tyler), Duke University Medical Center, Durham, NC. Dr Volmar is now with the Department of Pathology, University of North Carolina, Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Cummings","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Volmar, Cummings, Wang, Creager, and Xie) and Surgery (Dr Tyler), Duke University Medical Center, Durham, NC. Dr Volmar is now with the Department of Pathology, University of North Carolina, Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei Hua","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Volmar, Cummings, Wang, Creager, and Xie) and Surgery (Dr Tyler), Duke University Medical Center, Durham, NC. Dr Volmar is now with the Department of Pathology, University of North Carolina, Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Creager","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Volmar, Cummings, Wang, Creager, and Xie) and Surgery (Dr Tyler), Duke University Medical Center, Durham, NC. Dr Volmar is now with the Department of Pathology, University of North Carolina, Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas S.","family":"Tyler","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Volmar, Cummings, Wang, Creager, and Xie) and Surgery (Dr Tyler), Duke University Medical Center, Durham, NC. Dr Volmar is now with the Department of Pathology, University of North Carolina, Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Bill","family":"Xie","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (Drs Volmar, Cummings, Wang, Creager, and Xie) and Surgery (Dr Tyler), Duke University Medical Center, Durham, NC. Dr Volmar is now with the Department of Pathology, University of North Carolina, Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3906","reference":[{"key":"i1543-2165-129-5-e113-b1","article-title":"Tumors of the epidermal appendages.","author":"Elder, D.","unstructured":"Elder, D., R.Elenitsas, and B. D.Ragsdale. Tumors of the epidermal appendages.In: Lever's Histopathology of the Skin. 8th ed. Philadelphia, Pa: Lippincott-Raven; 1997:747\u2013804."},{"key":"i1543-2165-129-5-e113-b2","article-title":"Sweat gland neoplasms.","author":"Wick, M. R.","unstructured":"Wick, M. R. and P. E.Swanson. Sweat gland neoplasms.In: Cutaneous Adnexal Tumors: A Guide to Pathologic Diagnosis. Chicago, Ill: ASCP Press; 1991:1\u201378."},{"key":"i1543-2165-129-5-e113-b3","article-title":"Tumors of cutaneous appendages.","author":"Weedon, D.","unstructured":"Weedon, D.\n          \n          Tumors of cutaneous appendages.\n          In: Skin Pathology. 2nd ed. London, England: Churchill Livingston; 2002:859\u2013916."},{"key":"i1543-2165-129-5-e113-b4","series-title":"Am J Dermatopathol","first-page":"314","article-title":"Oncocytic nodular hidradenoma.","volume":"18","author":"Roth, M. J.","year":"1996","unstructured":"Roth, M. J., J. B.Stern, Y.Hijazi, H. M.Haupt, and A.Kumar. Oncocytic nodular hidradenoma.Am J Dermatopathol1996. 18:314\u2013316."},{"key":"i1543-2165-129-5-e113-b5","series-title":"J Am Acad Dermatol","first-page":"15","article-title":"Nodular hidradenoma and hidradenocarcinoma: a 10-year review.","volume":"12","author":"Hernandez-Perez, E.","year":"1985","unstructured":"Hernandez-Perez, E. and R.Cestoni-Parducci. Nodular hidradenoma and hidradenocarcinoma: a 10-year review.J Am Acad Dermatol1985. 12:15\u201320."},{"key":"i1543-2165-129-5-e113-b6","series-title":"Diagn Cytopathol","first-page":"395","article-title":"Fine-needle aspiration of nodular hidradenoma: a case report.","volume":"15","author":"Gottschalk-Sabag, S.","year":"1996","unstructured":"Gottschalk-Sabag, S. and T.Glick. Fine-needle aspiration of nodular hidradenoma: a case report.Diagn Cytopathol1996. 15:395\u2013397."},{"key":"i1543-2165-129-5-e113-b7","series-title":"J Cutan Pathol","first-page":"30","article-title":"Histogenesis of clear cell hidradenoma: immunohistochemical study of keratin expression.","volume":"24","author":"Ohnishi, T.","year":"1997","unstructured":"Ohnishi, T. and S.Watanabe. Histogenesis of clear cell hidradenoma: immunohistochemical study of keratin expression.J Cutan Pathol1997. 24:30\u201336."},{"key":"i1543-2165-129-5-e113-b8","series-title":"Dermatol Surg","first-page":"387","article-title":"Nodular hidradenoma: a report of 3 cases and review of the literature.","volume":"24","author":"Stratigos, A. J.","year":"1998","unstructured":"Stratigos, A. J., S.Olbricht, T. H.Kwan, and K. E.Bowers. Nodular hidradenoma: a report of 3 cases and review of the literature.Dermatol Surg1998. 