{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:12:47Z","timestamp":1770822767364,"version":"3.50.1"},"reference-count":15,"publisher":"Archives of Pathology and Laboratory Medicine","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We present a case of aldosterone-secreting adrenocortical carcinoma with concomitant myelolipoma. To the best of our knowledge, this is the first such reported case. The patient was a 43-year-old man with severe hypertension. Clinical workup revealed an increased serum aldosterone level, hypokalemia, and metabolic alkalosis, and a left adrenal mass was found on computed tomography. The patient underwent a unilateral adrenalectomy, which led to improvement in blood pressure, the serum potassium level, and aldosterone concentration. The tumor weighed 70 g and measured 5.0 cm. On microscopic examination, we found necrosis, focal cytologic atypia, diffuse eosinophilic cells comprising more than 75% of the tumor, 5 to 7 mitotic figures per 50 high-power fields, rare atypical mitosis, and venous invasion. At the periphery of the tumor but within the capsule, microscopic areas of myelolipoma were seen. Ki-67 staining was positive in 20% of the tumor cells. Although rare, aldosterone-secreting carcinoma associated with myelolipoma should be included in the differential diagnosis of adrenal gland masses.<\/jats:p>","DOI":"10.5858\/2005-129-e144-acwcmi","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T19:33:40Z","timestamp":1612985620000},"page":"e144-e147","source":"Crossref","is-referenced-by-count":19,"title":["Adrenocortical Carcinoma With Concomitant Myelolipoma in a Patient With Hyperaldosteronism"],"prefix":"10.5858","volume":"129","author":[{"given":"Xichun","family":"Sun","sequence":"first","affiliation":[{"name":"From the Department of Pathology, The University of Texas Medical Branch at Galveston (Drs Sun and Castro); the Department of Pathology, The Methodist Hospital, Houston, Tex (Dr Ayala); and the Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston (Dr Ayala)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Ayala","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, The University of Texas Medical Branch at Galveston (Drs Sun and Castro); the Department of Pathology, The Methodist Hospital, Houston, Tex (Dr Ayala); and the Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston (Dr Ayala)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia Y.","family":"Castro","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, The University of Texas Medical Branch at Galveston (Drs Sun and Castro); the Department of Pathology, The Methodist Hospital, Houston, Tex (Dr Ayala); and the Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston (Dr Ayala)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3906","reference":[{"key":"2021020922510858000_i1543-2165-129-6-e144-b1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/jso.2930550306","article-title":"Adrenal adenocarcinoma: review of 53 cases.","volume":"55","author":"Zografos","year":"1994","journal-title":"J Surg Oncol"},{"key":"2021020922510858000_i1543-2165-129-6-e144-b2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/00000478-198403000-00001","article-title":"Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors.","volume":"8","author":"Weiss","year":"1984","journal-title":"Am J Surg Pathol"},{"key":"2021020922510858000_i1543-2165-129-6-e144-b3","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1067\/msy.2002.128476","article-title":"Aldosterone-secreting adrenocortical carcinomas are associated with unique operative risks and outcomes.","volume":"132","author":"Kendrick","year":"2002","journal-title":"Surgery"},{"key":"2021020922510858000_i1543-2165-129-6-e144-b4","doi-asserted-by":"crossref","first-page":"736","DOI":"10.5858\/2002-126-0736-MAWAG","article-title":"Myelolipoma associated with adrenal ganglioneuroma.","volume":"126","author":"Merchant","year":"2002","journal-title":"Arch Pathol Lab Med"},{"key":"2021020922510858000_i1543-2165-129-6-e144-b5","first-page":"895","article-title":"Hematopoietic elements associated with adrenal glands: a study of the spectrum of change in nine cases.","volume":"118","author":"Goetz","year":"1994","journal-title":"Arch Pathol Lab Med"},{"key":"2021020922510858000_i1543-2165-129-6-e144-b6","doi-asserted-by":"crossref","first-page":"329","DOI":"10.5858\/2003-127-e329-CMTOTA","article-title":"Corticomedullary mixed tumor of the adrenal gland with concurrent adrenal myelolipoma.","volume":"127","author":"Chu","year":"2003","journal-title":"Arch Pathol Lab Med"},{"key":"2021020922510858000_i1543-2165-129-6-e144-b7","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s003450050101","article-title":"Adrenocortical carcinoma.","volume":"17","author":"Schulick","year":"1999","journal-title":"World J Urol"},{"key":"2021020922510858000_i1543-2165-129-6-e144-b8","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/1097-0142(197907)44:1<239::AID-CNCR2820440139>3.0.CO;2-R","article-title":"Adrenal cortical carcinoma: clinical and pathologic study of 49 cases.","volume":"44","author":"King","year":"1979","journal-title":"Cancer"},{"key":"2021020922510858000_i1543-2165-129-6-e144-b9","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1365-2559.1984.tb02328.x","article-title":"An unusual variant of MEN syndrome: a case report.","volume":"8","author":"Banik","year":"1984","journal-title":"Histopathology"},{"key":"2021020922510858000_i1543-2165-129-6-e144-b10","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1148\/radiology.208.1.9646797","article-title":"Myelolipoma: CT and pathologic features.","volume":"208","author":"Kenney","year":"1998","journal-title":"Radiology"},{"key":"2021020922510858000_i1543-2165-129-6-e144-b11","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1097\/00004728-198509000-00024","article-title":"Adrenal myelolipoma associated with Conn syndrome: CT evaluation.","volume":"9","author":"Whaley","year":"1985","journal-title":"J Comput Assist Tomogr"},{"key":"2021020922510858000_i1543-2165-129-6-e144-b12","doi-asserted-by":"crossref","first-page":"227","DOI":"10.5858\/2003-127-227-COMACW","article-title":"A case of myxoid adrenocortical carcinoma with extensive lipomatous metaplasia.","volume":"127","author":"Izumi","year":"2003","journal-title":"Arch Pathol Lab Med"},{"key":"2021020922510858000_i1543-2165-129-6-e144-b13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/ajcp\/97.1.73","article-title":"New developments in the pathologic diagnosis of adrenal cortical neoplasms: a review.","volume":"97","author":"Medeiros","year":"1992","journal-title":"Am J Clin Pathol"},{"key":"2021020922510858000_i1543-2165-129-6-e144-b14","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/00000478-198903000-00004","article-title":"Pathological features of prognostic significance in adrenocortical carcinoma.","volume":"13","author":"Weiss","year":"1989","journal-title":"Am J Surg Pathol"},{"key":"2021020922510858000_i1543-2165-129-6-e144-b15","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0090-4295(00)00852-9","article-title":"Immunohistochemical assessment of Ki-67 in the differential diagnosis of adrenocortical tumors.","volume":"57","author":"Terzolo","year":"2001","journal-title":"Urology"}],"container-title":["Archives of Pathology &amp; 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