24:387\u2013391."},{"key":"i1543-2165-129-5-e113-b9","series-title":"Am J Dermatopathol","first-page":"592","article-title":"Phenotypic heterogeneity of nodular hidradenoma: immunohistochemical analysis with emphasis on cytokeratin expression.","volume":"18","author":"Biernat, W.","year":"1996","unstructured":"Biernat, W., R.Kordek, and L.Wozniak. Phenotypic heterogeneity of nodular hidradenoma: immunohistochemical analysis with emphasis on cytokeratin expression.Am J Dermatopathol1996. 18:592\u2013596."},{"key":"i1543-2165-129-5-e113-b10","series-title":"Am J Dermatopathol","first-page":"310","article-title":"Immunohistochemistry in the differential diagnosis of nodular hidradenoma and glomus tumor.","volume":"14","author":"Haupt, H. M.","year":"1992","unstructured":"Haupt, H. M., J. B.Stern, and S. J.Berlin. Immunohistochemistry in the differential diagnosis of nodular hidradenoma and glomus tumor.Am J Dermatopathol1992. 14:310\u2013314."},{"key":"i1543-2165-129-5-e113-b11","series-title":"Urol Int","first-page":"164","article-title":"Cutaneous metastases in renal cell carcinoma.","volume":"63","author":"Dorairajan, L. N.","year":"1999","unstructured":"Dorairajan, L. N., A. K.Hemal, and M.Aron. et al. Cutaneous metastases in renal cell carcinoma.Urol Int1999. 63:164\u2013167."},{"key":"i1543-2165-129-5-e113-b1","article-title":"Tumors of the epidermal appendages.","author":"Elder, D.","unstructured":"Elder, D., R.Elenitsas, and B. D.Ragsdale. Tumors of the epidermal appendages.In: Lever's Histopathology of the Skin. 8th ed. Philadelphia, Pa: Lippincott-Raven; 1997:747\u2013804."},{"key":"i1543-2165-129-5-e113-b2","article-title":"Sweat gland neoplasms.","author":"Wick, M. R.","unstructured":"Wick, M. R. and P. E.Swanson. Sweat gland neoplasms.In: Cutaneous Adnexal Tumors: A Guide to Pathologic Diagnosis. Chicago, Ill: ASCP Press; 1991:1\u201378."},{"key":"i1543-2165-129-5-e113-b3","article-title":"Tumors of cutaneous appendages.","author":"Weedon, D.","unstructured":"Weedon, D.\n          \n          Tumors of cutaneous appendages.\n          In: Skin Pathology. 2nd ed. London, England: Churchill Livingston; 2002:859\u2013916."},{"key":"i1543-2165-129-5-e113-b4","series-title":"Am J Dermatopathol","first-page":"314","article-title":"Oncocytic nodular hidradenoma.","volume":"18","author":"Roth, M. J.","year":"1996","unstructured":"Roth, M. J., J. B.Stern, Y.Hijazi, H. M.Haupt, and A.Kumar. Oncocytic nodular hidradenoma.Am J Dermatopathol1996. 18:314\u2013316."},{"key":"i1543-2165-129-5-e113-b5","series-title":"J Am Acad Dermatol","first-page":"15","article-title":"Nodular hidradenoma and hidradenocarcinoma: a 10-year review.","volume":"12","author":"Hernandez-Perez, E.","year":"1985","unstructured":"Hernandez-Perez, E. and R.Cestoni-Parducci. Nodular hidradenoma and hidradenocarcinoma: a 10-year review.J Am Acad Dermatol1985. 12:15\u201320."},{"key":"i1543-2165-129-5-e113-b6","series-title":"Diagn Cytopathol","first-page":"395","article-title":"Fine-needle aspiration of nodular hidradenoma: a case report.","volume":"15","author":"Gottschalk-Sabag, S.","year":"1996","unstructured":"Gottschalk-Sabag, S. and T.Glick. Fine-needle aspiration of nodular hidradenoma: a case report.Diagn Cytopathol1996. 15:395\u2013397."},{"key":"i1543-2165-129-5-e113-b7","series-title":"J Cutan Pathol","first-page":"30","article-title":"Histogenesis of clear cell hidradenoma: immunohistochemical study of keratin expression.","volume":"24","author":"Ohnishi, T.","year":"1997","unstructured":"Ohnishi, T. and S.Watanabe. Histogenesis of clear cell hidradenoma: immunohistochemical study of keratin expression.J Cutan Pathol1997. 24:30\u201336."},{"key":"i1543-2165-129-5-e113-b8","series-title":"Dermatol Surg","first-page":"387","article-title":"Nodular hidradenoma: a report of 3 cases and review of the literature.","volume":"24","author":"Stratigos, A. J.","year":"1998","unstructured":"Stratigos, A. J., S.Olbricht, T. H.Kwan, and K. E.Bowers. Nodular hidradenoma: a report of 3 cases and review of the literature.Dermatol Surg1998. 24:387\u2013391."},{"key":"i1543-2165-129-5-e113-b9","series-title":"Am J Dermatopathol","first-page":"592","article-title":"Phenotypic heterogeneity of nodular hidradenoma: immunohistochemical analysis with emphasis on cytokeratin expression.","volume":"18","author":"Biernat, W.","year":"1996","unstructured":"Biernat, W., R.Kordek, and L.Wozniak. 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